Details for: SPN

Gene ID: 6693

Symbol: SPN

Ensembl ID: ENSG00000197471

Description: sialophorin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.32
    Marker Score: 6775
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.18
    Marker Score: 22138
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.18
    Marker Score: 6887
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.12
    Marker Score: 1535
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.01
    Marker Score: 51509
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.99
    Marker Score: 639
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.89
    Marker Score: 12074
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.74
    Marker Score: 7122
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.73
    Marker Score: 4188
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.72
    Marker Score: 741
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.69
    Marker Score: 2495
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.67
    Marker Score: 584
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.63
    Marker Score: 9885
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.58
    Marker Score: 1386
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1140
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.52
    Marker Score: 2962
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.48
    Marker Score: 14655
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.47
    Marker Score: 1482
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.47
    Marker Score: 732
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.45
    Marker Score: 1397
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.44
    Marker Score: 4047
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.42
    Marker Score: 3921
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.42
    Marker Score: 440
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.41
    Marker Score: 1947
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.4
    Marker Score: 956
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.39
    Marker Score: 1052
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.34
    Marker Score: 1900
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.32
    Marker Score: 15311.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.31
    Marker Score: 5609
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.29
    Marker Score: 631
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.28
    Marker Score: 1305.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.28
    Marker Score: 929
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.28
    Marker Score: 736
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.27
    Marker Score: 319
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.26
    Marker Score: 3131
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.25
    Marker Score: 66315
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.25
    Marker Score: 845
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.25
    Marker Score: 616
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.2
    Marker Score: 304
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.19
    Marker Score: 758
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.19
    Marker Score: 2131
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.18
    Marker Score: 994
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.16
    Marker Score: 2831
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.16
    Marker Score: 1285
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.15
    Marker Score: 844
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.15
    Marker Score: 1206
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.14
    Marker Score: 2229
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4757
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.13
    Marker Score: 581
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.11
    Marker Score: 481
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.11
    Marker Score: 365
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.1
    Marker Score: 864
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.1
    Marker Score: 605
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.09
    Marker Score: 535
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.08
    Marker Score: 693
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.07
    Marker Score: 778.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.07
    Marker Score: 59686
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.06
    Marker Score: 371
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.06
    Marker Score: 322
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.04
    Marker Score: 640
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.03
    Marker Score: 1873
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.02
    Marker Score: 537
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71751
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47977
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.99
    Marker Score: 924
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.97
    Marker Score: 1263
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.97
    Marker Score: 559
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.97
    Marker Score: 863.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 655
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.96
    Marker Score: 2623
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.96
    Marker Score: 789
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 397
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.94
    Marker Score: 801
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.93
    Marker Score: 1604
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.93
    Marker Score: 1230
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.93
    Marker Score: 965
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.91
    Marker Score: 659
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5190
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.9
    Marker Score: 236
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.88
    Marker Score: 1004
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.88
    Marker Score: 658
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.87
    Marker Score: 2243.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.86
    Marker Score: 590
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.85
    Marker Score: 501
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.85
    Marker Score: 193
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.85
    Marker Score: 1001
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.84
    Marker Score: 185
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.81
    Marker Score: 212
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.78
    Marker Score: 216
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.77
    Marker Score: 333
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1240

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Other Information

**Key Characteristics:** The SPN gene is characterized by its involvement in multiple signaling pathways, including apoptotic signaling, cell surface receptor signaling, and immune response regulation. It also interacts with various proteins, such as heat shock proteins, Hsp70, and leukocyte-specific proteins, such as LEUK_HUMAN (Leukosialin). The gene's expression is widespread, with significant expression in innate lymphoid cells, T cells, monocytes, and other cell types. Notably, SPN is also involved in negative regulation of cell adhesion, T cell proliferation, and type IV hypersensitivity reactions. **Pathways and Functions:** SPN's involvement in multiple signaling pathways underscores its multifaceted role in immune regulation. Key pathways include: 1. **Apoptotic signaling pathway**: SPN modulates apoptosis by interacting with pro-apoptotic proteins, thereby regulating cell death and survival. 2. **Cell surface receptor signaling pathway**: SPN acts as a transmembrane receptor, mediating signals that regulate cell adhesion, migration, and proliferation. 3. **Immune response regulation**: SPN influences the immune response by modulating the activity of immune cells, including T cells, monocytes, and natural killer cells. 4. **Cell surface interactions at the vascular wall**: SPN interacts with endothelial cells, modulating leukocyte recruitment and inflammation. 5. **Cell surface receptor signaling pathway**: SPN regulates signaling pathways involved in cell adhesion, migration, and proliferation. **Clinical Significance:** The clinical significance of SPN lies in its potential role in various diseases, including: 1. **Immune-related disorders**: Dysregulation of SPN may contribute to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer**: Alterations in SPN expression may influence tumor progression and metastasis. 3. **Infectious diseases**: SPN's role in regulating immune responses may impact the outcome of infections, such as HIV and tuberculosis. 4. **Vascular diseases**: SPN's interaction with endothelial cells may contribute to the development of vascular diseases, such as atherosclerosis and hypertension. In conclusion, the SPN gene is a complex and multifaceted regulator of immune responses and cellular processes. Further research is necessary to fully elucidate the clinical significance of SPN and its potential as a therapeutic target for various diseases.

Genular Protein ID: 4061138004

Symbol: LEUK_HUMAN

Name: Leukosialin

UniProtKB Accession Codes:

P16150 A8K9B1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 37 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2521952

Title: Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16.

PubMed ID: 2521952

DOI: 10.1073/pnas.86.4.1328

PubMed ID: 2784859

Title: Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.

PubMed ID: 2784859

DOI: 10.1073/pnas.86.8.2819

PubMed ID: 2241892

Title: Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins.

PubMed ID: 2241892

DOI: 10.1042/bj2700569

PubMed ID: 1827122

Title: A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes.

PubMed ID: 1827122

DOI: 10.1016/s0021-9258(18)93000-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1731338

Title: Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin).

PubMed ID: 1731338

DOI: 10.1073/pnas.89.2.663

PubMed ID: 3711098

Title: Purification and chemical composition of gpL115, the human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome.

PubMed ID: 3711098

DOI: 10.1016/s0021-9258(17)38423-5

PubMed ID: 2530225

Title: Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate.

PubMed ID: 2530225

DOI: 10.1016/s0021-9258(18)51541-6

PubMed ID: 15003504

Title: CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression.

PubMed ID: 15003504

DOI: 10.1016/j.bbrc.2004.02.011

PubMed ID: 15540986

Title: Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

PubMed ID: 15540986

DOI: 10.1042/bj20041387

PubMed ID: 18036228

Title: CD43 signals induce type one lineage commitment of human CD4+ T cells.

PubMed ID: 18036228

DOI: 10.1186/1471-2172-8-30

PubMed ID: 18586676

Title: The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase.

PubMed ID: 18586676

DOI: 10.1074/jbc.m710286200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24328034

Title: CD43 signals prepare human T cells to receive cytokine differentiation signals.

PubMed ID: 24328034

DOI: 10.1002/jcp.24430

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 400
  • Mass: 40322
  • Checksum: C9C9AB8435D5E1FE
  • Sequence:
    • MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT SDPKADSTGD 
QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI KMSSVPQETP HATSHPAVPI 
TANSLGSHTV TGGTITTNSP ETSSRTSGAP VTTAASSLET SRGTSGPPLT MATVSLETSK 
GTSGPPVTMA TDSLETSTGT TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA 
STVPFRNPDE NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV 
DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK SRQGSLAMEE 
LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.