Details for: SPN

Gene ID: 6693

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SPN

Ensembl ID: ENSG00000197471

Description: sialophorin

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD14-low, CD16-positive monocyte CL0002396
    CSI 97.22
    rCSI 74.9%
    PRS 13.86
  • hematopoietic stem cell CL0000037
    CSI 58.9
    rCSI 39.15%
    PRS 18.18
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 57.78
    rCSI 52.18%
    PRS 13.52
  • common myeloid progenitor CL0000049
    CSI 54.74
    rCSI 44.26%
    PRS 15.08
  • granulocyte monocyte progenitor cell CL0000557
    CSI 31.99
    rCSI 27.7%
    PRS 17.04
  • activated type II NK T cell CL0000931
    CSI 25.35
    rCSI 28.53%
    PRS 24.35
  • promyelocyte CL0000836
    CSI 25.21
    rCSI 36.36%
    PRS 21.15
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 20.06
    rCSI 13.37%
    PRS 38.32
  • common lymphoid progenitor CL0000051
    CSI 19.04
    rCSI 25.44%
    PRS 28.85
  • GABAergic neuron CL0000617
    CSI 11.82
    rCSI 39.61%
    PRS 10.35
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 10.78
    rCSI 55.67%
    PRS 29.53
  • hematopoietic precursor cell CL0008001
    CSI 10.12
    rCSI 10.41%
    PRS 24.71
  • basophil mast progenitor cell CL0002028
    CSI 9.62
    rCSI 51.32%
    PRS 52.98
  • double negative thymocyte CL0002489
    CSI 7.47
    rCSI 5.19%
    PRS 17.88
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 7.27
    rCSI 28.29%
    PRS 24.84
  • eosinophil CL0000771
    CSI 6.13
    rCSI 40.2%
    PRS 38.55
  • group 3 innate lymphoid cell CL0001071
    CSI 5.62
    rCSI 4.23%
    PRS 15.85
  • gamma-delta T cell CL0000798
    CSI 5.37
    rCSI 6.31%
    PRS 70.32
  • helper T cell CL0000912
    CSI 5
    rCSI 7.07%
    PRS 21
  • megakaryocyte progenitor cell CL0000553
    CSI 4.75
    rCSI 86.87%
    PRS 43.42
  • thymocyte CL0000893
    CSI 4.65
    rCSI 16.53%
    PRS 46.19
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 4.53
    rCSI 3.4%
    PRS 42.25
  • non-classical monocyte CL0000875
    CSI 4.36
    rCSI 7%
    PRS 44.25
  • mature NK T cell CL0000814
    CSI 3.6
    rCSI 4.61%
    PRS 56.02
  • alveolar macrophage CL0000583
    CSI 3.28
    rCSI 5.39%
    PRS 17.77
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 3.12
    rCSI 3.26%
    PRS 43.71
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 2.57
    rCSI 2.06%
    PRS 27.28
  • Langerhans cell CL0000453
    CSI 2.33
    rCSI 3.56%
    PRS 26.57
  • primitive red blood cell CL0002355
    CSI 2.25
    rCSI 12.12%
    PRS 27.76
  • common dendritic progenitor CL0001029
    CSI 2.2
    rCSI 2.76%
    PRS 19.45
  • erythroid progenitor cell CL0000038
    CSI 2.17
    rCSI 12.45%
    PRS 23.27
  • promonocyte CL0000559
    CSI 2.16
    rCSI 3.7%
    PRS 20.49
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 2.1
    rCSI 2.86%
    PRS 35.9
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 1.73
    rCSI 1.31%
    PRS 19.94
  • small pre-B-II cell CL0000954
    CSI 1.47
    rCSI 1.41%
    PRS 31.03
  • plasmablast CL0000980
    CSI 1.39
    rCSI 1.09%
    PRS 18.12
  • naive T cell CL0000898
    CSI 1.38
    rCSI 0.96%
    PRS 21.46
  • immature B cell CL0000816
    CSI 1.34
    rCSI 1%
    PRS 22.39
  • plasmacytoid dendritic cell, human CL0001058
    CSI 1.32
    rCSI 0.92%
    PRS 15.99
  • mononuclear phagocyte CL0000113
    CSI 1.29
    rCSI 2.84%
    PRS 16.88
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.26
    rCSI 1.29%
    PRS 21.62
  • precursor B cell CL0000817
    CSI 1.26
    rCSI 1.1%
    PRS 20.07
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 1.26
    rCSI 3.25%
    PRS 38.72
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 1.24
    rCSI 1.93%
    PRS 36.08
  • mucosal invariant T cell CL0000940
    CSI 1.07
    rCSI 0.86%
    PRS 24.17
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.01
    rCSI 1.38%
    PRS 30.85
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 0.94
    rCSI 0.93%
    PRS 42.28
  • early lymphoid progenitor CL0000936
    CSI 0.91
    rCSI 0.8%
    PRS 17.16
  • T-helper 17 cell CL0000899
    CSI 0.86
    rCSI 0.68%
    PRS 26.91
  • memory T cell CL0000813
    CSI 0.83
    rCSI 1.59%
    PRS 33.85
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 0.77
    rCSI 0.45%
    PRS 20.91
  • mature T cell CL0002419
    CSI 0.75
    rCSI 0.58%
    PRS 21.95
  • innate lymphoid cell CL0001065
    CSI 0.69
    rCSI 1.42%
    PRS 22.85
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 0.66
    rCSI 1.59%
    PRS 24.07
  • natural T-regulatory cell CL0000903
    CSI 0.66
    rCSI 1.25%
    PRS 40.61
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.61
    rCSI 3.04%
    PRS 19.91
  • monocyte CL0000576
    CSI 0.6
    rCSI 1.09%
    PRS 39.8
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 0.57
    rCSI 0.74%
    PRS 21.37
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 0.56
    rCSI 0.55%
    PRS 23.76
  • T follicular helper cell CL0002038
    CSI 0.53
    rCSI 0.4%
    PRS 24.49
  • intermediate monocyte CL0002393
    CSI 0.52
    rCSI 0.78%
    PRS 15.08
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 0.48
    rCSI 0.35%
    PRS 20.71
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 0.46
    rCSI 0.55%
    PRS 17.94
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 0.45
    rCSI 0.41%
    PRS 22.97
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 0.42
    rCSI 0.84%
    PRS 25.41
  • fraction A pre-pro B cell CL0002045
    CSI 0.41
    rCSI 0.47%
    PRS 30.87
  • professional antigen presenting cell CL0000145
    CSI 0.37
    rCSI 1.26%
    PRS 51.95
  • mature alpha-beta T cell CL0000791
    CSI 0.34
    rCSI 1.25%
    PRS 25.96
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 0.34
    rCSI 0.59%
    PRS 30.26
  • erythrocyte CL0000232
    CSI 0.34
    rCSI 0.77%
    PRS 21.04
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 0.34
    rCSI 3.95%
    PRS 54.5
  • granulocyte CL0000094
    CSI 0.34
    rCSI 0.52%
    PRS 19.25
  • myeloid dendritic cell CL0000782
    CSI 0.33
    rCSI 0.48%
    PRS 22.5
  • intraepithelial lymphocyte CL0002496
    CSI 0.31
    rCSI 0.84%
    PRS 55.69
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 0.3
    rCSI 0.2%
    PRS 18.27
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 0.26
    rCSI 0.31%
    PRS 26.36
  • dendritic cell, human CL0001056
    CSI 0.25
    rCSI 0.39%
    PRS 17.84
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.22
    rCSI 1.35%
    PRS 33.6
  • large pre-B-II cell CL0000957
    CSI 0.21
    rCSI 0.59%
    PRS 25.93
  • erythroblast CL0000765
    CSI 0.18
    rCSI 0.47%
    PRS 24.71
  • myeloid dendritic cell, human CL0001057
    CSI 0.16
    rCSI 0.92%
    PRS 46.53
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 0.14
    rCSI 0.63%
    PRS 50.44
  • antibody secreting cell CL0000946
    CSI 0.13
    rCSI 0.57%
    PRS 57.04
  • myeloid leukocyte CL0000766
    CSI 0.11
    rCSI 0.11%
    PRS 15.47
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.11
    rCSI 1.15%
    PRS 54.16
  • group 2 innate lymphoid cell CL0001069
    CSI 0.08
    rCSI 0.41%
    PRS 49.06
  • megakaryocyte CL0000556
    CSI 0.07
    rCSI 0.31%
    PRS 26.82
  • cytotoxic T cell CL0000910
    CSI 0.07
    rCSI 0.39%
    PRS 22.08
  • double negative T regulatory cell CL0011024
    CSI 0.07
    rCSI 1.25%
    PRS 69.57
  • pre-conventional dendritic cell CL0002010
    CSI 0.07
    rCSI 0.87%
    PRS 46.82
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.06
    rCSI 0.07%
    PRS 19.61
  • pro-B cell CL0000826
    CSI -0.1
    rCSI -0.08%
    PRS 15.23
  • lung macrophage CL1001603
    CSI -0.22
    rCSI -0.5%
    PRS 17.34
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI -1.02
    rCSI -2.93%
    PRS 22.18
  • IgA plasma cell CL0000987
    CSI -1.16
    rCSI -1.18%
    PRS 28.12
  • CD4-positive helper T cell CL0000492
    CSI -1.63
    rCSI -1.23%
    PRS 20.84
  • elicited macrophage CL0000861
    CSI -2.8
    rCSI -2.57%
    PRS 17.51
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI -3.54
    rCSI -3.27%
    PRS 27.48
  • alpha-beta T cell CL0000789
    CSI -10.93
    rCSI -12.81%
    PRS 20.26

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SPN](/details-gene/6693), also known as sialophorin (CD43), is a protein-coding gene located on chromosome 16p11.2. It encodes leukosialin, a major sialoglycoprotein expressed on the surface of most hematopoietic cells. Functionally, [SPN](/details-gene/6693) acts as a transmembrane signaling receptor involved in a wide array of immune processes, including cell adhesion, migration, T-cell activation, and defense responses. Expression data indicate that **Overall**, [SPN](/details-gene/6693) is a particularly significant marker for myeloid lineage cells, especially the [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) population, and is highly expressed in various hematopoietic progenitor cells. Clinically, defects in this gene are associated with Wiskott-Aldrich syndrome ([OMIM: 182160](https://omim.org/entry/182160)), an X-linked immunodeficiency, underscoring its critical role in immune system development and function ([Link](https://doi.org/10.1073/pnas.86.8.2819)). ## Cellular Roles and Expression Landscape The expression profile of [SPN](/details-gene/6693) firmly establishes its identity as a key gene within the hematopoietic system. **Overall**, its significance is highest in cells of the myeloid lineage and in hematopoietic precursors. It is the top marker for [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 97.22), a subset of monocytes involved in inflammatory responses. Furthermore, its high significance in a cascade of progenitor cells, including [hematopoietic stem cell](/details-cell/CL0000037), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), [common myeloid progenitor](/details-cell/CL0000049), and [granulocyte monocyte progenitor cell](/details-cell/CL0000557), suggests a fundamental role beginning at the earliest stages of blood cell development. While primarily associated with the myeloid lineage, [SPN](/details-gene/6693) also shows relevance in certain lymphoid populations, such as [activated type II NK T cell](/details-cell/CL0000931) and [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939), consistent with its function in the broader immune response. Conversely, the gene's low to negative significance in several mature lymphocyte subsets provides crucial context. Its low expression in [alpha-beta T cell](/details-cell/CL0000789) and [activated CD4-positive, alpha-beta T cell](/details-cell/CL0000896) indicates that while [SPN](/details-gene/6693) is involved in T-cell biology, it may not be a ubiquitous marker of all mature T-cells, potentially playing a more specialized role during development, activation, or in specific subsets. This pattern suggests that its expression is dynamically regulated as cells differentiate and mature within the hematopoietic tree. ## Pathways and Molecular Function The molecular functions of [SPN](/details-gene/6693) are intrinsically linked to its role as a [transmembrane signaling receptor activity](/details-cell/GO:0004888) located on the [external side of plasma membrane](/details-cell/GO:0009897). Its protein product, CD43, participates in a diverse set of biological processes critical for immune surveillance and response. The gene is annotated to pathways such as [immune response](/details-cell/GO:0006955), [cellular defense response](/details-cell/GO:0006968), and [defense response to bacterium](/details-cell/GO:0042742), which aligns with its high expression in monocytes and natural killer cells. A notable aspect of [SPN](/details-gene/6693) function is its complex, dual role in T-cell regulation. Gene Ontology annotations point to its involvement in both [positive regulation of t cell proliferation](/details-cell/GO:0042102) and [negative regulation of t cell proliferation](/details-cell/GO:0042130), as well as [T cell costimulation](/details-cell/GO:0031295). This suggests that the signaling output of CD43 is highly context-dependent, potentially influenced by post-translational modifications, ligand binding, or interaction with other surface molecules. Research has shown that CD43 signaling can drive the commitment of human CD4+ T cells toward a Th1 lineage ([Link](https://doi.org/10.1186/1471-2172-8-30)), supporting its role in shaping adaptive immune responses. Furthermore, its involvement in processes like [negative regulation of cell adhesion](/details-cell/GO:0007162) and the Reactome pathway [Cell surface interactions at the vascular wall](/details-cell/R-HSA-202733) underscores its function as a physical regulator of cell-cell interactions, likely contributing to leukocyte trafficking and migration during inflammation. This is supported by its role in [chemotaxis](/details-cell/GO:0006935) and [leukocyte tethering or rolling](/details-cell/GO:0050901). ## Research Directions The intricate and sometimes paradoxical functions of [SPN](/details-gene/6693) present several avenues for future investigation. Its dual role in T-cell regulation and its dynamic expression pattern during hematopoiesis are particularly compelling areas for study. Based on the available data, two testable hypotheses can be proposed: 1. Given its high expression in hematopoietic stem and progenitor cells and its subsequent down-regulation in certain mature lymphocyte lineages, [SPN](/details-gene/6693) may function as a molecular switch influencing cell fate decisions during hematopoiesis. Specifically, the level of CD43 expression on a common lymphoid progenitor may modulate signaling pathways that bias differentiation towards or away from the T-cell lineage. 2. The contradictory roles of [SPN](/details-gene/6693) in T-cell proliferation are likely governed by proteolytic processing of its protein product, CD43. It is hypothesized that the ratio of full-length to cleaved CD43 on the cell surface determines the net signaling outcome upon ligand engagement, with the soluble extracellular domain and the remaining membrane-tethered fragment potentially having distinct or even opposing functions, as suggested by studies on its cleavage ([Link](https://doi.org/10.1074/jbc.m710286200)). A key experiment to test the second hypothesis would be to use primary human CD4+ T-cells and manipulate the proteolytic environment. T-cells could be cultured with specific inhibitors of proteases known to cleave CD43, such as gamma-secretase or cathepsin G. Following T-cell receptor activation, proliferation could be quantified using a dye dilution assay (e.g., CFSE), while cytokine production is measured by ELISA. Simultaneously, the cleavage status of CD43 could be assessed via Western blot or flow cytometry with antibodies specific to the extracellular or intracellular domains. A direct correlation between the inhibition of CD43 cleavage and a shift in proliferative or cytokine response would provide strong evidence that proteolytic processing is a key regulatory mechanism for its function. **Therapeutic Potential:** As a broadly expressed cell surface protein on hematopoietic cells, targeting [SPN](/details-gene/6693) systemically could pose a risk of on-target, off-tumor toxicity. However, its accessibility to antibody-based therapies makes it an attractive candidate in specific contexts. In autoimmune diseases characterized by excessive leukocyte infiltration, an antibody blocking CD43 function could potentially reduce inflammation by modulating cell adhesion and migration. In the context of hematological malignancies, if overexpressed, CD43 could serve as a target for antibody-drug conjugates or CAR-T cell therapy, where the goal would be targeted cell killing. For Wiskott-Aldrich syndrome, therapeutic strategies would focus on restoring its function through gene therapy rather than inhibition.

Genular Protein ID: 4061138004

Symbol: LEUK_HUMAN

Name: Leukosialin

UniProtKB Accession Codes:

P16150 A8K9B1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 37 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2521952

Title: Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16.

PubMed ID: 2521952

DOI: 10.1073/pnas.86.4.1328

PubMed ID: 2784859

Title: Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.

PubMed ID: 2784859

DOI: 10.1073/pnas.86.8.2819

PubMed ID: 2241892

Title: Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins.

PubMed ID: 2241892

DOI: 10.1042/bj2700569

PubMed ID: 1827122

Title: A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes.

PubMed ID: 1827122

DOI: 10.1016/s0021-9258(18)93000-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1731338

Title: Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin).

PubMed ID: 1731338

DOI: 10.1073/pnas.89.2.663

PubMed ID: 3711098

Title: Purification and chemical composition of gpL115, the human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome.

PubMed ID: 3711098

DOI: 10.1016/s0021-9258(17)38423-5

PubMed ID: 2530225

Title: Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate.

PubMed ID: 2530225

DOI: 10.1016/s0021-9258(18)51541-6

PubMed ID: 15003504

Title: CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression.

PubMed ID: 15003504

DOI: 10.1016/j.bbrc.2004.02.011

PubMed ID: 15540986

Title: Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

PubMed ID: 15540986

DOI: 10.1042/bj20041387

PubMed ID: 18036228

Title: CD43 signals induce type one lineage commitment of human CD4+ T cells.

PubMed ID: 18036228

DOI: 10.1186/1471-2172-8-30

PubMed ID: 18586676

Title: The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase.

PubMed ID: 18586676

DOI: 10.1074/jbc.m710286200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24328034

Title: CD43 signals prepare human T cells to receive cytokine differentiation signals.

PubMed ID: 24328034

DOI: 10.1002/jcp.24430

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 400
  • Mass: 40322
  • Checksum: C9C9AB8435D5E1FE
  • Sequence:
    • MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT SDPKADSTGD 
QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI KMSSVPQETP HATSHPAVPI 
TANSLGSHTV TGGTITTNSP ETSSRTSGAP VTTAASSLET SRGTSGPPLT MATVSLETSK 
GTSGPPVTMA TDSLETSTGT TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA 
STVPFRNPDE NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV 
DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK SRQGSLAMEE 
LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP