Details for: SPN

Gene ID: 6693

Symbol: SPN

Ensembl ID: ENSG00000197471

Description: sialophorin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 39.7866
    Cell Significance Index: -16.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.7686
    Cell Significance Index: -15.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.2303
    Cell Significance Index: -15.5500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 22.6721
    Cell Significance Index: 10.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.2393
    Cell Significance Index: -12.9100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 6.9756
    Cell Significance Index: 44.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5939
    Cell Significance Index: -8.1300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 6.0361
    Cell Significance Index: 16.1700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 5.8742
    Cell Significance Index: 38.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.0838
    Cell Significance Index: 109.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0111
    Cell Significance Index: -12.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.1719
    Cell Significance Index: 204.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1244
    Cell Significance Index: 91.7600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 2.9130
    Cell Significance Index: 20.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6355
    Cell Significance Index: -10.4000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 2.1216
    Cell Significance Index: -0.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.5156
    Cell Significance Index: -4.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3524
    Cell Significance Index: 29.3000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.3244
    Cell Significance Index: 13.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1357
    Cell Significance Index: 20.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7649
    Cell Significance Index: 145.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5722
    Cell Significance Index: 56.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4386
    Cell Significance Index: 395.9900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.3609
    Cell Significance Index: 3.8400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.3270
    Cell Significance Index: 3.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2890
    Cell Significance Index: 47.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2129
    Cell Significance Index: 132.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1837
    Cell Significance Index: 19.9800
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1153
    Cell Significance Index: 0.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0754
    Cell Significance Index: 1.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0636
    Cell Significance Index: 4.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0135
    Cell Significance Index: 1.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0087
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0037
    Cell Significance Index: -0.0200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0042
    Cell Significance Index: -0.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0055
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0080
    Cell Significance Index: -4.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0086
    Cell Significance Index: -1.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0107
    Cell Significance Index: -8.1200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0154
    Cell Significance Index: -0.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0157
    Cell Significance Index: -8.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0163
    Cell Significance Index: -2.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0174
    Cell Significance Index: -0.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0186
    Cell Significance Index: -13.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0223
    Cell Significance Index: -0.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0245
    Cell Significance Index: -10.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0269
    Cell Significance Index: -9.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0278
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0301
    Cell Significance Index: -3.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0325
    Cell Significance Index: -9.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0374
    Cell Significance Index: -1.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0412
    Cell Significance Index: -1.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0444
    Cell Significance Index: -8.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0646
    Cell Significance Index: -1.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0653
    Cell Significance Index: -11.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0653
    Cell Significance Index: -2.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0681
    Cell Significance Index: -9.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0704
    Cell Significance Index: -1.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0710
    Cell Significance Index: -4.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0757
    Cell Significance Index: -7.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0946
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0984
    Cell Significance Index: -11.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1010
    Cell Significance Index: -12.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1062
    Cell Significance Index: -13.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1152
    Cell Significance Index: -8.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1344
    Cell Significance Index: -8.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1442
    Cell Significance Index: -6.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1559
    Cell Significance Index: -6.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1573
    Cell Significance Index: -20.1700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1626
    Cell Significance Index: -2.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1682
    Cell Significance Index: -2.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1742
    Cell Significance Index: -10.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1751
    Cell Significance Index: -9.8300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1782
    Cell Significance Index: -1.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1823
    Cell Significance Index: -9.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1877
    Cell Significance Index: -13.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1964
    Cell Significance Index: -10.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2049
    Cell Significance Index: -9.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2105
    Cell Significance Index: -3.5400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2123
    Cell Significance Index: -1.8900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2235
    Cell Significance Index: -3.0400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2687
    Cell Significance Index: -2.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2757
    Cell Significance Index: -2.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2784
    Cell Significance Index: -7.3200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2832
    Cell Significance Index: -2.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2924
    Cell Significance Index: -10.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3020
    Cell Significance Index: -7.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3031
    Cell Significance Index: -15.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3155
    Cell Significance Index: -10.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3199
    Cell Significance Index: -4.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3228
    Cell Significance Index: -10.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3340
    Cell Significance Index: -6.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3394
    Cell Significance Index: -12.4600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3586
    Cell Significance Index: -3.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3589
    Cell Significance Index: -5.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3591
    Cell Significance Index: -4.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SPN gene is characterized by its involvement in multiple signaling pathways, including apoptotic signaling, cell surface receptor signaling, and immune response regulation. It also interacts with various proteins, such as heat shock proteins, Hsp70, and leukocyte-specific proteins, such as LEUK_HUMAN (Leukosialin). The gene's expression is widespread, with significant expression in innate lymphoid cells, T cells, monocytes, and other cell types. Notably, SPN is also involved in negative regulation of cell adhesion, T cell proliferation, and type IV hypersensitivity reactions. **Pathways and Functions:** SPN's involvement in multiple signaling pathways underscores its multifaceted role in immune regulation. Key pathways include: 1. **Apoptotic signaling pathway**: SPN modulates apoptosis by interacting with pro-apoptotic proteins, thereby regulating cell death and survival. 2. **Cell surface receptor signaling pathway**: SPN acts as a transmembrane receptor, mediating signals that regulate cell adhesion, migration, and proliferation. 3. **Immune response regulation**: SPN influences the immune response by modulating the activity of immune cells, including T cells, monocytes, and natural killer cells. 4. **Cell surface interactions at the vascular wall**: SPN interacts with endothelial cells, modulating leukocyte recruitment and inflammation. 5. **Cell surface receptor signaling pathway**: SPN regulates signaling pathways involved in cell adhesion, migration, and proliferation. **Clinical Significance:** The clinical significance of SPN lies in its potential role in various diseases, including: 1. **Immune-related disorders**: Dysregulation of SPN may contribute to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer**: Alterations in SPN expression may influence tumor progression and metastasis. 3. **Infectious diseases**: SPN's role in regulating immune responses may impact the outcome of infections, such as HIV and tuberculosis. 4. **Vascular diseases**: SPN's interaction with endothelial cells may contribute to the development of vascular diseases, such as atherosclerosis and hypertension. In conclusion, the SPN gene is a complex and multifaceted regulator of immune responses and cellular processes. Further research is necessary to fully elucidate the clinical significance of SPN and its potential as a therapeutic target for various diseases.

Genular Protein ID: 4061138004

Symbol: LEUK_HUMAN

Name: Leukosialin

UniProtKB Accession Codes:

P16150 A8K9B1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 37 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2521952

Title: Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16.

PubMed ID: 2521952

DOI: 10.1073/pnas.86.4.1328

PubMed ID: 2784859

Title: Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.

PubMed ID: 2784859

DOI: 10.1073/pnas.86.8.2819

PubMed ID: 2241892

Title: Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins.

PubMed ID: 2241892

DOI: 10.1042/bj2700569

PubMed ID: 1827122

Title: A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes.

PubMed ID: 1827122

DOI: 10.1016/s0021-9258(18)93000-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1731338

Title: Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin).

PubMed ID: 1731338

DOI: 10.1073/pnas.89.2.663

PubMed ID: 3711098

Title: Purification and chemical composition of gpL115, the human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome.

PubMed ID: 3711098

DOI: 10.1016/s0021-9258(17)38423-5

PubMed ID: 2530225

Title: Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate.

PubMed ID: 2530225

DOI: 10.1016/s0021-9258(18)51541-6

PubMed ID: 15003504

Title: CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression.

PubMed ID: 15003504

DOI: 10.1016/j.bbrc.2004.02.011

PubMed ID: 15540986

Title: Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

PubMed ID: 15540986

DOI: 10.1042/bj20041387

PubMed ID: 18036228

Title: CD43 signals induce type one lineage commitment of human CD4+ T cells.

PubMed ID: 18036228

DOI: 10.1186/1471-2172-8-30

PubMed ID: 18586676

Title: The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase.

PubMed ID: 18586676

DOI: 10.1074/jbc.m710286200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24328034

Title: CD43 signals prepare human T cells to receive cytokine differentiation signals.

PubMed ID: 24328034

DOI: 10.1002/jcp.24430

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 400
  • Mass: 40322
  • Checksum: C9C9AB8435D5E1FE
  • Sequence:
    • MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT SDPKADSTGD 
QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI KMSSVPQETP HATSHPAVPI 
TANSLGSHTV TGGTITTNSP ETSSRTSGAP VTTAASSLET SRGTSGPPLT MATVSLETSK 
GTSGPPVTMA TDSLETSTGT TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA 
STVPFRNPDE NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV 
DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK SRQGSLAMEE 
LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.