Details for: TRIM21

Gene ID: 6737

Symbol: TRIM21

Ensembl ID: ENSG00000132109

Description: tripartite motif containing 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 40.2455
    Cell Significance Index: -6.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.0853
    Cell Significance Index: -6.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.5843
    Cell Significance Index: -7.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.0336
    Cell Significance Index: -7.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1843
    Cell Significance Index: -7.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3965
    Cell Significance Index: -6.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0121
    Cell Significance Index: -7.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8693
    Cell Significance Index: 355.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9145
    Cell Significance Index: 54.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8748
    Cell Significance Index: 789.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7642
    Cell Significance Index: 83.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5788
    Cell Significance Index: 17.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5690
    Cell Significance Index: 92.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4250
    Cell Significance Index: 29.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3896
    Cell Significance Index: 7.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3758
    Cell Significance Index: 43.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3016
    Cell Significance Index: 8.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2206
    Cell Significance Index: 4.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2199
    Cell Significance Index: 3.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2121
    Cell Significance Index: 20.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1739
    Cell Significance Index: 5.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1613
    Cell Significance Index: 8.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1294
    Cell Significance Index: 6.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1002
    Cell Significance Index: 12.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0876
    Cell Significance Index: 3.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0810
    Cell Significance Index: 35.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0762
    Cell Significance Index: 41.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0731
    Cell Significance Index: 10.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0719
    Cell Significance Index: 1.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0644
    Cell Significance Index: 1.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0615
    Cell Significance Index: 11.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0605
    Cell Significance Index: 7.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0595
    Cell Significance Index: 7.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0510
    Cell Significance Index: 1.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0411
    Cell Significance Index: 2.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0341
    Cell Significance Index: 1.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0305
    Cell Significance Index: 1.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0250
    Cell Significance Index: 0.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0183
    Cell Significance Index: 0.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0013
    Cell Significance Index: 0.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0019
    Cell Significance Index: -0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0030
    Cell Significance Index: -0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0057
    Cell Significance Index: -8.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0072
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -5.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0107
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0115
    Cell Significance Index: -1.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0116
    Cell Significance Index: -3.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0145
    Cell Significance Index: -0.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0167
    Cell Significance Index: -7.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0208
    Cell Significance Index: -3.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0216
    Cell Significance Index: -7.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0259
    Cell Significance Index: -1.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0308
    Cell Significance Index: -0.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0338
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0352
    Cell Significance Index: -7.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0396
    Cell Significance Index: -0.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0433
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0434
    Cell Significance Index: -9.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0469
    Cell Significance Index: -1.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0515
    Cell Significance Index: -1.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0589
    Cell Significance Index: -0.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0729
    Cell Significance Index: -1.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0731
    Cell Significance Index: -1.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0758
    Cell Significance Index: -7.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0834
    Cell Significance Index: -6.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0905
    Cell Significance Index: -5.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0981
    Cell Significance Index: -7.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1015
    Cell Significance Index: -1.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1018
    Cell Significance Index: -2.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1089
    Cell Significance Index: -0.9200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1130
    Cell Significance Index: -1.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1194
    Cell Significance Index: -6.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1207
    Cell Significance Index: -7.6100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1210
    Cell Significance Index: -1.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1212
    Cell Significance Index: -7.4500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1235
    Cell Significance Index: -0.8100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1271
    Cell Significance Index: -0.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1289
    Cell Significance Index: -8.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1461
    Cell Significance Index: -7.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1702
    Cell Significance Index: -5.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1786
    Cell Significance Index: -3.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1810
    Cell Significance Index: -5.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1821
    Cell Significance Index: -4.6800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1834
    Cell Significance Index: -1.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1870
    Cell Significance Index: -8.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1878
    Cell Significance Index: -6.5800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1975
    Cell Significance Index: -2.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2062
    Cell Significance Index: -7.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2078
    Cell Significance Index: -4.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2145
    Cell Significance Index: -6.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2184
    Cell Significance Index: -8.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIM21 is a 278-amino acid protein that belongs to the TRIM family, which consists of approximately 70 members. The protein is characterized by its three distinct domains: a RING (Ring finger) domain, a B-box domain, and a coiled-coil domain. The RING domain is responsible for the ubiquitination activity of TRIM21, while the B-box domain regulates the protein's interaction with target proteins. The coiled-coil domain mediates dimerization and oligomerization of TRIM21. **Pathways and Functions:** TRIM21 is involved in various cellular processes, including: 1. **Adaptive Immune System:** TRIM21 regulates the activity of immune cells, such as T cells and B cells, by modulating the expression of key transcription factors, such as NF-κB and IRF3. 2. **Antigen Processing and Presentation:** TRIM21 plays a crucial role in the processing and presentation of antigens to CD8+ T cells via MHC class I molecules. 3. **Autophagy:** TRIM21 regulates autophagy by targeting proteins involved in the autophagic process, such as LC3 and Beclin-1. 4. **Stress Response:** TRIM21 is involved in the regulation of cellular stress responses, including endoplasmic reticulum stress and cytosolic DNA stress. 5. **Cytokine Signaling:** TRIM21 modulates cytokine signaling pathways, including the NF-κB and JAK/STAT pathways. **Clinical Significance:** TRIM21 has been implicated in various diseases, including: 1. **Autoimmune Diseases:** TRIM21 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates the activity of immune cells and cytokine signaling pathways. 2. **Cancer:** TRIM21 has been identified as a tumor suppressor protein, regulating the expression of genes involved in cell cycle and apoptosis. 3. **Neurological Disorders:** TRIM21 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in neuronal survival and function. 4. **Infectious Diseases:** TRIM21 has been identified as a key regulator of innate immune responses to viral infections, including HIV and influenza. In conclusion, TRIM21 is a multifaceted regulator of immune responses and cellular stress, with implications for various diseases. Further research is needed to fully elucidate the mechanisms by which TRIM21 regulates cellular processes and to develop therapeutic strategies targeting this protein. **References:** * [Insert relevant references] Note: This is a hypothetical article, and you should not use it as a reference without proper citation and validation.

Genular Protein ID: 1869400886

Symbol: RO52_HUMAN

Name: E3 ubiquitin-protein ligase TRIM21

UniProtKB Accession Codes:

P19474 Q5XPV5 Q96RF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1985094

Title: Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes.

PubMed ID: 1985094

DOI: 10.1172/jci114968

PubMed ID: 1985112

Title: Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.

PubMed ID: 1985112

DOI: 10.1172/jci115003

PubMed ID: 7713506

Title: The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1).

PubMed ID: 7713506

DOI: 10.1006/geno.1994.1664

PubMed ID: 8625517

Title: Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species.

PubMed ID: 8625517

DOI: 10.1046/j.1365-2249.1996.16726.x

PubMed ID: 9933563

Title: A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region.

PubMed ID: 9933563

DOI: 10.1006/geno.1998.5659

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7561701

Title: 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.

PubMed ID: 7561701

DOI: 10.1084/jem.182.4.983

PubMed ID: 8666824

Title: Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen.

PubMed ID: 8666824

PubMed ID: 12699405

Title: Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?

PubMed ID: 12699405

DOI: 10.1046/j.1365-2249.2003.02153.x

PubMed ID: 16297862

Title: Autoantigen Ro52 is an E3 ubiquitin ligase.

PubMed ID: 16297862

DOI: 10.1016/j.bbrc.2005.11.029

PubMed ID: 16316627

Title: Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.

PubMed ID: 16316627

DOI: 10.1016/j.bbrc.2005.11.076

PubMed ID: 16472766

Title: UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself.

PubMed ID: 16472766

DOI: 10.1016/j.bbrc.2006.01.144

PubMed ID: 16880511

Title: Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.

PubMed ID: 16880511

DOI: 10.1128/mcb.01630-05

PubMed ID: 17156811

Title: Unique features of TRIM5alpha among closely related human TRIM family members.

PubMed ID: 17156811

DOI: 10.1016/j.virol.2006.10.035

PubMed ID: 18361920

Title: SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity.

PubMed ID: 18361920

DOI: 10.1016/j.bbrc.2008.03.075

PubMed ID: 18845142

Title: The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.

PubMed ID: 18845142

DOI: 10.1016/j.yexcr.2008.09.011

PubMed ID: 18641315

Title: The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.

PubMed ID: 18641315

DOI: 10.4049/jimmunol.181.3.1780

PubMed ID: 18022694

Title: Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system.

PubMed ID: 18022694

DOI: 10.1016/j.molimm.2007.10.023

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19675099

Title: Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling.

PubMed ID: 19675099

DOI: 10.1093/jb/mvp127

PubMed ID: 20407604

Title: Extraordinary antigenicity of the human Ro52 autoantigen.

PubMed ID: 20407604

PubMed ID: 20013343

Title: Dynamic movements of Ro52 cytoplasmic bodies along microtubules.

PubMed ID: 20013343

DOI: 10.1007/s00418-009-0669-y

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 26342464

Title: Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.

PubMed ID: 26342464

DOI: 10.1016/j.virol.2015.08.013

PubMed ID: 29743353

Title: TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS.

PubMed ID: 29743353

DOI: 10.1128/jvi.00321-18

PubMed ID: 31852783

Title: Severe Fever with Thrombocytopenia Syndrome Virus NSs Interacts with TRIM21 To Activate the p62-Keap1-Nrf2 Pathway.

PubMed ID: 31852783

DOI: 10.1128/jvi.01684-19

PubMed ID: 36359729

Title: FIP200 Methylation by SETD2 Prevents Trim21-Induced Degradation and Preserves Autophagy Initiation.

PubMed ID: 36359729

DOI: 10.3390/cells11213333

PubMed ID: 36426955

Title: TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a.

PubMed ID: 36426955

DOI: 10.4049/jimmunol.2200163

PubMed ID: 36692217

Title: Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.

PubMed ID: 36692217

DOI: 10.1080/15548627.2022.2164427

Sequence Information:

  • Length: 475
  • Mass: 54170
  • Checksum: DDFF2944AFC629FB
  • Sequence:
    • MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL 
KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 
RDHAMVPLEE AAQEYQEKLQ VALGELRRKQ ELAEKLEVEI AIKRADWKKT VETQKSRIHA 
EFVQQKNFLV EEEQRQLQEL EKDEREQLRI LGEKEAKLAQ QSQALQELIS ELDRRCHSSA 
LELLQEVIIV LERSESWNLK DLDITSPELR SVCHVPGLKK MLRTCAVHIT LDPDTANPWL 
ILSEDRRQVR LGDTQQSIPG NEERFDSYPM VLGAQHFHSG KHYWEVDVTG KEAWDLGVCR 
DSVRRKGHFL LSSKSGFWTI WLWNKQKYEA GTYPQTPLHL QVPPCQVGIF LDYEAGMVSF 
YNITDHGSLI YSFSECAFTG PLRPFFSPGF NDGGKNTAPL TLCPLNIGSQ GSTDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.