Details for: RO60
Gene ID: 6738
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RO60
Ensembl ID: ENSG00000116747
Description: Ro60, Y RNA binding protein
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 18.53rCSI 10.94%PRS 47.14
-
CSI 16.18rCSI 34.4%PRS 41.8
-
CSI 15.34rCSI 49.24%PRS 43.01
-
CSI 11.81rCSI 7.96%PRS 42.72
-
CSI 11.16rCSI 24.45%PRS 43.88
-
CSI 10.21rCSI 18%PRS 33.46
-
CSI 9.84rCSI 17.35%PRS 42.56
-
CSI 7.27rCSI 6.71%PRS 35.5
-
CSI 5.34rCSI 8.13%PRS 31.9
-
CSI 4.95rCSI 3.72%PRS 36.97
-
CSI 4.93rCSI 7.99%PRS 33.63
-
CSI 4.8rCSI 7.72%PRS 23.71
-
CSI 4.79rCSI 10.75%PRS 22.44
-
CSI 4.67rCSI 22.39%PRS 32.34
-
CSI 4.63rCSI 20.56%PRS 33.09
-
CSI 4.61rCSI 9.57%PRS 33.36
-
CSI 4.61rCSI 6.28%PRS 62.98
-
CSI 4.54rCSI 3.16%PRS 41.26
-
CSI 4.49rCSI 4.16%PRS 54.29
-
CSI 4.46rCSI 13.16%PRS 38.96
-
CSI 4.44rCSI 4.43%PRS 29.55
-
CSI 4.33rCSI 15.68%PRS 52.6
-
CSI 4.06rCSI 3.15%PRS 33.96
-
CSI 3.98rCSI 11.52%PRS 37.23
-
CSI 3.97rCSI 7.87%PRS 34.51
-
CSI 3.83rCSI 3.03%PRS 24.31
-
CSI 3.79rCSI 6.03%PRS 29.1
-
CSI 3.65rCSI 2.55%PRS 36.04
-
CSI 3.64rCSI 2.53%PRS 45.99
-
CSI 3.6rCSI 22.46%PRS 28.37
-
CSI 3.54rCSI 4.22%PRS 21.78
-
CSI 3.51rCSI 9.88%PRS 37.44
-
CSI 3.47rCSI 7.94%PRS 33.87
-
CSI 3.47rCSI 17.1%PRS 44.56
-
CSI 3.38rCSI 2.74%PRS 35.19
-
CSI 3.23rCSI 2.59%PRS 54.92
-
CSI 3.21rCSI 7.71%PRS 50.59
-
CSI 3.2rCSI 2.37%PRS 29.51
-
CSI 2.98rCSI 4.38%PRS 31.88
-
CSI 2.95rCSI 4.03%PRS 38.35
-
CSI 2.93rCSI 7.59%PRS 31.54
-
CSI 2.93rCSI 5.25%PRS 32.64
-
CSI 2.86rCSI 15.39%PRS 50.67
-
CSI 2.72rCSI 4.16%PRS 50.64
-
CSI 2.7rCSI 2.02%PRS 48.49
-
CSI 2.7rCSI 7.12%PRS 40.54
-
CSI 2.57rCSI 2.04%PRS 55.08
-
CSI 2.53rCSI 4.47%PRS 21.15
-
CSI 2.51rCSI 3.59%PRS 36.94
-
CSI 2.47rCSI 3.67%PRS 37.69
-
CSI 2.43rCSI 3.25%PRS 41.8
-
CSI 2.4rCSI 3.69%PRS 39.59
-
CSI 2.36rCSI 3.76%PRS 29.47
-
CSI 2.36rCSI 2.65%PRS 49.82
-
CSI 2.35rCSI 3.66%PRS 61.44
-
CSI 2.28rCSI 5.49%PRS 45.2
-
CSI 2.24rCSI 2.85%PRS 38.93
-
CSI 2.19rCSI 6.29%PRS 49.83
-
CSI 2.18rCSI 2.24%PRS 50.85
-
CSI 2.18rCSI 4.97%PRS 29.57
-
CSI 2.17rCSI 3.33%PRS 40.35
-
CSI 2.11rCSI 2.2%PRS 34.92
-
CSI 2.1rCSI 2.51%PRS 53.45
-
CSI 2.07rCSI 11.89%PRS 45.49
-
CSI 2.04rCSI 4.76%PRS 62.13
-
CSI 2.04rCSI 4.95%PRS 21.25
-
CSI 2rCSI 2.77%PRS 41.06
-
CSI 1.99rCSI 2.88%PRS 49.39
-
CSI 1.97rCSI 1.41%PRS 45.69
-
CSI 1.94rCSI 1.68%PRS 37.86
-
CSI 1.94rCSI 4.9%PRS 41.6
-
CSI 1.93rCSI 1.79%PRS 34.16
-
CSI 1.93rCSI 2.47%PRS 38.73
-
CSI 1.9rCSI 2.81%PRS 38.59
-
CSI 1.89rCSI 1.68%PRS 33.93
-
CSI 1.88rCSI 3.29%PRS 27.86
-
CSI 1.88rCSI 1.63%PRS 42.32
-
CSI 1.85rCSI 1.93%PRS 67.63
-
CSI 1.84rCSI 3.69%PRS 26.14
-
CSI 1.82rCSI 2.89%PRS 43.39
-
CSI 1.78rCSI 2.45%PRS 55.11
-
CSI 1.78rCSI 2.37%PRS 37.9
-
CSI 1.77rCSI 42.73%PRS 22.15
-
CSI 1.76rCSI 2.07%PRS 47.49
-
CSI 1.76rCSI 2.83%PRS 26.88
-
CSI 1.75rCSI 1.84%PRS 32.1
-
CSI 1.75rCSI 8.76%PRS 43.96
-
CSI 1.73rCSI 3.15%PRS 29.77
-
CSI 1.73rCSI 1.64%PRS 35.5
-
CSI 1.72rCSI 2.53%PRS 44.04
-
CSI 1.71rCSI 1.42%PRS 34.97
-
CSI 1.71rCSI 4.87%PRS 35.52
-
CSI 1.71rCSI 1.68%PRS 48.68
-
CSI 1.7rCSI 1.49%PRS 43.52
-
CSI 1.69rCSI 1.49%PRS 38.93
-
CSI 1.69rCSI 1.12%PRS 38.67
-
CSI 1.69rCSI 6.33%PRS 29.23
-
CSI 1.68rCSI 1.62%PRS 26.5
-
CSI 1.67rCSI 40.09%PRS 21.35
-
CSI 1.67rCSI 1.83%PRS 37.9
-
CSI 0.1rCSI 0.9%PRS 51.6%
-
CSI 0.1rCSI 2.4%PRS 74.0%
-
CSI 0.2rCSI 0.9%PRS 46.6%
-
CSI 0.2rCSI 2.4%PRS 55.6%
-
CSI 0.2rCSI 0.6%PRS 29.1%
-
CSI 0.3rCSI 1.7%PRS 66.8%
-
CSI 0.3rCSI 4.1%PRS 63.2%
-
CSI 0.3rCSI 1.7%PRS 23.0%
-
CSI 0.4rCSI 3.4%PRS 79.0%
-
CSI 0.4rCSI 2.1%PRS 45.9%
-
CSI 0.5rCSI 2.1%PRS 50.9%
-
CSI 0.6rCSI 0.4%PRS 32.8%
-
CSI 0.6rCSI 1.2%PRS 25.2%
-
CSI 0.6rCSI 3.7%PRS 57.5%
-
CSI 0.6rCSI 1.7%PRS 49.7%
-
CSI 0.6rCSI 4.3%PRS 24.4%
-
CSI 0.6rCSI 0.8%PRS 45.6%
-
CSI 0.6rCSI 1.9%PRS 24.8%
-
CSI 0.6rCSI 0.6%PRS 31.6%
-
CSI 0.6rCSI 1.5%PRS 26.0%
-
CSI 0.6rCSI 3.1%PRS 35.5%
-
CSI 0.6rCSI 3.4%PRS 49.5%
-
CSI 0.6rCSI 0.9%PRS 27.4%
-
CSI 0.6rCSI 3.4%PRS 45.1%
-
CSI 0.7rCSI 2.6%PRS 22.7%
-
CSI 0.7rCSI 1.6%PRS 39.9%
-
CSI 0.7rCSI 2.7%PRS 30.5%
-
CSI 0.7rCSI 2.0%PRS 27.7%
-
CSI 0.7rCSI 2.2%PRS 22.9%
-
CSI 0.7rCSI 2.7%PRS 54.5%
-
CSI 0.7rCSI 1.1%PRS 35.6%
-
CSI 0.7rCSI 4.1%PRS 59.6%
-
CSI 0.8rCSI 2.1%PRS 50.3%
-
CSI 0.8rCSI 2.5%PRS 31.3%
-
CSI 0.8rCSI 1.0%PRS 33.0%
-
CSI 0.8rCSI 2.9%PRS 20.9%
-
CSI 0.8rCSI 2.1%PRS 32.2%
-
CSI 0.8rCSI 2.1%PRS 26.9%
-
CSI 0.9rCSI 1.9%PRS 48.4%
-
CSI 0.9rCSI 1.2%PRS 42.4%
-
CSI 0.9rCSI 1.3%PRS 50.5%
-
CSI 0.9rCSI 1.2%PRS 46.8%
-
CSI 0.9rCSI 3.1%PRS 50.8%
-
CSI 0.9rCSI 1.4%PRS 32.6%
-
CSI 0.9rCSI 1.1%PRS 52.9%
-
CSI 0.9rCSI 1.0%PRS 32.2%
-
CSI 0.9rCSI 1.0%PRS 34.7%
-
CSI 1.0rCSI 3.4%PRS 48.5%
-
CSI 1.0rCSI 2.0%PRS 57.4%
-
CSI 1.0rCSI 2.5%PRS 34.5%
-
CSI 1.0rCSI 1.8%PRS 26.1%
-
CSI 1.0rCSI 1.1%PRS 26.2%
-
CSI 1.0rCSI 1.8%PRS 49.6%
-
CSI 1.0rCSI 1.6%PRS 37.3%
-
CSI 1.0rCSI 7.5%PRS 64.2%
-
CSI 1.0rCSI 1.6%PRS 34.6%
-
CSI 1.1rCSI 1.7%PRS 35.0%
-
CSI 1.1rCSI 1.1%PRS 39.7%
-
CSI 1.1rCSI 2.0%PRS 43.1%
-
CSI 1.1rCSI 1.4%PRS 22.6%
-
CSI 1.1rCSI 2.4%PRS 31.8%
-
CSI 1.1rCSI 3.2%PRS 59.1%
-
CSI 1.1rCSI 2.0%PRS 29.1%
-
CSI 1.1rCSI 1.6%PRS 44.2%
-
CSI 1.2rCSI 1.7%PRS 44.1%
-
CSI 1.2rCSI 1.7%PRS 32.0%
-
CSI 1.2rCSI 1.0%PRS 32.8%
-
CSI 1.2rCSI 1.5%PRS 20.6%
-
CSI 1.2rCSI 2.9%PRS 28.4%
-
CSI 1.3rCSI 1.3%PRS 46.2%
-
CSI 1.3rCSI 8.6%PRS 54.6%
-
CSI 1.3rCSI 1.7%PRS 29.5%
-
CSI 1.3rCSI 1.9%PRS 38.6%
-
CSI 1.3rCSI 2.1%PRS 21.9%
-
CSI 1.3rCSI 3.2%PRS 32.6%
-
CSI 1.3rCSI 1.6%PRS 40.9%
-
CSI 1.3rCSI 2.0%PRS 51.9%
-
CSI 1.3rCSI 2.2%PRS 43.4%
-
CSI 1.3rCSI 1.1%PRS 34.7%
-
CSI 1.3rCSI 1.5%PRS 30.1%
-
CSI 1.3rCSI 1.8%PRS 37.0%
-
CSI 1.3rCSI 1.9%PRS 36.6%
-
CSI 1.3rCSI 3.4%PRS 38.9%
-
CSI 1.3rCSI 2.5%PRS 70.0%
-
CSI 1.3rCSI 10.5%PRS 53.6%
-
CSI 1.3rCSI 1.7%PRS 32.8%
-
CSI 1.4rCSI 5.5%PRS 33.8%
-
CSI 1.4rCSI 3.6%PRS 47.5%
-
CSI 1.4rCSI 1.8%PRS 36.2%
-
CSI 1.4rCSI 2.0%PRS 35.7%
-
CSI 1.4rCSI 2.4%PRS 26.8%
-
CSI 1.4rCSI 3.7%PRS 61.3%
-
CSI 1.4rCSI 1.4%PRS 58.7%
-
CSI 1.4rCSI 1.1%PRS 45.3%
-
CSI 1.4rCSI 2.0%PRS 34.4%
-
CSI 1.4rCSI 2.3%PRS 27.0%
-
CSI 1.4rCSI 1.7%PRS 45.2%
-
CSI 1.5rCSI 2.0%PRS 32.6%
-
CSI 1.5rCSI 1.3%PRS 25.6%
-
CSI 1.5rCSI 1.8%PRS 36.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 363853676
Symbol: RO60_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3200833
Title: Molecular analysis of the 60-kDa human Ro ribonucleoprotein.
PubMed ID: 3200833
PubMed ID: 2649513
Title: Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen.
PubMed ID: 2649513
DOI: 10.1172/jci114013
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10545525
Title: Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies.
PubMed ID: 10545525
DOI: 10.1172/jci8003
PubMed ID: 10668799
Title: Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins.
PubMed ID: 10668799
PubMed ID: 18056422
Title: Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.
PubMed ID: 18056422
DOI: 10.1101/gad.1603907
PubMed ID: 17289661
Title: Molecular composition of IMP1 ribonucleoprotein granules.
PubMed ID: 17289661
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26382853
Title: The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.
PubMed ID: 26382853
Sequence Information:
- Length: 538
- Mass: 60671
- Checksum: CD735B1DF2B13098
- Sequence:
MEESVNQMQP LNEKQIANSQ DGYVWQVTDM NRLHRFLCFG SEGGTYYIKE QKLGLENAEA LIRLIEDGRG CEVIQEIKSF SQEGRTTKQE PMLFALAICS QCSDISTKQA AFKAVSEVCR IPTHLFTFIQ FKKDLKESMK CGMWGRALRK AIADWYNEKG GMALALAVTK YKQRNGWSHK DLLRLSHLKP SSEGLAIVTK YITKGWKEVH ELYKEKALSV ETEKLLKYLE AVEKVKRTRD ELEVIHLIEE HRLVREHLLT NHLKSKEVWK ALLQEMPLTA LLRNLGKMTA NSVLEPGNSE VSLVCEKLCN EKLLKKARIH PFHILIALET YKTGHGLRGK LKWRPDEEIL KALDAAFYKT FKTVEPTGKR FLLAVDVSAS MNQRVLGSIL NASTVAAAMC MVVTRTEKDS YVVAFSDEMV PCPVTTDMTL QQVLMAMSQI PAGGTDCSLP MIWAQKTNTP ADVFIVFTDN ETFAGGVHPA IALREYRKKM DIPAKLIVCG MTSNGFTIAD PDDRGMLDMC GFDTGALDVI RNFTLDMI
Genular Protein ID: 3411088213
Symbol: G5E9R9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 263
- Mass: 28858
- Checksum: DA536816CB22FD62
- Sequence:
MPLTALLRNL GKMTANSVLE PGNSEVSLVC EKLCNEKLLK KARIHPFHIL IALETYKTGH GLRGKLKWRP DEEILKALDA AFYKTFKTVE PTGKRFLLAV DVSASMNQRV LGSILNASTV AAAMCMVVTR TEKDSYVVAF SDEMVPCPVT TDMTLQQVLM AMSQIPAGGT DCSLPMIWAQ KTNTPADVFI VFTDNETFAG GVHPAIALRE YRKKMDIPAK LIVCGMTSNG FTIADPDDRG MLDMCGFDTG ALDVIRNFTL DMI