Details for: RO60

Gene ID: 6738

Symbol: RO60

Ensembl ID: ENSG00000116747

Description: Ro60, Y RNA binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 299.1413
    Cell Significance Index: -46.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 201.7794
    Cell Significance Index: -51.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 127.8270
    Cell Significance Index: -60.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 119.3087
    Cell Significance Index: -48.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.2761
    Cell Significance Index: -56.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 90.6527
    Cell Significance Index: -60.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.0818
    Cell Significance Index: -48.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.5410
    Cell Significance Index: -56.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.8513
    Cell Significance Index: -50.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8959
    Cell Significance Index: -58.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.6292
    Cell Significance Index: -38.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4040
    Cell Significance Index: -22.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8337
    Cell Significance Index: 115.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6078
    Cell Significance Index: 55.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3080
    Cell Significance Index: 259.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2496
    Cell Significance Index: 250.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2360
    Cell Significance Index: 169.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1739
    Cell Significance Index: 150.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1647
    Cell Significance Index: 60.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9914
    Cell Significance Index: 26.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8665
    Cell Significance Index: 106.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8119
    Cell Significance Index: 48.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7978
    Cell Significance Index: 49.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7654
    Cell Significance Index: 42.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7382
    Cell Significance Index: 264.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6954
    Cell Significance Index: 125.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6335
    Cell Significance Index: 13.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6070
    Cell Significance Index: 31.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5764
    Cell Significance Index: 67.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5558
    Cell Significance Index: 245.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4560
    Cell Significance Index: 5.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4460
    Cell Significance Index: 28.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4101
    Cell Significance Index: 223.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3699
    Cell Significance Index: 70.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3328
    Cell Significance Index: 36.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3092
    Cell Significance Index: 279.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2406
    Cell Significance Index: 31.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2360
    Cell Significance Index: 163.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2220
    Cell Significance Index: 15.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2143
    Cell Significance Index: 15.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1455
    Cell Significance Index: 7.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1443
    Cell Significance Index: 11.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1336
    Cell Significance Index: 3.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0890
    Cell Significance Index: 4.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0693
    Cell Significance Index: 4.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0605
    Cell Significance Index: 113.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0563
    Cell Significance Index: 1.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0452
    Cell Significance Index: 28.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0223
    Cell Significance Index: 10.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0072
    Cell Significance Index: 11.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0060
    Cell Significance Index: 0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -10.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0155
    Cell Significance Index: -21.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0212
    Cell Significance Index: -0.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0316
    Cell Significance Index: -1.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0388
    Cell Significance Index: -6.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0466
    Cell Significance Index: -35.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0573
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0574
    Cell Significance Index: -42.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0580
    Cell Significance Index: -0.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0700
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0720
    Cell Significance Index: -12.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0813
    Cell Significance Index: -3.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0902
    Cell Significance Index: -50.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0952
    Cell Significance Index: -9.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1077
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1242
    Cell Significance Index: -77.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1346
    Cell Significance Index: -15.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1400
    Cell Significance Index: -7.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1515
    Cell Significance Index: -22.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1581
    Cell Significance Index: -45.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1743
    Cell Significance Index: -5.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1795
    Cell Significance Index: -2.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2018
    Cell Significance Index: -4.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2103
    Cell Significance Index: -14.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2248
    Cell Significance Index: -10.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2982
    Cell Significance Index: -62.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3127
    Cell Significance Index: -13.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3393
    Cell Significance Index: -5.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3613
    Cell Significance Index: -42.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3617
    Cell Significance Index: -7.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4099
    Cell Significance Index: -8.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4389
    Cell Significance Index: -16.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4986
    Cell Significance Index: -51.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5323
    Cell Significance Index: -17.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5518
    Cell Significance Index: -43.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5632
    Cell Significance Index: -16.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5909
    Cell Significance Index: -14.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5986
    Cell Significance Index: -17.6300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6325
    Cell Significance Index: -5.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7115
    Cell Significance Index: -18.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7291
    Cell Significance Index: -44.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7520
    Cell Significance Index: -10.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7670
    Cell Significance Index: -31.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7796
    Cell Significance Index: -4.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8361
    Cell Significance Index: -9.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8674
    Cell Significance Index: -22.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8778
    Cell Significance Index: -23.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9003
    Cell Significance Index: -11.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA-binding protein**: RO60 is a member of the Y RNA-binding protein family, characterized by its ability to bind to small nuclear RNAs (snRNAs), specifically the Y RNAs. 2. **Wide tissue expression**: RO60 is expressed in various cell types, including cardiac muscle cells, extravillous trophoblasts, unswitched memory B cells, eye photoreceptor cells, skeletal muscle satellite stem cells, and epithelial cells of the nephron. 3. **Immune system involvement**: RO60 is significantly expressed in cells involved in immune responses, such as unswitched memory B cells and skeletal muscle satellite stem cells. 4. **Cellular homeostasis**: RO60 is also involved in maintaining cellular homeostasis, as evidenced by its expression in cardiac muscle cells and skeletal muscle satellite stem cells. **Pathways and Functions:** 1. **Cellular response to interferon-alpha**: RO60 is involved in the cellular response to interferon-alpha, a cytokine that plays a crucial role in immune regulation. 2. **Cilium assembly**: RO60 is required for cilium assembly, a process essential for maintaining cellular homeostasis and function. 3. **Regulation of gene expression**: RO60 influences the regulation of gene expression by binding to snRNAs and modulating the activity of RNA polymerase III. 4. **Ribonucleoprotein complex**: RO60 is a component of ribonucleoprotein complexes, which are involved in various cellular processes, including transcription and translation. **Clinical Significance:** 1. **Immune system disorders**: Alterations in RO60 expression have been linked to immune system disorders, such as autoimmune diseases and immunodeficiencies. 2. **Cancer**: RO60 has been implicated in cancer development and progression, particularly in cancers with impaired immune surveillance. 3. **Neurological disorders**: RO60 has been associated with neurological disorders, such as multiple sclerosis and Parkinson's disease, where disruptions in immune regulation and cellular homeostasis play a crucial role. 4. **Regulatory T cell function**: RO60 has been shown to influence the function of regulatory T cells, which are essential for maintaining immune homeostasis and preventing autoimmune diseases. In conclusion, the RO60 gene is a critical component of the human genome that plays a pivotal role in regulating gene expression, immune responses, and cellular homeostasis. Further research is necessary to fully elucidate the functions and clinical significance of RO60, but it is clear that this gene is an important regulator of cellular processes.

Genular Protein ID: 363853676

Symbol: RO60_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3200833

Title: Molecular analysis of the 60-kDa human Ro ribonucleoprotein.

PubMed ID: 3200833

DOI: 10.1073/pnas.85.24.9479

PubMed ID: 2649513

Title: Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen.

PubMed ID: 2649513

DOI: 10.1172/jci114013

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10545525

Title: Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies.

PubMed ID: 10545525

DOI: 10.1172/jci8003

PubMed ID: 10668799

Title: Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins.

PubMed ID: 10668799

DOI: 10.1017/s1355838200990277

PubMed ID: 18056422

Title: Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.

PubMed ID: 18056422

DOI: 10.1101/gad.1603907

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26382853

Title: The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.

PubMed ID: 26382853

DOI: 10.1126/science.aac7442

Sequence Information:

  • Length: 538
  • Mass: 60671
  • Checksum: CD735B1DF2B13098
  • Sequence:
  • MEESVNQMQP LNEKQIANSQ DGYVWQVTDM NRLHRFLCFG SEGGTYYIKE QKLGLENAEA 
    LIRLIEDGRG CEVIQEIKSF SQEGRTTKQE PMLFALAICS QCSDISTKQA AFKAVSEVCR 
    IPTHLFTFIQ FKKDLKESMK CGMWGRALRK AIADWYNEKG GMALALAVTK YKQRNGWSHK 
    DLLRLSHLKP SSEGLAIVTK YITKGWKEVH ELYKEKALSV ETEKLLKYLE AVEKVKRTRD 
    ELEVIHLIEE HRLVREHLLT NHLKSKEVWK ALLQEMPLTA LLRNLGKMTA NSVLEPGNSE 
    VSLVCEKLCN EKLLKKARIH PFHILIALET YKTGHGLRGK LKWRPDEEIL KALDAAFYKT 
    FKTVEPTGKR FLLAVDVSAS MNQRVLGSIL NASTVAAAMC MVVTRTEKDS YVVAFSDEMV 
    PCPVTTDMTL QQVLMAMSQI PAGGTDCSLP MIWAQKTNTP ADVFIVFTDN ETFAGGVHPA 
    IALREYRKKM DIPAKLIVCG MTSNGFTIAD PDDRGMLDMC GFDTGALDVI RNFTLDMI

Genular Protein ID: 3411088213

Symbol: G5E9R9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 263
  • Mass: 28858
  • Checksum: DA536816CB22FD62
  • Sequence:
  • MPLTALLRNL GKMTANSVLE PGNSEVSLVC EKLCNEKLLK KARIHPFHIL IALETYKTGH 
    GLRGKLKWRP DEEILKALDA AFYKTFKTVE PTGKRFLLAV DVSASMNQRV LGSILNASTV 
    AAAMCMVVTR TEKDSYVVAF SDEMVPCPVT TDMTLQQVLM AMSQIPAGGT DCSLPMIWAQ 
    KTNTPADVFI VFTDNETFAG GVHPAIALRE YRKKMDIPAK LIVCGMTSNG FTIADPDDRG 
    MLDMCGFDTG ALDVIRNFTL DMI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.