Details for: TAF7

Gene ID: 6879

Symbol: TAF7

Ensembl ID: ENSG00000178913

Description: TATA-box binding protein associated factor 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 375.2606
    Cell Significance Index: -58.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 167.8341
    Cell Significance Index: -42.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 157.3744
    Cell Significance Index: -64.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 136.7018
    Cell Significance Index: -64.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 123.0984
    Cell Significance Index: -63.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 96.5840
    Cell Significance Index: -64.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.5776
    Cell Significance Index: -62.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9909
    Cell Significance Index: -48.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.4240
    Cell Significance Index: -64.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1882
    Cell Significance Index: -46.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8681
    Cell Significance Index: -17.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0952
    Cell Significance Index: 84.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.8933
    Cell Significance Index: 100.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.7777
    Cell Significance Index: 145.8400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.3833
    Cell Significance Index: 18.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3296
    Cell Significance Index: 18.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1838
    Cell Significance Index: 299.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9155
    Cell Significance Index: 123.5800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9099
    Cell Significance Index: 33.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9067
    Cell Significance Index: 39.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8681
    Cell Significance Index: 53.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6290
    Cell Significance Index: 208.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5807
    Cell Significance Index: 74.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4879
    Cell Significance Index: 242.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4153
    Cell Significance Index: 772.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4112
    Cell Significance Index: 166.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3313
    Cell Significance Index: 35.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2550
    Cell Significance Index: 56.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2113
    Cell Significance Index: 119.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1895
    Cell Significance Index: 525.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0287
    Cell Significance Index: 126.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9903
    Cell Significance Index: 127.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9674
    Cell Significance Index: 22.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8644
    Cell Significance Index: 11.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8176
    Cell Significance Index: 147.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8072
    Cell Significance Index: 728.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7614
    Cell Significance Index: 35.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7150
    Cell Significance Index: 53.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6825
    Cell Significance Index: 19.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6577
    Cell Significance Index: 7.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6459
    Cell Significance Index: 7.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6338
    Cell Significance Index: 125.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4710
    Cell Significance Index: 33.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4649
    Cell Significance Index: 88.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4178
    Cell Significance Index: 83.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4159
    Cell Significance Index: 45.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3327
    Cell Significance Index: 3.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2572
    Cell Significance Index: 16.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2539
    Cell Significance Index: 6.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2258
    Cell Significance Index: 11.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1962
    Cell Significance Index: 11.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1869
    Cell Significance Index: 67.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1461
    Cell Significance Index: 24.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0905
    Cell Significance Index: 3.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0499
    Cell Significance Index: 0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0160
    Cell Significance Index: 11.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0022
    Cell Significance Index: 2.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0066
    Cell Significance Index: -12.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0240
    Cell Significance Index: -0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0265
    Cell Significance Index: -48.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0314
    Cell Significance Index: -48.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0361
    Cell Significance Index: -22.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0488
    Cell Significance Index: -4.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0521
    Cell Significance Index: -33.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0596
    Cell Significance Index: -33.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1099
    Cell Significance Index: -49.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1202
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1213
    Cell Significance Index: -25.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1553
    Cell Significance Index: -17.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1758
    Cell Significance Index: -50.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1889
    Cell Significance Index: -1.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2189
    Cell Significance Index: -5.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2247
    Cell Significance Index: -26.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2608
    Cell Significance Index: -29.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3112
    Cell Significance Index: -7.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3268
    Cell Significance Index: -47.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3801
    Cell Significance Index: -29.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4020
    Cell Significance Index: -27.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4126
    Cell Significance Index: -13.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5165
    Cell Significance Index: -7.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5314
    Cell Significance Index: -7.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5571
    Cell Significance Index: -16.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5848
    Cell Significance Index: -46.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6069
    Cell Significance Index: -63.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6305
    Cell Significance Index: -15.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6652
    Cell Significance Index: -11.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7150
    Cell Significance Index: -4.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7188
    Cell Significance Index: -19.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7441
    Cell Significance Index: -16.1200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7525
    Cell Significance Index: -10.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8099
    Cell Significance Index: -21.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9556
    Cell Significance Index: -58.5900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.0303
    Cell Significance Index: -6.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0938
    Cell Significance Index: -48.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1676
    Cell Significance Index: -21.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.2999
    Cell Significance Index: -25.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3093
    Cell Significance Index: -49.5800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.3140
    Cell Significance Index: -7.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAF7 is a 55-kDa protein that belongs to the TAF family, which plays a central role in the recruitment of RNAPII to promoters and enhancers. TAF7 exhibits a unique ability to interact with multiple transcription factors, including TFIID, TFIIA, and TFIIB, thereby facilitating the assembly of the pre-initiation complex (PIC). This complex is essential for the initiation of transcription by RNAPII. TAF7 also exhibits a high degree of plasticity, allowing it to adapt to different transcriptional contexts and respond to various stimuli. **Pathways and Functions:** TAF7 is involved in various cellular pathways, including: 1. **Transcriptional Regulation:** TAF7 interacts with RNAPII and other transcription factors to regulate gene expression. It plays a critical role in the recruitment of RNAPII to promoters and enhancers, facilitating the initiation of transcription. 2. **Cell Proliferation and Differentiation:** TAF7 has been implicated in the regulation of cell proliferation and differentiation. Its dysregulation has been linked to various cancers, where it can contribute to oncogenesis. 3. **HIV Infection:** TAF7 has been shown to play a critical role in the regulation of HIV transcription. It interacts with the HIV transcription factor, Tat, to facilitate the initiation of transcription. 4. **DNA Repair:** TAF7 has been implicated in the regulation of DNA repair pathways. It interacts with proteins involved in nucleotide excision repair (NER) and base excision repair (BER) to facilitate the repair of DNA damage. **Clinical Significance:** Dysregulation of TAF7 has been linked to various diseases, including: 1. **Cancer:** TAF7 has been implicated in the development and progression of various cancers, including prostate, breast, and lung cancer. 2. **HIV Infection:** TAF7 plays a critical role in the regulation of HIV transcription, and its dysregulation can contribute to the pathogenesis of HIV infection. 3. **Autoimmune Disorders:** TAF7 has been implicated in the regulation of immune responses, and its dysregulation has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus. 4. **Neurological Disorders:** TAF7 has been implicated in the regulation of gene expression in the nervous system, and its dysregulation has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TAF7 is a multifaceted gene that plays a critical role in transcriptional regulation, cell proliferation, and differentiation. Its dysregulation has been linked to various diseases, highlighting the importance of understanding the complex mechanisms underlying its function. Further research is necessary to unravel the mysteries of TAF7 and to explore its therapeutic potential in the treatment of various diseases.

Genular Protein ID: 1084545750

Symbol: TAF7_HUMAN

Name: Transcription initiation factor TFIID subunit 7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8702684

Title: Multiple interactions between hTAFII55 and other TFIID subunits. Requirements for the formation of stable ternary complexes between hTAFII55 and the TATA-binding protein.

PubMed ID: 8702684

DOI: 10.1074/jbc.271.33.19774

PubMed ID: 7824954

Title: Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators.

PubMed ID: 7824954

DOI: 10.1126/science.7824954

PubMed ID: 11340078

Title: The intronless and TATA-less human TAFII55 gene contains a functional initiator and a downstream promoter element.

PubMed ID: 11340078

DOI: 10.1074/jbc.m102875200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10438527

Title: Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription.

PubMed ID: 10438527

DOI: 10.1074/jbc.274.33.23480

PubMed ID: 11592977

Title: TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.

PubMed ID: 11592977

DOI: 10.1073/pnas.211444798

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 20937824

Title: Novel functions for TAF7, a regulator of TAF1-independent transcription.

PubMed ID: 20937824

DOI: 10.1074/jbc.m110.173864

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16415881

Title: Structural basis for the methylation site specificity of SET7/9.

PubMed ID: 16415881

DOI: 10.1038/nsmb1045

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22711989

Title: Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.

PubMed ID: 22711989

DOI: 10.1128/mcb.00416-12

PubMed ID: 24036077

Title: Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.

PubMed ID: 24036077

DOI: 10.1016/j.bbagrm.2013.09.001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29203640

Title: Transforming Growth Factor beta-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC.

PubMed ID: 29203640

DOI: 10.1128/mcb.00449-17

PubMed ID: 25412659

Title: Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.

PubMed ID: 25412659

DOI: 10.1038/cr.2014.148

PubMed ID: 27007846

Title: Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

PubMed ID: 27007846

DOI: 10.1038/nature17394

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 349
  • Mass: 40259
  • Checksum: 0AAFD3E33E3CCD6E
  • Sequence:
  • MSKSKDDAPH ELESQFILRL PPEYASTVRR AVQSGHVNLK DRLTIELHPD GRHGIVRVDR 
    VPLASKLVDL PCVMESLKTI DKKTFYKTAD ICQMLVSTVD GDLYPPVEEP VASTDPKASK 
    KKDKDKEKKF IWNHGITLPL KNVRKRRFRK TAKKKYIESP DVEKEVKRLL STDAEAVSTR 
    WEIIAEDETK EAENQGLDIS SPGMSGHRQG HDSLEHDELR EIFNDLSSSS EDEDETQHQD 
    EEDINIIDTE EDLERQLQDK LNESDEQHQE NEGTNQLVMG IQKQIDNMKG KLQETQDRAK 
    RQEDLIMKVE NLALKNRFQA VLDELKQKED REKEQLSSLQ EELESLLEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.