Details for: TBCA

Gene ID: 6902

Symbol: TBCA

Ensembl ID: ENSG00000171530

Description: tubulin folding cofactor A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 691.6316
    Cell Significance Index: -107.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 382.0719
    Cell Significance Index: -96.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 297.3679
    Cell Significance Index: -122.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 262.3471
    Cell Significance Index: -123.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 234.6831
    Cell Significance Index: -120.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 185.3292
    Cell Significance Index: -124.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 97.4812
    Cell Significance Index: -120.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.9560
    Cell Significance Index: -99.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.6266
    Cell Significance Index: -124.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.7644
    Cell Significance Index: -91.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.7400
    Cell Significance Index: -47.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.6802
    Cell Significance Index: 149.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.8604
    Cell Significance Index: 1398.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.2350
    Cell Significance Index: 520.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.9427
    Cell Significance Index: 710.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.5607
    Cell Significance Index: 488.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.5571
    Cell Significance Index: 167.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.3567
    Cell Significance Index: 89.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.2713
    Cell Significance Index: 649.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1843
    Cell Significance Index: 1739.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1639
    Cell Significance Index: 29.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.0886
    Cell Significance Index: 24.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.9625
    Cell Significance Index: 62.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7235
    Cell Significance Index: 78.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6522
    Cell Significance Index: 72.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4341
    Cell Significance Index: 181.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3982
    Cell Significance Index: 309.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.3939
    Cell Significance Index: 282.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1821
    Cell Significance Index: 101.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1198
    Cell Significance Index: 1913.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0336
    Cell Significance Index: 407.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0215
    Cell Significance Index: 893.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9376
    Cell Significance Index: 125.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9026
    Cell Significance Index: 43.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8625
    Cell Significance Index: 238.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8624
    Cell Significance Index: 131.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8612
    Cell Significance Index: 54.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4708
    Cell Significance Index: 51.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3871
    Cell Significance Index: 15.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3380
    Cell Significance Index: 70.2500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3332
    Cell Significance Index: 8.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2462
    Cell Significance Index: 15.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1548
    Cell Significance Index: 59.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1530
    Cell Significance Index: 413.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7441
    Cell Significance Index: 127.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5079
    Cell Significance Index: 23.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4945
    Cell Significance Index: 27.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4651
    Cell Significance Index: 28.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3506
    Cell Significance Index: 6.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2816
    Cell Significance Index: 17.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2283
    Cell Significance Index: 17.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1959
    Cell Significance Index: 148.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1641
    Cell Significance Index: 309.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1419
    Cell Significance Index: 27.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1236
    Cell Significance Index: 90.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1183
    Cell Significance Index: 1.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0971
    Cell Significance Index: 1.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0444
    Cell Significance Index: 1.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0310
    Cell Significance Index: 47.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0266
    Cell Significance Index: 16.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0182
    Cell Significance Index: 33.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0404
    Cell Significance Index: -18.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0535
    Cell Significance Index: -5.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0537
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0733
    Cell Significance Index: -45.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0813
    Cell Significance Index: -8.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0962
    Cell Significance Index: -3.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1559
    Cell Significance Index: -87.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2715
    Cell Significance Index: -57.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2758
    Cell Significance Index: -4.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3125
    Cell Significance Index: -21.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4157
    Cell Significance Index: -60.4200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.4238
    Cell Significance Index: -2.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4872
    Cell Significance Index: -8.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5380
    Cell Significance Index: -61.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5796
    Cell Significance Index: -15.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5968
    Cell Significance Index: -69.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6407
    Cell Significance Index: -73.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6408
    Cell Significance Index: -7.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6705
    Cell Significance Index: -53.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7837
    Cell Significance Index: -16.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8586
    Cell Significance Index: -21.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8730
    Cell Significance Index: -14.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0335
    Cell Significance Index: -107.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0497
    Cell Significance Index: -46.4300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1352
    Cell Significance Index: -8.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.1906
    Cell Significance Index: -71.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2996
    Cell Significance Index: -28.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3860
    Cell Significance Index: -52.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4402
    Cell Significance Index: -19.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6115
    Cell Significance Index: -98.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7428
    Cell Significance Index: -55.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.9795
    Cell Significance Index: -11.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.9987
    Cell Significance Index: -29.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.0818
    Cell Significance Index: -40.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.0979
    Cell Significance Index: -109.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.1524
    Cell Significance Index: -51.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.2364
    Cell Significance Index: -63.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TBCA gene encodes a protein called Tubulin-specific chaperone A (TBCA_HUMAN). The TBCA protein is a molecular chaperone that assists in the proper folding of tubulin proteins, which are essential for microtubule assembly and stability. The TBCA protein is characterized by its ability to bind to tubulin proteins and facilitate their correct folding, thereby preventing the formation of aberrant tubulin structures that can lead to cellular dysfunction. **Pathways and Functions:** The TBCA gene is involved in several cellular pathways that regulate protein folding, microtubule assembly, and cytoskeletal dynamics. These pathways include: 1. **Post-chaperonin tubulin folding pathway**: This pathway involves the TBCA protein, which binds to tubulin proteins and facilitates their correct folding. 2. **Protein-folding chaperone binding**: The TBCA protein interacts with other protein-folding chaperones to regulate the folding of tubulin proteins. 3. **Microtubule complex assembly**: The TBCA protein plays a critical role in the assembly of microtubules by facilitating the interaction between tubulin proteins. 4. **Beta-tubulin binding**: The TBCA protein binds to beta-tubulin, a subunit of microtubules, to regulate microtubule stability and dynamics. **Functions:** The TBCA gene has several functions that are essential for maintaining cellular homeostasis and preventing disease: 1. **Protein folding regulation**: The TBCA protein regulates the folding of tubulin proteins, ensuring that microtubules are assembled correctly and functionally. 2. **Microtubule stability and dynamics**: The TBCA protein maintains microtubule stability and regulates their dynamics, which is essential for cellular processes such as cell division, migration, and signaling. 3. **Cellular differentiation and development**: The TBCA gene is involved in the regulation of cellular differentiation and development, particularly in the formation of microtubules and the establishment of cellular polarity. **Clinical Significance:** Dysregulation of the TBCA gene has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in the TBCA gene have been associated with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: The TBCA gene is involved in the regulation of microtubule dynamics, which is essential for cancer cell proliferation and metastasis. 3. **Muscular dystrophy**: The TBCA gene is involved in the regulation of muscle cell differentiation and maintenance, which is essential for muscular dystrophy. In conclusion, the TBCA gene plays a critical role in regulating protein folding, microtubule assembly, and cytoskeletal dynamics. Dysregulation of the TBCA gene has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms of the TBCA gene and its role in human disease.

Genular Protein ID: 1707209241

Symbol: TBCA_HUMAN

Name: Tubulin-specific chaperone A

UniProtKB Accession Codes:

O75347 B4DT30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 12054808

Title: Three-dimensional structure of human tubulin chaperone cofactor A.

PubMed ID: 12054808

DOI: 10.1016/s0022-2836(02)00185-7

Sequence Information:

  • Length: 108
  • Mass: 12855
  • Checksum: 222D8D945A5CD162
  • Sequence:
    • MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQAEILQES 
RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV LDSVKLEA

Genular Protein ID: 1925137538

Symbol: E5RIX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5RIX8

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 79
  • Mass: 9397
  • Checksum: 8E5920DCEF5D9AC0
  • Sequence:
    • MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI KKQENEKDLE 
EAEEYKEARL VLDSVKLEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.