Details for: THBD

Gene ID: 7056

Symbol: THBD

Ensembl ID: ENSG00000178726

Description: thrombomodulin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.37
    Marker Score: 8560
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.29
    Marker Score: 1974
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.29
    Marker Score: 3328
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.14
    Marker Score: 13015
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.03
    Marker Score: 2323
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.85
    Marker Score: 3703
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.77
    Marker Score: 2994
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.65
    Marker Score: 933
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.61
    Marker Score: 627
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1152
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.44
    Marker Score: 36950
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.4
    Marker Score: 337
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.4
    Marker Score: 297
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.29
    Marker Score: 1384
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.24
    Marker Score: 1245.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2474
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.21
    Marker Score: 282
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.2
    Marker Score: 291
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4785
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.07
    Marker Score: 493
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.07
    Marker Score: 282
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1
    Marker Score: 906
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1
    Marker Score: 1472
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 651
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.93
    Marker Score: 384
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.91
    Marker Score: 567
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5174
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.88
    Marker Score: 786
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.87
    Marker Score: 274
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.84
    Marker Score: 2179
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.83
    Marker Score: 408
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 615
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.77
    Marker Score: 196
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.76
    Marker Score: 836
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.76
    Marker Score: 5908
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.74
    Marker Score: 465
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.7
    Marker Score: 658
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.69
    Marker Score: 161
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1273
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.67
    Marker Score: 214
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 208
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.64
    Marker Score: 645
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.63
    Marker Score: 909
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.62
    Marker Score: 657
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6
    Marker Score: 248
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.6
    Marker Score: 5132
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 374
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.58
    Marker Score: 456
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.57
    Marker Score: 631
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.55
    Marker Score: 583
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.55
    Marker Score: 884
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.54
    Marker Score: 1292
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.53
    Marker Score: 116
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.53
    Marker Score: 145
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.52
    Marker Score: 356
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.52
    Marker Score: 433
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.5
    Marker Score: 6739
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.5
    Marker Score: 187
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.49
    Marker Score: 2043
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.47
    Marker Score: 125
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.47
    Marker Score: 567
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.46
    Marker Score: 1129
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 445
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 6971
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.44
    Marker Score: 177
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.44
    Marker Score: 567
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.44
    Marker Score: 424
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 208
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.43
    Marker Score: 121
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.43
    Marker Score: 227
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.43
    Marker Score: 829
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.42
    Marker Score: 542
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.41
    Marker Score: 364
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.39
    Marker Score: 391
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.39
    Marker Score: 179
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.37
    Marker Score: 98
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.36
    Marker Score: 100
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.36
    Marker Score: 123
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.36
    Marker Score: 219
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.36
    Marker Score: 886
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.35
    Marker Score: 275
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.35
    Marker Score: 120

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Other Information

**Key Characteristics:** 1. **Thrombin-binding domain**: THBD contains a thrombin-binding domain that facilitates the binding of thrombin, a key enzyme in the coagulation cascade. 2. **Serine protease domain**: The serine protease domain of THBD is involved in the activation of protein C, a key regulator of blood coagulation. 3. **Transmembrane structure**: THBD has a transmembrane structure that allows it to interact with the extracellular matrix and other cell surface proteins. 4. **Cell-type specificity**: THBD is expressed on various cell types, including endothelial cells, macrophages, and lymphangioblasts, suggesting its role in different physiological and pathological processes. **Pathways and Functions:** 1. **Coagulation regulation**: THBD modulates the coagulation cascade by binding to thrombin and activating protein C, a potent anticoagulant. 2. **Fibrinolysis regulation**: THBD also regulates fibrinolysis by interacting with plasminogen activators and inhibitors. 3. **Immune response modulation**: THBD interacts with various signaling pathways, including the JAK-STAT and NF-κB pathways, to modulate immune responses. 4. **Vascular permeability regulation**: THBD plays a role in regulating vascular permeability by interacting with endothelial cells and influencing the expression of adhesion molecules. **Clinical Significance:** 1. **Thrombotic disorders**: Mutations in the THBD gene have been associated with thrombotic disorders, such as deep vein thrombosis and pulmonary embolism. 2. **Inflammatory diseases**: THBD has been implicated in the pathogenesis of inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 3. **Cancer**: THBD has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role in tumorigenesis. 4. **Pregnancy complications**: THBD has been associated with pregnancy complications, including preeclampsia and intrauterine growth restriction. In conclusion, THBD plays a critical role in regulating blood coagulation, fibrinolysis, and immune responses. Its dysregulation has been implicated in various clinical disorders, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 771984426

Symbol: TRBM_HUMAN

Name: Thrombomodulin

UniProtKB Accession Codes:

P07204 Q8IV29 Q9UC32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 8 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 13 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2820710

Title: Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

PubMed ID: 2820710

DOI: 10.1002/j.1460-2075.1987.tb02448.x

PubMed ID: 2822087

Title: Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene.

PubMed ID: 2822087

DOI: 10.1021/bi00388a025

PubMed ID: 2819876

Title: Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

PubMed ID: 2819876

DOI: 10.1073/pnas.84.18.6425

PubMed ID: 2836377

Title: Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C.

PubMed ID: 2836377

DOI: 10.1093/oxfordjournals.jbchem.a122261

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8216207

Title: Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine 474.

PubMed ID: 8216207

DOI: 10.1042/bj2950131

PubMed ID: 8390446

Title: Urinary thrombomodulin, its isolation and characterization.

PubMed ID: 8390446

DOI: 10.1093/oxfordjournals.jbchem.a124063

PubMed ID: 27055590

Title: LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.

PubMed ID: 27055590

DOI: 10.1016/j.bbrc.2016.04.007

PubMed ID: 7559494

Title: The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin.

PubMed ID: 7559494

DOI: 10.1074/jbc.270.40.23366

PubMed ID: 8528067

Title: Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin.

PubMed ID: 8528067

DOI: 10.1002/pro.5560040904

PubMed ID: 7947766

Title: Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects.

PubMed ID: 7947766

DOI: 10.1021/bi00250a007

PubMed ID: 8745396

Title: Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin.

PubMed ID: 8745396

DOI: 10.1002/pro.5560050202

PubMed ID: 9367781

Title: Structure of the fifth EGF-like domain of thrombomodulin: an EGF-like domain with a novel disulfide-bonding pattern.

PubMed ID: 9367781

DOI: 10.1006/jmbi.1997.1356

PubMed ID: 7811989

Title: The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease.

PubMed ID: 7811989

PubMed ID: 9198186

Title: Thrombomodulin gene variations and thromboembolic disease.

PubMed ID: 9198186

PubMed ID: 9157575

Title: A common thrombomodulin amino acid dimorphism is associated with myocardial infarction.

PubMed ID: 9157575

PubMed ID: 9843165

Title: A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men.

PubMed ID: 9843165

PubMed ID: 11245641

Title: Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease.

PubMed ID: 11245641

DOI: 10.1161/01.cir.103.10.1386

PubMed ID: 12139752

Title: Mutations in the thrombomodulin gene are rare in patients with severe thrombophilia.

PubMed ID: 12139752

DOI: 10.1046/j.1365-2141.2002.03644.x

PubMed ID: 19625716

Title: Thrombomodulin mutations in atypical hemolytic-uremic syndrome.

PubMed ID: 19625716

DOI: 10.1056/nejmoa0810739

PubMed ID: 20513133

Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

PubMed ID: 20513133

DOI: 10.1002/humu.21256

Sequence Information:

  • Length: 575
  • Mass: 60329
  • Checksum: 9AF03CD151227D52
  • Sequence:
    • MLGVLVLGAL ALAGLGFPAP AEPQPGGSQC VEHDCFALYP GPATFLNASQ ICDGLRGHLM 
TVRSSVAADV ISLLLNGDGG VGRRRLWIGL QLPPGCGDPK RLGPLRGFQW VTGDNNTSYS 
RWARLDLNGA PLCGPLCVAV SAAEATVPSE PIWEEQQCEV KADGFLCEFH FPATCRPLAV 
EPGAAAAAVS ITYGTPFAAR GADFQALPVG SSAAVAPLGL QLMCTAPPGA VQGHWAREAP 
GAWDCSVENG GCEHACNAIP GAPRCQCPAG AALQADGRSC TASATQSCND LCEHFCVPNP 
DQPGSYSCMC ETGYRLAADQ HRCEDVDDCI LEPSPCPQRC VNTQGGFECH CYPNYDLVDG 
ECVEPVDPCF RANCEYQCQP LNQTSYLCVC AEGFAPIPHE PHRCQMFCNQ TACPADCDPN 
TQASCECPEG YILDDGFICT DIDECENGGF CSGVCHNLPG TFECICGPDS ALARHIGTDC 
DSGKVDGGDS GSGEPPPSPT PGSTLTPPAV GLVHSGLLIG ISIASLCLVV ALLALLCHLR 
KKQGAARAKM EYKCAAPSKE VVLQHVRTER TPQRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.