Details for: TSPAN4

Gene ID: 7106

Symbol: TSPAN4

Ensembl ID: ENSG00000214063

Description: tetraspanin 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.98
    Marker Score: 4315
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.38
    Marker Score: 6222
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.3
    Marker Score: 9915
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.18
    Marker Score: 2177
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.05
    Marker Score: 1129
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.91
    Marker Score: 613
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.91
    Marker Score: 2296
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.83
    Marker Score: 420
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.74
    Marker Score: 4426
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.72
    Marker Score: 2370
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.69
    Marker Score: 2720
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.65
    Marker Score: 14514
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.63
    Marker Score: 1537
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.56
    Marker Score: 10171
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5
    Marker Score: 24155
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.49
    Marker Score: 421
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.47
    Marker Score: 732
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.47
    Marker Score: 2930
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.45
    Marker Score: 327
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.4
    Marker Score: 439
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.38
    Marker Score: 335
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.36
    Marker Score: 2300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.35
    Marker Score: 17792
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.33
    Marker Score: 1289
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.31
    Marker Score: 623
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.31
    Marker Score: 44462
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.3
    Marker Score: 276
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.26
    Marker Score: 14212
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.26
    Marker Score: 1136
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.25
    Marker Score: 560
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.23
    Marker Score: 1324.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.23
    Marker Score: 304
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.17
    Marker Score: 7586
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.15
    Marker Score: 822
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.14
    Marker Score: 266
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.14
    Marker Score: 1185
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.14
    Marker Score: 291
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.14
    Marker Score: 1402
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.13
    Marker Score: 413
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.12
    Marker Score: 1005
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17460
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.11
    Marker Score: 1707.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.11
    Marker Score: 739
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.1
    Marker Score: 626
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.09
    Marker Score: 1591
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.09
    Marker Score: 1313
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.08
    Marker Score: 2944
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.06
    Marker Score: 1328.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.04
    Marker Score: 609
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.04
    Marker Score: 1043
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.04
    Marker Score: 654
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.03
    Marker Score: 5432
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.03
    Marker Score: 1151
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.02
    Marker Score: 560
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.02
    Marker Score: 293
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71712
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47936
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.98
    Marker Score: 903
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.98
    Marker Score: 1146
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.98
    Marker Score: 25049
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.98
    Marker Score: 248
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.97
    Marker Score: 391
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.95
    Marker Score: 808
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.95
    Marker Score: 3365
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.94
    Marker Score: 227
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.94
    Marker Score: 2212
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.93
    Marker Score: 388
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.92
    Marker Score: 3859
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.92
    Marker Score: 573
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.91
    Marker Score: 380
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2730
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.9
    Marker Score: 524
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.88
    Marker Score: 891
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.88
    Marker Score: 395
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.88
    Marker Score: 1438
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.88
    Marker Score: 3439
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.87
    Marker Score: 925
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.87
    Marker Score: 1005
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.87
    Marker Score: 338
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.85
    Marker Score: 498
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1218
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.85
    Marker Score: 967
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.84
    Marker Score: 222
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.84
    Marker Score: 554
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 271
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4781
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.83
    Marker Score: 471
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.83
    Marker Score: 4092
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.83
    Marker Score: 288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 628
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.82
    Marker Score: 248
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.82
    Marker Score: 309
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.81
    Marker Score: 878
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325.5

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Other Information

**Key Characteristics** 1. **Expression Pattern**: TSPAN4 is highly expressed in various cell types, including alveolar capillary type 2 endothelial cells, fibroblasts, and immune cells like Kupffer cells and Hofbauer cells. 2. **Tetraspanin Structure**: TSPAN4 spans the plasma membrane four times, allowing it to interact with multiple partners and participate in various cellular processes. 3. **Functionality**: TSPAN4 plays a role in cell adhesion, signaling, and immune response, highlighting its importance in maintaining tissue homeostasis and regulating immune cell function. **Pathways and Functions** 1. **Antigen Binding**: TSPAN4 interacts with integrins and other proteins to regulate antigen binding and presentation, which is crucial for the proper functioning of the immune system. 2. **Focal Adhesion**: TSPAN4 participates in the formation of focal adhesions, which are critical for cell adhesion and migration, particularly in immune cells. 3. **Integrin Binding**: TSPAN4 regulates integrin binding, which is essential for cell adhesion, migration, and signaling. 4. **Protein-Containing Complex Assembly**: TSPAN4 is involved in the assembly of protein-containing complexes, which are essential for maintaining cellular structure and function. 5. **Vesicle Formation**: TSPAN4 regulates vesicle formation and trafficking, which is critical for the proper functioning of immune cells. **Clinical Significance** 1. **Immune Response**: TSPAN4 plays a crucial role in regulating immune response, particularly in the context of inflammation and tissue damage. 2. **Cancer**: Alterations in TSPAN4 expression have been linked to various cancers, including lung cancer, highlighting its potential as a therapeutic target. 3. **Infectious Diseases**: TSPAN4 may play a role in the regulation of immune responses to infectious diseases, such as pneumonia and tuberculosis. 4. **Regenerative Medicine**: TSPAN4 may be involved in the regulation of tissue repair and regeneration, particularly in the context of lung injury. In conclusion, TSPAN4 is a complex gene that plays a significant role in immune response, cellular interactions, and tissue homeostasis. Further research is needed to fully elucidate the functions of TSPAN4 and its clinical significance, particularly in the context of immune-related diseases and cancer.

Genular Protein ID: 522703696

Symbol: TSN4_HUMAN

Name: Tetraspanin-4

UniProtKB Accession Codes:

O14817 Q6IAP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9360996

Title: NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.

PubMed ID: 9360996

DOI: 10.1074/jbc.272.46.29181

PubMed ID: 9714763

Title: Sequences and expression of six new members of the tetraspanin/TM4SF family.

PubMed ID: 9714763

DOI: 10.1016/s0167-4781(98)00087-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 238
  • Mass: 26118
  • Checksum: A6B9A5633065A492
  • Sequence:
    • MARACLQAVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGS FATLSSSFPS LSAANLLIIT 
GAFVMAIGFV GCLGAIKENK CLLLTFFLLL LLVFLLEATI AILFFAYTDK IDRYAQQDLK 
KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV SNYTDWFEVY NATRVPDSCC LEFSESCGLH 
APGTWWKAPC YETVKVWLQE NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA

Genular Protein ID: 1490712763

Symbol: A8MVV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MVV6 B7WPM8

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 3 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 5 RuleBase 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 174
  • Mass: 19448
  • Checksum: 1675491DE205E14A
  • Sequence:
    • MAIGFVGCLG AIKENKCLLL TFFLLLLLVF LLEATIAILF FAYTDKIDRY AQQDLKKGLH 
LYGTQGNVGL TNAWSIIQTD FRCCGVSNYT DWFEVYNATR VPDSCCLEFS ESCGLHAPGT 
WWKAPCYETV KVWLQENLLA VGIFGLCTAL VQILGLTFAM TMYCQVVKAD TYCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.