Details for: TSPAN4

Gene ID: 7106

Symbol: TSPAN4

Ensembl ID: ENSG00000214063

Description: tetraspanin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 193.1271
    Cell Significance Index: -30.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.8015
    Cell Significance Index: -28.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.7411
    Cell Significance Index: -31.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.6954
    Cell Significance Index: -27.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.6081
    Cell Significance Index: -27.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.1422
    Cell Significance Index: -29.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.7826
    Cell Significance Index: -27.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.2807
    Cell Significance Index: -31.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1909
    Cell Significance Index: -27.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7682
    Cell Significance Index: -19.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8560
    Cell Significance Index: -31.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.5199
    Cell Significance Index: 44.5300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.1653
    Cell Significance Index: 8.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9597
    Cell Significance Index: 102.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7464
    Cell Significance Index: 19.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4252
    Cell Significance Index: 182.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2727
    Cell Significance Index: 24.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2249
    Cell Significance Index: 168.2100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.0595
    Cell Significance Index: 2.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0549
    Cell Significance Index: 22.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8927
    Cell Significance Index: 25.5900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8732
    Cell Significance Index: 5.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4376
    Cell Significance Index: 193.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4141
    Cell Significance Index: 20.9300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3557
    Cell Significance Index: 2.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3407
    Cell Significance Index: 67.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3260
    Cell Significance Index: 178.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3136
    Cell Significance Index: 1.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2657
    Cell Significance Index: 50.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2428
    Cell Significance Index: 11.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1918
    Cell Significance Index: 22.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1858
    Cell Significance Index: 2.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1705
    Cell Significance Index: 153.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1699
    Cell Significance Index: 117.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0860
    Cell Significance Index: 1.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0841
    Cell Significance Index: 2.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0815
    Cell Significance Index: 61.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0805
    Cell Significance Index: 28.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0795
    Cell Significance Index: 7.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0601
    Cell Significance Index: 113.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0475
    Cell Significance Index: 1.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0297
    Cell Significance Index: 54.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0216
    Cell Significance Index: 33.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0181
    Cell Significance Index: 24.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0175
    Cell Significance Index: 11.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0163
    Cell Significance Index: 0.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0152
    Cell Significance Index: 1.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0096
    Cell Significance Index: 1.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0069
    Cell Significance Index: 0.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0195
    Cell Significance Index: -8.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0321
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0445
    Cell Significance Index: -32.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0494
    Cell Significance Index: -7.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0521
    Cell Significance Index: -9.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0524
    Cell Significance Index: -3.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0547
    Cell Significance Index: -6.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0578
    Cell Significance Index: -32.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0615
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0684
    Cell Significance Index: -42.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0866
    Cell Significance Index: -24.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0868
    Cell Significance Index: -6.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0875
    Cell Significance Index: -3.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0880
    Cell Significance Index: -17.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1186
    Cell Significance Index: -20.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1393
    Cell Significance Index: -15.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1647
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1758
    Cell Significance Index: -37.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1836
    Cell Significance Index: -8.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1926
    Cell Significance Index: -3.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2211
    Cell Significance Index: -26.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2212
    Cell Significance Index: -5.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2444
    Cell Significance Index: -6.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2639
    Cell Significance Index: -6.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2691
    Cell Significance Index: -28.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2713
    Cell Significance Index: -8.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2742
    Cell Significance Index: -16.8100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2864
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3013
    Cell Significance Index: -16.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3107
    Cell Significance Index: -2.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3168
    Cell Significance Index: -20.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3279
    Cell Significance Index: -5.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3413
    Cell Significance Index: -17.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3493
    Cell Significance Index: -24.1600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3548
    Cell Significance Index: -2.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3604
    Cell Significance Index: -28.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3773
    Cell Significance Index: -23.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3988
    Cell Significance Index: -24.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4085
    Cell Significance Index: -6.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4303
    Cell Significance Index: -25.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4764
    Cell Significance Index: -32.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4766
    Cell Significance Index: -24.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5775
    Cell Significance Index: -16.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5825
    Cell Significance Index: -4.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5904
    Cell Significance Index: -17.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6204
    Cell Significance Index: -13.4400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6454
    Cell Significance Index: -4.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6580
    Cell Significance Index: -16.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6841
    Cell Significance Index: -30.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression Pattern**: TSPAN4 is highly expressed in various cell types, including alveolar capillary type 2 endothelial cells, fibroblasts, and immune cells like Kupffer cells and Hofbauer cells. 2. **Tetraspanin Structure**: TSPAN4 spans the plasma membrane four times, allowing it to interact with multiple partners and participate in various cellular processes. 3. **Functionality**: TSPAN4 plays a role in cell adhesion, signaling, and immune response, highlighting its importance in maintaining tissue homeostasis and regulating immune cell function. **Pathways and Functions** 1. **Antigen Binding**: TSPAN4 interacts with integrins and other proteins to regulate antigen binding and presentation, which is crucial for the proper functioning of the immune system. 2. **Focal Adhesion**: TSPAN4 participates in the formation of focal adhesions, which are critical for cell adhesion and migration, particularly in immune cells. 3. **Integrin Binding**: TSPAN4 regulates integrin binding, which is essential for cell adhesion, migration, and signaling. 4. **Protein-Containing Complex Assembly**: TSPAN4 is involved in the assembly of protein-containing complexes, which are essential for maintaining cellular structure and function. 5. **Vesicle Formation**: TSPAN4 regulates vesicle formation and trafficking, which is critical for the proper functioning of immune cells. **Clinical Significance** 1. **Immune Response**: TSPAN4 plays a crucial role in regulating immune response, particularly in the context of inflammation and tissue damage. 2. **Cancer**: Alterations in TSPAN4 expression have been linked to various cancers, including lung cancer, highlighting its potential as a therapeutic target. 3. **Infectious Diseases**: TSPAN4 may play a role in the regulation of immune responses to infectious diseases, such as pneumonia and tuberculosis. 4. **Regenerative Medicine**: TSPAN4 may be involved in the regulation of tissue repair and regeneration, particularly in the context of lung injury. In conclusion, TSPAN4 is a complex gene that plays a significant role in immune response, cellular interactions, and tissue homeostasis. Further research is needed to fully elucidate the functions of TSPAN4 and its clinical significance, particularly in the context of immune-related diseases and cancer.

Genular Protein ID: 522703696

Symbol: TSN4_HUMAN

Name: Tetraspanin-4

UniProtKB Accession Codes:

O14817 Q6IAP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 6 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9360996

Title: NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.

PubMed ID: 9360996

DOI: 10.1074/jbc.272.46.29181

PubMed ID: 9714763

Title: Sequences and expression of six new members of the tetraspanin/TM4SF family.

PubMed ID: 9714763

DOI: 10.1016/s0167-4781(98)00087-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25342562

Title: Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration.

PubMed ID: 25342562

DOI: 10.1038/cr.2014.135

PubMed ID: 31371828

Title: Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains.

PubMed ID: 31371828

DOI: 10.1038/s41556-019-0367-5

PubMed ID: 34439793

Title: Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor.

PubMed ID: 34439793

DOI: 10.3390/biom11081127

PubMed ID: 36252000

Title: Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature.

PubMed ID: 36252000

DOI: 10.1073/pnas.2208993119

PubMed ID: 36823145

Title: Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes.

PubMed ID: 36823145

DOI: 10.1038/s41467-023-36596-9

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 238
  • Mass: 26118
  • Checksum: A6B9A5633065A492
  • Sequence:
    • MARACLQAVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGS FATLSSSFPS LSAANLLIIT 
GAFVMAIGFV GCLGAIKENK CLLLTFFLLL LLVFLLEATI AILFFAYTDK IDRYAQQDLK 
KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV SNYTDWFEVY NATRVPDSCC LEFSESCGLH 
APGTWWKAPC YETVKVWLQE NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA

Genular Protein ID: 1490712763

Symbol: A8MVV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MVV6 B7WPM8

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 5 RuleBase 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 174
  • Mass: 19448
  • Checksum: 1675491DE205E14A
  • Sequence:
    • MAIGFVGCLG AIKENKCLLL TFFLLLLLVF LLEATIAILF FAYTDKIDRY AQQDLKKGLH 
LYGTQGNVGL TNAWSIIQTD FRCCGVSNYT DWFEVYNATR VPDSCCLEFS ESCGLHAPGT 
WWKAPCYETV KVWLQENLLA VGIFGLCTAL VQILGLTFAM TMYCQVVKAD TYCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.