Details for: TMPO

Gene ID: 7112

Symbol: TMPO

Ensembl ID: ENSG00000120802

Description: thymopoietin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 128.9606
    Cell Significance Index: -32.7100
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.1217
    Cell Significance Index: -17.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 95.0364
    Cell Significance Index: -39.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.6477
    Cell Significance Index: -34.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.6435
    Cell Significance Index: -39.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.2779
    Cell Significance Index: -40.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.9399
    Cell Significance Index: -39.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.9000
    Cell Significance Index: -35.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.0660
    Cell Significance Index: -37.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.7596
    Cell Significance Index: -36.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2981
    Cell Significance Index: -31.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9239
    Cell Significance Index: -39.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1547
    Cell Significance Index: -13.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.7498
    Cell Significance Index: 154.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8664
    Cell Significance Index: 220.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8263
    Cell Significance Index: 362.4300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.7066
    Cell Significance Index: 8.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6539
    Cell Significance Index: 17.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4613
    Cell Significance Index: 50.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0518
    Cell Significance Index: 30.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0042
    Cell Significance Index: 109.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9924
    Cell Significance Index: 64.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8713
    Cell Significance Index: 20.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8245
    Cell Significance Index: 21.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8144
    Cell Significance Index: 42.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7750
    Cell Significance Index: 35.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7529
    Cell Significance Index: 679.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7381
    Cell Significance Index: 403.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7323
    Cell Significance Index: 146.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6923
    Cell Significance Index: 14.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6767
    Cell Significance Index: 14.6600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5796
    Cell Significance Index: 8.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5585
    Cell Significance Index: 90.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5511
    Cell Significance Index: 15.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5258
    Cell Significance Index: 64.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4905
    Cell Significance Index: 88.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4873
    Cell Significance Index: 29.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4775
    Cell Significance Index: 65.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4544
    Cell Significance Index: 200.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4087
    Cell Significance Index: 25.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4060
    Cell Significance Index: 5.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3526
    Cell Significance Index: 126.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3509
    Cell Significance Index: 9.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3027
    Cell Significance Index: 57.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1756
    Cell Significance Index: 10.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1473
    Cell Significance Index: 25.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1373
    Cell Significance Index: 13.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1164
    Cell Significance Index: 4.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1087
    Cell Significance Index: 5.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0703
    Cell Significance Index: 9.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0356
    Cell Significance Index: 1.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0321
    Cell Significance Index: 59.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0298
    Cell Significance Index: 45.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0250
    Cell Significance Index: 47.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0086
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0128
    Cell Significance Index: -7.9700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0149
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -11.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0173
    Cell Significance Index: -11.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0201
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0206
    Cell Significance Index: -15.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0278
    Cell Significance Index: -37.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0287
    Cell Significance Index: -21.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0401
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0407
    Cell Significance Index: -22.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0431
    Cell Significance Index: -4.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0809
    Cell Significance Index: -4.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0843
    Cell Significance Index: -12.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0848
    Cell Significance Index: -3.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0998
    Cell Significance Index: -5.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1009
    Cell Significance Index: -29.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1028
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1071
    Cell Significance Index: -22.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1119
    Cell Significance Index: -13.0400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1262
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1617
    Cell Significance Index: -18.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1662
    Cell Significance Index: -1.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1816
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2006
    Cell Significance Index: -22.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2043
    Cell Significance Index: -26.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2054
    Cell Significance Index: -3.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2135
    Cell Significance Index: -5.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2271
    Cell Significance Index: -6.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2394
    Cell Significance Index: -16.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2459
    Cell Significance Index: -6.5900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.2780
    Cell Significance Index: -1.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3010
    Cell Significance Index: -7.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3208
    Cell Significance Index: -24.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3337
    Cell Significance Index: -24.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3436
    Cell Significance Index: -9.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3445
    Cell Significance Index: -35.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3463
    Cell Significance Index: -9.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4107
    Cell Significance Index: -32.5300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4221
    Cell Significance Index: -2.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4915
    Cell Significance Index: -8.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5377
    Cell Significance Index: -32.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6380
    Cell Significance Index: -28.2200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6949
    Cell Significance Index: -4.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell-type specific expression**: TMPO is expressed in a range of cell types, including thymocytes, NK T cells, granulosa cells, and neural crest cells, highlighting its potential role in diverse cellular processes. 2. **Regulation of cell cycle**: TMPO is involved in the regulation of the cell cycle, particularly in the transition from mitosis to the G1 phase, suggesting its role in controlling cellular proliferation. 3. **Nuclear envelope dynamics**: TMPO is implicated in the regulation of nuclear envelope dynamics, including its assembly and disassembly, which is essential for cell cycle progression and cellular differentiation. 4. **Signaling pathways**: TMPO is involved in various signaling pathways, including those mediated by Rho GTPases, which are critical for cell migration, proliferation, and differentiation. **Pathways and Functions** TMPO's involvement in various cellular processes can be attributed to its participation in the following pathways and functions: 1. **Cadherin binding**: TMPO interacts with cadherins, which are essential adhesion molecules that regulate cell-cell interactions and tissue organization. 2. **Cdc42 GTPase cycle**: TMPO regulates the activity of Cdc42, a key GTPase involved in cell cycle progression, cell migration, and cytoskeletal organization. 3. **Cell cycle regulation**: TMPO modulates the cell cycle by regulating the transition from mitosis to the G1 phase, ensuring proper cellular proliferation and differentiation. 4. **Nuclear envelope reassembly**: TMPO is involved in the reassembly of the nuclear envelope after mitosis, which is essential for maintaining nuclear integrity and regulating gene expression. 5. **Rho GTPase signaling**: TMPO regulates the activity of Rho GTPases, which are critical for cell migration, proliferation, and differentiation. **Clinical Significance** TMPO's involvement in immune cell development and function has significant implications for the understanding and treatment of various diseases, including: 1. **Immunodeficiency disorders**: TMPO's role in thymocyte development and function makes it a potential target for the treatment of immunodeficiency disorders, such as thymic dysplasia and severe combined immunodeficiency. 2. **Cancer**: TMPO's involvement in cell cycle regulation and nuclear envelope dynamics positions it as a potential regulator of cancer cell proliferation and differentiation. 3. **Reproductive disorders**: TMPO's expression in granulosa cells and Leydig cells makes it a potential target for the treatment of reproductive disorders, such as infertility and testicular dysfunction. In conclusion, TMPO is a multifunctional gene that plays a critical role in regulating cellular processes, including cell cycle progression, nuclear envelope dynamics, and signaling pathways. Its involvement in immune cell development and function has significant implications for the understanding and treatment of various diseases, making it an attractive target for further research and therapeutic intervention.

Genular Protein ID: 1189690402

Symbol: LAP2A_HUMAN

Name: Lamina-associated polypeptide 2, isoform alpha

UniProtKB Accession Codes:

P42166 P08918 P08919 Q14860 Q16295

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7517549

Title: Three distinct human thymopoietins are derived from alternatively spliced mRNAs.

PubMed ID: 7517549

DOI: 10.1073/pnas.91.14.6283

PubMed ID: 8530026

Title: Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2.

PubMed ID: 8530026

DOI: 10.1006/geno.1995.1131

PubMed ID: 7703909

Title: A new thymopoietin precursor gene from human thymus.

PubMed ID: 7703909

PubMed ID: 3473468

Title: Isolation and complete amino acid sequence of human thymopoietin and splenin.

PubMed ID: 3473468

DOI: 10.1073/pnas.84.11.3545

PubMed ID: 8016147

Title:

PubMed ID: 8016147

DOI: 10.1073/pnas.91.13.6249

PubMed ID: 9707448

Title: Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics.

PubMed ID: 9707448

DOI: 10.1093/emboj/17.16.4887

PubMed ID: 10984438

Title: Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins.

PubMed ID: 10984438

DOI: 10.1242/jcs.113.19.3473

PubMed ID: 12475961

Title: Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein.

PubMed ID: 12475961

DOI: 10.1091/mbc.e02-07-0450

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 11500367

Title: Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.

PubMed ID: 11500367

DOI: 10.1093/emboj/20.16.4399

PubMed ID: 11435115

Title: Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.

PubMed ID: 11435115

DOI: 10.1016/s0969-2126(01)00611-6

PubMed ID: 16247757

Title: Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy.

PubMed ID: 16247757

DOI: 10.1002/humu.20250

PubMed ID: 27896284

Title: Analyses of more than 60,000 exomes questions the role of numerous genes previously associated with dilated cardiomyopathy.

PubMed ID: 27896284

DOI: 10.1002/mgg3.245

Sequence Information:

  • Length: 694
  • Mass: 75492
  • Checksum: 1B514B0FB61D0D75
  • Sequence:
    • MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK 
GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL 
LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS 
DRYSDNEEGK KKEHKKVKST RDIVPFSELG TTPSGGGFFQ GISFPEISTR PPLGSTELQA 
AKKVHTSKGD LPREPLVATN LPGRGQLQKL ASERNLFISC KSSHDRCLEK SSSSSSQPEH 
SAMLVSTAAS PSLIKETTTG YYKDIVENIC GREKSGIQPL CPERSHISDQ SPLSSKRKAL 
EESESSQLIS PPLAQAIRDY VNSLLVQGGV GSLPGTSNSM PPLDVENIQK RIDQSKFQET 
EFLSPPRKVP RLSEKSVEER DSGSFVAFQN IPGSELMSSF AKTVVSHSLT TLGLEVAKQS 
QHDKIDASEL SFPFHESILK VIEEEWQQVD RQLPSLACKY PVSSREATQI LSVPKVDDEI 
LGFISEATPL GGIQAASTES CNQQLDLALC RAYEAAASAL QIATHTAFVA KAMQADISQA 
AQILSSDPSR THQALGILSK TYDAASYICE AAFDEVKMAA HTMGNATVGR RYLWLKDCKI 
NLASKNKLAS TPFKGGTLFG GEVCKVIKKR GNKH

Genular Protein ID: 1814914812

Symbol: LAP2B_HUMAN

Name: Lamina-associated polypeptide 2, isoforms beta/gamma

UniProtKB Accession Codes:

P42167 A2T926 Q14861

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 Pumba 1 Reactome 13 RefSeq 3 SMART 2 SMR 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7517549

Title: Three distinct human thymopoietins are derived from alternatively spliced mRNAs.

PubMed ID: 7517549

DOI: 10.1073/pnas.91.14.6283

PubMed ID: 18403046

Title: LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression.

PubMed ID: 18403046

DOI: 10.1016/j.ejcb.2008.01.014

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8530026

Title: Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2.

PubMed ID: 8530026

DOI: 10.1006/geno.1995.1131

PubMed ID: 9490046

Title: Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin.

PubMed ID: 9490046

DOI: 10.1046/j.1432-1327.1998.2510729.x

PubMed ID: 12538639

Title: HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication.

PubMed ID: 12538639

DOI: 10.1083/jcb.200210026

PubMed ID: 10806084

Title: Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics.

PubMed ID: 10806084

DOI: 10.1006/jsbi.2000.4212

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 11500367

Title: Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.

PubMed ID: 11500367

DOI: 10.1093/emboj/20.16.4399

PubMed ID: 11435115

Title: Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.

PubMed ID: 11435115

DOI: 10.1016/s0969-2126(01)00611-6

Sequence Information:

  • Length: 454
  • Mass: 50670
  • Checksum: 03277C5723117909
  • Sequence:
    • MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK 
GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL 
LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS 
DRYSDNEEDS KIELKLEKRE PLKGRAKTPV TLKQRRVEHN QSYSQAGITE TEWTSGSSKG 
GPLQALTRES TRGSRRTPRK RVETSEHFRI DGPVISESTP IAETIMASSN ESLVVNRVTG 
NFKHASPILP ITEFSDIPRR APKKPLTRAE VGEKTEERRV ERDILKEMFP YEASTPTGIS 
ASCRRPIKGA AGRPLELSDF RMEESFSSKY VPKYVPLADV KSEKTKKGRS IPVWIKILLF 
VVVAVFLFLV YQAMETNQVN PFSNFLHVDP RKSN

Genular Protein ID: 1118450729

Symbol: Q59G12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59G12

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 2 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 378
  • Mass: 41806
  • Checksum: D73087A941C65F75
  • Sequence:
    • GSEAAARSPA RSKRAGVSGG GKGCGEGASQ IPEMPEFLED PSVLTKDKLK SELVANNVTL 
PAGEQRKDVY VQLYLQHLTA RNRPPLPAGT NSKGPPDFSS DEEREPTPVL GSGAAAAGRS 
RAAVGRKATK KTDKPRQEDK DDLDVTELTN EDLLDQLVKY GVNPGPIVGT TRKLYEKKLL 
KLREQGTESR SSTPLPTISS SAENTRQNGS NDSDRYSDNE EDSKIELKLE KREPLKGRAK 
TPVTLKQRRV EHNQVGEKTE ERRVERDILK EMFPYEASTP TGISASCRRP IKGAAGRPLE 
LSDFRMEESF SSKYVPKYVP LADVKSEKTK KGRSIPVWIK ILLFVVVAVF LFLVYQAMET 
NQVNPFSNFL HVDPRKSN

Genular Protein ID: 2309660591

Symbol: G5E972_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E972

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.M700120-MCP200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 414
  • Mass: 46306
  • Checksum: D36CC78A5EEE7679
  • Sequence:
    • MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK 
GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL 
LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS 
DRYSDNEEDS KIELKLEKRE PLKGRAKTPV TLKQRRVEHN QVETSEHFRI DGPVISESTP 
IAETIMASSN ESLVVNRVTG NFKHASPILP ITEFSDIPRR APKKPLTRAE VGEKTEERRV 
ERDILKEMFP YEASTPTGIS ASCRRPIKGA AGRPLELSDF RMEESFSSKY VPKYVPLADV 
KSEKTKKGRS IPVWIKILLF VVVAVFLFLV YQAMETNQVN PFSNFLHVDP RKSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.