Details for: TPM1

Gene ID: 7168

Symbol: TPM1

Ensembl ID: ENSG00000140416

Description: tropomyosin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.64
    Marker Score: 7347
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.12
    Marker Score: 114476
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 4.58
    Marker Score: 4371
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.23
    Marker Score: 56283
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.1
    Marker Score: 5509
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.94
    Marker Score: 1296
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.89
    Marker Score: 51341
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.83
    Marker Score: 9744
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.79
    Marker Score: 1216
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.54
    Marker Score: 2521
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.42
    Marker Score: 7503
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.39
    Marker Score: 6372
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.36
    Marker Score: 11942.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.35
    Marker Score: 4604
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.32
    Marker Score: 2529
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.2
    Marker Score: 3873
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.16
    Marker Score: 15512.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.15
    Marker Score: 6069
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.14
    Marker Score: 3008
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.02
    Marker Score: 3733
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.95
    Marker Score: 1118
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.92
    Marker Score: 18995
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.92
    Marker Score: 9161
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.91
    Marker Score: 11228
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.91
    Marker Score: 100728
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.9
    Marker Score: 13934
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.85
    Marker Score: 899
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.84
    Marker Score: 31978
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.83
    Marker Score: 12215
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.82
    Marker Score: 1855
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.8
    Marker Score: 3493
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.77
    Marker Score: 2359
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.66
    Marker Score: 6260
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.63
    Marker Score: 9336
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.55
    Marker Score: 2938
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.53
    Marker Score: 16117
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.51
    Marker Score: 3871
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.44
    Marker Score: 1427
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.44
    Marker Score: 1319.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.43
    Marker Score: 865
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.43
    Marker Score: 2464
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.42
    Marker Score: 5053
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.42
    Marker Score: 685
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.37
    Marker Score: 2286
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.35
    Marker Score: 3615
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.32
    Marker Score: 9676
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.31
    Marker Score: 4093
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.31
    Marker Score: 6035
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.29
    Marker Score: 3803
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.26
    Marker Score: 1349
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.24
    Marker Score: 634
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.21
    Marker Score: 1137
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.2
    Marker Score: 646
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.18
    Marker Score: 1879
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.18
    Marker Score: 2333
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.18
    Marker Score: 4947
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.18
    Marker Score: 790
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.18
    Marker Score: 2259
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.16
    Marker Score: 2332
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.15
    Marker Score: 6124
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.13
    Marker Score: 1175.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.13
    Marker Score: 4862
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.13
    Marker Score: 1422
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.13
    Marker Score: 1525
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.13
    Marker Score: 3614
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.11
    Marker Score: 676
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.11
    Marker Score: 537
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.11
    Marker Score: 1024
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.11
    Marker Score: 474
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.06
    Marker Score: 856
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.05
    Marker Score: 1931
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.04
    Marker Score: 1186
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.03
    Marker Score: 4960.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.03
    Marker Score: 4821
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.02
    Marker Score: 1125
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.02
    Marker Score: 2139
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.02
    Marker Score: 2267
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.02
    Marker Score: 5089
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.99
    Marker Score: 8343
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.98
    Marker Score: 3157
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.98
    Marker Score: 3956
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.98
    Marker Score: 1972
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.97
    Marker Score: 489
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.96
    Marker Score: 822
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.96
    Marker Score: 1081
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.96
    Marker Score: 819
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.93
    Marker Score: 668
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.92
    Marker Score: 572
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.91
    Marker Score: 5198
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.9
    Marker Score: 1109
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.85
    Marker Score: 694.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.82
    Marker Score: 759
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.8
    Marker Score: 889
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.79
    Marker Score: 3028
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.76
    Marker Score: 643
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.76
    Marker Score: 2209
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.75
    Marker Score: 2535
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.75
    Marker Score: 1866
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.74
    Marker Score: 1558
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.72
    Marker Score: 496

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** TPM1 is a 310-kDa protein consisting of two identical subunits (alpha-1 and alpha-2) that are coiled together to form a long, helical structure. Each subunit has a conserved region (residues 1-73) that binds to actin filaments, while the N- and C-termini are involved in dimerization and interactions with other proteins. TPM1 is highly expressed in muscle cells, with a strong presence in cardiac muscle cells, smooth muscle cells, and uterine smooth muscle cells. The protein's expression is also detected in other cell types, including endothelial cells, mesothelial cells, and renal interstitial pericytes. **Pathways and Functions** TPM1 is involved in various cellular processes, including: 1. **Muscle Contraction**: TPM1 regulates muscle contraction by binding to actin filaments and influencing their dynamics. This interaction is essential for the proper functioning of the sarcomere, the functional unit of striated muscle tissue. 2. **Cytoskeleton Organization**: TPM1 plays a crucial role in maintaining the organization and structure of the cytoskeleton, particularly in muscle cells and endothelial cells. 3. **Cell Adhesion**: TPM1 interacts with other proteins to regulate cell adhesion, including the regulation of vascular associated smooth muscle cell migration and proliferation. 4. **Cell Migration**: TPM1 is involved in the regulation of cell migration, particularly in the context of vascular associated smooth muscle cell migration. 5. **Stress Fiber Assembly**: TPM1 regulates the assembly of stress fibers, which are important for cell shape and cytoskeleton organization. 6. **Regulation of Heart Contraction**: TPM1 is involved in the regulation of heart contraction, particularly in the context of cardiac muscle cells. **Clinical Significance** Dysregulation of TPM1 has been implicated in various diseases, including: 1. **Muscular Dystrophy**: TPM1 mutations have been identified in patients with muscular dystrophy, highlighting the protein's importance in muscle function and integrity. 2. **Cardiovascular Disease**: TPM1 dysregulation has been linked to cardiovascular disease, including arrhythmias and cardiac failure. 3. **Cancer**: TPM1 is overexpressed in certain types of cancer, including breast cancer and colon cancer, suggesting its potential role in tumorigenesis. 4. **Wound Healing**: TPM1 is involved in the regulation of wound healing, particularly in the context of vascular associated smooth muscle cell migration and proliferation. In conclusion, TPM1 is a critical protein that plays a central role in regulating muscle contraction, cell shape, and cytoskeleton organization. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining proper cellular function and integrity.

Genular Protein ID: 916414167

Symbol: TPM1_HUMAN

Name: Tropomyosin alpha-1 chain

UniProtKB Accession Codes:

P09493 B7Z5T7 D9YZV2 D9YZV3 D9YZV8 P09494 P10469 Q6DV89 Q6DV90 Q7Z6L8 Q86W64 Q96IK2 Q9UCI1 Q9UCI2 Q9UCY9 Q9Y427

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 22 EMDB 6 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 36 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 9 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 2 RefSeq 11 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 3 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3548719

Title: Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein.

PubMed ID: 3548719

DOI: 10.1016/0006-291x(87)91486-0

PubMed ID: 3336357

Title: Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.

PubMed ID: 3336357

DOI: 10.1128/mcb.8.1.160-168.1988

PubMed ID: 3336363

Title: Human hTM alpha gene: expression in muscle and nonmuscle tissue.

PubMed ID: 3336363

DOI: 10.1128/mcb.8.1.433-440.1988

PubMed ID: 15249230

Title: Expression of a novel cardiac-specific tropomyosin isoform in humans.

PubMed ID: 15249230

DOI: 10.1016/j.bbrc.2004.06.084

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3138425

Title: Evolution of tropomyosin functional domains: differential splicing and genomic constraints.

PubMed ID: 3138425

DOI: 10.1007/bf02100079

PubMed ID: 8450225

Title: Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis.

PubMed ID: 8450225

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 17895359

Title: DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress.

PubMed ID: 17895359

DOI: 10.1242/jcs.003251

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23170982

Title: alpha-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains.

PubMed ID: 23170982

DOI: 10.1021/bi301323n

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26873245

Title: Localization of the binding interface between leiomodin-2 and alpha-tropomyosin.

PubMed ID: 26873245

DOI: 10.1016/j.bbapap.2016.02.009

PubMed ID: 8205619

Title: Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.

PubMed ID: 8205619

DOI: 10.1016/0092-8674(94)90054-x

PubMed ID: 8523464

Title: Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy.

PubMed ID: 8523464

DOI: 10.1016/0022-2828(95)90026-8

PubMed ID: 7898523

Title: Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.

PubMed ID: 7898523

DOI: 10.1056/nejm199504203321603

PubMed ID: 9822100

Title: The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.

PubMed ID: 9822100

DOI: 10.1016/s0735-1097(98)00448-3

PubMed ID: 11273725

Title: Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy.

PubMed ID: 11273725

DOI: 10.1006/jmcc.2000.1339

PubMed ID: 12974739

Title: Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy.

PubMed ID: 12974739

DOI: 10.1034/j.1399-0004.2003.00151.x

PubMed ID: 21551322

Title: Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype.

PubMed ID: 21551322

DOI: 10.1161/circgenetics.110.959270

Sequence Information:

  • Length: 284
  • Mass: 32709
  • Checksum: F57139E2B0972F4D
  • Sequence:
    • MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE 
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI

Genular Protein ID: 2265387308

Symbol: B7Z722_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z722

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 2 Gene3D 2 GenomeRNAi 1 IntAct 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 248
  • Mass: 28608
  • Checksum: A175BDD53107B563
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EEKVAHAKEE NLSMHQMLDQ 
TLLELNNM

Genular Protein ID: 1595397331

Symbol: A0A0K0K1I0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0K0K1I0

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 284
  • Mass: 32866
  • Checksum: D45DBCA97BC3C6EE
  • Sequence:
    • MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 
ERAELSEGQV RQLEEQLRIM DQTLKALMAA EDKYSQKEDR YEEEIKVLSD KLKEAETRAE 
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSM

Genular Protein ID: 4253140696

Symbol: F5H7S3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H7S3

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 245
  • Mass: 28525
  • Checksum: 599EF5A43C1BF72F
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGQVRQLEEQ LRIMDQTLKA LMAAEDKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNELKL 
ALNED

Genular Protein ID: 3923985425

Symbol: H7BYY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BYY1

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 248
  • Mass: 28747
  • Checksum: 8699389EFA535CC0
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGQVRQLEEQ LRIMDQTLKA LMAAEDKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EEKVAHAKEE NLSMHQMLDQ 
TLLELNNM

Genular Protein ID: 3389703617

Symbol: O15513_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15513

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 GO 2 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 48
  • Mass: 5600
  • Checksum: B78E20CBC3CD263E
  • Sequence:
    • NRAEFAERSV TKLEKSIDDL EEKVAHAKEE NLSMHQMLDQ TLLELNNM

Genular Protein ID: 3739120136

Symbol: H0YK48_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YK48

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 248
  • Mass: 28580
  • Checksum: 8E56EE9F0800DF6E
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDELYAQKLK YKAISEELDH 
ALNDMTSI

Genular Protein ID: 27406300

Symbol: D9YZV5_HUMAN

Name: N/A

UniProtKB Accession Codes:

D9YZV5

Database IDs:

ARBA 9 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 3 Gene3D 3 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 284
  • Mass: 32876
  • Checksum: FDBEEFE342C4ACE3
  • Sequence:
    • MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 
ERAELSEGQV RQLEEQLRIM DQTLKALMAA EDKYSQKEDR YEEEIKVLSD KLKEAETRAE 
FAERSVTKLE KSIDDLEEKV AHAKEENLSM HQMLDQTLLE LNNM

Genular Protein ID: 3773458461

Symbol: D9YZV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

D9YZV7

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 ExpressionAtlas 1 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 245
  • Mass: 28385
  • Checksum: 1255A14D9F26E29F
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNELKL 
ALNED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.