Details for: TPM1

Gene ID: 7168

Symbol: TPM1

Ensembl ID: ENSG00000140416

Description: tropomyosin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 523.6419
    Cell Significance Index: -81.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 373.0829
    Cell Significance Index: -94.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 252.0830
    Cell Significance Index: -103.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 209.0982
    Cell Significance Index: -98.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 204.7718
    Cell Significance Index: -83.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 193.1432
    Cell Significance Index: -99.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 150.5315
    Cell Significance Index: -101.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 87.3219
    Cell Significance Index: -83.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 76.7505
    Cell Significance Index: -94.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.6014
    Cell Significance Index: -98.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.6905
    Cell Significance Index: -97.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.4705
    Cell Significance Index: -46.9900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 18.4758
    Cell Significance Index: 97.2200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 12.3761
    Cell Significance Index: 76.1700
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 12.2758
    Cell Significance Index: 35.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 9.0507
    Cell Significance Index: 133.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 7.8846
    Cell Significance Index: 605.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.4267
    Cell Significance Index: 113.5900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 5.0906
    Cell Significance Index: 31.6300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 4.7610
    Cell Significance Index: 76.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 4.4864
    Cell Significance Index: 487.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.3920
    Cell Significance Index: 563.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.0415
    Cell Significance Index: 301.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.8891
    Cell Significance Index: 534.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.8507
    Cell Significance Index: 133.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.7434
    Cell Significance Index: 2044.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.5454
    Cell Significance Index: 45.4100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 3.1260
    Cell Significance Index: 44.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9858
    Cell Significance Index: 140.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3290
    Cell Significance Index: 164.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2702
    Cell Significance Index: 102.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.2420
    Cell Significance Index: 1017.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.7718
    Cell Significance Index: 34.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.6795
    Cell Significance Index: 174.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6356
    Cell Significance Index: 47.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6118
    Cell Significance Index: 34.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5765
    Cell Significance Index: 203.6800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5618
    Cell Significance Index: 12.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5153
    Cell Significance Index: 41.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4983
    Cell Significance Index: 300.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4377
    Cell Significance Index: 635.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.2824
    Cell Significance Index: 2365.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2654
    Cell Significance Index: 59.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9674
    Cell Significance Index: 174.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9674
    Cell Significance Index: 22.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9612
    Cell Significance Index: 118.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9063
    Cell Significance Index: 325.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8432
    Cell Significance Index: 1587.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8249
    Cell Significance Index: 12.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7226
    Cell Significance Index: 1112.4000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7125
    Cell Significance Index: 12.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6660
    Cell Significance Index: 40.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6467
    Cell Significance Index: 63.9700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5238
    Cell Significance Index: 4.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5053
    Cell Significance Index: 100.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4193
    Cell Significance Index: 290.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3344
    Cell Significance Index: 17.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3275
    Cell Significance Index: 62.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2845
    Cell Significance Index: 48.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2612
    Cell Significance Index: 165.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2136
    Cell Significance Index: 3.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0870
    Cell Significance Index: 5.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0404
    Cell Significance Index: 1.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0028
    Cell Significance Index: 3.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0254
    Cell Significance Index: -2.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0351
    Cell Significance Index: -25.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0476
    Cell Significance Index: -35.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0848
    Cell Significance Index: -52.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0965
    Cell Significance Index: -9.8600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0999
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1239
    Cell Significance Index: -69.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1596
    Cell Significance Index: -10.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2264
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2312
    Cell Significance Index: -48.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2857
    Cell Significance Index: -82.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3270
    Cell Significance Index: -37.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4209
    Cell Significance Index: -61.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4378
    Cell Significance Index: -51.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5621
    Cell Significance Index: -19.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5621
    Cell Significance Index: -6.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5828
    Cell Significance Index: -30.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5951
    Cell Significance Index: -17.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6156
    Cell Significance Index: -27.2300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.7559
    Cell Significance Index: -3.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7703
    Cell Significance Index: -29.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8015
    Cell Significance Index: -25.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.8027
    Cell Significance Index: -94.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8661
    Cell Significance Index: -21.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0044
    Cell Significance Index: -52.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0417
    Cell Significance Index: -82.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1356
    Cell Significance Index: -29.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2014
    Cell Significance Index: -83.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.2085
    Cell Significance Index: -9.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2087
    Cell Significance Index: -35.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2279
    Cell Significance Index: -62.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2474
    Cell Significance Index: -70.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.2748
    Cell Significance Index: -27.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.2780
    Cell Significance Index: -30.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2931
    Cell Significance Index: -22.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TPM1 is a 310-kDa protein consisting of two identical subunits (alpha-1 and alpha-2) that are coiled together to form a long, helical structure. Each subunit has a conserved region (residues 1-73) that binds to actin filaments, while the N- and C-termini are involved in dimerization and interactions with other proteins. TPM1 is highly expressed in muscle cells, with a strong presence in cardiac muscle cells, smooth muscle cells, and uterine smooth muscle cells. The protein's expression is also detected in other cell types, including endothelial cells, mesothelial cells, and renal interstitial pericytes. **Pathways and Functions** TPM1 is involved in various cellular processes, including: 1. **Muscle Contraction**: TPM1 regulates muscle contraction by binding to actin filaments and influencing their dynamics. This interaction is essential for the proper functioning of the sarcomere, the functional unit of striated muscle tissue. 2. **Cytoskeleton Organization**: TPM1 plays a crucial role in maintaining the organization and structure of the cytoskeleton, particularly in muscle cells and endothelial cells. 3. **Cell Adhesion**: TPM1 interacts with other proteins to regulate cell adhesion, including the regulation of vascular associated smooth muscle cell migration and proliferation. 4. **Cell Migration**: TPM1 is involved in the regulation of cell migration, particularly in the context of vascular associated smooth muscle cell migration. 5. **Stress Fiber Assembly**: TPM1 regulates the assembly of stress fibers, which are important for cell shape and cytoskeleton organization. 6. **Regulation of Heart Contraction**: TPM1 is involved in the regulation of heart contraction, particularly in the context of cardiac muscle cells. **Clinical Significance** Dysregulation of TPM1 has been implicated in various diseases, including: 1. **Muscular Dystrophy**: TPM1 mutations have been identified in patients with muscular dystrophy, highlighting the protein's importance in muscle function and integrity. 2. **Cardiovascular Disease**: TPM1 dysregulation has been linked to cardiovascular disease, including arrhythmias and cardiac failure. 3. **Cancer**: TPM1 is overexpressed in certain types of cancer, including breast cancer and colon cancer, suggesting its potential role in tumorigenesis. 4. **Wound Healing**: TPM1 is involved in the regulation of wound healing, particularly in the context of vascular associated smooth muscle cell migration and proliferation. In conclusion, TPM1 is a critical protein that plays a central role in regulating muscle contraction, cell shape, and cytoskeleton organization. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining proper cellular function and integrity.

Genular Protein ID: 916414167

Symbol: TPM1_HUMAN

Name: Tropomyosin alpha-1 chain

UniProtKB Accession Codes:

P09493 B7Z5T7 D9YZV2 D9YZV3 D9YZV8 P09494 P10469 Q6DV89 Q6DV90 Q7Z6L8 Q86W64 Q96IK2 Q9UCI1 Q9UCI2 Q9UCY9 Q9Y427

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 22 EMDB 6 Ensembl 8 ExpressionAtlas 1 GO 36 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 2 RefSeq 11 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3548719

Title: Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein.

PubMed ID: 3548719

DOI: 10.1016/0006-291x(87)91486-0

PubMed ID: 3336357

Title: Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.

PubMed ID: 3336357

DOI: 10.1128/mcb.8.1.160-168.1988

PubMed ID: 3336363

Title: Human hTM alpha gene: expression in muscle and nonmuscle tissue.

PubMed ID: 3336363

DOI: 10.1128/mcb.8.1.433-440.1988

PubMed ID: 15249230

Title: Expression of a novel cardiac-specific tropomyosin isoform in humans.

PubMed ID: 15249230

DOI: 10.1016/j.bbrc.2004.06.084

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3138425

Title: Evolution of tropomyosin functional domains: differential splicing and genomic constraints.

PubMed ID: 3138425

DOI: 10.1007/bf02100079

PubMed ID: 8450225

Title: Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis.

PubMed ID: 8450225

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 17895359

Title: DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress.

PubMed ID: 17895359

DOI: 10.1242/jcs.003251

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23170982

Title: alpha-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains.

PubMed ID: 23170982

DOI: 10.1021/bi301323n

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26873245

Title: Localization of the binding interface between leiomodin-2 and alpha-tropomyosin.

PubMed ID: 26873245

DOI: 10.1016/j.bbapap.2016.02.009

PubMed ID: 8205619

Title: Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.

PubMed ID: 8205619

DOI: 10.1016/0092-8674(94)90054-x

PubMed ID: 8523464

Title: Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy.

PubMed ID: 8523464

DOI: 10.1016/0022-2828(95)90026-8

PubMed ID: 7898523

Title: Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.

PubMed ID: 7898523

DOI: 10.1056/nejm199504203321603

PubMed ID: 9822100

Title: The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.

PubMed ID: 9822100

DOI: 10.1016/s0735-1097(98)00448-3

PubMed ID: 11273725

Title: Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy.

PubMed ID: 11273725

DOI: 10.1006/jmcc.2000.1339

PubMed ID: 12974739

Title: Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy.

PubMed ID: 12974739

DOI: 10.1034/j.1399-0004.2003.00151.x

PubMed ID: 21551322

Title: Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype.

PubMed ID: 21551322

DOI: 10.1161/circgenetics.110.959270

Sequence Information:

  • Length: 284
  • Mass: 32709
  • Checksum: F57139E2B0972F4D
  • Sequence:
    • MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 
ERAELSEGKC AELEEELKTV TNNLKSLEAQ AEKYSQKEDR YEEEIKVLSD KLKEAETRAE 
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSI

Genular Protein ID: 3923985425

Symbol: H7BYY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BYY1

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 248
  • Mass: 28747
  • Checksum: 8699389EFA535CC0
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGQVRQLEEQ LRIMDQTLKA LMAAEDKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EEKVAHAKEE NLSMHQMLDQ 
TLLELNNM

Genular Protein ID: 27406300

Symbol: D9YZV5_HUMAN

Name: N/A

UniProtKB Accession Codes:

D9YZV5

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 6 Gene3D 3 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 284
  • Mass: 32876
  • Checksum: FDBEEFE342C4ACE3
  • Sequence:
    • MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 
ERAELSEGQV RQLEEQLRIM DQTLKALMAA EDKYSQKEDR YEEEIKVLSD KLKEAETRAE 
FAERSVTKLE KSIDDLEEKV AHAKEENLSM HQMLDQTLLE LNNM

Genular Protein ID: 3389703617

Symbol: O15513_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15513

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 48
  • Mass: 5600
  • Checksum: B78E20CBC3CD263E
  • Sequence:
    • NRAEFAERSV TKLEKSIDDL EEKVAHAKEE NLSMHQMLDQ TLLELNNM

Genular Protein ID: 3739120136

Symbol: H0YK48_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YK48

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 248
  • Mass: 28580
  • Checksum: 8E56EE9F0800DF6E
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDELYAQKLK YKAISEELDH 
ALNDMTSI

Genular Protein ID: 2265387308

Symbol: B7Z722_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z722

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 2 IntAct 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 248
  • Mass: 28608
  • Checksum: A175BDD53107B563
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EEKVAHAKEE NLSMHQMLDQ 
TLLELNNM

Genular Protein ID: 4253140696

Symbol: F5H7S3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H7S3

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 245
  • Mass: 28525
  • Checksum: 599EF5A43C1BF72F
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGQVRQLEEQ LRIMDQTLKA LMAAEDKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNELKL 
ALNED

Genular Protein ID: 1595397331

Symbol: A0A0K0K1I0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0K0K1I0

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 3 Gene3D 2 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 284
  • Mass: 32866
  • Checksum: D45DBCA97BC3C6EE
  • Sequence:
    • MDAIKKKMQM LKLDKENALD RAEQAEADKK AAEDRSKQLE DELVSLQKKL KGTEDELDKY 
SEALKDAQEK LELAEKKATD AEADVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 
DESERGMKVI ESRAQKDEEK MEIQEIQLKE AKHIAEDADR KYEEVARKLV IIESDLERAE 
ERAELSEGQV RQLEEQLRIM DQTLKALMAA EDKYSQKEDR YEEEIKVLSD KLKEAETRAE 
FAERSVTKLE KSIDDLEDEL YAQKLKYKAI SEELDHALND MTSM

Genular Protein ID: 3773458461

Symbol: D9YZV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

D9YZV7

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 245
  • Mass: 28385
  • Checksum: 1255A14D9F26E29F
  • Sequence:
    • MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA SLNRRIQLVE 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK DEEKMEIQEI QLKEAKHIAE 
DADRKYEEVA RKLVIIESDL ERAEERAELS EGKCAELEEE LKTVTNNLKS LEAQAEKYSQ 
KEDRYEEEIK VLSDKLKEAE TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNELKL 
ALNED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.