Details for: TRIO

Gene ID: 7204

Symbol: TRIO

Ensembl ID: ENSG00000038382

Description: trio Rho guanine nucleotide exchange factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 648.2359
    Cell Significance Index: -100.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 398.1969
    Cell Significance Index: -101.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 210.6656
    Cell Significance Index: -99.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 199.5780
    Cell Significance Index: -81.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 85.1957
    Cell Significance Index: -81.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 82.0062
    Cell Significance Index: -101.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.8249
    Cell Significance Index: -95.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.5807
    Cell Significance Index: -100.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 30.0468
    Cell Significance Index: -65.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.7752
    Cell Significance Index: -101.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.5213
    Cell Significance Index: 107.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.4023
    Cell Significance Index: 129.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.3376
    Cell Significance Index: 299.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.8785
    Cell Significance Index: 299.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.5100
    Cell Significance Index: 1617.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.0097
    Cell Significance Index: 307.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.6967
    Cell Significance Index: 248.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.1913
    Cell Significance Index: 640.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9613
    Cell Significance Index: 587.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.8514
    Cell Significance Index: 41.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.6248
    Cell Significance Index: 1191.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2299
    Cell Significance Index: 84.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.2201
    Cell Significance Index: 98.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.1523
    Cell Significance Index: 61.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.1095
    Cell Significance Index: 46.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0206
    Cell Significance Index: 1397.5100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.6369
    Cell Significance Index: 14.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5709
    Cell Significance Index: 43.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4203
    Cell Significance Index: 24.3400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.4072
    Cell Significance Index: 17.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2790
    Cell Significance Index: 1154.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.2704
    Cell Significance Index: 19.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.2084
    Cell Significance Index: 767.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0056
    Cell Significance Index: 1893.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7449
    Cell Significance Index: 51.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5793
    Cell Significance Index: 110.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5135
    Cell Significance Index: 14.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4917
    Cell Significance Index: 60.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4200
    Cell Significance Index: 75.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3702
    Cell Significance Index: 40.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3374
    Cell Significance Index: 458.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3324
    Cell Significance Index: 8.1100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3062
    Cell Significance Index: 3.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2891
    Cell Significance Index: 30.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2185
    Cell Significance Index: 1.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1694
    Cell Significance Index: 260.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1692
    Cell Significance Index: 312.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1546
    Cell Significance Index: 84.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0390
    Cell Significance Index: 0.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0299
    Cell Significance Index: 1.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0290
    Cell Significance Index: 0.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0781
    Cell Significance Index: -34.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0784
    Cell Significance Index: -58.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0950
    Cell Significance Index: -59.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0996
    Cell Significance Index: -2.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1032
    Cell Significance Index: -16.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1095
    Cell Significance Index: -80.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1171
    Cell Significance Index: -66.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1320
    Cell Significance Index: -6.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1334
    Cell Significance Index: -100.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2002
    Cell Significance Index: -27.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2077
    Cell Significance Index: -5.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2333
    Cell Significance Index: -23.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2358
    Cell Significance Index: -34.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2439
    Cell Significance Index: -14.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3043
    Cell Significance Index: -51.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3123
    Cell Significance Index: -89.8500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3194
    Cell Significance Index: -5.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3515
    Cell Significance Index: -74.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4086
    Cell Significance Index: -47.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4997
    Cell Significance Index: -9.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5257
    Cell Significance Index: -23.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5338
    Cell Significance Index: -62.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5703
    Cell Significance Index: -58.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5715
    Cell Significance Index: -73.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5950
    Cell Significance Index: -12.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.6430
    Cell Significance Index: -82.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7235
    Cell Significance Index: -53.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7382
    Cell Significance Index: -84.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7444
    Cell Significance Index: -10.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7506
    Cell Significance Index: -15.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7610
    Cell Significance Index: -39.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7954
    Cell Significance Index: -11.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8649
    Cell Significance Index: -44.9300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8861
    Cell Significance Index: -11.0500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.8875
    Cell Significance Index: -12.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9461
    Cell Significance Index: -108.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.0548
    Cell Significance Index: -15.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0853
    Cell Significance Index: -23.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1463
    Cell Significance Index: -90.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.1588
    Cell Significance Index: -74.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2269
    Cell Significance Index: -39.3000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.2557
    Cell Significance Index: -16.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3070
    Cell Significance Index: -80.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3118
    Cell Significance Index: -42.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3217
    Cell Significance Index: -42.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.3321
    Cell Significance Index: -94.2100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.3331
    Cell Significance Index: -16.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3604
    Cell Significance Index: -63.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.3934
    Cell Significance Index: -29.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIO is a triple functional domain protein, characterized by its unique structure and Rho GEF activity. Its ability to exchange GTP for GDP on Rho GTPases, such as Rac, Rho, and Cdc42, regulates various signaling pathways involved in cell migration, adhesion, and survival. TRIO's expression is widespread, with significant levels found in neuronal cells, where it is thought to play a role in axon guidance and neuronal projection morphogenesis. In immune cells, TRIO has been implicated in the regulation of cell death signaling, including the activation of JNK pathways. **Pathways and Functions:** TRIO's involvement in various signaling pathways underscores its importance in regulating cellular responses to different stimuli. Some of the key pathways and functions associated with TRIO include: 1. **Rho GTPase Cycle:** TRIO's Rho GEF activity regulates the Rho GTPase cycle, which is involved in cell migration, adhesion, and survival. 2. **Axon Guidance:** TRIO plays a crucial role in axon guidance, a process essential for neuronal development and function. 3. **Cell Death Signaling:** TRIO's activation of JNK pathways has been implicated in cell death signaling, highlighting its potential role in regulating immune responses. 4. **Neuronal Projection Morphogenesis:** TRIO's expression in neuronal cells suggests its involvement in the regulation of neuronal projection morphogenesis. 5. **Immune Cell Functions:** TRIO has been shown to regulate immune cell functions, including the activation of JNK pathways and the regulation of cell death signaling. **Clinical Significance:** The significance of TRIO in various cellular processes has far-reaching implications for the diagnosis and treatment of diseases. Some potential clinical applications of TRIO include: 1. **Neurological Disorders:** TRIO's involvement in axon guidance and neuronal projection morphogenesis makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Immune-Mediated Diseases:** TRIO's role in regulating immune cell functions and cell death signaling makes it a potential target for the treatment of immune-mediated diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** TRIO's involvement in cell migration and adhesion regulation makes it a potential target for the treatment of cancer. In conclusion, TRIO is a multifunctional protein that plays a crucial role in various cellular processes, including axon guidance, cell death signaling, and immune responses. Its widespread expression in different cell types and its involvement in various signaling pathways underscore its significance in both immune and non-immune cell contexts. Further research into TRIO's functions and clinical applications is necessary to fully appreciate its potential as a therapeutic target.

Genular Protein ID: 673225481

Symbol: TRIO_HUMAN

Name: Triple functional domain protein

UniProtKB Accession Codes:

O75962 D3DTD1 Q13458 Q59EQ7 Q6PJC9 Q6ZN05 Q8IWK8

Database IDs:

ABCD 1 AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 8 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EC 3 EMBL 13 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 7 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 23 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 Rhea 6 SIGNOR 1 SMART 8 SMR 1 STRING 1 SUPFAM 7 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8643598

Title: The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

PubMed ID: 8643598

DOI: 10.1073/pnas.93.11.5466

PubMed ID: 10341202

Title: Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth.

PubMed ID: 10341202

DOI: 10.1242/jcs.112.12.1825

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19846667

Title: Distinct roles for CARMIL isoforms in cell migration.

PubMed ID: 19846667

DOI: 10.1091/mbc.e08-10-1071

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22155786

Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

PubMed ID: 22155786

DOI: 10.1126/scisignal.2002060

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26721934

Title: TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function.

PubMed ID: 26721934

DOI: 10.1093/hmg/ddv618

PubMed ID: 27418539

Title: Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly.

PubMed ID: 27418539

DOI: 10.1136/jmedgenet-2016-103942

PubMed ID: 9790533

Title: NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio.

PubMed ID: 9790533

DOI: 10.1016/s0092-8674(00)81757-2

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 32109419

Title: Opposite modulation of RAC1 by mutations in TRIO is associated with distinct, domain-specific neurodevelopmental disorders.

PubMed ID: 32109419

DOI: 10.1016/j.ajhg.2020.01.018

Sequence Information:

  • Length: 3097
  • Mass: 346900
  • Checksum: EA9236DF88B0EA24
  • Sequence:
    • MSGSSGGAAA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 
KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 
KRGFTVIVDM RGSKWDSIKP LLKILQESFP CCIHVALIIK PDNFWQKQRT NFGSSKFEFE 
TNMVSLEGLT KVVDPSQLTP EFDGCLEYNH EEWIEIRVAF EDYISNATHM LSRLEELQDI 
LAKKELPQDL EGARNMIEEH SQLKKKVIKA PIEDLDLEGQ KLLQRIQSSE SFPKKNSGSG 
NADLQNLLPK VSTMLDRLHS TRQHLHQMWH VRKLKLDQCF QLRLFEQDAE KMFDWITHNK 
GLFLNSYTEI GTSHPHAMEL QTQHNHFAMN CMNVYVNINR IMSVANRLVE SGHYASQQIR 
QIASQLEQEW KAFAAALDER STLLDMSSIF HQKAEKYMSN VDSWCKACGE VDLPSELQDL 
EDAIHHHQGI YEHITLAYSE VSQDGKSLLD KLQRPLTPGS SDSLTASANY SKAVHHVLDV 
IHEVLHHQRQ LENIWQHRKV RLHQRLQLCV FQQDVQQVLD WIENHGEAFL SKHTGVGKSL 
HRARALQKRH EDFEEVAQNT YTNADKLLEA AEQLAQTGEC DPEEIYQAAH QLEDRIQDFV 
RRVEQRKILL DMSVSFHTHV KELWTWLEEL QKELLDDVYA ESVEAVQDLI KRFGQQQQTT 
LQVTVNVIKE GEDLIQQLRD SAISSNKTPH NSSINHIETV LQQLDEAQSQ MEELFQERKI 
KLELFLQLRI FERDAIDIIS DLESWNDELS QQMNDFDTED LTIAEQRLQH HADKALTMNN 
LTFDVIHQGQ DLLQYVNEVQ ASGVELLCDR DVDMATRVQD LLEFLHEKQQ ELDLAAEQHR 
KHLEQCVQLR HLQAEVKQVL GWIRNGESML NAGLITASSL QEAEQLQREH EQFQHAIEKT 
HQSALQVQQK AEAMLQANHY DMDMIRDCAE KVASHWQQLM LKMEDRLKLV NASVAFYKTS 
EQVCSVLESL EQEYKREEDW CGGADKLGPN SETDHVTPMI SKHLEQKEAF LKACTLARRN 
ADVFLKYLHR NSVNMPGMVT HIKAPEQQVK NILNELFQRE NRVLHYWTMR KRRLDQCQQY 
VVFERSAKQA LEWIHDNGEF YLSTHTSTGS SIQHTQELLK EHEEFQITAK QTKERVKLLI 
QLADGFCEKG HAHAAEIKKC VTAVDKRYRD FSLRMEKYRT SLEKALGISS DSNKSSKSLQ 
LDIIPASIPG SEVKLRDAAH ELNEEKRKSA RRKEFIMAEL IQTEKAYVRD LRECMDTYLW 
EMTSGVEEIP PGIVNKELII FGNMQEIYEF HNNIFLKELE KYEQLPEDVG HCFVTWADKF 
QMYVTYCKNK PDSTQLILEH AGSYFDEIQQ RHGLANSISS YLIKPVQRIT KYQLLLKELL 
TCCEEGKGEI KDGLEVMLSV PKRANDAMHL SMLEGFDENI ESQGELILQE SFQVWDPKTL 
IRKGRERHLF LFEMSLVFSK EVKDSSGRSK YLYKSKLFTS ELGVTEHVEG DPCKFALWVG 
RTPTSDNKIV LKASSIENKQ DWIKHIREVI QERTIHLKGA LKEPIHIPKT APATRQKGRR 
DGEDLDSQGD GSSQPDTISI ASRTSQNTLD SDKLSGGCEL TVVIHDFTAC NSNELTIRRG 
QTVEVLERPH DKPDWCLVRT TDRSPAAEGL VPCGSLCIAH SRSSMEMEGI FNHKDSLSVS 
SNDASPPASV ASLQPHMIGA QSSPGPKRPG NTLRKWLTSP VRRLSSGKAD GHVKKLAHKH 
KKSREVRKSA DAGSQKDSDD SAATPQDETV EERGRNEGLS SGTLSKSSSS GMQSCGEEEG 
EEGADAVPLP PPMAIQQHSL LQPDSQDDKA SSRLLVRPTS SETPSAAELV SAIEELVKSK 
MALEDRPSSL LVDQGDSSSP SFNPSDNSLL SSSSPIDEME ERKSSSLKRR HYVLQELVET 
ERDYVRDLGY VVEGYMALMK EDGVPDDMKG KDKIVFGNIH QIYDWHRDFF LGELEKCLED 
PEKLGSLFVK HERRLHMYIA YCQNKPKSEH IVSEYIDTFF EDLKQRLGHR LQLTDLLIKP 
VQRIMKYQLL LKDFLKYSKK ASLDTSELER AVEVMCIVPR RCNDMMNVGR LQGFDGKIVA 
QGKLLLQDTF LVTDQDAGLL PRCRERRIFL FEQIVIFSEP LDKKKGFSMP GFLFKNSIKV 
SCLCLEENVE NDPCKFALTS RTGDVVETFI LHSSSPSVRQ TWIHEINQIL ENQRNFLNAL 
TSPIEYQRNH SGGGGGGGSG GSGGGGGSGG GGAPSGGSGH SGGPSSCGGA PSTSRSRPSR 
IPQPVRHHPP VLVSSAASSQ AEADKMSGTS TPGPSLPPPG AAPEAGPSAP SRRPPGADAE 
GSEREAEPIP KMKVLESPRK GAANASGSSP DAPAKDARAS LGTLPLGKPR AGAASPLNSP 
LSSAVPSLGK EPFPPSSPLQ KGGSFWSSIP ASPASRPGSF TFPGDSDSLQ RQTPRHAAPG 
KDTDRMSTCS SASEQSVQST QSNGSESSSS SNISTMLVTH DYTAVKEDEI NVYQGEVVQI 
LASNQQNMFL VFRAATDQCP AAEGWIPGFV LGHTSAVIVE NPDGTLKKST SWHTALRLRK 
KSEKKDKDGK REGKLENGYR KSREGLSNKV SVKLLNPNYI YDVPPEFVIP LSEVTCETGE 
TVVLRCRVCG RPKASITWKG PEHNTLNNDG HYSISYSDLG EATLKIVGVT TEDDGIYTCI 
AVNDMGSASS SASLRVLGPG MDGIMVTWKD NFDSFYSEVA ELGRGRFSVV KKCDQKGTKR 
AVATKFVNKK LMKRDQVTHE LGILQSLQHP LLVGLLDTFE TPTSYILVLE MADQGRLLDC 
VVRWGSLTEG KIRAHLGEVL EAVRYLHNCR IAHLDLKPEN ILVDESLAKP TIKLADFGDA 
VQLNTTYYIH QLLGNPEFAA PEIILGNPVS LTSDTWSVGV LTYVLLSGVS PFLDDSVEET 
CLNICRLDFS FPDDYFKGVS QKAKEFVCFL LQEDPAKRPS AALALQEQWL QAGNGRSTGV 
LDTSRLTSFI ERRKHQNDVR PIRSIKNFLQ SRLLPRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.