Details for: GFUS

Gene ID: 7264

Symbol: GFUS

Ensembl ID: ENSG00000104522

Description: GDP-L-fucose synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.9010
    Cell Significance Index: -20.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 74.0385
    Cell Significance Index: -30.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.4851
    Cell Significance Index: -23.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.4003
    Cell Significance Index: -27.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.8203
    Cell Significance Index: -27.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.9242
    Cell Significance Index: -26.7900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.9808
    Cell Significance Index: -5.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.1691
    Cell Significance Index: -24.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.1239
    Cell Significance Index: -19.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5128
    Cell Significance Index: -25.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4307
    Cell Significance Index: -16.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.6734
    Cell Significance Index: 171.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6000
    Cell Significance Index: 21.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5818
    Cell Significance Index: 172.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4914
    Cell Significance Index: 43.8000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.3697
    Cell Significance Index: 11.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3342
    Cell Significance Index: 92.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2241
    Cell Significance Index: 63.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1032
    Cell Significance Index: 66.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0595
    Cell Significance Index: 956.6200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.0100
    Cell Significance Index: 15.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9024
    Cell Significance Index: 25.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8525
    Cell Significance Index: 7.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7678
    Cell Significance Index: 11.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7278
    Cell Significance Index: 51.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7203
    Cell Significance Index: 318.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7126
    Cell Significance Index: 45.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7115
    Cell Significance Index: 7.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6907
    Cell Significance Index: 51.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6688
    Cell Significance Index: 14.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5988
    Cell Significance Index: 16.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5824
    Cell Significance Index: 26.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5798
    Cell Significance Index: 13.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5452
    Cell Significance Index: 297.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4916
    Cell Significance Index: 57.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4514
    Cell Significance Index: 13.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4393
    Cell Significance Index: 56.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4349
    Cell Significance Index: 11.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4251
    Cell Significance Index: 52.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4226
    Cell Significance Index: 76.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4053
    Cell Significance Index: 19.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3974
    Cell Significance Index: 54.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3503
    Cell Significance Index: 3.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2898
    Cell Significance Index: 3.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2821
    Cell Significance Index: 2.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2743
    Cell Significance Index: 14.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2629
    Cell Significance Index: 3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2570
    Cell Significance Index: 8.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2403
    Cell Significance Index: 47.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2157
    Cell Significance Index: 41.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1658
    Cell Significance Index: 5.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1533
    Cell Significance Index: 4.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1194
    Cell Significance Index: 15.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1081
    Cell Significance Index: 17.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0869
    Cell Significance Index: 14.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0842
    Cell Significance Index: 16.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0790
    Cell Significance Index: 59.8000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0317
    Cell Significance Index: 0.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0236
    Cell Significance Index: 2.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0021
    Cell Significance Index: -0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0081
    Cell Significance Index: -2.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0115
    Cell Significance Index: -21.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0118
    Cell Significance Index: -8.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0130
    Cell Significance Index: -0.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0192
    Cell Significance Index: -35.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0230
    Cell Significance Index: -35.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0235
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0251
    Cell Significance Index: -2.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0258
    Cell Significance Index: -35.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0349
    Cell Significance Index: -22.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0355
    Cell Significance Index: -26.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0440
    Cell Significance Index: -24.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0467
    Cell Significance Index: -29.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0544
    Cell Significance Index: -6.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0563
    Cell Significance Index: -2.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0616
    Cell Significance Index: -27.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0759
    Cell Significance Index: -21.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1120
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1440
    Cell Significance Index: -30.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1604
    Cell Significance Index: -23.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1922
    Cell Significance Index: -10.0900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2162
    Cell Significance Index: -4.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2332
    Cell Significance Index: -5.8300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2342
    Cell Significance Index: -1.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2391
    Cell Significance Index: -6.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2456
    Cell Significance Index: -25.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2677
    Cell Significance Index: -4.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2787
    Cell Significance Index: -18.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2795
    Cell Significance Index: -22.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2980
    Cell Significance Index: -18.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3051
    Cell Significance Index: -23.4100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3282
    Cell Significance Index: -0.7400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3959
    Cell Significance Index: -5.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4040
    Cell Significance Index: -5.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4318
    Cell Significance Index: -24.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4770
    Cell Significance Index: -6.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4994
    Cell Significance Index: -14.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5009
    Cell Significance Index: -17.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GDP-L-fucose synthase activity**: GFUS catalyzes the conversion of GDP-D-mannose to GDP-L-fucose, a critical step in the biosynthesis of this sugar molecule. 2. **Enzyme specificity**: GFUS exhibits specificity for GDP-D-mannose, demonstrating its role in the glycosylation pathway. 3. **Cellular localization**: GFUS is primarily localized in the cytosol, where it is involved in the synthesis of glycoproteins and glycolipids. 4. **Regulatory pathways**: GFUS is regulated by various signaling pathways, including the electron transfer activity pathway, which is crucial for maintaining cellular homeostasis. **Pathways and Functions:** 1. **Glycosylation pathway**: GFUS is involved in the biosynthesis of GDP-L-fucose, which is essential for the formation of glycoproteins and glycolipids. 2. **Asparagine n-linked glycosylation**: GFUS plays a critical role in the synthesis of UDP-N-acetylglucosamine, a precursor molecule required for asparagine n-linked glycosylation. 3. **Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, LLO)**: GFUS is involved in the production of GDP-L-fucose, which is necessary for the formation of LLO. 4. **Electron transfer activity**: GFUS is part of the electron transfer activity pathway, which is crucial for maintaining cellular homeostasis and regulating various cellular processes. **Clinical Significance:** 1. **Glycosylation disorders**: Impairments in GFUS activity have been linked to various glycosylation disorders, including congenital disorders of glycosylation (CDG). 2. **Cancer and metastasis**: Alterations in GFUS expression have been observed in various cancers, including colorectal and breast cancer, highlighting its potential role in cancer progression and metastasis. 3. **Infectious diseases**: GFUS has been implicated in the pathogenesis of infectious diseases, such as malaria, where it plays a critical role in the synthesis of glycoproteins and glycolipids involved in host-pathogen interactions. 4. **Neurological disorders**: GFUS has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it is involved in the synthesis of glycoproteins and glycolipids required for neuronal function and survival. In conclusion, GFUS is a critical enzyme involved in the biosynthesis of GDP-L-fucose, a key sugar molecule required for various cellular processes, including glycosylation, cell adhesion, and protein modification. Its significance in various diseases, including glycosylation disorders, cancer, infectious diseases, and neurological disorders, highlights the importance of further research into the role of GFUS in human health and disease.

Genular Protein ID: 3873958274

Symbol: FCL_HUMAN

Name: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase

UniProtKB Accession Codes:

Q13630 B2R8Y7 D3DWK5 Q567Q9 Q9UDG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8910301

Title: Synthesis of GDP-L-fucose by the human FX protein.

PubMed ID: 8910301

DOI: 10.1074/jbc.271.44.27274

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7803801

Title: Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum-transplantation antigen P35B.

PubMed ID: 7803801

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23774504

Title: The crystal structure of human GDP-L-fucose synthase.

PubMed ID: 23774504

DOI: 10.1093/abbs/gmt066

Sequence Information:

  • Length: 321
  • Mass: 35893
  • Checksum: 94BB1FF61658007C
  • Sequence:
    • MGEPQGSMRI LVTGGSGLVG KAIQKVVADG AGLPGEDWVF VSSKDADLTD TAQTRALFEK 
VQPTHVIHLA AMVGGLFRNI KYNLDFWRKN VHMNDNVLHS AFEVGARKVV SCLSTCIFPD 
KTTYPIDETM IHNGPPHNSN FGYSYAKRMI DVQNRAYFQQ YGCTFTAVIP TNVFGPHDNF 
NIEDGHVLPG LIHKVHLAKS SGSALTVWGT GNPRRQFIYS LDLAQLFIWV LREYNEVEPI 
ILSVGEEDEV SIKEAAEAVV EAMDFHGEVT FDTTKSDGQF KKTASNSKLR TYLPDFRFTP 
FKQAVKETCA WFTDNYEQAR K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.