Details for: DNAJC7

Gene ID: 7266

Symbol: DNAJC7

Ensembl ID: ENSG00000168259

Description: DnaJ heat shock protein family (Hsp40) member C7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.68
    Marker Score: 48983
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.95
    Marker Score: 2632
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.6
    Marker Score: 1578.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.38
    Marker Score: 1682
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.14
    Marker Score: 1037
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.09
    Marker Score: 4402.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.08
    Marker Score: 1390
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.03
    Marker Score: 8413
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.96
    Marker Score: 1927
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9
    Marker Score: 19285
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.89
    Marker Score: 1005
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.88
    Marker Score: 1134
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.87
    Marker Score: 21699
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.85
    Marker Score: 1478
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.83
    Marker Score: 3714
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.82
    Marker Score: 6743
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.82
    Marker Score: 576
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2649
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8
    Marker Score: 62289.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.8
    Marker Score: 3752
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.77
    Marker Score: 627
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.76
    Marker Score: 1494
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.74
    Marker Score: 973
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.72
    Marker Score: 1817
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.72
    Marker Score: 1928
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.7
    Marker Score: 498
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.69
    Marker Score: 6646
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.69
    Marker Score: 1127
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.67
    Marker Score: 2357
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.66
    Marker Score: 14287
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.66
    Marker Score: 2936
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.65
    Marker Score: 496
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.64
    Marker Score: 2363
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.63
    Marker Score: 91385
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.63
    Marker Score: 6832.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.62
    Marker Score: 4034
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.62
    Marker Score: 6622
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6
    Marker Score: 18077
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.6
    Marker Score: 1497
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.59
    Marker Score: 2208
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.59
    Marker Score: 1697
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.58
    Marker Score: 2106
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.58
    Marker Score: 1911
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.58
    Marker Score: 378
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.58
    Marker Score: 1660
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 920
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.57
    Marker Score: 578
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.57
    Marker Score: 591
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.56
    Marker Score: 2721
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.56
    Marker Score: 464
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.53
    Marker Score: 4164.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56464
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.52
    Marker Score: 1828
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.52
    Marker Score: 1433
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.52
    Marker Score: 1621
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.52
    Marker Score: 1426
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.51
    Marker Score: 19860
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.5
    Marker Score: 1882
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.5
    Marker Score: 5336
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.5
    Marker Score: 2015
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 91958
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.49
    Marker Score: 609
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.48
    Marker Score: 1536
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.48
    Marker Score: 3368
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.48
    Marker Score: 835
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.47
    Marker Score: 4374
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.46
    Marker Score: 915
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.46
    Marker Score: 383
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.45
    Marker Score: 990
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.45
    Marker Score: 21687
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.45
    Marker Score: 12447
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.45
    Marker Score: 823
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.45
    Marker Score: 1516
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.45
    Marker Score: 28765
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.45
    Marker Score: 961
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.44
    Marker Score: 1092
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.44
    Marker Score: 622
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.44
    Marker Score: 3515.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.43
    Marker Score: 500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.43
    Marker Score: 1547
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.43
    Marker Score: 13466
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.43
    Marker Score: 11171
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 335
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.42
    Marker Score: 1722
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.42
    Marker Score: 53798
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.42
    Marker Score: 489
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.42
    Marker Score: 13449
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.41
    Marker Score: 1299
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.41
    Marker Score: 1500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.41
    Marker Score: 1558
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.41
    Marker Score: 3092
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.4
    Marker Score: 35978
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.4
    Marker Score: 470
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.4
    Marker Score: 797
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.39
    Marker Score: 1159
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.39
    Marker Score: 2207
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.39
    Marker Score: 1495
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.38
    Marker Score: 654
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.38
    Marker Score: 842
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.38
    Marker Score: 632

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Other Information

**Key Characteristics** 1. **Heat Shock Protein (HSP) Family Member**: DNAJC7 is a member of the Hsp40 family, which is characterized by its ability to interact with Hsp70 molecular chaperones to facilitate protein folding and degradation. 2. **Chaperone Cofactor-Dependent Protein Refolding**: DNAJC7 acts as a chaperone cofactor to facilitate the refolding of proteins that have been denatured due to heat stress or other forms of cellular stress. 3. **Regulation of Cellular Response to Heat**: DNAJC7 is involved in the regulation of the heat shock response, which is a complex cellular response to heat stress that involves the activation of heat shock transcription factors (HSFs) and the expression of heat shock proteins. 4. **Immune Response Regulation**: DNAJC7 is also involved in the regulation of immune responses, particularly in the activation of myeloid dendritic cells and the production of cytokines. **Pathways and Functions** 1. **Heat Shock Response**: DNAJC7 is involved in the regulation of the heat shock response, which is a complex cellular response to heat stress that involves the activation of heat shock transcription factors (HSFs) and the expression of heat shock proteins. 2. **Protein Refolding**: DNAJC7 acts as a chaperone cofactor to facilitate the refolding of proteins that have been denatured due to heat stress or other forms of cellular stress. 3. **Immune Response Regulation**: DNAJC7 is involved in the regulation of immune responses, particularly in the activation of myeloid dendritic cells and the production of cytokines. 4. **Cellular Homeostasis**: DNAJC7 plays a critical role in maintaining cellular homeostasis, particularly in response to heat stress, cellular stress, and immune responses. **Clinical Significance** 1. **Heat Stress-Related Diseases**: Dysregulation of DNAJC7 has been implicated in various heat stress-related diseases, including heat shock protein 70 (HSP70) related diseases. 2. **Immune Response-Related Diseases**: Dysregulation of DNAJC7 has also been implicated in various immune response-related diseases, including autoimmune diseases and cancer. 3. **Cancer Therapy**: DNAJC7 has been identified as a potential target for cancer therapy, particularly in the context of heat shock protein 70 (HSP70) related diseases. 4. **Personalized Medicine**: DNAJC7 has the potential to be used as a biomarker for personalized medicine, particularly in the context of heat stress and immune response-related diseases. In conclusion, DNAJC7 is a critical component of heat shock response and cellular homeostasis, and its dysregulation has been implicated in various heat stress-related and immune response-related diseases. Further research is needed to fully understand the role of DNAJC7 in maintaining cellular homeostasis and its potential as a therapeutic target for various diseases.

Genular Protein ID: 4038780398

Symbol: DNJC7_HUMAN

Name: DnaJ homolog subfamily C member 7

UniProtKB Accession Codes:

Q99615 Q7Z784

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8836031

Title: Identification and characterization of two novel tetratricopeptide repeat-containing genes.

PubMed ID: 8836031

DOI: 10.1089/dna.1996.15.727

PubMed ID: 10567422

Title: Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats.

PubMed ID: 10567422

DOI: 10.1074/jbc.274.48.34425

PubMed ID: 11573955

Title: The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.

PubMed ID: 11573955

DOI: 10.1006/bbrc.2001.5685

PubMed ID: 12853476

Title: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.

PubMed ID: 12853476

DOI: 10.1093/emboj/cdg362

PubMed ID: 14573755

Title: Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells.

PubMed ID: 14573755

DOI: 10.1124/mol.64.5.1069

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18620420

Title: Role of the cochaperone Tpr2 in Hsp90 chaperoning.

PubMed ID: 18620420

DOI: 10.1021/bi800770g

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 494
  • Mass: 56441
  • Checksum: 81C60CF71BFE951D
  • Sequence:
    • MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK 
NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ 
RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI 
LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA 
PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR 
GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT 
KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV 
QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS 
FEASGPGNFF FQFG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.