Details for: DNAJC7

Gene ID: 7266

Symbol: DNAJC7

Ensembl ID: ENSG00000168259

Description: DnaJ heat shock protein family (Hsp40) member C7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 418.3349
    Cell Significance Index: -65.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.3501
    Cell Significance Index: -59.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 166.5033
    Cell Significance Index: -78.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 151.6404
    Cell Significance Index: -61.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 150.7352
    Cell Significance Index: -62.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 137.4262
    Cell Significance Index: -70.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 117.0751
    Cell Significance Index: -78.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.8528
    Cell Significance Index: -71.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9762
    Cell Significance Index: -61.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.4767
    Cell Significance Index: -72.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.7466
    Cell Significance Index: -48.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.3090
    Cell Significance Index: -33.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1612
    Cell Significance Index: 1951.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.1111
    Cell Significance Index: 66.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7133
    Cell Significance Index: 102.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5284
    Cell Significance Index: 98.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5174
    Cell Significance Index: 304.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4477
    Cell Significance Index: 260.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4392
    Cell Significance Index: 176.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4059
    Cell Significance Index: 279.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3621
    Cell Significance Index: 187.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3552
    Cell Significance Index: 220.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3002
    Cell Significance Index: 17.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2183
    Cell Significance Index: 665.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1447
    Cell Significance Index: 60.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8396
    Cell Significance Index: 371.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8384
    Cell Significance Index: 52.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8190
    Cell Significance Index: 96.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7792
    Cell Significance Index: 35.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7383
    Cell Significance Index: 264.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7182
    Cell Significance Index: 19.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6998
    Cell Significance Index: 32.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6204
    Cell Significance Index: 43.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5890
    Cell Significance Index: 27.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5669
    Cell Significance Index: 29.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5371
    Cell Significance Index: 41.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5148
    Cell Significance Index: 66.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4605
    Cell Significance Index: 5.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4434
    Cell Significance Index: 33.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4396
    Cell Significance Index: 11.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4322
    Cell Significance Index: 15.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4140
    Cell Significance Index: 11.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3875
    Cell Significance Index: 50.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3782
    Cell Significance Index: 261.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1639
    Cell Significance Index: 3.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1366
    Cell Significance Index: 26.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1321
    Cell Significance Index: 248.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1069
    Cell Significance Index: 6.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1060
    Cell Significance Index: 7.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0705
    Cell Significance Index: 129.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0659
    Cell Significance Index: 101.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0627
    Cell Significance Index: 3.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0345
    Cell Significance Index: 46.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0257
    Cell Significance Index: 16.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0193
    Cell Significance Index: 14.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0110
    Cell Significance Index: 4.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0246
    Cell Significance Index: -4.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0360
    Cell Significance Index: -27.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0433
    Cell Significance Index: -1.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0453
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0741
    Cell Significance Index: -54.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0914
    Cell Significance Index: -9.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1188
    Cell Significance Index: -67.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1330
    Cell Significance Index: -83.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1401
    Cell Significance Index: -2.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1910
    Cell Significance Index: -3.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2058
    Cell Significance Index: -5.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2132
    Cell Significance Index: -30.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2760
    Cell Significance Index: -18.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3003
    Cell Significance Index: -35.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3100
    Cell Significance Index: -35.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3356
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3799
    Cell Significance Index: -80.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4073
    Cell Significance Index: -10.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4519
    Cell Significance Index: -19.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4821
    Cell Significance Index: -14.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5966
    Cell Significance Index: -47.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6089
    Cell Significance Index: -6.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6128
    Cell Significance Index: -63.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6323
    Cell Significance Index: -10.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6840
    Cell Significance Index: -25.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7567
    Cell Significance Index: -21.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8403
    Cell Significance Index: -21.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8544
    Cell Significance Index: -19.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8677
    Cell Significance Index: -12.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9239
    Cell Significance Index: -20.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9335
    Cell Significance Index: -20.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0213
    Cell Significance Index: -27.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0324
    Cell Significance Index: -20.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1078
    Cell Significance Index: -32.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1590
    Cell Significance Index: -37.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1632
    Cell Significance Index: -60.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2195
    Cell Significance Index: -34.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2478
    Cell Significance Index: -76.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.2825
    Cell Significance Index: -10.2400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.4243
    Cell Significance Index: -19.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.4636
    Cell Significance Index: -35.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4881
    Cell Significance Index: -15.4100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.5860
    Cell Significance Index: -10.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Heat Shock Protein (HSP) Family Member**: DNAJC7 is a member of the Hsp40 family, which is characterized by its ability to interact with Hsp70 molecular chaperones to facilitate protein folding and degradation. 2. **Chaperone Cofactor-Dependent Protein Refolding**: DNAJC7 acts as a chaperone cofactor to facilitate the refolding of proteins that have been denatured due to heat stress or other forms of cellular stress. 3. **Regulation of Cellular Response to Heat**: DNAJC7 is involved in the regulation of the heat shock response, which is a complex cellular response to heat stress that involves the activation of heat shock transcription factors (HSFs) and the expression of heat shock proteins. 4. **Immune Response Regulation**: DNAJC7 is also involved in the regulation of immune responses, particularly in the activation of myeloid dendritic cells and the production of cytokines. **Pathways and Functions** 1. **Heat Shock Response**: DNAJC7 is involved in the regulation of the heat shock response, which is a complex cellular response to heat stress that involves the activation of heat shock transcription factors (HSFs) and the expression of heat shock proteins. 2. **Protein Refolding**: DNAJC7 acts as a chaperone cofactor to facilitate the refolding of proteins that have been denatured due to heat stress or other forms of cellular stress. 3. **Immune Response Regulation**: DNAJC7 is involved in the regulation of immune responses, particularly in the activation of myeloid dendritic cells and the production of cytokines. 4. **Cellular Homeostasis**: DNAJC7 plays a critical role in maintaining cellular homeostasis, particularly in response to heat stress, cellular stress, and immune responses. **Clinical Significance** 1. **Heat Stress-Related Diseases**: Dysregulation of DNAJC7 has been implicated in various heat stress-related diseases, including heat shock protein 70 (HSP70) related diseases. 2. **Immune Response-Related Diseases**: Dysregulation of DNAJC7 has also been implicated in various immune response-related diseases, including autoimmune diseases and cancer. 3. **Cancer Therapy**: DNAJC7 has been identified as a potential target for cancer therapy, particularly in the context of heat shock protein 70 (HSP70) related diseases. 4. **Personalized Medicine**: DNAJC7 has the potential to be used as a biomarker for personalized medicine, particularly in the context of heat stress and immune response-related diseases. In conclusion, DNAJC7 is a critical component of heat shock response and cellular homeostasis, and its dysregulation has been implicated in various heat stress-related and immune response-related diseases. Further research is needed to fully understand the role of DNAJC7 in maintaining cellular homeostasis and its potential as a therapeutic target for various diseases.

Genular Protein ID: 4038780398

Symbol: DNJC7_HUMAN

Name: DnaJ homolog subfamily C member 7

UniProtKB Accession Codes:

Q99615 Q7Z784

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 8 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8836031

Title: Identification and characterization of two novel tetratricopeptide repeat-containing genes.

PubMed ID: 8836031

DOI: 10.1089/dna.1996.15.727

PubMed ID: 10567422

Title: Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats.

PubMed ID: 10567422

DOI: 10.1074/jbc.274.48.34425

PubMed ID: 11573955

Title: The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.

PubMed ID: 11573955

DOI: 10.1006/bbrc.2001.5685

PubMed ID: 12853476

Title: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.

PubMed ID: 12853476

DOI: 10.1093/emboj/cdg362

PubMed ID: 14573755

Title: Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells.

PubMed ID: 14573755

DOI: 10.1124/mol.64.5.1069

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18620420

Title: Role of the cochaperone Tpr2 in Hsp90 chaperoning.

PubMed ID: 18620420

DOI: 10.1021/bi800770g

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 494
  • Mass: 56441
  • Checksum: 81C60CF71BFE951D
  • Sequence:
    • MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK 
NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ 
RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI 
LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA 
PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR 
GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT 
KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV 
QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS 
FEASGPGNFF FQFG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.