Details for: USP1

Gene ID: 7398

Symbol: USP1

Ensembl ID: ENSG00000162607

Description: ubiquitin specific peptidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.1872
    Cell Significance Index: -20.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.5850
    Cell Significance Index: -26.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.8868
    Cell Significance Index: -36.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.9556
    Cell Significance Index: -30.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.6730
    Cell Significance Index: -34.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.3611
    Cell Significance Index: -36.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.6316
    Cell Significance Index: -30.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.9596
    Cell Significance Index: -33.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4452
    Cell Significance Index: -30.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8608
    Cell Significance Index: -34.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1557
    Cell Significance Index: -25.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5959
    Cell Significance Index: -7.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.6269
    Cell Significance Index: 306.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.2257
    Cell Significance Index: 153.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7345
    Cell Significance Index: 188.6700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.6687
    Cell Significance Index: 12.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5815
    Cell Significance Index: 99.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5031
    Cell Significance Index: 244.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.5024
    Cell Significance Index: 17.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4442
    Cell Significance Index: 170.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0155
    Cell Significance Index: 11.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9706
    Cell Significance Index: 26.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9407
    Cell Significance Index: 32.6900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8653
    Cell Significance Index: 6.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7878
    Cell Significance Index: 16.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7144
    Cell Significance Index: 70.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7065
    Cell Significance Index: 36.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7036
    Cell Significance Index: 96.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6288
    Cell Significance Index: 278.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6177
    Cell Significance Index: 34.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6092
    Cell Significance Index: 550.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5365
    Cell Significance Index: 28.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5138
    Cell Significance Index: 92.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4998
    Cell Significance Index: 272.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4937
    Cell Significance Index: 31.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4650
    Cell Significance Index: 92.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4613
    Cell Significance Index: 21.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4593
    Cell Significance Index: 56.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4440
    Cell Significance Index: 11.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4143
    Cell Significance Index: 53.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3778
    Cell Significance Index: 75.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3612
    Cell Significance Index: 16.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3587
    Cell Significance Index: 25.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3532
    Cell Significance Index: 16.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3004
    Cell Significance Index: 8.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2580
    Cell Significance Index: 5.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2153
    Cell Significance Index: 5.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1978
    Cell Significance Index: 4.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1955
    Cell Significance Index: 5.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1755
    Cell Significance Index: 62.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1526
    Cell Significance Index: 26.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1378
    Cell Significance Index: 26.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0925
    Cell Significance Index: 11.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0877
    Cell Significance Index: 2.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0851
    Cell Significance Index: 6.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0519
    Cell Significance Index: 35.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0504
    Cell Significance Index: 1.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0441
    Cell Significance Index: 2.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0070
    Cell Significance Index: -4.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0108
    Cell Significance Index: -0.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0131
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0165
    Cell Significance Index: -30.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0173
    Cell Significance Index: -13.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0178
    Cell Significance Index: -0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0209
    Cell Significance Index: -28.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0263
    Cell Significance Index: -16.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0354
    Cell Significance Index: -19.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0471
    Cell Significance Index: -4.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0523
    Cell Significance Index: -23.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0615
    Cell Significance Index: -1.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0688
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0718
    Cell Significance Index: -15.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0940
    Cell Significance Index: -27.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1043
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1057
    Cell Significance Index: -12.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1102
    Cell Significance Index: -12.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1444
    Cell Significance Index: -20.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1519
    Cell Significance Index: -3.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2048
    Cell Significance Index: -3.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2452
    Cell Significance Index: -2.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2455
    Cell Significance Index: -3.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2561
    Cell Significance Index: -7.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2843
    Cell Significance Index: -21.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3266
    Cell Significance Index: -34.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3614
    Cell Significance Index: -28.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3969
    Cell Significance Index: -26.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4419
    Cell Significance Index: -8.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4873
    Cell Significance Index: -29.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5719
    Cell Significance Index: -10.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6308
    Cell Significance Index: -18.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6372
    Cell Significance Index: -28.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6391
    Cell Significance Index: -8.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7160
    Cell Significance Index: -19.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7349
    Cell Significance Index: -18.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7539
    Cell Significance Index: -28.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7554
    Cell Significance Index: -27.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** USP1 is a member of the ubiquitin-specific protease family, characterized by its ability to remove ubiquitin from specific lysine residues on target proteins. This deubiquitination activity is critical for regulating protein function, localization, and stability. USP1 is also involved in the regulation of DNA repair pathways, particularly in the Fanconi anemia pathway, which is crucial for maintaining genomic integrity. Additionally, USP1 has been implicated in the positive regulation of error-prone translesion synthesis, a process that allows cells to bypass DNA damage and maintain genome stability. **Pathways and Functions:** USP1 is involved in several key pathways, including: 1. **DNA Damage Response:** USP1 plays a crucial role in the Fanconi anemia pathway, which is responsible for maintaining genomic stability in response to DNA damage. USP1 deubiquitinates proteins involved in this pathway, allowing cells to respond to DNA damage and prevent genomic instability. 2. **Error-Prone Translesion Synthesis:** USP1 regulates the activity of enzymes involved in error-prone translesion synthesis, a process that allows cells to bypass DNA damage and maintain genome stability. 3. **Receptor Signaling Pathway:** USP1 is involved in the positive regulation of receptor signaling pathways, including the Jak-Stat pathway, which is critical for immune cell function and development. 4. **Protein Binding and Deubiquitination:** USP1 binds to specific proteins, deubiquitinating them and regulating their function, localization, and stability. **Clinical Significance:** The dysregulation of USP1 has been implicated in various diseases, including cancer, where its loss can lead to genomic instability and increased cancer susceptibility. Additionally, USP1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysregulation can contribute to protein aggregation and neuronal dysfunction. Furthermore, USP1 has been shown to play a role in the development of immune cells, including T cells and B cells, highlighting its importance in immune function and disease. In conclusion, USP1 is a multifunctional gene that plays a critical role in maintaining genomic stability, regulating cell signaling pathways, and influencing cellular development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of USP1 and its role in human disease.

Genular Protein ID: 630006544

Symbol: UBP1_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 1

UniProtKB Accession Codes:

O94782 A0PJ95 D3DQ57 Q05BX7 Q59H66 Q9UFR0 Q9UNJ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 10 EMDB 5 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9806842

Title: Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease.

PubMed ID: 9806842

DOI: 10.1006/geno.1998.5554

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15694335

Title: The deubiquitinating enzyme USP1 regulates the Fanconi Anemia pathway.

PubMed ID: 15694335

DOI: 10.1016/j.molcel.2005.01.008

PubMed ID: 16531995

Title: Regulation of monoubiquitinated PCNA by DUB autocleavage.

PubMed ID: 16531995

DOI: 10.1038/ncb1378

PubMed ID: 18082604

Title: A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.

PubMed ID: 18082604

DOI: 10.1016/j.molcel.2007.09.031

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20147293

Title: Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

PubMed ID: 20147293

DOI: 10.1074/jbc.m109.092544

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26388029

Title: Structural insights into WD-repeat 48 activation of ubiquitin-specific protease 46.

PubMed ID: 26388029

DOI: 10.1016/j.str.2015.08.010

PubMed ID: 29775578

Title: C-terminal end-directed protein elimination by CRL2 ubiquitin ligases.

PubMed ID: 29775578

DOI: 10.1016/j.molcel.2018.04.006

PubMed ID: 30526872

Title: Recognition of the diglycine C-end degron by CRL2(KLHDC2) ubiquitin ligase.

PubMed ID: 30526872

DOI: 10.1016/j.molcel.2018.10.021

Sequence Information:

  • Length: 785
  • Mass: 88207
  • Checksum: 50AA2817A60810AF
  • Sequence:
    • MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS EYRASEIDQV 
VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKSGVK HLFNIISRKK 
EALKDEANQK DKGNCKEDSL ASYELICSLQ SLIISVEQLQ ASFLLNPEKY TDELATQPRR 
LLNTLRELNP MYEGYLQHDA QEVLQCILGN IQETCQLLKK EEVKNVAELP TKVEEIPHPK 
EEMNGINSIE MDSMRHSEDF KEKLPKGNGK RKSDTEFGNM KKKVKLSKEH QSLEENQRQT 
RSKRKATSDT LESPPKIIPK YISENESPRP SQKKSRVKIN WLKSATKQPS ILSKFCSLGK 
ITTNQGVKGQ SKENECDPEE DLGKCESDNT TNGCGLESPG NTVTPVNVNE VKPINKGEEQ 
IGFELVEKLF QGQLVLRTRC LECESLTERR EDFQDISVPV QEDELSKVEE SSEISPEPKT 
EMKTLRWAIS QFASVERIVG EDKYFCENCH HYTEAERSLL FDKMPEVITI HLKCFAASGL 
EFDCYGGGLS KINTPLLTPL KLSLEEWSTK PTNDSYGLFA VVMHSGITIS SGHYTASVKV 
TDLNSLELDK GNFVVDQMCE IGKPEPLNEE EARGVVENYN DEEVSIRVGG NTQPSKVLNK 
KNVEAIGLLG GQKSKADYEL YNKASNPDKV ASTAFAENRN SETSDTTGTH ESDRNKESSD 
QTGINISGFE NKISYVVQSL KEYEGKWLLF DDSEVKVTEE KDFLNSLSPS TSPTSTPYLL 
FYKKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.