Details for: VIM

Gene ID: 7431

Symbol: VIM

Ensembl ID: ENSG00000026025

Description: vimentin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1107.4593
    Cell Significance Index: -172.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 537.2799
    Cell Significance Index: -136.2800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 459.5002
    Cell Significance Index: -189.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 400.5591
    Cell Significance Index: -162.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 364.0791
    Cell Significance Index: -171.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 346.5885
    Cell Significance Index: -178.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 259.9914
    Cell Significance Index: -174.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 175.9741
    Cell Significance Index: -168.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 138.9993
    Cell Significance Index: -171.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 51.0214
    Cell Significance Index: -156.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 44.3380
    Cell Significance Index: -174.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 42.7079
    Cell Significance Index: -93.4700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 32.3854
    Cell Significance Index: 344.0900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 27.3054
    Cell Significance Index: 160.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.4661
    Cell Significance Index: -68.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 22.3341
    Cell Significance Index: 286.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 18.4078
    Cell Significance Index: 325.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 18.1917
    Cell Significance Index: 336.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 17.9007
    Cell Significance Index: 374.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 15.2485
    Cell Significance Index: 173.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.9791
    Cell Significance Index: 400.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 13.7506
    Cell Significance Index: 361.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 12.4329
    Cell Significance Index: 1593.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 10.2369
    Cell Significance Index: 300.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 10.2058
    Cell Significance Index: 1401.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.2041
    Cell Significance Index: 235.7500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 9.7591
    Cell Significance Index: 45.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 8.3047
    Cell Significance Index: 432.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.8482
    Cell Significance Index: 85.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.5383
    Cell Significance Index: 421.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.3019
    Cell Significance Index: 218.9900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 6.0693
    Cell Significance Index: 25.2600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.4903
    Cell Significance Index: 27.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.2194
    Cell Significance Index: 2304.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.6845
    Cell Significance Index: 71.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.8418
    Cell Significance Index: 133.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.8037
    Cell Significance Index: 157.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5764
    Cell Significance Index: 300.0000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.1967
    Cell Significance Index: 7.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0929
    Cell Significance Index: 186.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0054
    Cell Significance Index: 15.5600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.8494
    Cell Significance Index: 6.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7951
    Cell Significance Index: 102.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4660
    Cell Significance Index: 206.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4500
    Cell Significance Index: 406.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3400
    Cell Significance Index: 5.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2829
    Cell Significance Index: 179.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2226
    Cell Significance Index: 1.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1907
    Cell Significance Index: 351.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1852
    Cell Significance Index: 348.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1575
    Cell Significance Index: 18.5700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1482
    Cell Significance Index: 0.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1296
    Cell Significance Index: 176.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0942
    Cell Significance Index: 145.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0768
    Cell Significance Index: 15.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0362
    Cell Significance Index: 16.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0564
    Cell Significance Index: -41.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0777
    Cell Significance Index: -58.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1966
    Cell Significance Index: -22.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.2218
    Cell Significance Index: -162.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2412
    Cell Significance Index: -150.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2812
    Cell Significance Index: -28.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2814
    Cell Significance Index: -158.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4218
    Cell Significance Index: -68.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4613
    Cell Significance Index: -16.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4646
    Cell Significance Index: -166.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.5214
    Cell Significance Index: -93.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5671
    Cell Significance Index: -163.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5889
    Cell Significance Index: -85.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6025
    Cell Significance Index: -126.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6664
    Cell Significance Index: -40.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7124
    Cell Significance Index: -70.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7808
    Cell Significance Index: -90.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.7873
    Cell Significance Index: -96.8100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7940
    Cell Significance Index: -5.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.8907
    Cell Significance Index: -178.6800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.9927
    Cell Significance Index: -4.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.0189
    Cell Significance Index: -110.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1490
    Cell Significance Index: -131.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1712
    Cell Significance Index: -29.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.3231
    Cell Significance Index: -98.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5079
    Cell Significance Index: -157.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.6585
    Cell Significance Index: -87.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.7057
    Cell Significance Index: -130.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.8889
    Cell Significance Index: -130.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.9235
    Cell Significance Index: -55.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.9889
    Cell Significance Index: -140.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.0014
    Cell Significance Index: -53.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.1354
    Cell Significance Index: -169.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.1492
    Cell Significance Index: -97.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.2794
    Cell Significance Index: -136.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.3371
    Cell Significance Index: -143.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.4483
    Cell Significance Index: -154.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.5112
    Cell Significance Index: -43.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.6432
    Cell Significance Index: -133.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.7391
    Cell Significance Index: -87.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.7848
    Cell Significance Index: -187.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.7921
    Cell Significance Index: -130.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9082
    Cell Significance Index: -63.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -3.1995
    Cell Significance Index: -131.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Vimentin is a 55-kDa protein composed of three subunits, each consisting of 105 amino acids. It is the most abundant intermediate filament protein in human cells, with a high expression level in mesenchymal cells, such as fibroblasts, endothelial cells, and mesenchymal stem cells. Vimentin is characterized by its ability to form networks and bundles, which provide mechanical strength and resistance to cell deformation. Its unique structure allows it to interact with various signaling molecules, including kinases, phosphatases, and transcription factors. **Pathways and Functions:** Vimentin is involved in numerous cellular pathways, including: 1. **Cellular response to stress:** Vimentin helps maintain cell integrity and structure during stress, such as heat shock, oxidative stress, and mechanical stress. 2. **Cell migration and division:** Vimentin regulates cell migration and division by interacting with signaling molecules, such as Rho GTPases and microtubule-associated proteins. 3. **Signaling pathways:** Vimentin interacts with various signaling molecules, including kinases, phosphatases, and transcription factors, to regulate cell growth, differentiation, and survival. 4. **Immune responses:** Vimentin plays a role in the regulation of immune responses, including the activation of T cells and the production of cytokines. 5. **Autophagy and apoptosis:** Vimentin is involved in the regulation of autophagy and apoptosis, which are critical processes for maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of vimentin has been implicated in various diseases, including: 1. **Cancer:** Overexpression of vimentin has been observed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurodegenerative disorders:** Vimentin dysregulation has been linked to neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. 3. **Cardiovascular diseases:** Vimentin is involved in the regulation of cardiovascular function, and its dysregulation has been implicated in cardiovascular diseases, such as hypertension and atherosclerosis. In conclusion, vimentin is a multifunctional protein that plays a critical role in maintaining cellular structure and function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of vimentin regulation and its role in maintaining cellular homeostasis.

Genular Protein ID: 2534927467

Symbol: VIME_HUMAN

Name: N/A

UniProtKB Accession Codes:

P08670 B0YJC2 D3DRU4 Q15867 Q15868 Q15869 Q548L2 Q6LER9 Q8N850 Q96ML2 Q9NTM3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 6 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 28 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3467175

Title: Coding sequence and growth regulation of the human vimentin gene.

PubMed ID: 3467175

DOI: 10.1128/mcb.6.11.3614-3620.1986

PubMed ID: 2251132

Title: Nucleotide sequence of cDNA covering the complete coding part of the human vimentin gene.

PubMed ID: 2251132

DOI: 10.1093/nar/18.22.6692

PubMed ID: 14996095

Title: SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.

PubMed ID: 14996095

DOI: 10.1111/j.1365-2133.2004.05651.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2472876

Title: Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells.

PubMed ID: 2472876

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 3371665

Title: Nucleotide sequence of the human vimentin gene and regulation of its transcription in tissues and cultured cells.

PubMed ID: 3371665

DOI: 10.1016/0378-1119(88)90575-6

PubMed ID: 2323579

Title: Isolation of a human vimentin cDNA with a long 3'-noncoding region from a human osteosarcoma cell line (MG-63).

PubMed ID: 2323579

DOI: 10.1016/0378-1119(90)90295-3

PubMed ID: 9175763

Title: Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN.

PubMed ID: 9175763

DOI: 10.1006/bbrc.1997.6669

PubMed ID: 10852826

Title: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

PubMed ID: 10852826

DOI: 10.1242/jcs.113.13.2471

PubMed ID: 12458200

Title: Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process.

PubMed ID: 12458200

DOI: 10.1074/jbc.m210892200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14762106

Title: Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments.

PubMed ID: 14762106

DOI: 10.1242/jcs.00906

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15846844

Title: Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.

PubMed ID: 15846844

DOI: 10.1002/pmic.200401093

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16923132

Title: Interactions between epiplakin and intermediate filaments.

PubMed ID: 16923132

DOI: 10.1111/j.1346-8138.2006.00127.x

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16361107

Title: Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics.

PubMed ID: 16361107

DOI: 10.1016/j.nbd.2005.10.012

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17505058

Title: Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).

PubMed ID: 17505058

DOI: 10.1210/me.2006-0514

PubMed ID: 18811945

Title: The serine/threonine kinase Stk33 exhibits autophosphorylation and phosphorylates the intermediate filament protein Vimentin.

PubMed ID: 18811945

DOI: 10.1186/1471-2091-9-25

PubMed ID: 18408015

Title: Protein kinase Cepsilon binds peripherin and induces its aggregation, which is accompanied by apoptosis of neuroblastoma cells.

PubMed ID: 18408015

DOI: 10.1074/jbc.m710436200

PubMed ID: 18827015

Title: TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

PubMed ID: 18827015

DOI: 10.1242/jcs.029454

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19270731

Title: The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.

PubMed ID: 19270731

DOI: 10.1371/journal.pone.0004730

PubMed ID: 30707744

Title: Retraction: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network.

PubMed ID: 30707744

DOI: 10.1371/journal.pone.0211966

PubMed ID: 19386766

Title: Vimentin regulates scribble activity by protecting it from proteasomal degradation.

PubMed ID: 19386766

DOI: 10.1091/mbc.e08-02-0199

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068230

Title: Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.

PubMed ID: 20068230

DOI: 10.1126/scisignal.2000526

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21746880

Title: A novel role of vimentin filaments: binding and stabilization of collagen mRNAs.

PubMed ID: 21746880

DOI: 10.1128/mcb.05263-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21465480

Title: Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.

PubMed ID: 21465480

DOI: 10.1002/jcp.22782

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23325789

Title: cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.

PubMed ID: 23325789

DOI: 10.1091/mbc.e12-08-0597

PubMed ID: 25417112

Title: Target-selective protein S-nitrosylation by sequence motif recognition.

PubMed ID: 25417112

DOI: 10.1016/j.cell.2014.09.032

PubMed ID: 24940650

Title: Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

PubMed ID: 24940650

DOI: 10.1038/jid.2014.255

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26845719

Title: Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.

PubMed ID: 26845719

DOI: 10.1515/hsz-2015-0273

PubMed ID: 26694549

Title: Sporadic and familial congenital cataracts: mutational spectrum and new diagnoses using next-generation sequencing.

PubMed ID: 26694549

DOI: 10.1002/humu.22948

PubMed ID: 27812135

Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

PubMed ID: 27812135

DOI: 10.1371/journal.pone.0165420

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29496907

Title: Phosphoproteomics analysis identifies novel candidate substrates of the non-receptor tyrosine kinase, SRMS.

PubMed ID: 29496907

DOI: 10.1074/mcp.ra118.000643

PubMed ID: 11243787

Title: Divide-and-conquer crystallographic approach towards an atomic structure of intermediate filaments.

PubMed ID: 11243787

DOI: 10.1006/jmbi.2001.4442

PubMed ID: 11889032

Title: Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly.

PubMed ID: 11889032

DOI: 10.1093/emboj/21.6.1255

PubMed ID: 20176112

Title: Atomic structure of vimentin coil 2.

PubMed ID: 20176112

DOI: 10.1016/j.jsb.2010.02.012

PubMed ID: 22119849

Title: Stabilization of vimentin coil2 fragment via an engineered disulfide.

PubMed ID: 22119849

DOI: 10.1016/j.jsb.2011.11.014

PubMed ID: 19126778

Title: Dominant cataract formation in association with a vimentin assembly disrupting mutation.

PubMed ID: 19126778

DOI: 10.1093/hmg/ddn440

PubMed ID: 28450710

Title: Targeted exome sequencing of congenital cataracts related genes: broadening the mutation spectrum and genotype-phenotype correlations in 27 Chinese Han families.

PubMed ID: 28450710

DOI: 10.1038/s41598-017-01182-9

Sequence Information:

  • Length: 466
  • Mass: 53652
  • Checksum: BAB54026665B015A
  • Sequence:
    • MSTRSVSSSS YRRMFGGPGT ASRPSSSRSY VTTSTRTYSL GSALRPSTSR SLYASSPGGV 
YATRSSAVRL RSSVPGVRLL QDSVDFSLAD AINTEFKNTR TNEKVELQEL NDRFANYIDK 
VRFLEQQNKI LLAELEQLKG QGKSRLGDLY EEEMRELRRQ VDQLTNDKAR VEVERDNLAE 
DIMRLREKLQ EEMLQREEAE NTLQSFRQDV DNASLARLDL ERKVESLQEE IAFLKKLHEE 
EIQELQAQIQ EQHVQIDVDV SKPDLTAALR DVRQQYESVA AKNLQEAEEW YKSKFADLSE 
AANRNNDALR QAKQESTEYR RQVQSLTCEV DALKGTNESL ERQMREMEEN FAVEAANYQD 
TIGRLQDEIQ NMKEEMARHL REYQDLLNVK MALDIEIATY RKLLEGEESR ISLPLPNFSS 
LNLRETNLDS LPLVDTHSKR TLLIKTVETR DGQVINETSQ HHDDLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.