Details for: ZFAND5

Gene ID: 7763

Symbol: ZFAND5

Ensembl ID: ENSG00000107372

Description: zinc finger AN1-type containing 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 527.2422
    Cell Significance Index: -82.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 317.0199
    Cell Significance Index: -80.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 191.3107
    Cell Significance Index: -78.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 185.5874
    Cell Significance Index: -87.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 162.1742
    Cell Significance Index: -83.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 130.8377
    Cell Significance Index: -87.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.3041
    Cell Significance Index: -81.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.0329
    Cell Significance Index: -77.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.3635
    Cell Significance Index: -71.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.0930
    Cell Significance Index: -87.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.5867
    Cell Significance Index: -38.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.7708
    Cell Significance Index: 39.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.5509
    Cell Significance Index: 151.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.8546
    Cell Significance Index: 139.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.3483
    Cell Significance Index: 76.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.4586
    Cell Significance Index: 58.2600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.2035
    Cell Significance Index: 19.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.9819
    Cell Significance Index: 382.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.5993
    Cell Significance Index: 122.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3459
    Cell Significance Index: 174.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3241
    Cell Significance Index: 319.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2988
    Cell Significance Index: 282.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2330
    Cell Significance Index: 41.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1782
    Cell Significance Index: 392.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0005
    Cell Significance Index: 53.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7787
    Cell Significance Index: 43.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7651
    Cell Significance Index: 47.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7253
    Cell Significance Index: 45.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5535
    Cell Significance Index: 80.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4762
    Cell Significance Index: 190.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4637
    Cell Significance Index: 799.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3153
    Cell Significance Index: 263.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2929
    Cell Significance Index: 29.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2207
    Cell Significance Index: 198.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0099
    Cell Significance Index: 65.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8800
    Cell Significance Index: 389.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8781
    Cell Significance Index: 39.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8477
    Cell Significance Index: 1596.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8344
    Cell Significance Index: 753.4100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.8137
    Cell Significance Index: 13.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7398
    Cell Significance Index: 21.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6492
    Cell Significance Index: 22.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5930
    Cell Significance Index: 117.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5708
    Cell Significance Index: 40.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5643
    Cell Significance Index: 358.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4914
    Cell Significance Index: 176.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3870
    Cell Significance Index: 20.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3691
    Cell Significance Index: 17.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3529
    Cell Significance Index: 41.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2498
    Cell Significance Index: 183.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1416
    Cell Significance Index: 2.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1205
    Cell Significance Index: 9.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1044
    Cell Significance Index: 19.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0969
    Cell Significance Index: 16.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0573
    Cell Significance Index: 26.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0383
    Cell Significance Index: 70.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0191
    Cell Significance Index: 29.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0118
    Cell Significance Index: 1.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0004
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0383
    Cell Significance Index: -28.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0410
    Cell Significance Index: -55.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0554
    Cell Significance Index: -34.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0716
    Cell Significance Index: -7.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0862
    Cell Significance Index: -59.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0882
    Cell Significance Index: -6.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0922
    Cell Significance Index: -1.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1082
    Cell Significance Index: -61.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2016
    Cell Significance Index: -42.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2258
    Cell Significance Index: -15.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2330
    Cell Significance Index: -3.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2484
    Cell Significance Index: -71.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2716
    Cell Significance Index: -39.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3268
    Cell Significance Index: -5.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3402
    Cell Significance Index: -19.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3483
    Cell Significance Index: -39.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4180
    Cell Significance Index: -25.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4412
    Cell Significance Index: -45.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4456
    Cell Significance Index: -51.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4471
    Cell Significance Index: -6.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5712
    Cell Significance Index: -62.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6157
    Cell Significance Index: -3.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6760
    Cell Significance Index: -14.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6778
    Cell Significance Index: -29.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7013
    Cell Significance Index: -44.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7311
    Cell Significance Index: -15.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7383
    Cell Significance Index: -19.7500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.7449
    Cell Significance Index: -5.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7786
    Cell Significance Index: -21.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8890
    Cell Significance Index: -33.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9307
    Cell Significance Index: -27.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9944
    Cell Significance Index: -25.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1837
    Cell Significance Index: -10.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2473
    Cell Significance Index: -76.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.2481
    Cell Significance Index: -9.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2567
    Cell Significance Index: -40.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3628
    Cell Significance Index: -38.8900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -1.5163
    Cell Significance Index: -15.8300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.5478
    Cell Significance Index: -19.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6533
    Cell Significance Index: -48.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZFAND5 belongs to the zinc finger protein family, characterized by its AN1-type zinc finger domain, which is crucial for protein-DNA interactions. This protein is predominantly expressed in various cell types, including skeletal muscle satellite stem cells, fibroblasts, and non-classical monocytes. Its expression is also evident in developmental stages, such as in utero embryonic development and skeletal system morphogenesis. **Pathways and Functions:** ZFAND5 is involved in multiple signaling pathways that regulate cell growth, differentiation, and migration. Specifically, it is implicated in the platelet-derived growth factor receptor (PDGFR) signaling pathway, which is crucial for cell proliferation and migration. Additionally, ZFAND5 interacts with other proteins, such as DNA-binding proteins, to modulate gene expression and cellular processes. In the context of immune responses, ZFAND5 is expressed in non-classical monocytes, a subset of immune cells involved in the regulation of inflammation and tissue repair. Its role in modulating immune responses is further underscored by its expression in basal cells of prostate epithelium and Sertoli cells, which are essential for maintaining tissue homeostasis and immune privilege. **Clinical Significance:** The clinical implications of ZFAND5 are multifaceted. Its expression in skeletal muscle satellite stem cells suggests a potential role in muscle regeneration and repair. In the context of fibrosis, ZFAND5 may contribute to the development and progression of fibrotic diseases, such as those affecting the prostate, kidney, and liver. Furthermore, the involvement of ZFAND5 in PDGFR signaling pathways has significant implications for cancer research. Dysregulation of PDGFR signaling is a common feature of various cancers, including breast, lung, and prostate cancer. ZFAND5's role in modulating PDGFR signaling may provide insights into the development and progression of these cancers. In conclusion, ZFAND5 is a complex gene with far-reaching implications for our understanding of tissue development, immune responses, and disease pathology. Further research is needed to unravel the intricacies of ZFAND5 and its role in human health and disease. **Recommendations:** 1. Future studies should investigate the role of ZFAND5 in muscle regeneration and repair, particularly in the context of muscular dystrophy and other muscle-wasting disorders. 2. The involvement of ZFAND5 in fibrosis and cancer should be further explored, with a focus on understanding the molecular mechanisms underlying its role in these diseases. 3. The expression patterns and functional significance of ZFAND5 in various cell types and developmental stages should be further investigated to gain a deeper understanding of its biology. By shedding light on the enigmatic role of ZFAND5, we can uncover new avenues for the treatment and prevention of various diseases, ultimately improving human health and well-being.

Genular Protein ID: 2082467602

Symbol: ZFAN5_HUMAN

Name: AN1-type zinc finger protein 5

UniProtKB Accession Codes:

O76080 A8K484

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9758550

Title: Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19.

PubMed ID: 9758550

DOI: 10.1016/s0378-1119(98)00316-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14754897

Title: ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.

PubMed ID: 14754897

DOI: 10.1074/jbc.m309491200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 213
  • Mass: 23132
  • Checksum: E477504B1BA77753
  • Sequence:
    • MAQETNQTPG PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QQNSGRMSPM GTASGSNSPT 
SDSASVQRAD TSLNNCEGAA GSTSEKSRNV PVAALPVTQQ MTEMSISRED KITTPKTEVS 
EPVVTQPSPS VSQPSTSQSE EKAPELPKPK KNRCFMCRKK VGLTGFDCRC GNLFCGLHRY 
SDKHNCPYDY KAEAAAKIRK ENPVVVAEKI QRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.