Details for: ZFAND5

Gene ID: 7763

Symbol: ZFAND5

Ensembl ID: ENSG00000107372

Description: zinc finger AN1-type containing 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.66
    Marker Score: 3905
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.63
    Marker Score: 123589
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.19
    Marker Score: 2716
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.1
    Marker Score: 2039
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.03
    Marker Score: 7321
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.84
    Marker Score: 6947
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.84
    Marker Score: 16848.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.68
    Marker Score: 47538
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.64
    Marker Score: 2077
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.61
    Marker Score: 1781
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.61
    Marker Score: 145742
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.57
    Marker Score: 4820
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.47
    Marker Score: 4806
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.44
    Marker Score: 2795
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.44
    Marker Score: 10208
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.38
    Marker Score: 1861
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.36
    Marker Score: 3998.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.36
    Marker Score: 9106
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.36
    Marker Score: 2357
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.34
    Marker Score: 3448
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.34
    Marker Score: 973
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.31
    Marker Score: 15062.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.3
    Marker Score: 9545.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.24
    Marker Score: 11003
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.21
    Marker Score: 2327
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.21
    Marker Score: 56615
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.17
    Marker Score: 500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.16
    Marker Score: 732
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.15
    Marker Score: 3524.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.15
    Marker Score: 2074
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.14
    Marker Score: 24056.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.13
    Marker Score: 674
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.1
    Marker Score: 1174
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.1
    Marker Score: 5493
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.07
    Marker Score: 2430
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.07
    Marker Score: 511
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.06
    Marker Score: 492.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.06
    Marker Score: 800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.06
    Marker Score: 1197
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.05
    Marker Score: 71181
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.05
    Marker Score: 1140.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.05
    Marker Score: 2974.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.05
    Marker Score: 8823.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.02
    Marker Score: 10639
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.99
    Marker Score: 1162
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.98
    Marker Score: 2585
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.98
    Marker Score: 2554
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.97
    Marker Score: 720
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.97
    Marker Score: 5284
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.96
    Marker Score: 1228
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.95
    Marker Score: 2193
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.94
    Marker Score: 5038
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.94
    Marker Score: 1671
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.94
    Marker Score: 1328
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.93
    Marker Score: 1733
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.93
    Marker Score: 3856
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.93
    Marker Score: 11699
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.92
    Marker Score: 1377
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.91
    Marker Score: 929
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.91
    Marker Score: 1306
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.9
    Marker Score: 765
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.9
    Marker Score: 870
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.9
    Marker Score: 1248
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.89
    Marker Score: 2061
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.89
    Marker Score: 766
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.89
    Marker Score: 3002.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.89
    Marker Score: 1429
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.89
    Marker Score: 711
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.87
    Marker Score: 2694
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.86
    Marker Score: 1136
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.86
    Marker Score: 4222
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.86
    Marker Score: 463
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.86
    Marker Score: 648
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.86
    Marker Score: 7297
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.85
    Marker Score: 1064
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.85
    Marker Score: 755
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.85
    Marker Score: 1053.5
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.84
    Marker Score: 463
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.84
    Marker Score: 2276
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.83
    Marker Score: 4012
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.82
    Marker Score: 827
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.82
    Marker Score: 863
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.82
    Marker Score: 531
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.81
    Marker Score: 15765
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.81
    Marker Score: 445.5
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.81
    Marker Score: 760
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.81
    Marker Score: 623
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.8
    Marker Score: 4493
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.8
    Marker Score: 2104
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.8
    Marker Score: 5049
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.79
    Marker Score: 769.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.79
    Marker Score: 4508
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.79
    Marker Score: 1188
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.78
    Marker Score: 3155
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.77
    Marker Score: 6081
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.76
    Marker Score: 970
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.76
    Marker Score: 499.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.76
    Marker Score: 2190
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.76
    Marker Score: 533
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.76
    Marker Score: 6500

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** ZFAND5 belongs to the zinc finger protein family, characterized by its AN1-type zinc finger domain, which is crucial for protein-DNA interactions. This protein is predominantly expressed in various cell types, including skeletal muscle satellite stem cells, fibroblasts, and non-classical monocytes. Its expression is also evident in developmental stages, such as in utero embryonic development and skeletal system morphogenesis. **Pathways and Functions:** ZFAND5 is involved in multiple signaling pathways that regulate cell growth, differentiation, and migration. Specifically, it is implicated in the platelet-derived growth factor receptor (PDGFR) signaling pathway, which is crucial for cell proliferation and migration. Additionally, ZFAND5 interacts with other proteins, such as DNA-binding proteins, to modulate gene expression and cellular processes. In the context of immune responses, ZFAND5 is expressed in non-classical monocytes, a subset of immune cells involved in the regulation of inflammation and tissue repair. Its role in modulating immune responses is further underscored by its expression in basal cells of prostate epithelium and Sertoli cells, which are essential for maintaining tissue homeostasis and immune privilege. **Clinical Significance:** The clinical implications of ZFAND5 are multifaceted. Its expression in skeletal muscle satellite stem cells suggests a potential role in muscle regeneration and repair. In the context of fibrosis, ZFAND5 may contribute to the development and progression of fibrotic diseases, such as those affecting the prostate, kidney, and liver. Furthermore, the involvement of ZFAND5 in PDGFR signaling pathways has significant implications for cancer research. Dysregulation of PDGFR signaling is a common feature of various cancers, including breast, lung, and prostate cancer. ZFAND5's role in modulating PDGFR signaling may provide insights into the development and progression of these cancers. In conclusion, ZFAND5 is a complex gene with far-reaching implications for our understanding of tissue development, immune responses, and disease pathology. Further research is needed to unravel the intricacies of ZFAND5 and its role in human health and disease. **Recommendations:** 1. Future studies should investigate the role of ZFAND5 in muscle regeneration and repair, particularly in the context of muscular dystrophy and other muscle-wasting disorders. 2. The involvement of ZFAND5 in fibrosis and cancer should be further explored, with a focus on understanding the molecular mechanisms underlying its role in these diseases. 3. The expression patterns and functional significance of ZFAND5 in various cell types and developmental stages should be further investigated to gain a deeper understanding of its biology. By shedding light on the enigmatic role of ZFAND5, we can uncover new avenues for the treatment and prevention of various diseases, ultimately improving human health and well-being.

Genular Protein ID: 2082467602

Symbol: ZFAN5_HUMAN

Name: AN1-type zinc finger protein 5

UniProtKB Accession Codes:

O76080 A8K484

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9758550

Title: Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19.

PubMed ID: 9758550

DOI: 10.1016/s0378-1119(98)00316-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14754897

Title: ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.

PubMed ID: 14754897

DOI: 10.1074/jbc.m309491200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 213
  • Mass: 23132
  • Checksum: E477504B1BA77753
  • Sequence:
    • MAQETNQTPG PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QQNSGRMSPM GTASGSNSPT 
SDSASVQRAD TSLNNCEGAA GSTSEKSRNV PVAALPVTQQ MTEMSISRED KITTPKTEVS 
EPVVTQPSPS VSQPSTSQSE EKAPELPKPK KNRCFMCRKK VGLTGFDCRC GNLFCGLHRY 
SDKHNCPYDY KAEAAAKIRK ENPVVVAEKI QRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.