Details for: CSRP3

Gene ID: 8048

Symbol: CSRP3

Ensembl ID: ENSG00000129170

Description: cysteine and glycine rich protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 17.4397
    Cell Significance Index: 260.9100
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 14.0694
    Cell Significance Index: 40.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 9.4851
    Cell Significance Index: 231.4300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 5.3727
    Cell Significance Index: 86.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.2070
    Cell Significance Index: 62.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.7051
    Cell Significance Index: 207.5900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.8643
    Cell Significance Index: 14.9000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2563
    Cell Significance Index: 15.5400
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 0.4795
    Cell Significance Index: 3.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2841
    Cell Significance Index: 4.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2137
    Cell Significance Index: 24.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1759
    Cell Significance Index: 2.5300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0889
    Cell Significance Index: 1.3300
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.0606
    Cell Significance Index: 0.5800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0395
    Cell Significance Index: 0.5100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.0376
    Cell Significance Index: 0.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0293
    Cell Significance Index: 0.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0078
    Cell Significance Index: 0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0070
    Cell Significance Index: 1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0043
    Cell Significance Index: 8.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0005
    Cell Significance Index: 0.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.2200
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0024
    Cell Significance Index: -0.8500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0025
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0051
    Cell Significance Index: -2.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0059
    Cell Significance Index: -3.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0059
    Cell Significance Index: -1.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0064
    Cell Significance Index: -1.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0069
    Cell Significance Index: -1.3700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0096
    Cell Significance Index: -0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0107
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0119
    Cell Significance Index: -2.0300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0148
    Cell Significance Index: -0.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0190
    Cell Significance Index: -0.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0191
    Cell Significance Index: -0.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0199
    Cell Significance Index: -0.8100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0202
    Cell Significance Index: -0.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0233
    Cell Significance Index: -1.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0237
    Cell Significance Index: -2.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0241
    Cell Significance Index: -3.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0241
    Cell Significance Index: -1.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0250
    Cell Significance Index: -0.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0260
    Cell Significance Index: -1.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0266
    Cell Significance Index: -1.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0268
    Cell Significance Index: -0.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0274
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0282
    Cell Significance Index: -3.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0288
    Cell Significance Index: -1.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0325
    Cell Significance Index: -3.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0331
    Cell Significance Index: -3.4500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0334
    Cell Significance Index: -0.3500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0359
    Cell Significance Index: -0.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0368
    Cell Significance Index: -0.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0393
    Cell Significance Index: -2.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0430
    Cell Significance Index: -0.9000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0435
    Cell Significance Index: -0.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0437
    Cell Significance Index: -2.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0447
    Cell Significance Index: -0.6600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0457
    Cell Significance Index: -0.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0481
    Cell Significance Index: -2.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0516
    Cell Significance Index: -1.3800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0539
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0552
    Cell Significance Index: -0.6300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0559
    Cell Significance Index: -0.7200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0576
    Cell Significance Index: -0.7300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0586
    Cell Significance Index: -0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0598
    Cell Significance Index: -2.1000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0603
    Cell Significance Index: -1.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0619
    Cell Significance Index: -2.9100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0619
    Cell Significance Index: -0.5600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0656
    Cell Significance Index: -0.8900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0695
    Cell Significance Index: -0.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0734
    Cell Significance Index: -2.5700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0739
    Cell Significance Index: -0.7400
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: -0.0755
    Cell Significance Index: -0.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0762
    Cell Significance Index: -1.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0763
    Cell Significance Index: -2.4300
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: -0.0763
    Cell Significance Index: -0.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0771
    Cell Significance Index: -2.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0779
    Cell Significance Index: -2.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0800
    Cell Significance Index: -0.8700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0808
    Cell Significance Index: -1.1500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0809
    Cell Significance Index: -1.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0817
    Cell Significance Index: -1.6000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0818
    Cell Significance Index: -1.0200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0849
    Cell Significance Index: -0.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0865
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0868
    Cell Significance Index: -0.5400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0873
    Cell Significance Index: -0.4600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0887
    Cell Significance Index: -1.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0912
    Cell Significance Index: -2.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0922
    Cell Significance Index: -2.2100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0928
    Cell Significance Index: -1.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSRP3 is a small, cytoplasmic protein that belongs to the cysteine and glycine-rich protein family. It is characterized by its high content of cysteine and glycine residues, which confer its unique structural and functional properties. CSRP3 is predominantly expressed in cardiac and skeletal muscle cells, as well as in other cell types such as lymphocytes and endothelial cells. **Pathways and Functions:** CSRP3 is involved in various cellular pathways, including: 1. **Muscle contraction and relaxation**: CSRP3 regulates the organization of sarcomeres and the force of heart contraction, essential for maintaining cardiac function. 2. **Cytoskeleton organization**: CSRP3 interacts with actin and actinin, key components of the cytoskeleton, to regulate cell shape and movement. 3. **Cell signaling**: CSRP3 modulates signaling pathways, including insulin receptor signaling and protein kinase C, to regulate glucose homeostasis and cellular growth. 4. **Inflammatory response**: CSRP3 plays a role in regulating the inflammatory response, particularly in the context of cardiac injury and disease. 5. **Cellular homeostasis**: CSRP3 maintains cellular homeostasis by regulating protein localization, metal ion binding, and intracellular calcium ion homeostasis. **Clinical Significance:** Dysregulation of CSRP3 has been implicated in various cardiovascular and muscular diseases, including: 1. **Cardiac hypertrophy**: Altered CSRP3 expression has been linked to cardiac hypertrophy, a condition characterized by abnormal heart muscle growth. 2. **Muscular dystrophy**: CSRP3 mutations have been associated with muscular dystrophy, a group of genetic disorders that affect muscle function and strength. 3. **Hypertension**: Elevated CSRP3 levels have been observed in patients with hypertension, a condition characterized by high blood pressure. 4. **Heart failure**: CSRP3 dysregulation has been implicated in heart failure, a condition characterized by the heart's inability to pump blood effectively. In conclusion, CSRP3 is a multifunctional gene that plays a critical role in maintaining cardiac and skeletal muscle function. Its dysregulation has been implicated in various cardiovascular and muscular diseases, highlighting the importance of CSRP3 in understanding and treating these conditions. Further research is needed to fully elucidate the mechanisms by which CSRP3 regulates cellular processes and to develop therapeutic strategies for its manipulation.

Genular Protein ID: 2117368135

Symbol: CSRP3_HUMAN

Name: Cysteine and glycine-rich protein 3

UniProtKB Accession Codes:

P50461 Q9P131 S4S7M7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7490106

Title: Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization.

PubMed ID: 7490106

DOI: 10.1006/geno.1995.1200

PubMed ID: 24860983

Title: Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.

PubMed ID: 24860983

DOI: 10.1111/febs.12859

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15582318

Title: Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.

PubMed ID: 15582318

DOI: 10.1016/j.jacc.2004.08.058

PubMed ID: 15205937

Title: Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and alpha-actinin and their implication for hypertrophic cardiomyopathy.

PubMed ID: 15205937

DOI: 10.1007/s00441-004-0873-y

PubMed ID: 19752190

Title: Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.

PubMed ID: 19752190

DOI: 10.1128/mcb.00654-09

PubMed ID: 24934443

Title: Human muscle LIM protein dimerizes along the actin cytoskeleton and cross-links actin filaments.

PubMed ID: 24934443

DOI: 10.1128/mcb.00651-14

PubMed ID: 27353086

Title: MLP and CARP are linked to chronic PKCalpha signalling in dilated cardiomyopathy.

PubMed ID: 27353086

DOI: 10.1038/ncomms12120

PubMed ID: 19230835

Title: Structure and dynamics of the human muscle LIM protein.

PubMed ID: 19230835

DOI: 10.1016/j.febslet.2009.02.021

PubMed ID: 12507422

Title: The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.

PubMed ID: 12507422

DOI: 10.1016/s0092-8674(02)01226-6

PubMed ID: 12642359

Title: Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.

PubMed ID: 12642359

DOI: 10.1161/01.cir.0000056522.82563.5f

PubMed ID: 19412328

Title: Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy.

PubMed ID: 19412328

DOI: 10.1111/j.1752-8062.2008.00017.x

PubMed ID: 18505755

Title: Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy.

PubMed ID: 18505755

DOI: 10.1093/hmg/ddn160

Sequence Information:

  • Length: 194
  • Mass: 20969
  • Checksum: FDB6E4F8D258C35F
  • Sequence:
    • MPNWGGGAKC GACEKTVYHA EEIQCNGRSF HKTCFHCMAC RKALDSTTVA AHESEIYCKV 
CYGRRYGPKG IGYGQGAGCL STDTGEHLGL QFQQSPKPAR SVTTSNPSKF TAKFGESEKC 
PRCGKSVYAA EKVMGGGKPW HKTCFRCAIC GKSLESTNVT DKDGELYCKV CYAKNFGPTG 
IGFGGLTQQV EKKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.