Details for: CSRP3

Gene ID: 8048

Symbol: CSRP3

Ensembl ID: ENSG00000129170

Description: cysteine and glycine rich protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53050
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.42
    Marker Score: 1127
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.95
    Marker Score: 1491
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.9
    Marker Score: 64750.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.38
    Marker Score: 2398
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.37
    Marker Score: 1806
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.11
    Marker Score: 7509
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.09
    Marker Score: 12582
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2186
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.85
    Marker Score: 765
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.73
    Marker Score: 22947
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170244.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18533
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7508
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.9
    Marker Score: 1121
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1197
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.74
    Marker Score: 307
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.65
    Marker Score: 312
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.63
    Marker Score: 367
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 490
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.55
    Marker Score: 1134
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.54
    Marker Score: 315
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.53
    Marker Score: 479
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.5
    Marker Score: 151
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.5
    Marker Score: 1702.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.49
    Marker Score: 234.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 901
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 895.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.44
    Marker Score: 141
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.39
    Marker Score: 191
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.39
    Marker Score: 141
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 319
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.34
    Marker Score: 369
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.34
    Marker Score: 191
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.27
    Marker Score: 178
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.26
    Marker Score: 87
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 135
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.24
    Marker Score: 96
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.23
    Marker Score: 275
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.22
    Marker Score: 88
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.21
    Marker Score: 152
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.19
    Marker Score: 216
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 424.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.16
    Marker Score: 107
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.14
    Marker Score: 32.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.12
    Marker Score: 518
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.12
    Marker Score: 29.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 29.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.12
    Marker Score: 225
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 195
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.11
    Marker Score: 139
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 79
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.1
    Marker Score: 32.5
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.1
    Marker Score: 32.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.1
    Marker Score: 28.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 32.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.1
    Marker Score: 84
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 25.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 74
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.08
    Marker Score: 26.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.08
    Marker Score: 20.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 21.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.07
    Marker Score: 50

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Other Information

**Key Characteristics:** CSRP3 is a small, cytoplasmic protein that belongs to the cysteine and glycine-rich protein family. It is characterized by its high content of cysteine and glycine residues, which confer its unique structural and functional properties. CSRP3 is predominantly expressed in cardiac and skeletal muscle cells, as well as in other cell types such as lymphocytes and endothelial cells. **Pathways and Functions:** CSRP3 is involved in various cellular pathways, including: 1. **Muscle contraction and relaxation**: CSRP3 regulates the organization of sarcomeres and the force of heart contraction, essential for maintaining cardiac function. 2. **Cytoskeleton organization**: CSRP3 interacts with actin and actinin, key components of the cytoskeleton, to regulate cell shape and movement. 3. **Cell signaling**: CSRP3 modulates signaling pathways, including insulin receptor signaling and protein kinase C, to regulate glucose homeostasis and cellular growth. 4. **Inflammatory response**: CSRP3 plays a role in regulating the inflammatory response, particularly in the context of cardiac injury and disease. 5. **Cellular homeostasis**: CSRP3 maintains cellular homeostasis by regulating protein localization, metal ion binding, and intracellular calcium ion homeostasis. **Clinical Significance:** Dysregulation of CSRP3 has been implicated in various cardiovascular and muscular diseases, including: 1. **Cardiac hypertrophy**: Altered CSRP3 expression has been linked to cardiac hypertrophy, a condition characterized by abnormal heart muscle growth. 2. **Muscular dystrophy**: CSRP3 mutations have been associated with muscular dystrophy, a group of genetic disorders that affect muscle function and strength. 3. **Hypertension**: Elevated CSRP3 levels have been observed in patients with hypertension, a condition characterized by high blood pressure. 4. **Heart failure**: CSRP3 dysregulation has been implicated in heart failure, a condition characterized by the heart's inability to pump blood effectively. In conclusion, CSRP3 is a multifunctional gene that plays a critical role in maintaining cardiac and skeletal muscle function. Its dysregulation has been implicated in various cardiovascular and muscular diseases, highlighting the importance of CSRP3 in understanding and treating these conditions. Further research is needed to fully elucidate the mechanisms by which CSRP3 regulates cellular processes and to develop therapeutic strategies for its manipulation.

Genular Protein ID: 2117368135

Symbol: CSRP3_HUMAN

Name: Cysteine and glycine-rich protein 3

UniProtKB Accession Codes:

P50461 Q9P131 S4S7M7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7490106

Title: Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization.

PubMed ID: 7490106

DOI: 10.1006/geno.1995.1200

PubMed ID: 24860983

Title: Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.

PubMed ID: 24860983

DOI: 10.1111/febs.12859

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15582318

Title: Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.

PubMed ID: 15582318

DOI: 10.1016/j.jacc.2004.08.058

PubMed ID: 15205937

Title: Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and alpha-actinin and their implication for hypertrophic cardiomyopathy.

PubMed ID: 15205937

DOI: 10.1007/s00441-004-0873-y

PubMed ID: 19752190

Title: Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.

PubMed ID: 19752190

DOI: 10.1128/mcb.00654-09

PubMed ID: 24934443

Title: Human muscle LIM protein dimerizes along the actin cytoskeleton and cross-links actin filaments.

PubMed ID: 24934443

DOI: 10.1128/mcb.00651-14

PubMed ID: 27353086

Title: MLP and CARP are linked to chronic PKCalpha signalling in dilated cardiomyopathy.

PubMed ID: 27353086

DOI: 10.1038/ncomms12120

PubMed ID: 19230835

Title: Structure and dynamics of the human muscle LIM protein.

PubMed ID: 19230835

DOI: 10.1016/j.febslet.2009.02.021

PubMed ID: 12507422

Title: The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.

PubMed ID: 12507422

DOI: 10.1016/s0092-8674(02)01226-6

PubMed ID: 12642359

Title: Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy.

PubMed ID: 12642359

DOI: 10.1161/01.cir.0000056522.82563.5f

PubMed ID: 19412328

Title: Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy.

PubMed ID: 19412328

DOI: 10.1111/j.1752-8062.2008.00017.x

PubMed ID: 18505755

Title: Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy.

PubMed ID: 18505755

DOI: 10.1093/hmg/ddn160

Sequence Information:

  • Length: 194
  • Mass: 20969
  • Checksum: FDB6E4F8D258C35F
  • Sequence:
    • MPNWGGGAKC GACEKTVYHA EEIQCNGRSF HKTCFHCMAC RKALDSTTVA AHESEIYCKV 
CYGRRYGPKG IGYGQGAGCL STDTGEHLGL QFQQSPKPAR SVTTSNPSKF TAKFGESEKC 
PRCGKSVYAA EKVMGGGKPW HKTCFRCAIC GKSLESTNVT DKDGELYCKV CYAKNFGPTG 
IGFGGLTQQV EKKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.