Details for: FXR1

Gene ID: 8087

Symbol: FXR1

Ensembl ID: ENSG00000114416

Description: FMR1 autosomal homolog 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 528.6244
    Cell Significance Index: -82.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 301.0526
    Cell Significance Index: -76.3600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 236.1829
    Cell Significance Index: -97.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 192.5135
    Cell Significance Index: -90.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 184.3783
    Cell Significance Index: -74.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 166.4608
    Cell Significance Index: -85.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 135.3905
    Cell Significance Index: -90.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 79.0579
    Cell Significance Index: -75.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 70.6676
    Cell Significance Index: -87.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.8377
    Cell Significance Index: -82.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.6353
    Cell Significance Index: -89.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.5789
    Cell Significance Index: -69.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1690
    Cell Significance Index: -31.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.5404
    Cell Significance Index: 65.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2331
    Cell Significance Index: 443.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1528
    Cell Significance Index: 120.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0914
    Cell Significance Index: 51.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0342
    Cell Significance Index: 408.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8410
    Cell Significance Index: 113.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7881
    Cell Significance Index: 219.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7549
    Cell Significance Index: 240.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6427
    Cell Significance Index: 296.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5270
    Cell Significance Index: 547.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4514
    Cell Significance Index: 792.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1609
    Cell Significance Index: 60.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1279
    Cell Significance Index: 780.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1174
    Cell Significance Index: 494.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1164
    Cell Significance Index: 72.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0453
    Cell Significance Index: 80.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8143
    Cell Significance Index: 19.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7748
    Cell Significance Index: 21.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7427
    Cell Significance Index: 19.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7303
    Cell Significance Index: 51.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6998
    Cell Significance Index: 20.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6994
    Cell Significance Index: 32.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6476
    Cell Significance Index: 110.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6062
    Cell Significance Index: 28.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5739
    Cell Significance Index: 16.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5455
    Cell Significance Index: 64.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4409
    Cell Significance Index: 56.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4052
    Cell Significance Index: 25.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3415
    Cell Significance Index: 55.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2615
    Cell Significance Index: 492.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2547
    Cell Significance Index: 32.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2360
    Cell Significance Index: 213.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1739
    Cell Significance Index: 110.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1673
    Cell Significance Index: 8.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1492
    Cell Significance Index: 10.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1451
    Cell Significance Index: 1.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1353
    Cell Significance Index: 4.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1311
    Cell Significance Index: 201.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1272
    Cell Significance Index: 234.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0744
    Cell Significance Index: 33.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0707
    Cell Significance Index: 96.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0439
    Cell Significance Index: 4.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0271
    Cell Significance Index: 5.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0184
    Cell Significance Index: 0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0168
    Cell Significance Index: -0.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0478
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0481
    Cell Significance Index: -35.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0523
    Cell Significance Index: -2.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0671
    Cell Significance Index: -50.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0763
    Cell Significance Index: -47.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1106
    Cell Significance Index: -62.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1522
    Cell Significance Index: -6.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1528
    Cell Significance Index: -15.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1748
    Cell Significance Index: -13.0300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2070
    Cell Significance Index: -3.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2714
    Cell Significance Index: -78.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2791
    Cell Significance Index: -58.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2855
    Cell Significance Index: -41.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3113
    Cell Significance Index: -5.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3244
    Cell Significance Index: -5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3364
    Cell Significance Index: -17.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3402
    Cell Significance Index: -7.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3665
    Cell Significance Index: -13.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3873
    Cell Significance Index: -2.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4189
    Cell Significance Index: -48.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4850
    Cell Significance Index: -10.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4919
    Cell Significance Index: -56.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6509
    Cell Significance Index: -8.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6706
    Cell Significance Index: -9.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6822
    Cell Significance Index: -15.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6844
    Cell Significance Index: -71.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7400
    Cell Significance Index: -84.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7621
    Cell Significance Index: -16.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7711
    Cell Significance Index: -61.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9575
    Cell Significance Index: -7.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9627
    Cell Significance Index: -18.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0089
    Cell Significance Index: -27.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0137
    Cell Significance Index: -25.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.0164
    Cell Significance Index: -11.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2114
    Cell Significance Index: -34.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.2178
    Cell Significance Index: -35.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2878
    Cell Significance Index: -32.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3649
    Cell Significance Index: -43.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.4147
    Cell Significance Index: -49.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4492
    Cell Significance Index: -88.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7746
    Cell Significance Index: -58.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FXR1 is a member of the HMG-box family of transcription factors, characterized by the presence of a highly conserved HMG domain. This domain enables FXR1 to bind to specific DNA sequences, known as HMG boxes, which are located in the promoter regions of target genes. FXR1's ability to bind to these sequences allows it to regulate the expression of genes involved in various cellular processes, including cell proliferation, differentiation, and survival. FXR1's expression is tissue-specific, with high levels detected in neurons, muscle cells, and immune cells. **Pathways and Functions** FXR1's regulatory functions are mediated through its interactions with various signaling pathways and networks. Some of the key pathways and functions of FXR1 include: 1. **Neurodevelopment and synaptic plasticity**: FXR1 plays a critical role in the development and maturation of neurons, influencing the expression of genes involved in synaptic transmission and plasticity. 2. **Immune regulation**: FXR1 modulates the expression of genes involved in immune responses, including the regulation of inflammatory cytokines and the promotion of long-term synaptic potentiation. 3. **Cell proliferation and differentiation**: FXR1's ability to regulate gene expression through direct binding to DNA sequences enables it to influence cell proliferation, differentiation, and survival in various cell types. 4. **Circadian rhythm regulation**: FXR1's expression is regulated by the circadian clock, highlighting its role in maintaining the body's internal clock. **Clinical Significance** Dysregulation of FXR1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: FXR1's role in regulating synaptic plasticity and neuronal development has led to its association with neurodegenerative disorders, such as fragile X syndrome and Alzheimer's disease. 2. **Cancer**: FXR1's ability to regulate cell proliferation and differentiation has led to its involvement in various types of cancer, including leukemia and lymphoma. 3. **Autoimmune conditions**: FXR1's role in regulating immune responses has led to its association with autoimmune conditions, such as multiple sclerosis and rheumatoid arthritis. 4. **Skeletal muscle disorders**: FXR1's involvement in regulating muscle cell development and function has led to its association with skeletal muscle disorders, such as muscular dystrophy. In conclusion, FXR1 is a multifunctional transcription factor that plays a critical role in regulating various cellular processes, including development, synaptic plasticity, and inflammation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of FXR1's regulatory functions and its potential as a therapeutic target.

Genular Protein ID: 1747422834

Symbol: FXR1_HUMAN

Name: hFXR1p

UniProtKB Accession Codes:

P51114 A8K9B8 Q7Z450 Q8N6R8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 5 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 49 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7781595

Title: FXR1, an autosomal homolog of the fragile X mental retardation gene.

PubMed ID: 7781595

DOI: 10.1002/j.1460-2075.1995.tb07237.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7489725

Title: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.

PubMed ID: 7489725

DOI: 10.1002/j.1460-2075.1995.tb00220.x

PubMed ID: 8668200

Title: Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.

PubMed ID: 8668200

DOI: 10.1128/mcb.16.7.3825

PubMed ID: 9259278

Title: Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.

PubMed ID: 9259278

DOI: 10.1093/hmg/6.8.1315

PubMed ID: 11157796

Title: Evidence that fragile X mental retardation protein is a negative regulator of translation.

PubMed ID: 11157796

DOI: 10.1093/hmg/10.4.329

PubMed ID: 14532325

Title: Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs.

PubMed ID: 14532325

DOI: 10.1093/hmg/ddg335

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17382880

Title: AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.

PubMed ID: 17382880

DOI: 10.1016/j.cell.2007.01.038

PubMed ID: 18664458

Title: Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.

PubMed ID: 18664458

DOI: 10.1093/hmg/ddn219

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20417602

Title: A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.

PubMed ID: 20417602

DOI: 10.1016/j.molcel.2010.04.004

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21771594

Title: Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery.

PubMed ID: 21771594

DOI: 10.1016/j.febslet.2011.07.010

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25225333

Title: Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.

PubMed ID: 25225333

DOI: 10.1128/mcb.00766-14

PubMed ID: 27509095

Title: New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.

PubMed ID: 27509095

DOI: 10.1371/journal.ppat.1005810

PubMed ID: 29142209

Title: Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.

PubMed ID: 29142209

DOI: 10.1038/s41467-017-01199-8

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30067974

Title: FXR1 is an IL-19-responsive RNA-binding protein that destabilizes pro-inflammatory transcripts in vascular smooth muscle cells.

PubMed ID: 30067974

DOI: 10.1016/j.celrep.2018.07.002

PubMed ID: 30770808

Title: Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

PubMed ID: 30770808

DOI: 10.1038/s41467-019-08548-9

PubMed ID: 32706158

Title: Spatial control of nucleoporin condensation by fragile X-related proteins.

PubMed ID: 32706158

DOI: 10.15252/embj.2020104467

PubMed ID: 34731628

Title: RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.

PubMed ID: 34731628

DOI: 10.1016/j.celrep.2021.109934

PubMed ID: 35989368

Title: CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1.

PubMed ID: 35989368

DOI: 10.1038/s41388-022-02439-y

PubMed ID: 36306353

Title: Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.

PubMed ID: 36306353

DOI: 10.1126/sciadv.abo1304

PubMed ID: 21072162

Title: Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.

PubMed ID: 21072162

DOI: 10.1371/journal.pone.0013559

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 621
  • Mass: 69721
  • Checksum: 0474A9B593C7C228
  • Sequence:
    • MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 
EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 
VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 
VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 
IQQARKVPGV TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 
VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG TNSELSNPSE TESERKDELS 
DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS GGRGRGGPRG GKSSISSVLK DPDSNPYSLL 
DNTESDQTAD TDASESHHST NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY 
ISRAESQSRQ RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE 
EKINTLKEEN TQEAAVLNGV S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.