Details for: OR1D5

Gene ID: 8386

Symbol: OR1D5

Ensembl ID: ENSG00000262628

Description: olfactory receptor family 1 subfamily D member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0564
    Cell Significance Index: 0.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0405
    Cell Significance Index: 1.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0257
    Cell Significance Index: 0.4200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0222
    Cell Significance Index: 0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0066
    Cell Significance Index: -0.0500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0068
    Cell Significance Index: -0.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0070
    Cell Significance Index: -0.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0070
    Cell Significance Index: -0.1400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0074
    Cell Significance Index: -0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0075
    Cell Significance Index: -0.2600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0088
    Cell Significance Index: -0.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0105
    Cell Significance Index: -0.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0107
    Cell Significance Index: -0.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0114
    Cell Significance Index: -0.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0116
    Cell Significance Index: -0.1400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0119
    Cell Significance Index: -0.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0123
    Cell Significance Index: -0.2400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0128
    Cell Significance Index: -0.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0129
    Cell Significance Index: -0.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0132
    Cell Significance Index: -0.2200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0136
    Cell Significance Index: -0.1500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0143
    Cell Significance Index: -0.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0149
    Cell Significance Index: -0.1900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0151
    Cell Significance Index: -0.1600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0153
    Cell Significance Index: -0.1700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0161
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0180
    Cell Significance Index: -0.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0181
    Cell Significance Index: -0.2000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0197
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0211
    Cell Significance Index: -0.2000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0212
    Cell Significance Index: -0.1900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0219
    Cell Significance Index: -0.2800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0220
    Cell Significance Index: -0.1900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0222
    Cell Significance Index: -0.1200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0223
    Cell Significance Index: -0.2800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0225
    Cell Significance Index: -0.2000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0238
    Cell Significance Index: -0.2700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0250
    Cell Significance Index: -0.3100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0252
    Cell Significance Index: -0.2700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0256
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0273
    Cell Significance Index: -0.2800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0325
    Cell Significance Index: -0.2800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0326
    Cell Significance Index: -0.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR1D5 is a type of olfactory receptor that binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor (GPCR) Family:** As a GPCR, OR1D5 interacts with G proteins to initiate signal transduction pathways that regulate various cellular processes. 3. **High Expression in Multiple Cell Types:** OR1D5 is expressed in a diverse range of cell types, including pericytes, cardiac endothelial cells, and neurons, suggesting its involvement in multiple physiological processes. 4. **Signaling Pathways:** OR1D5 is involved in various signaling pathways, including detection of chemical stimuli, expression and translocation of olfactory receptors, and G protein-coupled receptor signaling. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR1D5 binds to odorant molecules, triggering a signaling cascade that regulates the perception of smell. 2. **Expression and Translocation of Olfactory Receptors:** OR1D5 plays a role in the expression and translocation of olfactory receptors, ensuring proper olfactory function. 3. **G Protein-Coupled Receptor Signaling:** OR1D5 interacts with G proteins to initiate signal transduction pathways that regulate various cellular processes. 4. **Sensory Perception:** OR1D5 is involved in the sensory perception of smell, allowing individuals to detect and distinguish various odorant molecules. 5. **Cardiovascular Function:** OR1D5 is expressed in cardiac endothelial cells and plays a role in cardiovascular function, suggesting its involvement in cardiovascular signaling pathways. **Clinical Significance:** The OR1D5 gene has potential implications in various diseases and disorders, including: 1. **Olfactory Dysfunction:** Alterations in OR1D5 expression or function may contribute to olfactory dysfunction, which can be a symptom of various neurological disorders. 2. **Cardiovascular Disease:** OR1D5's role in cardiovascular signaling pathways suggests its potential involvement in cardiovascular disease, including hypertension and cardiac arrhythmias. 3. **Neurological Disorders:** OR1D5's expression in neurons and its involvement in sensory perception suggest its potential role in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** OR1D5's expression in various cell types and its involvement in signaling pathways suggest its potential role in cancer development and progression. In conclusion, the OR1D5 gene is a vital component of the olfactory system and plays a broader role in various physiological processes. Further research is needed to fully elucidate the functions and clinical significance of OR1D5, but its potential implications in disease prevention and treatment are significant.

Genular Protein ID: 2303923671

Symbol: OR1D5_HUMAN

Name: Olfactory receptor 1D5

UniProtKB Accession Codes:

P58170 A0AUK4 Q96RA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 312
  • Mass: 35424
  • Checksum: 94D238A76AE37829
  • Sequence:
    • MDGDNQSENS QFLLLGISES PEQQRILFWM FLSMYLVTVL GNVLIILAIS SDSHLHTPMY 
FFLANLSFTD LFFVTNTIPK MLVNFQSQNK AISYAGCLTQ LYFLVSLVTL DNLILAVMAY 
DRYVATCCPL HYVTAMSPGL CVLLLSLCWG LSVLYGLLLT FLLTRVTFCG PREIHYLFCD 
MYILLWLACS NTHIIHTALI ATGCFIFLTP LGFMTTSYVR IVRTILQMPS ASKKYKTFST 
CASHLGVVSL FYGTLAMVYL QPLHTYSMKD SVATVMYAVL TPMMNPFIYR LRNKDMHGAP 
GRVLWRPFQR PK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.