Details for: LMO4

Gene ID: 8543

Symbol: LMO4

Ensembl ID: ENSG00000143013

Description: LIM domain only 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 450.4799
    Cell Significance Index: -70.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 266.4765
    Cell Significance Index: -67.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 162.0109
    Cell Significance Index: -66.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.3757
    Cell Significance Index: -71.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 139.6529
    Cell Significance Index: -56.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 125.9173
    Cell Significance Index: -64.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.7334
    Cell Significance Index: -57.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.7880
    Cell Significance Index: -71.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.6187
    Cell Significance Index: -65.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.9978
    Cell Significance Index: -71.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9386
    Cell Significance Index: -23.9400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 7.5177
    Cell Significance Index: 46.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1384
    Cell Significance Index: 83.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.0539
    Cell Significance Index: 87.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9100
    Cell Significance Index: 22.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8554
    Cell Significance Index: 572.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6895
    Cell Significance Index: 141.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5242
    Cell Significance Index: 1116.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3506
    Cell Significance Index: 1283.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9726
    Cell Significance Index: 91.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8598
    Cell Significance Index: 228.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7885
    Cell Significance Index: 1614.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7313
    Cell Significance Index: 106.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5388
    Cell Significance Index: 108.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4914
    Cell Significance Index: 32.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4505
    Cell Significance Index: 199.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4439
    Cell Significance Index: 67.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3524
    Cell Significance Index: 243.7900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3126
    Cell Significance Index: 16.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1760
    Cell Significance Index: 33.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1302
    Cell Significance Index: 72.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0708
    Cell Significance Index: 116.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8391
    Cell Significance Index: 136.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7560
    Cell Significance Index: 96.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5232
    Cell Significance Index: 36.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4580
    Cell Significance Index: 13.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4491
    Cell Significance Index: 12.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4313
    Cell Significance Index: 154.7100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3336
    Cell Significance Index: 4.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3025
    Cell Significance Index: 209.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2955
    Cell Significance Index: 10.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2019
    Cell Significance Index: 26.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1784
    Cell Significance Index: 21.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1722
    Cell Significance Index: 29.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0997
    Cell Significance Index: 19.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0920
    Cell Significance Index: 17.5000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0869
    Cell Significance Index: 0.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0863
    Cell Significance Index: 1.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0366
    Cell Significance Index: 1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0315
    Cell Significance Index: 59.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0223
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0327
    Cell Significance Index: -24.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0363
    Cell Significance Index: -66.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0431
    Cell Significance Index: -32.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0444
    Cell Significance Index: -68.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0476
    Cell Significance Index: -30.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0614
    Cell Significance Index: -83.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0908
    Cell Significance Index: -56.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1100
    Cell Significance Index: -62.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1156
    Cell Significance Index: -52.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1418
    Cell Significance Index: -14.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1854
    Cell Significance Index: -2.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2086
    Cell Significance Index: -60.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2219
    Cell Significance Index: -25.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3048
    Cell Significance Index: -35.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3227
    Cell Significance Index: -67.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3276
    Cell Significance Index: -9.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3309
    Cell Significance Index: -14.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3542
    Cell Significance Index: -51.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3550
    Cell Significance Index: -18.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4501
    Cell Significance Index: -10.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4640
    Cell Significance Index: -35.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4866
    Cell Significance Index: -55.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4875
    Cell Significance Index: -36.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5111
    Cell Significance Index: -17.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5993
    Cell Significance Index: -33.6300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.6195
    Cell Significance Index: -3.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6483
    Cell Significance Index: -51.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6620
    Cell Significance Index: -68.9300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6645
    Cell Significance Index: -4.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6765
    Cell Significance Index: -14.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6881
    Cell Significance Index: -46.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6999
    Cell Significance Index: -16.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7300
    Cell Significance Index: -15.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7660
    Cell Significance Index: -20.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8276
    Cell Significance Index: -31.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8410
    Cell Significance Index: -51.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9467
    Cell Significance Index: -59.6700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9620
    Cell Significance Index: -12.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0273
    Cell Significance Index: -20.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0355
    Cell Significance Index: -53.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0818
    Cell Significance Index: -34.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.3452
    Cell Significance Index: -13.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3698
    Cell Significance Index: -36.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3749
    Cell Significance Index: -50.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3778
    Cell Significance Index: -34.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.4072
    Cell Significance Index: -11.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4083
    Cell Significance Index: -26.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.5380
    Cell Significance Index: -24.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LMO4 is a transcriptional regulator that possesses a LIM domain, a characteristic feature of the LIM-only family of proteins. This domain is essential for the protein's ability to interact with other proteins and DNA. LMO4 is primarily expressed in mesodermal cells, epithelial cells, and cells of the nervous system, including motor neurons and interneurons. Its expression is also observed in cells of the thymus, prostate, and ovary, suggesting a broad role in cell development and differentiation. **Pathways and Functions:** LMO4 is involved in various signaling pathways that regulate cell migration, differentiation, and development. Some of the key pathways and functions of LMO4 include: 1. **Cell migration:** LMO4 regulates the expression of genes involved in cell migration, including those involved in the planar cell polarity (PCP) pathway. This pathway is crucial for the proper orientation and migration of cells during development and tissue repair. 2. **Neural tube closure:** LMO4 is essential for the closure of the neural tube, a critical process in the development of the central nervous system. It regulates the expression of genes involved in the formation of the neural plate and the subsequent closure of the tube. 3. **Motor neuron differentiation:** LMO4 is required for the differentiation of motor neurons, which are essential for the control of movement and muscle function. It regulates the expression of genes involved in the specification of motor neuron fate. 4. **Transcriptional regulation:** LMO4 acts as a transcriptional regulator, modulating the expression of genes involved in various cellular processes. It interacts with other transcriptional regulators, such as RNA polymerase II and the transcriptional co-repressor complex, to fine-tune gene expression. **Clinical Significance:** Dysregulation of LMO4 has been implicated in various diseases, including: 1. **Neurological disorders:** Mutations in LMO4 have been associated with neurological disorders, such as spina bifida and neural tube defects. 2. **Cancer:** LMO4 is overexpressed in certain types of cancer, including prostate cancer and breast cancer, suggesting a role in tumorigenesis. 3. **Immunological disorders:** LMO4 is expressed in immune cells, including basophils, and has been implicated in the regulation of immune responses. In conclusion, LMO4 is a multifaceted transcriptional regulator that plays a critical role in cell migration, differentiation, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further studies are necessary to fully elucidate the mechanisms by which LMO4 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1741075231

Symbol: LMO4_HUMAN

Name: LIM domain transcription factor LMO4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10209267

Title: Molecular cloning of LMO4, a new human LIM domain gene.

PubMed ID: 10209267

DOI: 10.1016/s0167-4781(99)00037-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23353824

Title: Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.

PubMed ID: 23353824

DOI: 10.1016/j.jmb.2013.01.017

Sequence Information:

  • Length: 165
  • Mass: 17994
  • Checksum: C8AC295144AD7787
  • Sequence:
  • MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI 
    GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN 
    RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.