Details for: PLA2G4C

Gene ID: 8605

Symbol: PLA2G4C

Ensembl ID: ENSG00000105499

Description: phospholipase A2 group IVC

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.5525
    Cell Significance Index: -22.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.4957
    Cell Significance Index: -22.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.0563
    Cell Significance Index: -20.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.0485
    Cell Significance Index: -16.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.3624
    Cell Significance Index: -22.6400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.0517
    Cell Significance Index: -16.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 6.3866
    Cell Significance Index: 402.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7526
    Cell Significance Index: -22.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3185
    Cell Significance Index: -11.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9505
    Cell Significance Index: 101.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.9374
    Cell Significance Index: 49.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5115
    Cell Significance Index: 303.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.4845
    Cell Significance Index: 36.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0802
    Cell Significance Index: 387.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0144
    Cell Significance Index: 44.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0138
    Cell Significance Index: 38.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8765
    Cell Significance Index: 166.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8641
    Cell Significance Index: 6.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8125
    Cell Significance Index: 62.3500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.5503
    Cell Significance Index: 8.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5386
    Cell Significance Index: 6.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5145
    Cell Significance Index: 34.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4910
    Cell Significance Index: 14.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4690
    Cell Significance Index: 423.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4424
    Cell Significance Index: 27.1900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.4064
    Cell Significance Index: 3.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2982
    Cell Significance Index: 9.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2951
    Cell Significance Index: 29.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2722
    Cell Significance Index: 7.3000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2178
    Cell Significance Index: 2.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2112
    Cell Significance Index: 34.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2070
    Cell Significance Index: 4.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1422
    Cell Significance Index: 3.4100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1303
    Cell Significance Index: 2.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1226
    Cell Significance Index: 13.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0932
    Cell Significance Index: 18.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0927
    Cell Significance Index: 4.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0591
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0558
    Cell Significance Index: 105.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0496
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0492
    Cell Significance Index: 1.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0360
    Cell Significance Index: 16.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0347
    Cell Significance Index: 1.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0335
    Cell Significance Index: 2.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0234
    Cell Significance Index: 31.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0152
    Cell Significance Index: 9.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0129
    Cell Significance Index: 0.2800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0117
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0104
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0122
    Cell Significance Index: -1.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0191
    Cell Significance Index: -8.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0227
    Cell Significance Index: -16.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0235
    Cell Significance Index: -17.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0288
    Cell Significance Index: -15.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0290
    Cell Significance Index: -21.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0296
    Cell Significance Index: -16.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0347
    Cell Significance Index: -21.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0384
    Cell Significance Index: -5.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0404
    Cell Significance Index: -1.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0540
    Cell Significance Index: -5.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0569
    Cell Significance Index: -9.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0580
    Cell Significance Index: -1.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0619
    Cell Significance Index: -17.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0629
    Cell Significance Index: -0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0633
    Cell Significance Index: -11.4100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0689
    Cell Significance Index: -0.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0731
    Cell Significance Index: -9.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0764
    Cell Significance Index: -4.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1011
    Cell Significance Index: -12.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1016
    Cell Significance Index: -21.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1017
    Cell Significance Index: -11.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1113
    Cell Significance Index: -13.6800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1441
    Cell Significance Index: -2.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1486
    Cell Significance Index: -4.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1555
    Cell Significance Index: -2.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1616
    Cell Significance Index: -18.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1641
    Cell Significance Index: -19.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1723
    Cell Significance Index: -8.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1735
    Cell Significance Index: -18.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1814
    Cell Significance Index: -8.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2158
    Cell Significance Index: -4.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2198
    Cell Significance Index: -3.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2220
    Cell Significance Index: -4.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2246
    Cell Significance Index: -16.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2271
    Cell Significance Index: -17.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2367
    Cell Significance Index: -4.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2425
    Cell Significance Index: -17.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2580
    Cell Significance Index: -15.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2681
    Cell Significance Index: -3.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2696
    Cell Significance Index: -15.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2720
    Cell Significance Index: -5.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2761
    Cell Significance Index: -17.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2830
    Cell Significance Index: -7.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2832
    Cell Significance Index: -9.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3112
    Cell Significance Index: -10.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3159
    Cell Significance Index: -4.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3425
    Cell Significance Index: -17.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3558
    Cell Significance Index: -17.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLA2G4C is a member of the phospholipase A2 family, characterized by its ability to hydrolyze phospholipids into free fatty acids and lysophospholipids. This enzyme is predominantly cytosolic, with a high degree of expression in neurons and immune cells. The gene has been identified as a critical regulator of inflammatory responses, and its dysregulation has been implicated in various diseases, including neurological disorders and cancer. **Pathways and Functions:** PLA2G4C is involved in multiple signaling pathways, including: 1. **Acyl chain remodeling of phospholipids**: PLA2G4C hydrolyzes phospholipids, leading to the production of free fatty acids and lysophospholipids, which are essential for various cellular processes, including membrane fluidity and signaling. 2. **Arachidonic acid metabolic process**: PLA2G4C is involved in the production of arachidonic acid, a precursor to pro-inflammatory eicosanoids. 3. **Inflammatory response**: PLA2G4C regulates the production of pro-inflammatory mediators, such as prostaglandins and leukotrienes, which are critical for the initiation and resolution of inflammation. 4. **Intracellular signaling**: PLA2G4C interacts with various signaling molecules, including calcium, phospholipids, and proteins, to regulate cellular responses. **Clinical Significance:** Dysregulation of PLA2G4C has been implicated in various diseases, including: 1. **Neurological disorders**: PLA2G4C has been associated with Alzheimer's disease, Parkinson's disease, and multiple sclerosis, suggesting its role in neuroinflammation and neuronal function. 2. **Cancer**: PLA2G4C has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. 3. **Autoimmune diseases**: PLA2G4C has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, suggesting its role in the regulation of immune responses. In conclusion, PLA2G4C is a crucial enzyme involved in the regulation of inflammatory responses and immune cell function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of PLA2G4C and its potential as a therapeutic target.

Genular Protein ID: 250144367

Symbol: PA24C_HUMAN

Name: Cytosolic phospholipase A2 gamma

UniProtKB Accession Codes:

Q9UP65 B2RB71 B4DI40 O75457 Q6IBI8 Q9UG68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 87 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 40 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9705332

Title: A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2.

PubMed ID: 9705332

DOI: 10.1074/jbc.273.34.21926

PubMed ID: 10085124

Title: Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2.

PubMed ID: 10085124

DOI: 10.1074/jbc.274.13.8823

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10358058

Title: Molecular characterization of cytosolic phospholipase A2-beta.

PubMed ID: 10358058

DOI: 10.1074/jbc.274.24.17063

PubMed ID: 14529291

Title: Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis.

PubMed ID: 14529291

DOI: 10.1021/bi034611q

PubMed ID: 15944408

Title: Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma).

PubMed ID: 15944408

DOI: 10.1093/jb/mvi067

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19501189

Title: Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma).

PubMed ID: 19501189

DOI: 10.1016/j.bbalip.2009.05.008

PubMed ID: 23015700

Title: Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly.

PubMed ID: 23015700

DOI: 10.1128/jvi.01785-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28336330

Title: Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation.

PubMed ID: 28336330

DOI: 10.1016/j.bbalip.2017.03.007

PubMed ID: 28639618

Title: HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation.

PubMed ID: 28639618

DOI: 10.1038/ncomms15890

Sequence Information:

  • Length: 541
  • Mass: 60939
  • Checksum: A114B2A614EA4632
  • Sequence:
    • MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG GGLRAHIACL 
GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA LEADLKHRFT RQEWDLAKSL 
QKTIQAARSE NYSLTDFWAY MVISKQTREL PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ 
PSWQEARAPE TWFEFTPHHA GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG 
SALGNTEVIR EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED 
EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI CASKWEWGTT 
HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP TREVHLILSF DFSAGDPFET 
IRATTDYCRR HKIPFPQVEE AELDLWSKAP ASCYILKGET GPVVMHFPLF NIDACGGDIE 
AWSDTYDTFK LADTYTLDVV VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL 
A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.