Details for: RUVBL1

Gene ID: 8607

Symbol: RUVBL1

Ensembl ID: ENSG00000175792

Description: RuvB like AAA ATPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 158.7320
    Cell Significance Index: -24.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.1696
    Cell Significance Index: -22.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.4290
    Cell Significance Index: -29.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.0210
    Cell Significance Index: -31.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.1804
    Cell Significance Index: -26.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 46.3323
    Cell Significance Index: -31.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.8923
    Cell Significance Index: -26.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9425
    Cell Significance Index: -29.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3585
    Cell Significance Index: -25.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8154
    Cell Significance Index: -30.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0265
    Cell Significance Index: -18.5100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.2598
    Cell Significance Index: 84.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6141
    Cell Significance Index: 159.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2763
    Cell Significance Index: 697.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1878
    Cell Significance Index: 235.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0747
    Cell Significance Index: 970.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0358
    Cell Significance Index: 11.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9069
    Cell Significance Index: 147.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7726
    Cell Significance Index: 95.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7573
    Cell Significance Index: 20.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7492
    Cell Significance Index: 17.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6897
    Cell Significance Index: 9.4100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6715
    Cell Significance Index: 5.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6252
    Cell Significance Index: 40.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6069
    Cell Significance Index: 21.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5987
    Cell Significance Index: 4.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5917
    Cell Significance Index: 69.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5877
    Cell Significance Index: 105.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5400
    Cell Significance Index: 37.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5380
    Cell Significance Index: 38.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5054
    Cell Significance Index: 101.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4702
    Cell Significance Index: 4.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4582
    Cell Significance Index: 202.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3997
    Cell Significance Index: 11.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3923
    Cell Significance Index: 11.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2991
    Cell Significance Index: 56.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2943
    Cell Significance Index: 15.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2635
    Cell Significance Index: 6.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2627
    Cell Significance Index: 36.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2602
    Cell Significance Index: 16.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2346
    Cell Significance Index: 4.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2306
    Cell Significance Index: 82.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1960
    Cell Significance Index: 15.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1895
    Cell Significance Index: 5.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1629
    Cell Significance Index: 3.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1538
    Cell Significance Index: 106.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1371
    Cell Significance Index: 17.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1242
    Cell Significance Index: 3.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1102
    Cell Significance Index: 5.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0916
    Cell Significance Index: 5.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0855
    Cell Significance Index: 11.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0804
    Cell Significance Index: 3.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0616
    Cell Significance Index: 2.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0466
    Cell Significance Index: 0.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0412
    Cell Significance Index: 1.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0381
    Cell Significance Index: 0.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0347
    Cell Significance Index: 1.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0299
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0243
    Cell Significance Index: 45.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0212
    Cell Significance Index: 32.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0155
    Cell Significance Index: 9.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0155
    Cell Significance Index: 0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0137
    Cell Significance Index: 25.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0122
    Cell Significance Index: 16.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0116
    Cell Significance Index: 0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0082
    Cell Significance Index: 0.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0017
    Cell Significance Index: -0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0223
    Cell Significance Index: -3.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0336
    Cell Significance Index: -15.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0395
    Cell Significance Index: -29.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0448
    Cell Significance Index: -6.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0543
    Cell Significance Index: -30.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0594
    Cell Significance Index: -37.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0645
    Cell Significance Index: -6.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0815
    Cell Significance Index: -23.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1008
    Cell Significance Index: -11.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1121
    Cell Significance Index: -3.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1173
    Cell Significance Index: -2.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1319
    Cell Significance Index: -3.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1569
    Cell Significance Index: -6.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1607
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1757
    Cell Significance Index: -37.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1786
    Cell Significance Index: -20.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1992
    Cell Significance Index: -13.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2173
    Cell Significance Index: -11.4100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2199
    Cell Significance Index: -1.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2509
    Cell Significance Index: -9.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2777
    Cell Significance Index: -4.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2789
    Cell Significance Index: -29.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2947
    Cell Significance Index: -23.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3247
    Cell Significance Index: -5.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3544
    Cell Significance Index: -9.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3867
    Cell Significance Index: -11.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3901
    Cell Significance Index: -4.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4087
    Cell Significance Index: -25.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4250
    Cell Significance Index: -10.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4858
    Cell Significance Index: -7.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RUVBL1 is a member of the RuvB family of helicases, which are known for their ability to unwind double-stranded DNA. The RuvB complex is composed of three subunits: RuvA, RuvB, and RuvC. RUVBL1 is a RuvB-like subunit that shares high sequence similarity with RuvB. This gene has been implicated in various cellular processes, including DNA damage recognition, DNA recombination, and DNA repair. **Pathways and Functions** RUVBL1 is involved in several key pathways, including: 1. **DNA Repair**: RUVBL1 is a component of the RuvB complex, which is responsible for DNA repair, particularly in the context of double-strand breaks. 2. **Cell Cycle Regulation**: RUVBL1 plays a role in regulating the cell cycle, particularly in the G2/M phase, where it helps to maintain genome stability. 3. **Wnt Signaling**: RUVBL1 is a positive regulator of Wnt signaling, which is a key pathway involved in cell proliferation, differentiation, and survival. 4. **Telomere Maintenance**: RUVBL1 is involved in telomere maintenance, particularly in response to DNA damage. **Functions** RUVBL1 has several functional roles, including: 1. **DNA Helicase Activity**: RUVBL1 exhibits helicase activity, which is essential for unwinding double-stranded DNA. 2. **DNA Damage Recognition**: RUVBL1 recognizes DNA damage and facilitates the recruitment of other DNA repair proteins. 3. **Protein-Protein Interactions**: RUVBL1 interacts with various proteins, including histones, transcription factors, and DNA repair enzymes. 4. **Chromatin Remodeling**: RUVBL1 is involved in chromatin remodeling, particularly in the context of DNA repair and transcription. **Clinical Significance** Dysregulation of RUVBL1 has been implicated in various diseases, including: 1. **Cancer**: RUVBL1 is often overexpressed in cancer cells, where it contributes to genome instability and tumorigenesis. 2. **Neurodegenerative Diseases**: RUVBL1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it contributes to DNA damage and oxidative stress. 3. **Genetic Disorders**: RUVBL1 mutations have been associated with genetic disorders, such as Fanconi anemia and Bloom syndrome, where it contributes to genome instability and increased cancer risk. In conclusion, RUVBL1 is a critical gene that plays a pivotal role in maintaining genome stability, regulating the cell cycle, and modulating Wnt signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of RUVBL1 in human health and disease. Further research is needed to elucidate the mechanisms by which RUVBL1 regulates cellular processes and to explore its potential as a therapeutic target for cancer and other diseases.

Genular Protein ID: 2851611922

Symbol: RUVB1_HUMAN

Name: 49 kDa TATA box-binding protein-interacting protein

UniProtKB Accession Codes:

Q9Y265 B2R5S0 P82276 Q1KMR0 Q53HK5 Q53HL7 Q53Y27 Q9BSX9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 7 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 EMDB 22 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 2 Rhea 2 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9588198

Title: TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human.

PubMed ID: 9588198

DOI: 10.1006/bbrc.1998.8504

PubMed ID: 9813143

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PubMed ID: 9813143

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PubMed ID: 9774387

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PubMed ID: 9843967

Title: Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein.

PubMed ID: 9843967

DOI: 10.1073/pnas.95.25.14787

PubMed ID: 10524211

Title: Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins.

PubMed ID: 10524211

DOI: 10.1016/s0167-4781(99)00104-9

PubMed ID: 11027681

Title: Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a.

PubMed ID: 11027681

DOI: 10.1074/jbc.m004919200

PubMed ID: 14702039

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PubMed ID: 14702039

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PubMed ID: 19054851

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PubMed ID: 19054851

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PubMed ID: 15489334

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PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10882073

Title: An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc.

PubMed ID: 10882073

DOI: 10.1016/s1097-2765(00)80427-x

PubMed ID: 12963728

Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

PubMed ID: 12963728

DOI: 10.1074/jbc.c300389200

PubMed ID: 10966108

Title: Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.

PubMed ID: 10966108

DOI: 10.1016/s0092-8674(00)00051-9

PubMed ID: 14506706

Title: The ATP-dependent helicase RUVBL1/TIP49a associates with tubulin during mitosis.

PubMed ID: 14506706

DOI: 10.1002/cm.10136

PubMed ID: 10428817

Title: TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a.

PubMed ID: 10428817

DOI: 10.1074/jbc.274.32.22437

PubMed ID: 11080158

Title: Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.

PubMed ID: 11080158

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PubMed ID: 11839798

Title: BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.

PubMed ID: 11839798

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PubMed ID: 14695187

Title: TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.

PubMed ID: 14695187

PubMed ID: 14966270

Title: Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

PubMed ID: 14966270

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PubMed ID: 15960975

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PubMed ID: 15960975

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PubMed ID: 16230350

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PubMed ID: 16230350

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PubMed ID: 16014379

Title: The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription.

PubMed ID: 16014379

DOI: 10.1242/jcs.02437

PubMed ID: 17157868

Title: Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex.

PubMed ID: 17157868

DOI: 10.1016/j.jmb.2006.11.030

PubMed ID: 17761535

Title: Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex.

PubMed ID: 17761535

DOI: 10.1091/mbc.e07-03-0198

PubMed ID: 17636026

Title: A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.

PubMed ID: 17636026

DOI: 10.1128/mcb.01097-07

PubMed ID: 18026119

Title: A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.

PubMed ID: 18026119

DOI: 10.1038/nsmb1332

PubMed ID: 17967892

Title: Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.

PubMed ID: 17967892

DOI: 10.1128/mcb.00607-07

PubMed ID: 19299493

Title: Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.

PubMed ID: 19299493

DOI: 10.1093/hmg/ddp134

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20864032

Title: CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

PubMed ID: 20864032

DOI: 10.1016/j.molcel.2010.08.037

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21303910

Title: Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

PubMed ID: 21303910

DOI: 10.1074/jbc.m111.222505

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 25437307

Title: LINKIN, a new transmembrane protein necessary for cell adhesion.

PubMed ID: 25437307

DOI: 10.7554/elife.04449

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24463511

Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.

PubMed ID: 24463511

DOI: 10.1038/nature12922

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26812014

Title: WAC regulates mTOR activity by acting as an adaptor for the TTT and Pontin/Reptin complexes.

PubMed ID: 26812014

DOI: 10.1016/j.devcel.2015.12.019

PubMed ID: 28561026

Title: R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

PubMed ID: 28561026

DOI: 10.1038/ncomms15615

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31738558

Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

PubMed ID: 31738558

DOI: 10.1021/acs.jproteome.9b00599

PubMed ID: 33367824

Title: NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis.

PubMed ID: 33367824

DOI: 10.1093/nar/gkaa1226

PubMed ID: 36161484

Title: Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs.

PubMed ID: 36161484

DOI: 10.1093/nar/gkac817

PubMed ID: 17060327

Title: Crystal structure of the human AAA+ protein RuvBL1.

PubMed ID: 17060327

DOI: 10.1074/jbc.m605625200

PubMed ID: 33205750

Title: Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.

PubMed ID: 33205750

DOI: 10.7554/elife.63042

Sequence Information:

  • Length: 456
  • Mass: 50228
  • Checksum: 6095ADE692B1482B
  • Sequence:
    • MKIEEVKSTT KTQRIASHSH VKGLGLDESG LAKQAASGLV GQENAREACG VIVELIKSKK 
MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE VLMENFRRAI 
GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG LKTAKGTKQL KLDPSIFESL 
QKERVEAGDV IYIEANSGAV KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL 
HDLDVANARP QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF 
VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI 
IRTMLYTPQE MKQIIKIRAQ TEGINISEEA LNHLGEIGTK TTLRYSVQLL TPANLLAKIN 
GKDSIEKEHV EEISELFYDA KSSAKILADQ QDKYMK

Genular Protein ID: 1438135897

Symbol: B3KRS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRS7

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 13 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 2 RuleBase 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 315
  • Mass: 34683
  • Checksum: 47CD2DA8E4E5F5EF
  • Sequence:
    • MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE VLMENFRRAI 
GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG LKTAKGTKQL KLDPSIFESL 
QKERVEAGDV IYIEANSGAV KRQGGCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL 
HDLDVANARP QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF 
VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI 
IRTMLYTPQE MKQVP

Genular Protein ID: 282007763

Symbol: E7ETR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ETR0

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 6 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 2 RuleBase 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 315
  • Mass: 34782
  • Checksum: 5D7D260245EE45FE
  • Sequence:
    • MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE VLMENFRRAI 
GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG LKTAKGTKQL KLDPSIFESL 
QKERVEAGDV IYIEANSGAV KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL 
HDLDVANARP QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF 
VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI 
IRTMLYTPQE MKQVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.