Details for: EIF3G

Gene ID: 8666

Symbol: EIF3G

Ensembl ID: ENSG00000130811

Description: eukaryotic translation initiation factor 3 subunit G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 436.4647
    Cell Significance Index: -67.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 207.4369
    Cell Significance Index: -52.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 196.7726
    Cell Significance Index: -81.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 185.1044
    Cell Significance Index: -75.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 166.9270
    Cell Significance Index: -78.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 159.3358
    Cell Significance Index: -81.9600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 117.9544
    Cell Significance Index: -79.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 79.6864
    Cell Significance Index: -76.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.7111
    Cell Significance Index: -77.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.8310
    Cell Significance Index: -82.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.4631
    Cell Significance Index: -59.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.5332
    Cell Significance Index: -44.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.6644
    Cell Significance Index: -23.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 6.7405
    Cell Significance Index: 466.1400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 6.1649
    Cell Significance Index: 16.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.1722
    Cell Significance Index: 196.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.4979
    Cell Significance Index: 163.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.3968
    Cell Significance Index: 438.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1353
    Cell Significance Index: 430.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0195
    Cell Significance Index: 88.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.9513
    Cell Significance Index: 190.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8935
    Cell Significance Index: 204.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7898
    Cell Significance Index: 75.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7222
    Cell Significance Index: 21.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4735
    Cell Significance Index: 43.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4052
    Cell Significance Index: 433.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4024
    Cell Significance Index: 295.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3309
    Cell Significance Index: 48.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2440
    Cell Significance Index: 167.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2288
    Cell Significance Index: 24.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.2288
    Cell Significance Index: 25.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2274
    Cell Significance Index: 984.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1838
    Cell Significance Index: 62.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0276
    Cell Significance Index: 1107.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0171
    Cell Significance Index: 1821.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9124
    Cell Significance Index: 44.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8942
    Cell Significance Index: 223.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7140
    Cell Significance Index: 45.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4742
    Cell Significance Index: 188.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4629
    Cell Significance Index: 19.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3235
    Cell Significance Index: 45.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1548
    Cell Significance Index: 59.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1324
    Cell Significance Index: 20.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1264
    Cell Significance Index: 14.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8798
    Cell Significance Index: 19.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7954
    Cell Significance Index: 7.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6415
    Cell Significance Index: 17.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4716
    Cell Significance Index: 46.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3409
    Cell Significance Index: 15.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2625
    Cell Significance Index: 7.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2600
    Cell Significance Index: 1.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2473
    Cell Significance Index: 12.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1666
    Cell Significance Index: 33.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1558
    Cell Significance Index: 29.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0810
    Cell Significance Index: 13.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0727
    Cell Significance Index: 55.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0347
    Cell Significance Index: 0.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0291
    Cell Significance Index: 21.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0092
    Cell Significance Index: -0.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0320
    Cell Significance Index: -60.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0513
    Cell Significance Index: -94.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0612
    Cell Significance Index: -94.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0613
    Cell Significance Index: -3.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0716
    Cell Significance Index: -97.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0732
    Cell Significance Index: -14.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0825
    Cell Significance Index: -29.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0973
    Cell Significance Index: -72.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1087
    Cell Significance Index: -69.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1349
    Cell Significance Index: -76.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1464
    Cell Significance Index: -91.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1719
    Cell Significance Index: -78.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1989
    Cell Significance Index: -32.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2099
    Cell Significance Index: -60.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2641
    Cell Significance Index: -7.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2955
    Cell Significance Index: -7.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3237
    Cell Significance Index: -20.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3836
    Cell Significance Index: -13.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3918
    Cell Significance Index: -45.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4341
    Cell Significance Index: -91.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4512
    Cell Significance Index: -14.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4794
    Cell Significance Index: -54.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5094
    Cell Significance Index: -74.0400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6132
    Cell Significance Index: -4.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6587
    Cell Significance Index: -9.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6730
    Cell Significance Index: -53.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7398
    Cell Significance Index: -4.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7853
    Cell Significance Index: -81.7700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8336
    Cell Significance Index: -14.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8990
    Cell Significance Index: -45.4300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.9578
    Cell Significance Index: -8.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9685
    Cell Significance Index: -39.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0289
    Cell Significance Index: -63.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0409
    Cell Significance Index: -79.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0892
    Cell Significance Index: -66.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1444
    Cell Significance Index: -76.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1602
    Cell Significance Index: -12.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1738
    Cell Significance Index: -65.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1945
    Cell Significance Index: -25.4400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.2029
    Cell Significance Index: -7.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4318
    Cell Significance Index: -38.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF3G is a conserved protein that belongs to the eIF3 complex, which is essential for the initiation of eukaryotic translation. The eIF3 complex is composed of multiple subunits, with EIF3G being one of the key subunits. EIF3G is a GTPase that plays a crucial role in the formation of the 43S preinitiation complex, which is the first step in translation initiation. The protein is highly conserved across different species, suggesting its importance in eukaryotic cells. EIF3G's structure consists of a characteristic GTP-binding domain, which allows it to interact with other proteins and facilitate the formation of the 43S complex. The protein's C-terminal region contains a proline-rich motif, which is involved in protein-protein interactions. **Pathways and Functions:** EIF3G is involved in several key pathways, including: 1. **Activation of mRNA upon binding of the cap-binding complex and eIFs**: EIF3G plays a crucial role in the recognition of the mRNA cap and the binding of the eIF complex, which is essential for the initiation of translation. 2. **Binding to the 43S ribosomal subunit**: EIF3G's interaction with the 43S subunit is critical for the formation of the 43S preinitiation complex, which is the first step in translation initiation. 3. **GTP hydrolysis and joining of the 60S ribosomal subunit**: EIF3G's GTPase activity is essential for the hydrolysis of GTP and the joining of the 60S subunit to the 40S subunit, which completes the translation initiation process. 4. **Ribosomal scanning and start codon recognition**: EIF3G's interaction with the ribosome is critical for the scanning of the mRNA for the start codon and the recognition of the initiation codon. EIF3G's functions are essential for the regulation of protein synthesis, cell growth, and differentiation. The protein's involvement in translation initiation has been linked to several diseases, including cancer, where dysregulation of protein synthesis can contribute to tumorigenesis. **Clinical Significance:** EIF3G's involvement in translation initiation has been linked to several diseases, including: 1. **Cancer**: Dysregulation of protein synthesis is a hallmark of cancer, and EIF3G's involvement in translation initiation can contribute to tumorigenesis. 2. **Neurodegenerative diseases**: EIF3G's involvement in translation initiation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where dysregulation of protein synthesis can contribute to disease progression. 3. **Infectious diseases**: EIF3G's involvement in translation initiation has been linked to infectious diseases, such as HIV, where dysregulation of protein synthesis can contribute to viral replication and disease progression. In conclusion, EIF3G is a crucial component of the eukaryotic translation initiation complex, and its involvement in translation initiation has significant implications for cellular processes, including protein metabolism, ribosomal scanning, and start codon recognition. EIF3G's dysregulation has been linked to several diseases, highlighting the importance of this protein in maintaining cellular homeostasis. Further research into EIF3G's functions and clinical significance is necessary to fully understand its role in eukaryotic cells.

Genular Protein ID: 3957011177

Symbol: EIF3G_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75821 O14801 Q969U5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 EMDB 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9822659

Title: Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.

PubMed ID: 9822659

DOI: 10.1074/jbc.273.48.31901

PubMed ID: 9973622

Title: Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells.

PubMed ID: 9973622

DOI: 10.1093/nar/27.5.1331

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14519125

Title: Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3.

PubMed ID: 14519125

DOI: 10.1046/j.1432-1033.2003.03807.x

PubMed ID: 14688252

Title: The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro.

PubMed ID: 14688252

DOI: 10.1074/jbc.m312745200

PubMed ID: 15703437

Title: Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association.

PubMed ID: 15703437

DOI: 10.1261/rna.7215305

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17094969

Title: Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).

PubMed ID: 17094969

DOI: 10.1016/j.febslet.2006.10.049

PubMed ID: 16766523

Title: Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.

PubMed ID: 16766523

DOI: 10.1074/jbc.m605418200

PubMed ID: 17581632

Title: Reconstitution reveals the functional core of mammalian eIF3.

PubMed ID: 17581632

DOI: 10.1038/sj.emboj.7601765

PubMed ID: 17322308

Title: Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.

PubMed ID: 17322308

DOI: 10.1074/mcp.m600399-mcp200

PubMed ID: 18056426

Title: The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation.

PubMed ID: 18056426

DOI: 10.1101/gad.439507

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18599441

Title: Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

PubMed ID: 18599441

DOI: 10.1073/pnas.0801313105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26100019

Title: The DHX33 RNA Helicase Promotes mRNA Translation Initiation.

PubMed ID: 26100019

DOI: 10.1128/mcb.00315-15

PubMed ID: 25849773

Title: eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.

PubMed ID: 25849773

DOI: 10.1038/nature14267

PubMed ID: 27462815

Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

PubMed ID: 27462815

DOI: 10.1038/nature18954

PubMed ID: 16322461

Title: Structural roles for human translation factor eIF3 in initiation of protein synthesis.

PubMed ID: 16322461

DOI: 10.1126/science.1118977

Sequence Information:

  • Length: 320
  • Mass: 35611
  • Checksum: 7D7226FEDE9D6FBB
  • Sequence:
    • MPTGDFDSKP SWADQVEEEG EDDKCVTSEL LKGIPLATGD TSPEPELLPG APLPPPKEVI 
NGNIKTVTEY KIDEDGKKFK IVRTFRIETR KASKAVARRK NWKKFGNSEF DPPGPNVATT 
TVSDDVSMTF ITSKEDLNCQ EEEDPMNKLK GQKIVSCRIC KGDHWTTRCP YKDTLGPMQK 
ELAEQLGLST GEKEKLPGEL EPVQATQNKT GKYVPPSLRD GASRRGESMQ PNRRADDNAT 
IRVTNLSEDT RETDLQELFR PFGSISRIYL AKDKTTGQSK GFAFISFHRR EDAARAIAGV 
SGFGYDHLIL NVEWAKPSTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.