Details for: S1PR4

Gene ID: 8698

Symbol: S1PR4

Ensembl ID: ENSG00000125910

Description: sphingosine-1-phosphate receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.0176
    Cell Significance Index: -7.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.5427
    Cell Significance Index: -12.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 8.5931
    Cell Significance Index: 178.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5347
    Cell Significance Index: -9.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.5052
    Cell Significance Index: -1.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 5.5584
    Cell Significance Index: 195.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.2085
    Cell Significance Index: 123.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5730
    Cell Significance Index: 166.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.4133
    Cell Significance Index: 60.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1626
    Cell Significance Index: 62.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9698
    Cell Significance Index: -6.0500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.4148
    Cell Significance Index: 3.7900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.0592
    Cell Significance Index: 10.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9662
    Cell Significance Index: 20.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6639
    Cell Significance Index: 12.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5938
    Cell Significance Index: 113.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5340
    Cell Significance Index: 52.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5140
    Cell Significance Index: 13.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4272
    Cell Significance Index: 385.7700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.2692
    Cell Significance Index: 4.6400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2604
    Cell Significance Index: 2.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1734
    Cell Significance Index: 28.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1576
    Cell Significance Index: 17.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.1437
    Cell Significance Index: -0.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0972
    Cell Significance Index: 2.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0698
    Cell Significance Index: 8.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0672
    Cell Significance Index: 12.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0444
    Cell Significance Index: 5.2400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0139
    Cell Significance Index: 0.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0138
    Cell Significance Index: 0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0009
    Cell Significance Index: -0.0500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0018
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0107
    Cell Significance Index: -6.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0121
    Cell Significance Index: -0.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0124
    Cell Significance Index: -6.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0125
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0247
    Cell Significance Index: -1.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0291
    Cell Significance Index: -3.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0486
    Cell Significance Index: -9.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0488
    Cell Significance Index: -6.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0491
    Cell Significance Index: -9.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0504
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0579
    Cell Significance Index: -9.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0590
    Cell Significance Index: -1.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0602
    Cell Significance Index: -0.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0642
    Cell Significance Index: -6.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0673
    Cell Significance Index: -9.2400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0785
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0817
    Cell Significance Index: -9.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0850
    Cell Significance Index: -12.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0850
    Cell Significance Index: -10.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0876
    Cell Significance Index: -3.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0928
    Cell Significance Index: -9.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0942
    Cell Significance Index: -1.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1184
    Cell Significance Index: -7.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1243
    Cell Significance Index: -7.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1321
    Cell Significance Index: -10.1400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1352
    Cell Significance Index: -1.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1436
    Cell Significance Index: -6.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1450
    Cell Significance Index: -7.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1472
    Cell Significance Index: -10.9700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1519
    Cell Significance Index: -2.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1553
    Cell Significance Index: -4.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1570
    Cell Significance Index: -10.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1617
    Cell Significance Index: -7.5400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1640
    Cell Significance Index: -2.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1703
    Cell Significance Index: -10.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1937
    Cell Significance Index: -4.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2240
    Cell Significance Index: -9.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2377
    Cell Significance Index: -6.4700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2389
    Cell Significance Index: -3.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2531
    Cell Significance Index: -9.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2620
    Cell Significance Index: -9.9200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2687
    Cell Significance Index: -3.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2698
    Cell Significance Index: -9.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2777
    Cell Significance Index: -5.4300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2801
    Cell Significance Index: -3.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2882
    Cell Significance Index: -2.7700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3035
    Cell Significance Index: -2.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3118
    Cell Significance Index: -9.9300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3134
    Cell Significance Index: -2.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3180
    Cell Significance Index: -10.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3182
    Cell Significance Index: -6.6600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3291
    Cell Significance Index: -2.9000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3295
    Cell Significance Index: -3.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3348
    Cell Significance Index: -5.1800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3378
    Cell Significance Index: -3.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3458
    Cell Significance Index: -6.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3490
    Cell Significance Index: -3.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3559
    Cell Significance Index: -8.6200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3578
    Cell Significance Index: -5.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3583
    Cell Significance Index: -9.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3613
    Cell Significance Index: -12.5600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3621
    Cell Significance Index: -6.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3647
    Cell Significance Index: -9.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3700
    Cell Significance Index: -10.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-Protein Coupled Receptor:** S1PR4 belongs to the class A/1 (rhodopsin-like receptors) and is a G-protein coupled receptor that responds to sphingosine-1-phosphate (S1P). 2. **Sphingosine-1-Phosphate Binding:** S1PR4 binds to S1P, a bioactive lipid that plays a critical role in various cellular processes, including immune regulation and metabolic homeostasis. 3. **Tissue Distribution:** S1PR4 is expressed in various tissues, including the immune system, epithelial tissues, and the nervous system. 4. **Cellular Expression:** S1PR4 is significantly expressed in CD4-positive, alpha-beta memory T cells, enterocytes of the large intestine, and colon goblet cells. **Pathways and Functions:** 1. **Immune Response:** S1PR4 plays a crucial role in regulating immune responses, including T cell activation, proliferation, and differentiation. It modulates the activity of immune cells, such as T cells, B cells, and macrophages. 2. **Metabolic Homeostasis:** S1PR4 is involved in regulating metabolic processes, including glucose and lipid metabolism. It modulates the activity of enzymes involved in glucose and lipid metabolism, influencing energy homeostasis. 3. **Cellular Homeostasis:** S1PR4 regulates cellular homeostasis by modulating the activity of ion channels, pumps, and transporters, influencing cellular calcium and sodium concentrations. 4. **Signaling Pathways:** S1PR4 activates various signaling pathways, including the phospholipase C activity pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, and G protein-coupled receptor signaling pathway. **Clinical Significance:** 1. **Immune-Mediated Diseases:** S1PR4 plays a critical role in immune-mediated diseases, including multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. 2. **Metabolic Disorders:** S1PR4 is involved in metabolic disorders, including type 2 diabetes, obesity, and metabolic syndrome. 3. **Cancer:** S1PR4 is overexpressed in various types of cancer, including breast cancer, colon cancer, and lung cancer. 4. **Therapeutic Target:** S1PR4 is a potential therapeutic target for the treatment of immune-mediated diseases, metabolic disorders, and cancer. In conclusion, S1PR4 is a critical regulator of immune responses, metabolic homeostasis, and cellular homeostasis. Its dysregulation has been implicated in various diseases, including immune-mediated diseases, metabolic disorders, and cancer. Further research is needed to fully understand the mechanisms of S1PR4 and its potential therapeutic applications.

Genular Protein ID: 2597269283

Symbol: S1PR4_HUMAN

Name: Sphingosine 1-phosphate receptor 4

UniProtKB Accession Codes:

O95977 D6W612

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790765

Title: EDG6, a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.

PubMed ID: 9790765

DOI: 10.1006/geno.1998.5491

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10679247

Title: Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.

PubMed ID: 10679247

DOI: 10.1006/bbrc.2000.2162

PubMed ID: 10753843

Title: Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.

PubMed ID: 10753843

PubMed ID: 17443712

Title: Peptide design and structural characterization of a GPCR loop mimetic.

PubMed ID: 17443712

DOI: 10.1002/bip.20745

Sequence Information:

  • Length: 384
  • Mass: 41623
  • Checksum: 369A7BC56AB46A47
  • Sequence:
    • MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR GLSVAASCLV 
VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL ANVLLSGART FRLAPAQWFL 
REGLLFTALA ASTFSLLFTA GERFATMVRP VAESGATKTS RVYGFIGLCW LLAALLGMLP 
LLGWNCLCAF DRCSSLLPLY SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP 
AARRKARRLL KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS 
AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST TDSSLRPRDS 
FRGSRSLSFR MREPLSSISS VRSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.