Details for: RAB11A

Gene ID: 8766

Symbol: RAB11A

Ensembl ID: ENSG00000103769

Description: RAB11A, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 513.4841
    Cell Significance Index: -79.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 297.3072
    Cell Significance Index: -75.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 211.3982
    Cell Significance Index: -87.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 190.0777
    Cell Significance Index: -89.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 188.8459
    Cell Significance Index: -76.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 165.6929
    Cell Significance Index: -85.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 133.8704
    Cell Significance Index: -89.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 80.7338
    Cell Significance Index: -77.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 69.9944
    Cell Significance Index: -86.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.7805
    Cell Significance Index: -74.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 27.1088
    Cell Significance Index: -59.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.5694
    Cell Significance Index: -89.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.3933
    Cell Significance Index: -68.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.1010
    Cell Significance Index: 37.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.7681
    Cell Significance Index: 64.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.4534
    Cell Significance Index: 150.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3963
    Cell Significance Index: 475.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3347
    Cell Significance Index: 62.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.3056
    Cell Significance Index: 374.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2850
    Cell Significance Index: 411.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2270
    Cell Significance Index: 115.6900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.0289
    Cell Significance Index: 25.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0045
    Cell Significance Index: 246.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9778
    Cell Significance Index: 1080.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8681
    Cell Significance Index: 139.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5982
    Cell Significance Index: 75.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5317
    Cell Significance Index: 85.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3944
    Cell Significance Index: 24.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3908
    Cell Significance Index: 15.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.3268
    Cell Significance Index: 31.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.1608
    Cell Significance Index: 2185.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1237
    Cell Significance Index: 52.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1061
    Cell Significance Index: 151.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1007
    Cell Significance Index: 486.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0711
    Cell Significance Index: 105.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0515
    Cell Significance Index: 135.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0510
    Cell Significance Index: 123.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0474
    Cell Significance Index: 27.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.0113
    Cell Significance Index: 1556.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9440
    Cell Significance Index: 189.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9426
    Cell Significance Index: 338.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.9114
    Cell Significance Index: 1680.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9052
    Cell Significance Index: 24.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8434
    Cell Significance Index: 64.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8258
    Cell Significance Index: 31.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8098
    Cell Significance Index: 28.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7621
    Cell Significance Index: 33.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7058
    Cell Significance Index: 15.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5431
    Cell Significance Index: 15.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5391
    Cell Significance Index: 11.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5015
    Cell Significance Index: 33.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4684
    Cell Significance Index: 2.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4600
    Cell Significance Index: 625.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4547
    Cell Significance Index: 7.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4324
    Cell Significance Index: 274.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3868
    Cell Significance Index: 49.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3013
    Cell Significance Index: 15.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2886
    Cell Significance Index: 20.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2446
    Cell Significance Index: 46.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1743
    Cell Significance Index: 7.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1476
    Cell Significance Index: 25.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1161
    Cell Significance Index: 6.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1041
    Cell Significance Index: 2.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0988
    Cell Significance Index: 1.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0894
    Cell Significance Index: 5.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0691
    Cell Significance Index: 31.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0546
    Cell Significance Index: 37.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0069
    Cell Significance Index: 5.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0225
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0473
    Cell Significance Index: -29.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0565
    Cell Significance Index: -0.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0912
    Cell Significance Index: -9.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1042
    Cell Significance Index: -58.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1409
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1702
    Cell Significance Index: -35.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1901
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2172
    Cell Significance Index: -24.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2351
    Cell Significance Index: -26.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2422
    Cell Significance Index: -35.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2458
    Cell Significance Index: -70.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2637
    Cell Significance Index: -7.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2738
    Cell Significance Index: -6.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3290
    Cell Significance Index: -2.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4109
    Cell Significance Index: -14.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4140
    Cell Significance Index: -43.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4421
    Cell Significance Index: -11.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4742
    Cell Significance Index: -6.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4967
    Cell Significance Index: -57.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5186
    Cell Significance Index: -16.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5187
    Cell Significance Index: -32.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5280
    Cell Significance Index: -7.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7867
    Cell Significance Index: -62.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9020
    Cell Significance Index: -25.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9199
    Cell Significance Index: -23.5000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1972
    Cell Significance Index: -17.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.2014
    Cell Significance Index: -8.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.2198
    Cell Significance Index: -15.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2707
    Cell Significance Index: -23.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB11A exhibits several key characteristics that distinguish it from other RAS superfamily members: 1. **GTPase activity**: RAB11A possesses intrinsic GTPase activity, which allows it to hydrolyze GTP to GDP, regulating its activity and membrane localization. 2. **Geranylgeranylation**: RAB11A is geranylgeranylated, a post-translational modification that anchors it to the plasma membrane and regulates its activity. 3. **Regulation of membrane trafficking**: RAB11A regulates membrane trafficking by controlling the fusion and fission of vesicles, as well as the targeting of proteins to specific membrane compartments. 4. **Protein localization**: RAB11A regulates protein localization by controlling the targeting of proteins to specific membrane compartments, such as the Golgi apparatus and endosomes. **Pathways and Functions** RAB11A is involved in various cellular pathways and functions, including: 1. **Membrane trafficking**: RAB11A regulates membrane trafficking by controlling the fusion and fission of vesicles, as well as the targeting of proteins to specific membrane compartments. 2. **Protein localization**: RAB11A regulates protein localization by controlling the targeting of proteins to specific membrane compartments, such as the Golgi apparatus and endosomes. 3. **Vesicle-mediated transport**: RAB11A regulates vesicle-mediated transport by controlling the targeting of proteins to specific membrane compartments. 4. **Endocytic recycling**: RAB11A regulates endocytic recycling by controlling the targeting of proteins to specific membrane compartments, such as the Golgi apparatus and endosomes. 5. **Cell migration**: RAB11A regulates cell migration by controlling the targeting of proteins to specific membrane compartments, such as the plasma membrane and endosomes. **Clinical Significance** RAB11A has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: RAB11A has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates membrane trafficking and protein localization. 2. **Cancer**: RAB11A has been implicated in cancer, where it regulates membrane trafficking and protein localization, contributing to tumor progression and metastasis. 3. **Infectious diseases**: RAB11A has been implicated in infectious diseases, such as tuberculosis, where it regulates membrane trafficking and protein localization, contributing to pathogenesis. In conclusion, RAB11A is a critical regulator of membrane trafficking and cellular processes, and its dysfunction has been implicated in various diseases. Further research is necessary to fully understand the mechanisms by which RAB11A regulates membrane trafficking and protein localization, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1932796333

Symbol: RB11A_HUMAN

Name: YL8

UniProtKB Accession Codes:

P62491 B2R4B6 B4DT13 P24410 Q5TZN9 Q9JLX1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 28 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1704119

Title: Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3.

PubMed ID: 1704119

PubMed ID: 9662449

Title: Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins.

PubMed ID: 9662449

DOI: 10.1016/s0014-5793(98)00607-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10077598

Title: Identification of a putative effector protein for rab11 that participates in transferrin recycling.

PubMed ID: 10077598

DOI: 10.1073/pnas.96.6.2840

PubMed ID: 11495908

Title: Identification and characterization of a family of Rab11-interacting proteins.

PubMed ID: 11495908

DOI: 10.1074/jbc.m104831200

PubMed ID: 12470645

Title: Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.

PubMed ID: 12470645

DOI: 10.1016/s0006-291x(02)02720-1

PubMed ID: 11786538

Title: Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.

PubMed ID: 11786538

DOI: 10.1074/jbc.m108665200

PubMed ID: 11994279

Title: Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain.

PubMed ID: 11994279

DOI: 10.1074/jbc.m200757200

PubMed ID: 15280022

Title: Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis.

PubMed ID: 15280022

DOI: 10.1016/j.febslet.2004.06.068

PubMed ID: 15173169

Title: Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins.

PubMed ID: 15173169

DOI: 10.1074/jbc.m404633200

PubMed ID: 15304524

Title: The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane.

PubMed ID: 15304524

DOI: 10.1242/jcs.01280

PubMed ID: 15181150

Title: The RCP-Rab11 complex regulates endocytic protein sorting.

PubMed ID: 15181150

DOI: 10.1091/mbc.e03-12-0918

PubMed ID: 16148947

Title: Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.

PubMed ID: 16148947

DOI: 10.1038/sj.emboj.7600803

PubMed ID: 15601896

Title: The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.

PubMed ID: 15601896

DOI: 10.1091/mbc.e04-10-0927

PubMed ID: 15689490

Title: Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin.

PubMed ID: 15689490

DOI: 10.1091/mbc.e04-10-0867

PubMed ID: 17082457

Title: Protrudin induces neurite formation by directional membrane trafficking.

PubMed ID: 17082457

DOI: 10.1126/science.1134027

PubMed ID: 17462998

Title: Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells.

PubMed ID: 17462998

DOI: 10.1074/jbc.m608531200

PubMed ID: 17229837

Title: Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.

PubMed ID: 17229837

DOI: 10.1073/pnas.0610500104

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 19542231

Title: Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface.

PubMed ID: 19542231

DOI: 10.1074/jbc.m109.034355

PubMed ID: 20026645

Title: Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment.

PubMed ID: 20026645

DOI: 10.1242/jcs.052670

PubMed ID: 20890297

Title: A molecular network for de novo generation of the apical surface and lumen.

PubMed ID: 20890297

DOI: 10.1038/ncb2106

PubMed ID: 20190753

Title: Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization.

PubMed ID: 20190753

DOI: 10.1038/ng.538

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21976701

Title: Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.

PubMed ID: 21976701

DOI: 10.1091/mbc.e11-01-0068

PubMed ID: 21282656

Title: Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.

PubMed ID: 21282656

DOI: 10.1073/pnas.1010754108

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 22613832

Title: TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.

PubMed ID: 22613832

DOI: 10.1083/jcb.201111079

PubMed ID: 23535298

Title: UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.

PubMed ID: 23535298

DOI: 10.4161/cc.24404

PubMed ID: 24023390

Title: Large-scale top down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

PubMed ID: 24023390

DOI: 10.1074/mcp.m113.030114

PubMed ID: 26506309

Title: REI-1 is a guanine nucleotide exchange factor regulating RAB-11 localization and function in C. elegans embryos.

PubMed ID: 26506309

DOI: 10.1016/j.devcel.2015.09.013

PubMed ID: 25673879

Title: The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.

PubMed ID: 25673879

DOI: 10.1242/jcs.162925

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28017832

Title: Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification.

PubMed ID: 28017832

DOI: 10.1016/j.jid.2016.12.010

PubMed ID: 28384198

Title: TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells.

PubMed ID: 28384198

DOI: 10.1371/journal.pone.0174883

PubMed ID: 29514919

Title: The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution.

PubMed ID: 29514919

DOI: 10.1083/jcb.201709123

PubMed ID: 31204173

Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

PubMed ID: 31204173

DOI: 10.1016/j.devcel.2019.05.022

PubMed ID: 31308374

Title: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.

PubMed ID: 31308374

DOI: 10.1038/s41467-019-10812-x

PubMed ID: 31578334

Title:

PubMed ID: 31578334

DOI: 10.1038/s41467-019-12454-5

PubMed ID: 32974215

Title: The Salmonella effector SseK3 targets small Rab GTPases.

PubMed ID: 32974215

DOI: 10.3389/fcimb.2020.00419

PubMed ID: 32344433

Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.

PubMed ID: 32344433

DOI: 10.1083/jcb.201811014

PubMed ID: 36604604

Title: ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity.

PubMed ID: 36604604

DOI: 10.1038/s41380-022-01940-w

PubMed ID: 16034420

Title: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

PubMed ID: 16034420

DOI: 10.1038/nature03798

PubMed ID: 15837192

Title: Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein.

PubMed ID: 15837192

DOI: 10.1016/j.str.2005.01.014

PubMed ID: 17007872

Title: Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes.

PubMed ID: 17007872

DOI: 10.1016/j.jmb.2006.08.064

PubMed ID: 17030804

Title: Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.

PubMed ID: 17030804

DOI: 10.1073/pnas.0605357103

PubMed ID: 16905101

Title: Crystal structure of rab11 in complex with rab11 family interacting protein 2.

PubMed ID: 16905101

DOI: 10.1016/j.str.2006.06.010

PubMed ID: 26258637

Title: Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11.

PubMed ID: 26258637

DOI: 10.1038/nsmb.3065

PubMed ID: 30217979

Title: Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

PubMed ID: 30217979

DOI: 10.1038/s41467-018-06196-z

Sequence Information:

  • Length: 216
  • Mass: 24394
  • Checksum: 76FC1E113A29B269
  • Sequence:
    • MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI 
KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM 
LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF IETSALDSTN VEAAFQTILT EIYRIVSQKQ 
MSDRRENDMS PSNNVVPIHV PPTTENKPKV QCCQNI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.