Details for: TNFRSF18

Gene ID: 8784

Symbol: TNFRSF18

Ensembl ID: ENSG00000186891

Description: TNF receptor superfamily member 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.6178
    Cell Significance Index: -8.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.2644
    Cell Significance Index: -7.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.4365
    Cell Significance Index: -9.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.0038
    Cell Significance Index: -8.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 11.8482
    Cell Significance Index: 245.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 10.7716
    Cell Significance Index: 378.5000
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 10.5716
    Cell Significance Index: 31.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.7399
    Cell Significance Index: -8.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8865
    Cell Significance Index: 122.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.9906
    Cell Significance Index: 117.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2694
    Cell Significance Index: 49.1700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.2398
    Cell Significance Index: 38.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1617
    Cell Significance Index: -8.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.8330
    Cell Significance Index: -5.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2209
    Cell Significance Index: 232.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0897
    Cell Significance Index: 16.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0246
    Cell Significance Index: 101.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7918
    Cell Significance Index: 714.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6290
    Cell Significance Index: 40.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4938
    Cell Significance Index: 80.3100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.4591
    Cell Significance Index: 4.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4523
    Cell Significance Index: 199.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4490
    Cell Significance Index: 33.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4225
    Cell Significance Index: 45.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3301
    Cell Significance Index: 7.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2159
    Cell Significance Index: 14.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1929
    Cell Significance Index: 9.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1857
    Cell Significance Index: 101.4300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1176
    Cell Significance Index: 0.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1118
    Cell Significance Index: 7.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0779
    Cell Significance Index: 9.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0773
    Cell Significance Index: 4.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0754
    Cell Significance Index: 9.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0372
    Cell Significance Index: 7.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0057
    Cell Significance Index: -10.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0068
    Cell Significance Index: -10.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0083
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0133
    Cell Significance Index: -2.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0152
    Cell Significance Index: -8.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0153
    Cell Significance Index: -9.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0164
    Cell Significance Index: -0.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0191
    Cell Significance Index: -6.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0225
    Cell Significance Index: -10.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0249
    Cell Significance Index: -2.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0288
    Cell Significance Index: -8.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0309
    Cell Significance Index: -6.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0311
    Cell Significance Index: -4.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0324
    Cell Significance Index: -3.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0421
    Cell Significance Index: -1.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0421
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0481
    Cell Significance Index: -10.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0521
    Cell Significance Index: -6.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0540
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0547
    Cell Significance Index: -9.3400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0559
    Cell Significance Index: -0.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0597
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0698
    Cell Significance Index: -8.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0720
    Cell Significance Index: -7.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0809
    Cell Significance Index: -8.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0874
    Cell Significance Index: -4.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1052
    Cell Significance Index: -6.6300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1096
    Cell Significance Index: -1.8900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1200
    Cell Significance Index: -1.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1253
    Cell Significance Index: -9.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1283
    Cell Significance Index: -8.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1328
    Cell Significance Index: -6.1900
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: -0.1383
    Cell Significance Index: -0.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1406
    Cell Significance Index: -3.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1486
    Cell Significance Index: -3.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1546
    Cell Significance Index: -2.3300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1584
    Cell Significance Index: -1.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1734
    Cell Significance Index: -9.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1781
    Cell Significance Index: -6.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1818
    Cell Significance Index: -10.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1884
    Cell Significance Index: -6.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1939
    Cell Significance Index: -10.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2027
    Cell Significance Index: -5.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2032
    Cell Significance Index: -5.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2038
    Cell Significance Index: -6.4900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2038
    Cell Significance Index: -2.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2204
    Cell Significance Index: -9.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2208
    Cell Significance Index: -7.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2253
    Cell Significance Index: -7.8300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.2254
    Cell Significance Index: -2.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2367
    Cell Significance Index: -3.9000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2461
    Cell Significance Index: -4.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2548
    Cell Significance Index: -3.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2595
    Cell Significance Index: -9.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2673
    Cell Significance Index: -5.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2683
    Cell Significance Index: -6.5000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2701
    Cell Significance Index: -3.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TNF Receptor Superfamily Member:** TNFRSF18 is a member of the TNF receptor superfamily, which consists of a group of receptors that share structural similarities and interact with TNF ligands. 2. **Multifaceted Function:** TNFRSF18 is involved in various cellular processes, including apoptosis, immune responses, cell adhesion, and transcriptional regulation. 3. **Significant Expression in Immune Cells:** TNFRSF18 is expressed in multiple immune cells, including T cells, natural killer cells, and dendritic cells. 4. **Involvement in NF-κB Signaling Pathway:** TNFRSF18 interacts with the NF-κB signaling pathway, which plays a crucial role in the regulation of immune responses and inflammation. 5. **Regulation of Regulatory T Cells:** TNFRSF18 is involved in the development and function of regulatory T cells, which are essential for maintaining immune tolerance and preventing autoimmune diseases. **Pathways and Functions:** 1. **Apoptotic Process:** TNFRSF18 is involved in the regulation of apoptosis, a process of programmed cell death that plays a crucial role in maintaining tissue homeostasis. 2. **Cytokine Signaling in Immune System:** TNFRSF18 interacts with cytokines, such as TNF-α, to regulate immune responses and inflammation. 3. **External Side of Plasma Membrane:** TNFRSF18 is located on the external side of the plasma membrane, where it interacts with its ligands and other signaling molecules. 4. **Transcriptional Regulation:** TNFRSF18 regulates gene expression by interacting with transcription factors, such as Runx1 and Foxp3. 5. **Immune System:** TNFRSF18 plays a crucial role in the regulation of immune responses, including the development and function of T cells, B cells, and natural killer cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Abnormalities in TNFRSF18 expression and function have been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** TNFRSF18 is overexpressed in certain types of cancer, including breast cancer and colon cancer, where it promotes tumor growth and metastasis. 3. **Inflammatory Disorders:** TNFRSF18 is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in inflammatory disorders, such as psoriasis and Crohn's disease. 4. **Immunotherapy:** TNFRSF18 is a potential target for immunotherapies, such as checkpoint inhibitors, which can modulate its activity and enhance anti-tumor responses. In conclusion, TNFRSF18 is a multifaceted gene that plays a crucial role in the regulation of immune responses, apoptosis, and transcriptional regulation. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and inflammatory disorders. Further research is needed to fully understand the complexities of TNFRSF18 and its potential as a therapeutic target.

Genular Protein ID: 1663282157

Symbol: TNR18_HUMAN

Name: Tumor necrosis factor receptor superfamily member 18

UniProtKB Accession Codes:

Q9Y5U5 B1AME1 O95851 Q5U0I4 Q9NYJ9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10074428

Title: Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.

PubMed ID: 10074428

DOI: 10.1016/s0960-9822(99)80093-1

PubMed ID: 10037686

Title: Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand.

PubMed ID: 10037686

DOI: 10.1074/jbc.274.10.6056

PubMed ID: 10836847

Title: Identification of three novel mRNA splice variants of GITR.

PubMed ID: 10836847

DOI: 10.1038/sj.cdd.4400670

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 241
  • Mass: 26000
  • Checksum: 90DC3B4AA7E82CBE
  • Sequence:
    • MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC RVHTTRCCRD 
YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV QSQGKFSFGF QCIDCASGTF 
SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN AVCVPGSPPA EPLGWLTVVL LAVAACVLLL 
TSAQLGLHIW QLRSQCMWPR ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW 
V

Genular Protein ID: 846333318

Symbol: A0A0R7FDM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0R7FDM1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 RefSeq 1 SAM 2 SMART 2

Sequence Information:

  • Length: 347
  • Mass: 36682
  • Checksum: 730C97255CDD13A2
  • Sequence:
    • MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC RVHTTRCCRD 
YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV QSQGKFSFGF QCIDCASGTF 
SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN AVCVPGSPPA EPLGWLTVVL LAVAACVLLL 
TSAQLGLHIW QLRSQCMWPR GLSQPGAGRW EHGCLLTVAP LQRPSCCWRC RRRPKTPEAA 
SSPRKSGASD RQRRRGGWET CGCEPGRPPG PPTAASPSPG APQAAGALRS ALGRALLPWQ 
QKWVQEGGSD QRPGPCSSAA AAGPCRRERE TQSWPPSSLA GPDGVGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.