Details for: TNFRSF10D

Gene ID: 8793

Symbol: TNFRSF10D

Ensembl ID: ENSG00000173530

Description: TNF receptor superfamily member 10d

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.0282
    Cell Significance Index: -15.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.1345
    Cell Significance Index: -15.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8634
    Cell Significance Index: -15.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0243
    Cell Significance Index: -15.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2883
    Cell Significance Index: -10.1000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.1412
    Cell Significance Index: 7.9800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2745
    Cell Significance Index: 18.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1823
    Cell Significance Index: 225.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1098
    Cell Significance Index: 10.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6325
    Cell Significance Index: 28.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5877
    Cell Significance Index: 530.6900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5723
    Cell Significance Index: 4.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5694
    Cell Significance Index: 113.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3999
    Cell Significance Index: 43.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3898
    Cell Significance Index: 63.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3848
    Cell Significance Index: 23.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3804
    Cell Significance Index: 48.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3394
    Cell Significance Index: 4.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3333
    Cell Significance Index: 7.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3246
    Cell Significance Index: 5.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2872
    Cell Significance Index: 8.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.2306
    Cell Significance Index: 2.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2304
    Cell Significance Index: 28.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2245
    Cell Significance Index: 2.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2238
    Cell Significance Index: 22.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2004
    Cell Significance Index: 5.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1839
    Cell Significance Index: 3.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1810
    Cell Significance Index: 9.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1738
    Cell Significance Index: 1.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1084
    Cell Significance Index: 59.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0995
    Cell Significance Index: 11.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0483
    Cell Significance Index: 30.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0392
    Cell Significance Index: 0.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0115
    Cell Significance Index: 5.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0044
    Cell Significance Index: 0.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0043
    Cell Significance Index: 0.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0012
    Cell Significance Index: 0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0061
    Cell Significance Index: -11.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0108
    Cell Significance Index: -6.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0151
    Cell Significance Index: -0.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0181
    Cell Significance Index: -13.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0265
    Cell Significance Index: -5.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0271
    Cell Significance Index: -4.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0297
    Cell Significance Index: -0.8300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0307
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0343
    Cell Significance Index: -9.8700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0408
    Cell Significance Index: -0.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0413
    Cell Significance Index: -14.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0570
    Cell Significance Index: -0.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0592
    Cell Significance Index: -8.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0674
    Cell Significance Index: -7.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0689
    Cell Significance Index: -13.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0735
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0766
    Cell Significance Index: -1.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0768
    Cell Significance Index: -9.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0880
    Cell Significance Index: -6.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0975
    Cell Significance Index: -12.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0995
    Cell Significance Index: -4.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1005
    Cell Significance Index: -4.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1170
    Cell Significance Index: -7.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1215
    Cell Significance Index: -3.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1275
    Cell Significance Index: -2.7200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1491
    Cell Significance Index: -2.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1506
    Cell Significance Index: -15.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1533
    Cell Significance Index: -2.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1588
    Cell Significance Index: -9.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1661
    Cell Significance Index: -6.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1687
    Cell Significance Index: -13.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1691
    Cell Significance Index: -3.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1692
    Cell Significance Index: -12.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1739
    Cell Significance Index: -9.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1895
    Cell Significance Index: -14.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1954
    Cell Significance Index: -6.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1961
    Cell Significance Index: -5.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2132
    Cell Significance Index: -3.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2359
    Cell Significance Index: -15.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2429
    Cell Significance Index: -10.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2463
    Cell Significance Index: -15.1400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2490
    Cell Significance Index: -3.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2505
    Cell Significance Index: -3.7800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2706
    Cell Significance Index: -2.3000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2854
    Cell Significance Index: -2.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2960
    Cell Significance Index: -4.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3153
    Cell Significance Index: -8.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3207
    Cell Significance Index: -16.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3284
    Cell Significance Index: -6.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3346
    Cell Significance Index: -8.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3397
    Cell Significance Index: -9.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3494
    Cell Significance Index: -6.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3776
    Cell Significance Index: -16.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TNFRSF10D gene shares structural homology with other members of the tumor necrosis factor receptor superfamily, which are characterized by the presence of a type I transmembrane domain, a single cytoplasmic tail, and a ligand-binding extracellular domain. The TNFRSF10D receptor is activated by binding to its ligand, which triggers a cascade of intracellular signaling events that regulate various cellular processes. Notably, the TNFRSF10D receptor has been shown to be involved in the regulation of apoptosis, a process of programmed cell death that plays a critical role in maintaining tissue homeostasis and preventing disease. **Pathways and Functions** The TNFRSF10D receptor is involved in several key signaling pathways, including: 1. **Apoptotic process**: The TNFRSF10D receptor is activated by binding to its ligand, which triggers a cascade of signaling events that regulate apoptosis. This receptor is also involved in the regulation of the apoptotic machinery, including the activation of caspases and the regulation of pro-apoptotic and anti-apoptotic proteins. 2. **Cell surface interactions**: The TNFRSF10D receptor is involved in the regulation of cell surface interactions, including cell adhesion and migration. This receptor is also involved in the regulation of immune responses, including the activation of immune cells and the regulation of inflammatory responses. 3. **Death receptor signaling**: The TNFRSF10D receptor is a death receptor, which is activated by binding to its ligand and triggers a cascade of signaling events that regulate apoptosis. 4. **Transcriptional regulation**: The TNFRSF10D receptor is also involved in the regulation of gene expression, including the transcriptional regulation of genes involved in apoptosis and immune responses. **Clinical Significance** The TNFRSF10D gene has been implicated in various diseases, including: 1. **Inflammatory disorders**: The TNFRSF10D receptor is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in various inflammatory disorders, including rheumatoid arthritis and inflammatory bowel disease. 2. **Cancer**: The TNFRSF10D receptor is involved in the regulation of apoptosis, and its dysregulation has been implicated in various types of cancer, including lung and breast cancer. 3. **Neurological disorders**: The TNFRSF10D receptor is involved in the regulation of cell surface interactions and apoptosis, and its dysregulation has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the TNFRSF10D gene plays a critical role in regulating various cellular processes, including apoptosis, cell surface interactions, and signal transduction. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of this gene and its role in human disease.

Genular Protein ID: 511692964

Symbol: TR10D_HUMAN

Name: Tumor necrosis factor receptor superfamily member 10D

UniProtKB Accession Codes:

Q9UBN6 B2R8W0 Q9Y6Q4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9382840

Title: A novel receptor for Apo2L/TRAIL contains a truncated death domain.

PubMed ID: 9382840

DOI: 10.1016/s0960-9822(06)00422-2

PubMed ID: 9430226

Title: The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain.

PubMed ID: 9430226

DOI: 10.1016/s1074-7613(00)80399-4

PubMed ID: 9537512

Title: TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling.

PubMed ID: 9537512

DOI: 10.1016/s0014-5793(98)00135-5

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 386
  • Mass: 41849
  • Checksum: 8D15E577D214852A
  • Sequence:
    • MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR 
QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV 
CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC 
KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL 
KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL 
AELTGVTVEL PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE 
TIQDQLVGSE KLFYEEDEAG SATSCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.