Details for: TNFRSF10C

Gene ID: 8794

Symbol: TNFRSF10C

Ensembl ID: ENSG00000173535

Description: TNF receptor superfamily member 10c

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.0585
    Cell Significance Index: -3.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.4728
    Cell Significance Index: -2.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7254
    Cell Significance Index: 105.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2189
    Cell Significance Index: 32.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5303
    Cell Significance Index: 100.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3666
    Cell Significance Index: 36.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3475
    Cell Significance Index: 7.4000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.3210
    Cell Significance Index: 4.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2870
    Cell Significance Index: 259.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2014
    Cell Significance Index: 21.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1897
    Cell Significance Index: 30.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1757
    Cell Significance Index: 10.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1676
    Cell Significance Index: 19.5300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.1463
    Cell Significance Index: 2.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1070
    Cell Significance Index: 7.4000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1012
    Cell Significance Index: 1.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0577
    Cell Significance Index: 0.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0547
    Cell Significance Index: 1.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0531
    Cell Significance Index: 9.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0514
    Cell Significance Index: 1.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0240
    Cell Significance Index: 13.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0198
    Cell Significance Index: 0.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0137
    Cell Significance Index: 0.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0066
    Cell Significance Index: 0.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0056
    Cell Significance Index: 0.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0032
    Cell Significance Index: 0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0005
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0035
    Cell Significance Index: -2.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0042
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0058
    Cell Significance Index: -1.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0060
    Cell Significance Index: -3.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0070
    Cell Significance Index: -0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0074
    Cell Significance Index: -2.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0097
    Cell Significance Index: -1.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0125
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0128
    Cell Significance Index: -2.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0140
    Cell Significance Index: -0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0143
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0176
    Cell Significance Index: -3.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0215
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0218
    Cell Significance Index: -2.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0224
    Cell Significance Index: -3.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0236
    Cell Significance Index: -3.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0279
    Cell Significance Index: -1.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0309
    Cell Significance Index: -0.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0337
    Cell Significance Index: -1.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0352
    Cell Significance Index: -2.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0357
    Cell Significance Index: -0.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0362
    Cell Significance Index: -1.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0375
    Cell Significance Index: -2.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0386
    Cell Significance Index: -2.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0398
    Cell Significance Index: -1.6300
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0443
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0466
    Cell Significance Index: -0.7700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0497
    Cell Significance Index: -0.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0530
    Cell Significance Index: -3.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0560
    Cell Significance Index: -3.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0567
    Cell Significance Index: -1.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0583
    Cell Significance Index: -1.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0627
    Cell Significance Index: -2.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0677
    Cell Significance Index: -2.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0713
    Cell Significance Index: -3.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0731
    Cell Significance Index: -0.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0762
    Cell Significance Index: -2.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0769
    Cell Significance Index: -1.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0771
    Cell Significance Index: -3.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0794
    Cell Significance Index: -1.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0834
    Cell Significance Index: -2.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0857
    Cell Significance Index: -2.7300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0870
    Cell Significance Index: -1.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0880
    Cell Significance Index: -3.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0900
    Cell Significance Index: -2.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0903
    Cell Significance Index: -3.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0927
    Cell Significance Index: -2.0300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0992
    Cell Significance Index: -1.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1001
    Cell Significance Index: -1.5000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1001
    Cell Significance Index: -1.3100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1067
    Cell Significance Index: -1.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1092
    Cell Significance Index: -3.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1129
    Cell Significance Index: -1.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1156
    Cell Significance Index: -2.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1167
    Cell Significance Index: -2.9100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1240
    Cell Significance Index: -1.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1251
    Cell Significance Index: -3.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1257
    Cell Significance Index: -3.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1269
    Cell Significance Index: -3.4600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1284
    Cell Significance Index: -1.2200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1306
    Cell Significance Index: -1.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1316
    Cell Significance Index: -1.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1320
    Cell Significance Index: -3.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFRSF10C is a type II transmembrane receptor, consisting of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular death domain. This receptor is primarily expressed on the surface of intestinal epithelial cells, including absorptive cells, tuft cells, and GABAergic interneurons in the cerebral cortex. Its expression is also observed in other cell types, such as transit amplifying cells in the small intestine and colon. **Pathways and Functions:** TNFRSF10C is involved in various signaling pathways, including the Trail-activated apoptotic signaling pathway, which is mediated by the interaction with its ligand, TRAIL-R3 (DR5). This interaction triggers the activation of caspase-8, leading to the induction of apoptosis in sensitive cells. Additionally, TNFRSF10C is involved in the regulation of cell growth and differentiation through its interaction with other signaling molecules, such as TRAF3 and TRAF6. **Clinical Significance:** TNFRSF10C has been implicated in various diseases, including cancer, inflammatory disorders, and neurodegenerative diseases. For instance, its overexpression has been observed in certain types of cancer, such as colon and breast cancer, suggesting its potential as a diagnostic biomarker. Moreover, TNFRSF10C has been shown to play a role in the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting the gastrointestinal tract. Furthermore, TNFRSF10C has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to neuronal apoptosis and degeneration. The identification of TNFRSF10C as a critical regulator of apoptosis and cell growth has significant implications for the development of novel therapeutic strategies targeting this receptor. In conclusion, TNFRSF10C is a complex gene that plays a critical role in regulating various cellular processes, including apoptosis, cell growth, and differentiation. Its dysregulation has been implicated in various diseases, making it an attractive target for therapeutic interventions. Further research is necessary to fully elucidate the mechanisms of TNFRSF10C and its clinical significance, ultimately leading to the development of novel treatments for these debilitating diseases.

Genular Protein ID: 1138516863

Symbol: TR10C_HUMAN

Name: Tumor necrosis factor receptor superfamily member 10C

UniProtKB Accession Codes:

O14798 O14755 Q08AS6 Q6FH98 Q6UXM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9325248

Title: Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.

PubMed ID: 9325248

DOI: 10.1074/jbc.272.41.25417

PubMed ID: 9314565

Title: Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family.

PubMed ID: 9314565

DOI: 10.1084/jem.186.7.1165

PubMed ID: 9242610

Title: An antagonist decoy receptor and a death domain-containing receptor for TRAIL.

PubMed ID: 9242610

DOI: 10.1126/science.277.5327.815

PubMed ID: 9242611

Title: Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

PubMed ID: 9242611

DOI: 10.1126/science.277.5327.818

PubMed ID: 9373179

Title: Characterization of two receptors for TRAIL.

PubMed ID: 9373179

DOI: 10.1016/s0014-5793(97)01231-3

PubMed ID: 9551946

Title: Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL.

PubMed ID: 9551946

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 259
  • Mass: 27407
  • Checksum: 40CBF7FCEEAE4C69
  • Sequence:
    • MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG EECPAGSHRS 
EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS CTMTRDTVCQ CKEGTFRNEN 
SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV EEFGANATVE TPAAEETMNT SPGTPAPAAE 
ETMNTSPGTP APAAEETMTT SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY 
LSCTIVGIIV LIVLLIVFV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.