Details for: TNFRSF10A

Gene ID: 8797

Symbol: TNFRSF10A

Ensembl ID: ENSG00000104689

Description: TNF receptor superfamily member 10a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.4893
    Cell Significance Index: -8.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.4759
    Cell Significance Index: -7.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.4335
    Cell Significance Index: -7.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.6014
    Cell Significance Index: -8.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.3268
    Cell Significance Index: -7.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.7805
    Cell Significance Index: -8.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0423
    Cell Significance Index: -8.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8683
    Cell Significance Index: -8.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9892
    Cell Significance Index: 27.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0874
    Cell Significance Index: 126.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9592
    Cell Significance Index: 26.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8715
    Cell Significance Index: 52.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7773
    Cell Significance Index: 11.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7477
    Cell Significance Index: 33.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7457
    Cell Significance Index: 20.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7235
    Cell Significance Index: 143.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6971
    Cell Significance Index: 20.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6226
    Cell Significance Index: 67.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5737
    Cell Significance Index: 12.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5608
    Cell Significance Index: 506.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5059
    Cell Significance Index: 26.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4801
    Cell Significance Index: 25.0100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4269
    Cell Significance Index: 4.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4098
    Cell Significance Index: 6.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4072
    Cell Significance Index: 66.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3968
    Cell Significance Index: 5.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3781
    Cell Significance Index: 4.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3242
    Cell Significance Index: 22.4200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3203
    Cell Significance Index: 4.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3155
    Cell Significance Index: 6.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2711
    Cell Significance Index: 12.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2318
    Cell Significance Index: 22.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2160
    Cell Significance Index: 26.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1575
    Cell Significance Index: 28.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1517
    Cell Significance Index: 5.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1395
    Cell Significance Index: 76.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1291
    Cell Significance Index: 24.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1223
    Cell Significance Index: 15.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1129
    Cell Significance Index: 2.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1096
    Cell Significance Index: 8.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0983
    Cell Significance Index: 11.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0840
    Cell Significance Index: 2.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0776
    Cell Significance Index: 2.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0738
    Cell Significance Index: 1.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0566
    Cell Significance Index: 25.0200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0537
    Cell Significance Index: 0.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0364
    Cell Significance Index: 0.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0242
    Cell Significance Index: 0.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0049
    Cell Significance Index: 0.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0036
    Cell Significance Index: -2.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0081
    Cell Significance Index: -0.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0102
    Cell Significance Index: -2.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0127
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0134
    Cell Significance Index: -8.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0137
    Cell Significance Index: -0.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0161
    Cell Significance Index: -9.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0175
    Cell Significance Index: -2.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0184
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0198
    Cell Significance Index: -2.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0247
    Cell Significance Index: -2.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0260
    Cell Significance Index: -7.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0429
    Cell Significance Index: -9.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0479
    Cell Significance Index: -6.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0497
    Cell Significance Index: -6.8200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0591
    Cell Significance Index: -0.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0592
    Cell Significance Index: -2.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0701
    Cell Significance Index: -4.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0795
    Cell Significance Index: -8.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1053
    Cell Significance Index: -8.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1063
    Cell Significance Index: -8.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1064
    Cell Significance Index: -0.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1176
    Cell Significance Index: -7.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1178
    Cell Significance Index: -7.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1217
    Cell Significance Index: -7.6700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1341
    Cell Significance Index: -1.8600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1357
    Cell Significance Index: -0.8400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1358
    Cell Significance Index: -2.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1379
    Cell Significance Index: -6.9700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1414
    Cell Significance Index: -1.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1420
    Cell Significance Index: -8.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1468
    Cell Significance Index: -8.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1482
    Cell Significance Index: -2.5400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1546
    Cell Significance Index: -1.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1607
    Cell Significance Index: -4.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1748
    Cell Significance Index: -1.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1809
    Cell Significance Index: -6.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1885
    Cell Significance Index: -8.3400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2019
    Cell Significance Index: -2.6400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2021
    Cell Significance Index: -3.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2044
    Cell Significance Index: -7.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFRSF10A is a type I transmembrane receptor that belongs to the tumor necrosis factor receptor superfamily. It is characterized by its high affinity for TRAIL, a ligand that selectively induces apoptosis in various cancer cells while sparing normal cells. The receptor is expressed on the surface of cells, where it can interact with TRAIL and initiate the signaling cascade. TNFRSF10A is also known to interact with other proteins, including c-FLIP, which can modulate its activity. **Pathways and Functions** The signaling pathway initiated by TNFRSF10A and TRAIL involves the activation of NF-κB-inducing kinase (NIK), which in turn activates caspase-8. This enzyme cleaves and activates downstream caspases, leading to the activation of caspase-3, which ultimately triggers apoptosis. TNFRSF10A also interacts with other signaling pathways, including the extrinsic apoptotic signaling pathway and the NF-κB pathway. These interactions can modulate the receptor's activity and influence cell survival and death. **Clinical Significance** TNFRSF10A and its ligand, TRAIL, have been implicated in various diseases, including cancer, autoimmune disorders, and cardiovascular disease. TRAIL has been explored as a potential therapeutic agent for cancer treatment due to its ability to selectively induce apoptosis in cancer cells. However, its use is limited by its toxicity to normal cells. TNFRSF10A has also been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, where it is thought to contribute to the activation of immune cells. Furthermore, TNFRSF10A has been shown to play a role in the regulation of apoptosis in various cell types, including neurons and endothelial cells. In addition, TNFRSF10A has been identified as a potential biomarker for various diseases, including cancer and cardiovascular disease. Its expression levels can be used to predict disease outcomes and monitor treatment response. Overall, TNFRSF10A is a critical regulator of apoptosis and immune responses, and its dysregulation has been implicated in various diseases. **Regulation and Interactions** TNFRSF10A is regulated by various proteins, including c-FLIP, which can modulate its activity. The receptor's expression is also influenced by transcriptional regulators, such as TP53, which can regulate its expression and activity. TNFRSF10A interacts with other proteins, including TRAIL, which binds to the receptor and initiates the signaling cascade. The receptor also interacts with other signaling molecules, including NF-κB-inducing kinase (NIK) and caspase-8, which are involved in the apoptotic pathway. **Implications for Therapy** TNFRSF10A has been explored as a potential therapeutic target for various diseases, including cancer and autoimmune disorders. TRAIL has been used as a therapeutic agent to selectively induce apoptosis in cancer cells. However, its use is limited by its toxicity to normal cells. TNFRSF10A has also been explored as a potential therapeutic target for autoimmune diseases, such as rheumatoid arthritis, where it is thought to contribute to the activation of immune cells. Further research is needed to fully understand the role of TNFRSF10A in disease and to develop effective therapeutic strategies. In conclusion, TNFRSF10A is a critical regulator of apoptosis and immune responses, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand its role in disease and to develop effective therapeutic strategies.

Genular Protein ID: 1783399251

Symbol: TR10A_HUMAN

Name: Tumor necrosis factor receptor superfamily member 10A

UniProtKB Accession Codes:

O00220 A8K5I4 Q53Y72 Q96E62

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9082980

Title: The receptor for the cytotoxic ligand TRAIL.

PubMed ID: 9082980

DOI: 10.1126/science.276.5309.111

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430227

Title: Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.

PubMed ID: 9430227

DOI: 10.1016/s1074-7613(00)80400-8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18165900

Title: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.

PubMed ID: 18165900

DOI: 10.1007/s10495-007-0171-8

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 19090789

Title: Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling.

PubMed ID: 19090789

DOI: 10.1042/bj20081212

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22240897

Title: Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells.

PubMed ID: 22240897

DOI: 10.1038/cdd.2011.209

PubMed ID: 23498957

Title: Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

PubMed ID: 23498957

DOI: 10.1016/j.chom.2013.02.003

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 38532423

Title: Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck.

PubMed ID: 38532423

DOI: 10.1186/s12929-024-01023-8

PubMed ID: 26457518

Title: The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

PubMed ID: 26457518

DOI: 10.1107/s2053230x15016416

Sequence Information:

  • Length: 468
  • Mass: 50089
  • Checksum: 7E96619D0BDC0CD4
  • Sequence:
    • MAPPPARVHL GAFLAVTPNP GSAASGTEAA AATPSKVWGS SAGRIEPRGG GRGALPTSMG 
QHGPSARARA GRAPGPRPAR EASPRLRVHK TFKFVVVGVL LQVVPSSAAT IKLHDQSIGT 
QQWEHSPLGE LCPPGSHRSE HPGACNRCTE GVGYTNASNN LFACLPCTAC KSDEEERSPC 
TTTRNTACQC KPGTFRNDNS AEMCRKCSRG CPRGMVKVKD CTPWSDIECV HKESGNGHNI 
WVILVVTLVV PLLLVAVLIV CCCIGSGCGG DPKCMDRVCF WRLGLLRGPG AEDNAHNEIL 
SNADSLSTFV SEQQMESQEP ADLTGVTVQS PGEAQCLLGP AEAEGSQRRR LLVPANGADP 
TETLMLFFDK FANIVPFDSW DQLMRQLDLT KNEIDVVRAG TAGPGDALYA MLMKWVNKTG 
RNASIHTLLD ALERMEERHA REKIQDLLVD SGKFIYLEDG TGSAVSLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.