Details for: IL18R1

Gene ID: 8809

Symbol: IL18R1

Ensembl ID: ENSG00000115604

Description: interleukin 18 receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.2035
    Cell Significance Index: -8.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.4221
    Cell Significance Index: -7.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.8212
    Cell Significance Index: -7.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.1883
    Cell Significance Index: -8.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5777
    Cell Significance Index: -8.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8258
    Cell Significance Index: -7.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0527
    Cell Significance Index: -8.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9419
    Cell Significance Index: -4.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.6865
    Cell Significance Index: -5.1800
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.7949
    Cell Significance Index: 5.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5891
    Cell Significance Index: 26.7000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5882
    Cell Significance Index: 8.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.5844
    Cell Significance Index: 9.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5237
    Cell Significance Index: 99.6600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4963
    Cell Significance Index: 5.1400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.4522
    Cell Significance Index: 2.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3912
    Cell Significance Index: 11.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3655
    Cell Significance Index: 7.7900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3648
    Cell Significance Index: 2.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3481
    Cell Significance Index: 7.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3040
    Cell Significance Index: 30.0700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2768
    Cell Significance Index: 2.8700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.2753
    Cell Significance Index: 3.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2658
    Cell Significance Index: 15.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2052
    Cell Significance Index: 185.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2006
    Cell Significance Index: 138.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1880
    Cell Significance Index: 20.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1544
    Cell Significance Index: 19.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1529
    Cell Significance Index: 4.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1484
    Cell Significance Index: 24.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1152
    Cell Significance Index: 22.8600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0908
    Cell Significance Index: 0.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0851
    Cell Significance Index: 5.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0526
    Cell Significance Index: 1.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0471
    Cell Significance Index: 25.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0452
    Cell Significance Index: 1.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0311
    Cell Significance Index: 2.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0152
    Cell Significance Index: 6.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0149
    Cell Significance Index: 0.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0120
    Cell Significance Index: 0.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0060
    Cell Significance Index: 0.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0110
    Cell Significance Index: -8.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0135
    Cell Significance Index: -6.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0143
    Cell Significance Index: -2.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0143
    Cell Significance Index: -8.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0146
    Cell Significance Index: -0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0159
    Cell Significance Index: -5.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0160
    Cell Significance Index: -3.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0170
    Cell Significance Index: -2.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0206
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0221
    Cell Significance Index: -6.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0222
    Cell Significance Index: -2.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0232
    Cell Significance Index: -1.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0329
    Cell Significance Index: -3.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0348
    Cell Significance Index: -1.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0360
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0385
    Cell Significance Index: -8.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0402
    Cell Significance Index: -6.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0496
    Cell Significance Index: -5.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0607
    Cell Significance Index: -6.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0662
    Cell Significance Index: -8.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0764
    Cell Significance Index: -7.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0794
    Cell Significance Index: -1.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0798
    Cell Significance Index: -6.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0811
    Cell Significance Index: -3.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0920
    Cell Significance Index: -4.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1060
    Cell Significance Index: -2.4500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1114
    Cell Significance Index: -1.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1151
    Cell Significance Index: -7.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1163
    Cell Significance Index: -8.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1167
    Cell Significance Index: -3.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1174
    Cell Significance Index: -3.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1176
    Cell Significance Index: -6.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1187
    Cell Significance Index: -1.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1196
    Cell Significance Index: -7.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1208
    Cell Significance Index: -3.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1213
    Cell Significance Index: -6.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1225
    Cell Significance Index: -7.5300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1251
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1256
    Cell Significance Index: -3.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1296
    Cell Significance Index: -8.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1308
    Cell Significance Index: -1.9300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1348
    Cell Significance Index: -0.9700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1355
    Cell Significance Index: -3.3800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1559
    Cell Significance Index: -1.5200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1566
    Cell Significance Index: -2.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1601
    Cell Significance Index: -4.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1725
    Cell Significance Index: -7.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1911
    Cell Significance Index: -7.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL18R1 is a single-pass transmembrane receptor that belongs to the interleukin-1 receptor family. It is composed of two subunits, IL-18Rα and IL-18Rβ, which form a heterodimeric receptor that binds to IL-18 with high affinity. The binding of IL-18 to IL18R1 triggers a signaling cascade that activates various transcription factors, including nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), leading to the production of pro-inflammatory cytokines and chemokines. **Pathways and Functions:** IL18R1 is involved in several key signaling pathways, including: 1. **Cytokine signaling in immune system**: IL18R1 plays a crucial role in the signaling pathways of IL-18, which promotes the production of IFN-γ and activates NK cells. 2. **Immune response**: IL18R1 is involved in the activation of immune cells, including NK cells, macrophages, and T cells, which are essential for the elimination of pathogens and tumor cells. 3. **Inflammatory response**: IL18R1 is expressed in various tissues, including the brain, heart, and lungs, and its dysregulation has been implicated in inflammatory diseases, such as multiple sclerosis, rheumatoid arthritis, and asthma. 4. **Interleukin-1 family signaling**: IL18R1 is a member of the interleukin-1 receptor family and shares structural and functional similarities with other interleukin-1 receptors. **Clinical Significance:** Dysregulation of IL18R1 has been implicated in various diseases, including: 1. **Autoimmune disorders**: IL18R1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cardiovascular diseases**: IL18R1 has been shown to play a role in the development of cardiovascular diseases, including atherosclerosis and heart failure. 3. **Cancer**: IL18R1 has been implicated in the progression of various cancers, including lung, breast, and colon cancer. 4. **Neurological disorders**: IL18R1 has been shown to play a role in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In conclusion, the IL18R1 gene is a critical component of the innate immune system, and its dysregulation has been implicated in various diseases. Further research is needed to elucidate the mechanisms by which IL18R1 regulates immune responses and to explore its therapeutic potential in the treatment of diseases.

Genular Protein ID: 3045351616

Symbol: IL18R_HUMAN

Name: Interleukin-18 receptor 1

UniProtKB Accession Codes:

Q13478 B2R9Y5 Q52LC9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChEMBL 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 2 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626725

Title: IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.

PubMed ID: 8626725

DOI: 10.1074/jbc.271.8.3967

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9325300

Title: Purification and characterization of the human interleukin-18 receptor.

PubMed ID: 9325300

DOI: 10.1074/jbc.272.41.25737

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 10925275

Title: IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.

PubMed ID: 10925275

DOI: 10.4049/jimmunol.165.4.1933

PubMed ID: 11046021

Title: IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

PubMed ID: 11046021

DOI: 10.4049/jimmunol.165.9.4950

PubMed ID: 14528293

Title: The structure and binding mode of interleukin-18.

PubMed ID: 14528293

DOI: 10.1038/nsb993

PubMed ID: 37993714

Title: Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.

PubMed ID: 37993714

DOI: 10.1038/s41586-023-06742-w

PubMed ID: 25261253

Title: Structural basis for the specific recognition of IL-18 by its alpha receptor.

PubMed ID: 25261253

DOI: 10.1016/j.febslet.2014.09.019

PubMed ID: 25500532

Title: The structural basis for receptor recognition of human interleukin-18.

PubMed ID: 25500532

DOI: 10.1038/ncomms6340

Sequence Information:

  • Length: 541
  • Mass: 62304
  • Checksum: 7173DB9C7EA71D32
  • Sequence:
    • MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE TTTKSWYKSS 
GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM KNYTQKWKLN VIRRNKHSCF 
TERQVTSKIV EVKKFFQITC ENSYYQTLVN STSLYKNCKK LLLENNKNPT IKKNAEFEDQ 
GYYSCVHFLH HNGKLFNITK TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL 
LNEEDVIYWM FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV 
ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI YRVDLVLFYR 
HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL PRVLEKHFGY KLCIFERDVV 
PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN EVRYELESGL HEALVERKIK IILIEFTPVT 
DFTFLPQSLK LLKSHRVLKW KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE 
S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.