Details for: TMSB10

Gene ID: 9168

Symbol: TMSB10

Ensembl ID: ENSG00000034510

Description: thymosin beta 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1711.5922
    Cell Significance Index: -266.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 931.6230
    Cell Significance Index: -236.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 760.7824
    Cell Significance Index: -313.4000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 615.3948
    Cell Significance Index: -316.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 614.6178
    Cell Significance Index: -290.1800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 435.0229
    Cell Significance Index: -291.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 219.0671
    Cell Significance Index: -270.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 83.5337
    Cell Significance Index: -256.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 74.4846
    Cell Significance Index: -293.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 47.6994
    Cell Significance Index: -127.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 47.1948
    Cell Significance Index: -103.2900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 24.5341
    Cell Significance Index: 102.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 18.0792
    Cell Significance Index: 475.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 16.6126
    Cell Significance Index: 307.0500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 15.6849
    Cell Significance Index: 134.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 13.5242
    Cell Significance Index: 397.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.7158
    Cell Significance Index: 597.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.1118
    Cell Significance Index: 196.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.1290
    Cell Significance Index: 115.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 9.5962
    Cell Significance Index: 122.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 9.5497
    Cell Significance Index: 5215.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.7719
    Cell Significance Index: 183.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.1860
    Cell Significance Index: 1124.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.7347
    Cell Significance Index: 499.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.2043
    Cell Significance Index: 923.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.6689
    Cell Significance Index: 191.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.5479
    Cell Significance Index: 805.1200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.4021
    Cell Significance Index: 39.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.2456
    Cell Significance Index: 736.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.9308
    Cell Significance Index: 1069.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.9290
    Cell Significance Index: 441.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.7995
    Cell Significance Index: 749.2600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.8034
    Cell Significance Index: 28.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.7285
    Cell Significance Index: 2090.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.4907
    Cell Significance Index: 103.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.3704
    Cell Significance Index: 117.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.9568
    Cell Significance Index: 78.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2349
    Cell Significance Index: 101.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1488
    Cell Significance Index: 1940.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.0306
    Cell Significance Index: 1537.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7515
    Cell Significance Index: 91.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4502
    Cell Significance Index: 275.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4478
    Cell Significance Index: 15.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3995
    Cell Significance Index: 86.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1653
    Cell Significance Index: 233.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8963
    Cell Significance Index: 41.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8536
    Cell Significance Index: 60.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7145
    Cell Significance Index: 70.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6104
    Cell Significance Index: 104.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5379
    Cell Significance Index: 8.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2910
    Cell Significance Index: 10.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1736
    Cell Significance Index: 2.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0280
    Cell Significance Index: 2.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0068
    Cell Significance Index: 4.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0579
    Cell Significance Index: -0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.1112
    Cell Significance Index: -209.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1732
    Cell Significance Index: -319.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1774
    Cell Significance Index: -131.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1886
    Cell Significance Index: -290.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2441
    Cell Significance Index: -331.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3372
    Cell Significance Index: -66.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3797
    Cell Significance Index: -237.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.4052
    Cell Significance Index: -228.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4418
    Cell Significance Index: -158.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4423
    Cell Significance Index: -280.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6774
    Cell Significance Index: -307.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8608
    Cell Significance Index: -247.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8704
    Cell Significance Index: -8.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0461
    Cell Significance Index: -28.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -1.3552
    Cell Significance Index: -285.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3720
    Cell Significance Index: -36.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3982
    Cell Significance Index: -35.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4893
    Cell Significance Index: -47.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.5679
    Cell Significance Index: -179.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.6794
    Cell Significance Index: -195.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.6888
    Cell Significance Index: -183.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.7516
    Cell Significance Index: -98.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.9316
    Cell Significance Index: -100.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.0247
    Cell Significance Index: -294.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -2.1592
    Cell Significance Index: -17.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -2.2999
    Cell Significance Index: -262.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.3515
    Cell Significance Index: -58.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.3568
    Cell Significance Index: -51.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.5209
    Cell Significance Index: -70.4500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.6527
    Cell Significance Index: -45.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.8039
    Cell Significance Index: -291.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.9869
    Cell Significance Index: -200.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -3.0468
    Cell Significance Index: -241.3100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -3.5616
    Cell Significance Index: -22.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.6972
    Cell Significance Index: -283.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.9383
    Cell Significance Index: -113.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -4.4812
    Cell Significance Index: -87.4600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -4.7520
    Cell Significance Index: -12.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.7836
    Cell Significance Index: -293.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.0785
    Cell Significance Index: -69.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -5.2048
    Cell Significance Index: -328.0400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.2493
    Cell Significance Index: -37.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.5323
    Cell Significance Index: -162.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.9217
    Cell Significance Index: -32.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.4204
    Cell Significance Index: -283.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMSB10 is a 15-amino acid peptide that belongs to the thymosin family of peptides. It is characterized by its ability to bind to actin monomers and regulate their organization into filaments, which is essential for cell migration, shape changes, and intracellular transport. Additionally, TMSB10 interacts with various proteins, including actin-binding proteins, which further underscores its role in cytoskeletal organization and cell signaling. **Pathways and Functions:** TMSB10 is involved in several key pathways, including: 1. **Actin filament organization:** TMSB10 binds to actin monomers, promoting their polymerization into filaments, which is essential for cell shape changes, migration, and intracellular transport. 2. **Regulation of cell migration:** TMSB10 regulates the organization of the actin cytoskeleton, which is critical for cell migration, a process essential for immune responses, tissue repair, and development. 3. **Protein binding:** TMSB10 interacts with various proteins, including actin-binding proteins, which modulate its activity and influence cell signaling pathways. 4. **Sequestering of actin monomers:** TMSB10 can sequester actin monomers, preventing their polymerization and thereby regulating actin dynamics. **Clinical Significance:** Dysregulation of TMSB10 has been implicated in various diseases, including: 1. **Immune disorders:** Altered TMSB10 expression has been observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, highlighting its role in immune function and regulation. 2. **Cancer:** TMSB10 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential as a therapeutic target. 3. **Cardiovascular disease:** TMSB10 has been implicated in the regulation of endothelial cell function, which is critical in cardiovascular health. In conclusion, TMSB10 is a multifaceted gene involved in various cellular processes, including cell migration, cytoskeletal organization, and immune function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3990741792

Symbol: TYB10_HUMAN

Name: Thymosin beta-10

UniProtKB Accession Codes:

P63313 P13472 Q596K9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3365256

Title: Sequence of a human kidney cDNA clone encoding thymosin beta 10.

PubMed ID: 3365256

DOI: 10.1016/s0006-291x(88)80118-9

PubMed ID: 2169566

Title: Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma.

PubMed ID: 2169566

DOI: 10.1016/0169-328x(90)90057-k

PubMed ID: 8425765

Title: Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma.

PubMed ID: 8425765

DOI: 10.1002/ijc.2910530218

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 44
  • Mass: 5026
  • Checksum: 5485277C275A1C70
  • Sequence:
    • MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.