Details for: TMSB10

Gene ID: 9168

Symbol: TMSB10

Ensembl ID: ENSG00000034510

Description: thymosin beta 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.97
    Marker Score: 3375
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.97
    Marker Score: 15171
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.74
    Marker Score: 77189
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.64
    Marker Score: 10297
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 5.57
    Marker Score: 23224
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.45
    Marker Score: 15914
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.31
    Marker Score: 52564
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.3
    Marker Score: 3414
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.3
    Marker Score: 3844
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.25
    Marker Score: 10999
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.23
    Marker Score: 4190
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.1
    Marker Score: 1880.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.06
    Marker Score: 2600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.87
    Marker Score: 15355
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.84
    Marker Score: 6815
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.82
    Marker Score: 3457
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.81
    Marker Score: 163530
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.78
    Marker Score: 252485
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.73
    Marker Score: 24844
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.61
    Marker Score: 6702
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.58
    Marker Score: 7058
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.58
    Marker Score: 255939
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.56
    Marker Score: 6599
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.53
    Marker Score: 28878
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.49
    Marker Score: 59238
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.49
    Marker Score: 4023
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.46
    Marker Score: 1916
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.42
    Marker Score: 5460
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.42
    Marker Score: 3763.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.41
    Marker Score: 51265
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.41
    Marker Score: 7564
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.4
    Marker Score: 3929
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.39
    Marker Score: 4879
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.37
    Marker Score: 1044
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.36
    Marker Score: 5682
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.33
    Marker Score: 11963
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.32
    Marker Score: 5202
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.28
    Marker Score: 5000.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.28
    Marker Score: 1392
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.26
    Marker Score: 2592
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.25
    Marker Score: 10385
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.24
    Marker Score: 11902
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.22
    Marker Score: 4082
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.19
    Marker Score: 2456
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.16
    Marker Score: 3582
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 4.11
    Marker Score: 1776
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.1
    Marker Score: 17565
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.09
    Marker Score: 6030
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.08
    Marker Score: 3202
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.07
    Marker Score: 4377
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3935
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.99
    Marker Score: 3545
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.98
    Marker Score: 1055
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.96
    Marker Score: 25791
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.95
    Marker Score: 3368
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.94
    Marker Score: 4212
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.92
    Marker Score: 13936.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.9
    Marker Score: 1756
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.88
    Marker Score: 1020.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.84
    Marker Score: 10278.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.83
    Marker Score: 1398
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.82
    Marker Score: 4372
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.81
    Marker Score: 1638
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.8
    Marker Score: 872
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.8
    Marker Score: 3851
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.78
    Marker Score: 2215
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.77
    Marker Score: 1720
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.74
    Marker Score: 1675
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.73
    Marker Score: 3292
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.73
    Marker Score: 2472
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.73
    Marker Score: 1059
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.73
    Marker Score: 2058
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.73
    Marker Score: 9404
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.72
    Marker Score: 24172
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.71
    Marker Score: 18227
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.7
    Marker Score: 2578
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.7
    Marker Score: 4088.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.69
    Marker Score: 3538
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.69
    Marker Score: 1183
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.67
    Marker Score: 2256
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.67
    Marker Score: 5041
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.66
    Marker Score: 19226
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.66
    Marker Score: 1206
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.62
    Marker Score: 5762.5
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.62
    Marker Score: 959
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.61
    Marker Score: 28225.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.61
    Marker Score: 1871
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.61
    Marker Score: 1503.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.6
    Marker Score: 8175
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.6
    Marker Score: 3032
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.6
    Marker Score: 4248
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 3.59
    Marker Score: 2241
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.59
    Marker Score: 1010
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.59
    Marker Score: 9386
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.58
    Marker Score: 2711
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.58
    Marker Score: 1021.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.58
    Marker Score: 2407
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.57
    Marker Score: 2967
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.57
    Marker Score: 4179
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.56
    Marker Score: 21137

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - It is a transmembrane protein with a molecular weight of approximately 100 kDa. - It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. - It is involved in regulating cell migration, adhesion, and signaling pathways. **Pathways and functions:** - The TMSB10 gene is involved in the organization of the actin filament, a major cytoskeletal network that provides structural support and shape to cells. - It interacts with other cytoskeletal proteins, such as actin monomers and other cytoskeletal filaments. - It is involved in the regulation of cell migration by promoting the interaction between the actin filament and the cell's leading edge. - It also regulates cell adhesion by binding to extracellular matrix proteins and facilitating cell-cell interactions. - It is involved in signaling pathways that are activated by growth factors and cytokines. **Clinical significance:** - Mutations in the TMSB10 gene have been linked to several human diseases, including vascular disorders, cancer, and autoimmune diseases. - In vascular disorders, mutations in TMSB10 can lead to the formation of blood clots, which can cause serious health problems. - In cancer, mutations in TMSB10 can promote tumor growth and metastasis. - Therefore, understanding the role of TMSB10 in cell migration and signaling may provide new insights into the development of novel therapeutic strategies for diseases that are characterized by abnormal cell migration.

Genular Protein ID: 3990741792

Symbol: TYB10_HUMAN

Name: Thymosin beta-10

UniProtKB Accession Codes:

P63313 P13472 Q596K9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3365256

Title: Sequence of a human kidney cDNA clone encoding thymosin beta 10.

PubMed ID: 3365256

DOI: 10.1016/s0006-291x(88)80118-9

PubMed ID: 2169566

Title: Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma.

PubMed ID: 2169566

DOI: 10.1016/0169-328x(90)90057-k

PubMed ID: 8425765

Title: Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma.

PubMed ID: 8425765

DOI: 10.1002/ijc.2910530218

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 44
  • Mass: 5026
  • Checksum: 5485277C275A1C70
  • Sequence:
    • MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.