Details for: TMEM132C

Gene ID: 92293

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TMEM132C

Ensembl ID: ENSG00000181234

Description: transmembrane protein 132C

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • adipocyte CL0000136
    CSI 53.64
    rCSI 68.87%
    PRS 86.01
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 46.87
    rCSI 58.31%
    PRS 80.14
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 34.44
    rCSI 62.59%
    PRS 87.65
  • cerebral cortex endothelial cell CL1001602
    CSI 30.15
    rCSI 52.15%
    PRS 88.62
  • vascular leptomeningeal cell CL4023051
    CSI 24.92
    rCSI 43.68%
    PRS 90.28
  • oligodendrocyte precursor cell CL0002453
    CSI 24.42
    rCSI 53.73%
    PRS 77.66
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 18.78
    rCSI 58.72%
    PRS 85.12
  • sst GABAergic cortical interneuron CL4023017
    CSI 16.55
    rCSI 21.33%
    PRS 83.34
  • choroid plexus epithelial cell CL0000706
    CSI 16.46
    rCSI 26.95%
    PRS 87.14
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 15.52
    rCSI 26.05%
    PRS 82.33
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 14.98
    rCSI 56.62%
    PRS 82.52
  • epicardial adipocyte CL1000309
    CSI 14.11
    rCSI 45.91%
    PRS 90.65
  • glioblast CL0000030
    CSI 13.56
    rCSI 21.63%
    PRS 86.5
  • VIP GABAergic cortical interneuron CL4023016
    CSI 12.12
    rCSI 14.48%
    PRS 82.37
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 11.25
    rCSI 19.86%
    PRS 81.64
  • subcutaneous adipocyte CL0002521
    CSI 11.09
    rCSI 56.82%
    PRS 94.47
  • retinal bipolar neuron CL0000748
    CSI 11.06
    rCSI 20.72%
    PRS 85.96
  • rod bipolar cell CL0000751
    CSI 10.88
    rCSI 19.55%
    PRS 88.74
  • ependymal cell CL0000065
    CSI 10.72
    rCSI 21.74%
    PRS 77.53
  • endocardial cell CL0002350
    CSI 9.7
    rCSI 46.44%
    PRS 90.24
  • fibroblast of lung CL0002553
    CSI 8.98
    rCSI 8.36%
    PRS 94.11
  • inhibitory interneuron CL0000498
    CSI 8.97
    rCSI 20.7%
    PRS 85.47
  • sncg GABAergic cortical interneuron CL4023015
    CSI 8.69
    rCSI 13.97%
    PRS 83.3
  • diffuse bipolar 3b cell CL4033030
    CSI 8.11
    rCSI 53.84%
    PRS 87.83
  • retinal cone cell CL0000573
    CSI 8.09
    rCSI 13.03%
    PRS 86.12
  • interneuron CL0000099
    CSI 7.96
    rCSI 15.99%
    PRS 87.95
  • flat midget bipolar cell CL4033033
    CSI 7.79
    rCSI 55.69%
    PRS 84.75
  • mesothelial cell CL0000077
    CSI 7.76
    rCSI 30.35%
    PRS 79.39
  • myofibroblast cell CL0000186
    CSI 7.66
    rCSI 10.61%
    PRS 90.21
  • diffuse bipolar 2 cell CL4033028
    CSI 7.52
    rCSI 58.23%
    PRS 86.38
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 7.45
    rCSI 26.81%
    PRS 80.45
  • cardiac endothelial cell CL0010008
    CSI 6.98
    rCSI 28.16%
    PRS 93.53
  • glycinergic amacrine cell CL4030028
    CSI 6.93
    rCSI 18.05%
    PRS 87.89
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 6.42
    rCSI 15.62%
    PRS 80.18
  • dopaminergic neuron CL0000700
    CSI 5.61
    rCSI 31.7%
    PRS 83.81
  • cerebellar granule cell CL0001031
    CSI 5.36
    rCSI 7.89%
    PRS 88.84
  • astrocyte of the cerebral cortex CL0002605
    CSI 5.34
    rCSI 11.98%
    PRS 82.55
  • alveolar type 1 fibroblast cell CL4028004
    CSI 5.29
    rCSI 5.8%
    PRS 94.4
  • bronchus fibroblast of lung CL2000093
    CSI 4.79
    rCSI 3.89%
    PRS 92.4
  • mature astrocyte CL0002627
    CSI 4.7
    rCSI 19.96%
    PRS 87.15
  • amacrine cell CL0000561
    CSI 4.56
    rCSI 13.21%
    PRS 85.82
  • keratocyte CL0002363
    CSI 4.39
    rCSI 10.56%
    PRS 93.52
  • cerebellar neuron CL1001611
    CSI 4.33
    rCSI 38.09%
    PRS 82.28
  • GABAergic neuron CL0000617
    CSI 4.15
    rCSI 13.92%
    PRS 81.47
  • renal interstitial pericyte CL1001318
    CSI 3.64
    rCSI 10.03%
    PRS 91.16
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.37
    rCSI 29.07%
    PRS 88.51
  • retinal ganglion cell CL0000740
    CSI 3.29
    rCSI 7.28%
    PRS 84.18
  • cardiac neuron CL0010022
    CSI 3.24
    rCSI 10.37%
    PRS 92.02
  • serotonergic neuron CL0000850
    CSI 2.95
    rCSI 13.19%
    PRS 80.21
  • brain vascular cell CL4023072
    CSI 2.64
    rCSI 27.35%
    PRS 87.31
  • central nervous system neuron CL2000029
    CSI 2.41
    rCSI 17.68%
    PRS 86.24
  • retinal pigment epithelial cell CL0002586
    CSI 2.12
    rCSI 4.21%
    PRS 90
  • fibroblast of cardiac tissue CL0002548
    CSI 2.04
    rCSI 9.79%
    PRS 93.79
  • alveolar adventitial fibroblast CL4028006
    CSI 2.03
    rCSI 3.21%
    PRS 93.91
  • Bergmann glial cell CL0000644
    CSI 1.99
    rCSI 2.72%
    PRS 86.7
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.9
    rCSI 4.55%
    PRS 84.33
  • invaginating midget bipolar cell CL4033034
    CSI 1.76
    rCSI 10.37%
    PRS 85.36
  • ON parasol ganglion cell CL4033052
    CSI 1.68
    rCSI 23.85%
    PRS 86.49
  • cardiac blood vessel endothelial cell CL0010006
    CSI 1.44
    rCSI 10.15%
    PRS 88.02
  • GABAergic amacrine cell CL4030027
    CSI 1.2
    rCSI 4.11%
    PRS 81.93
  • glial cell CL0000125
    CSI 1.02
    rCSI 3.89%
    PRS 87.42
  • stromal cell CL0000499
    CSI 1.01
    rCSI 2.85%
    PRS 89.63
  • ON midget ganglion cell CL4033046
    CSI 0.95
    rCSI 19.41%
    PRS 85.59
  • OFF midget ganglion cell CL4033047
    CSI 0.88
    rCSI 17.97%
    PRS 86.28
  • mesenchymal cell CL0008019
    CSI 0.84
    rCSI 2.13%
    PRS 88.77
  • direct pathway medium spiny neuron CL4023026
    CSI 0.42
    rCSI 10.06%
    PRS 80.1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TMEM132C](/details-gene/92293) (transmembrane protein 132C) is a protein-coding gene located on human chromosome 12q24.32-q24.33. As its name implies, it is annotated as an integral membrane protein, though its specific molecular function remains largely uncharacterized based on current annotations ([Link](https://pubmed.ncbi.nlm.nih.gov/17974005/)). Expression data indicate a prominent and highly significant role in two distinct biological systems: adipose tissue and the central nervous system. It is the top expressed gene in [adipocyte](/details-cell/CL0000136) and also shows high significance across a wide array of neuronal and glial cell types, including various GABAergic interneurons and oligodendrocyte precursors, suggesting it may be involved in fundamental cellular processes within these specialized cells. ## Cellular Roles and Expression Landscape The expression profile of [TMEM132C](/details-gene/92293) highlights a dual-context role, with profound significance in both metabolic and neural tissues. **Overall**, the gene's most significant expression is observed in [adipocyte](/details-cell/CL0000136) (CSI: 53.64), suggesting it is a key functional component of fat cells. This is further supported by its notable expression in [epicardial adipocyte](/details-cell/CL1000309). Concurrently, [TMEM132C](/details-gene/92293) demonstrates a broad and significant footprint within the central nervous system. It is highly expressed in multiple subtypes of inhibitory neurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), [chandelier pvalb GABAergic cortical interneuron](/details-cell/CL4023036), [sst GABAergic cortical interneuron](/details-cell/CL4023017), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011), and [VIP GABAergic cortical interneuron](/details-cell/CL4023016). Its presence is also noted in excitatory [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012). Beyond neurons, [TMEM132C](/details-gene/92293) is a significant marker for glial lineage cells, particularly [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) and [oligodendrocyte precursor cell](/details-cell/CL0002453), suggesting a potential role in myelination. The gene is also highly expressed in specialized cells of the neurovascular unit, such as [cerebral cortex endothelial cell](/details-cell/CL1001602) and [vascular leptomeningeal cell](/details-cell/CL4023051), as well as in [choroid plexus epithelial cell](/details-cell/CL0000706). Finally, its expression in [glioblast](/details-cell/CL0000030) may indicate a role in brain tumorigenesis. ## Pathways and Molecular Function The functional role of [TMEM132C](/details-gene/92293) is poorly defined, with current annotations limited to high-level, general Gene Ontology terms such as [biological_process (GO:0008150)](https://www.ebi.ac.uk/QuickGO/term/GO:0008150) and [molecular_function (GO:0003674)](https://www.ebi.ac.uk/QuickGO/term/GO:0003674). The most specific annotation confirms its localization to the [membrane (GO:0016020)](https://www.ebi.ac.uk/QuickGO/term/GO:0016020), which is consistent with its predicted transmembrane structure. This membrane localization within the diverse neuronal, glial, and adipose cells where it is highly expressed suggests it may function as a receptor, channel, or adhesion molecule involved in cell-cell communication or signal transduction specific to these lineages. The initial characterization of the human chromosome 12 sequence first identified the locus of this gene ([Link](https://doi.org/10.1038/nature04569)). ## Research Directions The distinct, high-level expression of [TMEM132C](/details-gene/92293) in both the central nervous system and adipose tissue, coupled with a lack of functional data, presents several compelling avenues for future research. **Proposed Hypotheses:** 1. Given its high expression in oligodendrocyte precursor cells and various interneuron subtypes, [TMEM132C](/details-gene/92293) may play a critical role in neurodevelopment, specifically in the processes of oligodendrocyte maturation, myelination, or the establishment and maintenance of inhibitory synaptic circuits. 2. The premier expression of [TMEM132C](/details-gene/92293) in adipocytes suggests a primary function in metabolic regulation, such as lipid droplet formation, glucose uptake, or adipokine signaling. Its dual expression in the brain and fat tissue could indicate a role as a sensor or mediator in the gut-brain axis, linking systemic metabolic state to central nervous system function. 3. The significant expression in [glioblast](/details-cell/CL0000030) suggests that [TMEM132C](/details-gene/92293) might be co-opted during tumorigenesis to support tumor cell survival, proliferation, or metabolic reprogramming. **Experimental Approach:** To test the hypothesis that [TMEM132C](/details-gene/92293) is involved in myelination, a conditional knockout (cKO) mouse model could be generated using the Cre-loxP system to specifically delete the gene in oligodendrocyte precursor cells (e.g., using a *Pdgfra-CreER* driver). Following gene deletion, detailed histological and ultrastructural analysis of the brain and spinal cord could be performed to assess the efficiency of oligodendrocyte differentiation (via markers like CC1 and MBP) and the integrity of myelin sheaths using electron microscopy. Functional consequences could be evaluated through behavioral tests assessing motor coordination and nerve conduction velocity studies. **Therapeutic Potential:** The therapeutic potential of [TMEM132C](/details-gene/92293) is currently speculative but intriguing. As a transmembrane protein, it is a potentially accessible cell-surface target. If its function is confirmed to be critical for glioblastoma cell survival, it could represent a promising target for antibody-drug conjugates or CAR-T cell therapies aimed at eradicating brain tumors. Conversely, if its role in oligodendrocytes is found to be pro-myelinating, developing agonists or activators of [TMEM132C](/details-gene/92293) could be a novel therapeutic strategy for demyelinating diseases like multiple sclerosis.

Genular Protein ID: 1282289253

Symbol: T132C_HUMAN

Name: Transmembrane protein 132C

UniProtKB Accession Codes:

Q8N3T6 Q69YX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 1108
  • Mass: 121787
  • Checksum: FB0298520B3AAE2B
  • Sequence:
    • MRSEGAAPGP AAPLCGALSL LLGALLGKVI EGHGVTDNIQ RFSSLPPYLP VSYHILRAET 
SFFLKEANQD LLRNSSLQAR VESFFTYKTR QPPVLNASYG PFSVEKVVPL DLMLTSNFLG 
PTNKFSFDWK LKAHILRDKV YLSRPKVQVL FHIMGRDWDD HGAGEKLPCL RVFAFRETRE 
VRGSCRLKGD LGLCVAELEL LSSWFSAPTV GAGRKKSMDQ PEGTPVELYY TVHPGNERGD 
CAGGDFRKGN AIRPGKDGLE ETTSHLQRIG TVGLYRAQDS AQLSELRLDG NVVIWLPSRP 
VKQGEVVTAY VTISSNSSVD LFILRAKVKK GVNILSAQTR EPRQWGVKQE VGSGGKHVTA 
TVACQRLGPS PRNRSSSLFN EVVQMNFEIA SFSSLSGTQP ITWQVEYPRK GTTDIAVSEI 
FVSQKDLVGI VPLAMDTEIL NTAVLTGKTV AMPIKVVSVE ENSAVMDISE SVECKSTDED 
VIKVSERCDY IFVNGKEIKG KMDAVVNFTY QYLSAPLCVT VWVPRLPLQI EVSDTELSQI 
KGWRVPIVTN KRPTRESEDE DEEERRGRGC ALQYQHATVR VLTQFVSEGA GPWGQPNYLL 
SPNWQFDITH LVADFMKLEE PHVATLQDSR VLVGREVGMT TIQVLSPLSD SILAEKTITV 
LDDKVSVTDL AIQLVAGLSV ALYPNAENSK AVTAVVTAEE VLRTPKQEAV FSTWLQFSDG 
SVTPLDIYDT KDFSLAATSQ DEAVVSVPQP RSPRWPVVVA EGEGQGPLIR VDMTIAEACQ 
KSKRKSILAV GVGNVRVKFG QNDADSSPGG DYEEDEIKNH ASDRRQKGQH HERTGQDGHL 
YGSSPVEREE GALRRATTTA RSLLDNKVVK NSRADGGRLA GEGQLQNIPI DFTNFPAHVD 
LPKAGSGLEE NDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL KYRHKQVPLE 
GQASMTHSHD WVWLGNEAEL LESMGDAPPP QDEHTTIIDR GPGACEESNH LLLNGGSHKH 
VQSQIHRSAD SGGRQGREQK QDPLHSPTSK RKKVKFTTFT TIPPDDSCPT VNSIVSSNDE 
DIKWVCQDVA VGAPKELRNY LEKLKDKA