Details for: LINC01266

Gene ID: 101927215

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01266

Ensembl ID: ENSG00000224957

Description: long intergenic non-protein coding RNA 1266

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • melanocyte CL0000148
    CSI 16.54
    rCSI 12.25%
    PRS 85.03
  • cardiac muscle cell CL0000746
    CSI 13.92
    rCSI 19.97%
    PRS 81.09
  • fibroblast of lung CL0002553
    CSI 12.97
    rCSI 12.07%
    PRS 90.28
  • renal principal cell CL0005009
    CSI 11.56
    rCSI 30.03%
    PRS 88.55
  • alveolar type 1 fibroblast cell CL4028004
    CSI 11.45
    rCSI 12.54%
    PRS 90.64
  • retinal pigment epithelial cell CL0002586
    CSI 10.9
    rCSI 21.64%
    PRS 85.41
  • mesothelial cell CL0000077
    CSI 10.65
    rCSI 41.66%
    PRS 71.36
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 10.35
    rCSI 26.75%
    PRS 85.9
  • hepatic stellate cell CL0000632
    CSI 10.34
    rCSI 38.75%
    PRS 84.03
  • rod bipolar cell CL0000751
    CSI 10.07
    rCSI 18.09%
    PRS 83.86
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 8.7
    rCSI 21.14%
    PRS 72.97
  • retinal rod cell CL0000604
    CSI 8.49
    rCSI 14.97%
    PRS 84.96
  • Bergmann glial cell CL0000644
    CSI 7.88
    rCSI 10.79%
    PRS 81.25
  • cerebral cortex endothelial cell CL1001602
    CSI 7.85
    rCSI 13.58%
    PRS 83.34
  • regular atrial cardiac myocyte CL0002129
    CSI 6.02
    rCSI 19.38%
    PRS 85.79
  • retinal ganglion cell CL0000740
    CSI 5.88
    rCSI 12.98%
    PRS 78.01
  • alveolar adventitial fibroblast CL4028006
    CSI 5.57
    rCSI 8.79%
    PRS 89.99
  • retinal cone cell CL0000573
    CSI 5.47
    rCSI 8.81%
    PRS 81.09
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 5.36
    rCSI 13.97%
    PRS 90.49
  • epithelial cell of proximal tubule CL0002306
    CSI 5.26
    rCSI 12.83%
    PRS 82.21
  • kidney connecting tubule epithelial cell CL1000768
    CSI 5.07
    rCSI 12.85%
    PRS 82.31
  • adipocyte CL0000136
    CSI 5
    rCSI 6.42%
    PRS 80.67
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.97
    rCSI 11.15%
    PRS 75.75
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 4.94
    rCSI 42.65%
    PRS 83.73
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.9
    rCSI 6.95%
    PRS 86.64
  • retinal bipolar neuron CL0000748
    CSI 4.86
    rCSI 9.1%
    PRS 80.13
  • amacrine cell CL0000561
    CSI 4.62
    rCSI 13.38%
    PRS 80.33
  • myoepithelial cell CL0000185
    CSI 4.13
    rCSI 10.45%
    PRS 91.9
  • bronchus fibroblast of lung CL2000093
    CSI 3.92
    rCSI 3.18%
    PRS 88.42
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 3.87
    rCSI 14.63%
    PRS 75.52
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.83
    rCSI 4.77%
    PRS 73.05
  • Mueller cell CL0000636
    CSI 3.81
    rCSI 8.69%
    PRS 82.2
  • endocardial cell CL0002350
    CSI 3.77
    rCSI 18.05%
    PRS 85.21
  • renal interstitial pericyte CL1001318
    CSI 3.42
    rCSI 9.42%
    PRS 86.14
  • basal cell of epidermis CL0002187
    CSI 3.2
    rCSI 5.67%
    PRS 59.95
  • cerebellar granule cell CL0001031
    CSI 3.18
    rCSI 4.68%
    PRS 83.6
  • GABAergic amacrine cell CL4030027
    CSI 3.18
    rCSI 10.89%
    PRS 76.27
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 2.98
    rCSI 7.12%
    PRS 78.21
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.89
    rCSI 5.26%
    PRS 82.42
  • lung secretory cell CL1000272
    CSI 2.67
    rCSI 6.61%
    PRS 89.58
  • tracheobronchial smooth muscle cell CL0019019
    CSI 2.65
    rCSI 4.67%
    PRS 92.08
  • conjunctival epithelial cell CL1000432
    CSI 2.56
    rCSI 3.92%
    PRS 88.47
  • ON midget ganglion cell CL4033046
    CSI 2.46
    rCSI 50.08%
    PRS 80.18
  • lung neuroendocrine cell CL1000223
    CSI 2.43
    rCSI 3.59%
    PRS 91.1
  • direct pathway medium spiny neuron CL4023026
    CSI 2.38
    rCSI 56.87%
    PRS 72.96
  • mesangial cell CL0000650
    CSI 2.37
    rCSI 9.65%
    PRS 94.33
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.35
    rCSI 56.81%
    PRS 73.24
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 2.18
    rCSI 7.86%
    PRS 73.18
  • keratocyte CL0002363
    CSI 2.18
    rCSI 5.24%
    PRS 90.46
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 2.15
    rCSI 4.66%
    PRS 77.87
  • renal beta-intercalated cell CL0002201
    CSI 2.05
    rCSI 4.89%
    PRS 89.1
  • chondrocyte CL0000138
    CSI 2.03
    rCSI 3.22%
    PRS 84.05
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.91
    rCSI 20.21%
    PRS 85.22
  • parietal epithelial cell CL1000452
    CSI 1.88
    rCSI 5.02%
    PRS 83.2
  • choroid plexus epithelial cell CL0000706
    CSI 1.67
    rCSI 2.73%
    PRS 81.42
  • Hofbauer cell CL3000001
    CSI 1.58
    rCSI 2.99%
    PRS 94.11
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.55
    rCSI 1.86%
    PRS 75.31
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.3
    rCSI 1.57%
    PRS 69.86
  • stromal cell CL0000499
    CSI 1.26
    rCSI 3.54%
    PRS 85.09
  • blood vessel smooth muscle cell CL0019018
    CSI 0.79
    rCSI 6.4%
    PRS 85.75
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.62
    rCSI 1.94%
    PRS 78.49
  • ON parasol ganglion cell CL4033052
    CSI 0.47
    rCSI 6.68%
    PRS 81.24

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01266](/details-gene/101927215) is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 3p26.3. As a non-coding RNA, it is presumed to exert its function through regulatory mechanisms rather than by being translated into a protein. The expression profile of [LINC01266](/details-gene/101927215) is characterized by high specificity in a remarkably diverse set of cell types across multiple tissues. **Overall**, it shows the highest significance in [melanocytes](/details-cell/CL0000148), [cardiac muscle cells](/details-cell/CL0000746), and various fibroblasts, suggesting potential roles in cell differentiation, tissue homeostasis, and structural integrity. Its broad but selective expression pattern points towards a role as a regulator of specialized cellular functions rather than a ubiquitous housekeeping gene. ## Cellular Roles and Expression Landscape The expression data for [LINC01266](/details-gene/101927215) indicates a distinct and specialized cellular distribution, suggesting it is a key functional component in specific cell lineages rather than a broad tissue marker. - **Dermal and Pigment Cells:** The most significant expression is observed in [melanocytes](/details-cell/CL0000148) (CSI: 16.54), highlighting a potential role in pigmentation, melanocyte development, or response to UV radiation. - **Cardiovascular and Fibroblastic Cells:** [LINC01266](/details-gene/101927215) shows high significance in contractile and structural cells, including [cardiac muscle cells](/details-cell/CL0000746) (CSI: 13.92) and [fibroblasts of the lung](/details-cell/CL0002553) (CSI: 12.97). This pattern is reinforced by its prominence in [alveolar type 1 fibroblast cells](/details-cell/CL4028004) (CSI: 11.45), [hepatic stellate cells](/details-cell/CL0000632) (CSI: 10.34), and [mesothelial cells](/details-cell/CL0000077) (CSI: 10.65). This collective signature suggests a potential involvement in tissue architecture, mechanotransduction, or fibrotic processes. - **Epithelial and Endothelial Cells:** The lncRNA is a significant marker in specialized epithelial cells of the kidney, such as [renal principal cells](/details-cell/CL0005009) (CSI: 11.56) and [kidney loop of Henle thin ascending limb epithelial cells](/details-cell/CL1001107) (CSI: 10.35). Its expression in [cerebral cortex endothelial cells](/details-cell/CL1001602) (CSI: 7.85) may point to a role in the blood-brain barrier. - **Neural and Retinal Cells:** A notable expression signature is found within the nervous system, particularly the eye. High significance is observed in [retinal pigment epithelial cells](/details-cell/CL0002586) (CSI: 10.90), [rod bipolar cells](/details-cell/CL0000751) (CSI: 10.07), and [retinal rod cells](/details-cell/CL0000604) (CSI: 8.49). Furthermore, its expression in [L2/3-6 intratelencephalic projecting glutamatergic neurons](/details-cell/CL4023040) (CSI: 8.70) and [Bergmann glial cells](/details-cell/CL0000644) (CSI: 7.88) suggests a role in specialized neuronal or glial function. The diverse nature of these cell types—spanning ectodermal, mesodermal, and endodermal lineages—suggests that [LINC01266](/details-gene/101927215) may be regulated by developmental pathways that specify terminal differentiation across multiple organ systems. ## Pathways and Molecular Function The provided data does not include specific functional annotations from GO or Reactome pathway databases for [LINC01266](/details-gene/101927215). As a lncRNA, it is hypothesized to function at the transcriptional or post-transcriptional level. Potential mechanisms include acting as a scaffold for chromatin-modifying complexes, sequestering microRNAs (acting as a "sponge"), or directly binding to transcription factors to modulate gene expression. Its high expression in cell types heavily involved in fibrosis ([fibroblasts](/details-cell/CL0002553), [hepatic stellate cells](/details-cell/CL0000632)) and tissue remodeling ([cardiac muscle cells](/details-cell/CL0000746)) suggests a possible regulatory role in pathways governing cellular stress responses and extracellular matrix deposition, such as the TGF-beta signaling pathway. ## Research Directions The unique and highly specific expression pattern of [LINC01266](/details-gene/101927215) across diverse, terminally differentiated cells presents several avenues for future research. **Proposed Testable Hypotheses:** 1. Given its high expression in [fibroblasts of the lung](/details-cell/CL0002553), [cardiac muscle cells](/details-cell/CL0000746), and [hepatic stellate cells](/details-cell/CL0000632), [LINC01266](/details-gene/101927215) is a pro-fibrotic regulator that becomes upregulated upon tissue injury and promotes the differentiation of fibroblasts into myofibroblasts. 2. Based on its co-expression in multiple, functionally linked retinal cell types ([retinal rod cell](/details-cell/CL0000604), [rod bipolar cell](/details-cell/CL0000751), [retinal pigment epithelial cell](/details-cell/CL0002586)), [LINC01266](/details-gene/101927215) is essential for the maintenance and function of the phototransduction cascade or the structural integrity of the outer retina. 3. The top-ranked expression in [melanocytes](/details-cell/CL0000148) suggests that [LINC01266](/details-gene/101927215) regulates melanogenesis by modulating the expression or activity of key transcription factors like MITF. **Suggested Experimental Approach:** To test the hypothesis that [LINC01266](/details-gene/101927215) is a pro-fibrotic regulator (Hypothesis 1), an *in vitro* study could be conducted. Primary human lung fibroblasts would be stimulated with TGF-beta1 to induce a fibrotic response. The expression of [LINC01266](/details-gene/101927215) would be quantified using qRT-PCR. Subsequently, [LINC01266](/details-gene/101927215) could be silenced using locked nucleic acid (LNA) GapmeRs or an siRNA-based approach. The effect of this knockdown on the expression of key fibrotic markers, such as alpha-smooth muscle actin (ACTA2) and collagen type I (COL1A1), would be assessed at both the mRNA and protein levels. Furthermore, RNA-sequencing following [LINC01266](/details-gene/101927215) knockdown could reveal its downstream transcriptional targets and affected pathways. **Therapeutic Potential:** The high cell-type specificity of [LINC01266](/details-gene/101927215) makes it an intriguing therapeutic target. If its role as a pro-fibrotic factor is confirmed in diseases such as idiopathic pulmonary fibrosis, cardiac fibrosis, or liver cirrhosis, its **inhibition** could be a viable therapeutic strategy. LncRNAs can be targeted with modalities like antisense oligonucleotides (ASOs) or siRNAs. The specificity of its expression may help to limit off-target effects. However, its significant presence in diverse critical tissues, including the heart, retina, and brain, mandates a thorough safety assessment, as systemic delivery of an inhibitor could lead to unintended consequences in these other organ systems.