Details for: RACK1

Gene ID: 10399

Symbol: RACK1

Ensembl ID: ENSG00000204628

Description: receptor for activated C kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 9.05
    Marker Score: 9804
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.1
    Marker Score: 4080.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.93
    Marker Score: 12517
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 5.86
    Marker Score: 1717
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.54
    Marker Score: 11604.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.3
    Marker Score: 71224.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.18
    Marker Score: 3658
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.17
    Marker Score: 7956
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.16
    Marker Score: 51112
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.15
    Marker Score: 4125.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.06
    Marker Score: 3258
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.02
    Marker Score: 14638.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.9
    Marker Score: 166798
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.81
    Marker Score: 3450
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.79
    Marker Score: 15131
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.71
    Marker Score: 249087
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.69
    Marker Score: 1728
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.65
    Marker Score: 3511.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.58
    Marker Score: 2779
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.57
    Marker Score: 3882
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.54
    Marker Score: 3295
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.51
    Marker Score: 5877.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.49
    Marker Score: 2309
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.48
    Marker Score: 59047
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 4.39
    Marker Score: 2573
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.29
    Marker Score: 49859
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.29
    Marker Score: 2609
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.29
    Marker Score: 239640
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.25
    Marker Score: 22341
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.18
    Marker Score: 11556.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.18
    Marker Score: 3728
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.16
    Marker Score: 11674
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.16
    Marker Score: 7132.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.13
    Marker Score: 3994.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.1
    Marker Score: 9340
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17513
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.08
    Marker Score: 9974
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.08
    Marker Score: 4536
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.06
    Marker Score: 3457
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.05
    Marker Score: 3456
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.04
    Marker Score: 1313
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.04
    Marker Score: 2083
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.02
    Marker Score: 29942.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.02
    Marker Score: 960
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 4.01
    Marker Score: 4014.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3932.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.97
    Marker Score: 14095
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.97
    Marker Score: 4235
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.96
    Marker Score: 3107
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.93
    Marker Score: 5790
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.89
    Marker Score: 7309.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.86
    Marker Score: 25153
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.85
    Marker Score: 9798.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.85
    Marker Score: 4643
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.83
    Marker Score: 1724
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.81
    Marker Score: 10208
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.81
    Marker Score: 2979
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.78
    Marker Score: 15708
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.78
    Marker Score: 2487
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.77
    Marker Score: 3128
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.77
    Marker Score: 3169
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.73
    Marker Score: 2478
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.73
    Marker Score: 24242
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.71
    Marker Score: 2050
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.7
    Marker Score: 3299.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.69
    Marker Score: 2626
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.69
    Marker Score: 1215
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 3.68
    Marker Score: 8285.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.68
    Marker Score: 2052
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.65
    Marker Score: 3243
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.64
    Marker Score: 6621
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.63
    Marker Score: 1562
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.62
    Marker Score: 17784.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.6
    Marker Score: 2384
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.58
    Marker Score: 22810
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.56
    Marker Score: 13794
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.56
    Marker Score: 1595.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.56
    Marker Score: 3344
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.56
    Marker Score: 3172
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.53
    Marker Score: 4900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.52
    Marker Score: 5773
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.52
    Marker Score: 932
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.52
    Marker Score: 4024
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.51
    Marker Score: 7976
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 3.49
    Marker Score: 3629
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.49
    Marker Score: 4117
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.48
    Marker Score: 20646.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.47
    Marker Score: 8756
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.47
    Marker Score: 913
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.47
    Marker Score: 2506
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.46
    Marker Score: 794
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.46
    Marker Score: 1261
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.44
    Marker Score: 913
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.43
    Marker Score: 1951
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.43
    Marker Score: 3797
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.43
    Marker Score: 30126.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.43
    Marker Score: 1100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.42
    Marker Score: 1426
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.42
    Marker Score: 3675
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.4
    Marker Score: 1979

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Other Information

**Key characteristics:** - RACK1 is a type I transmembrane receptor that is expressed in high levels in cells that are involved in immune responses. - It is a key regulator of the activation of the C kinase/protein kinase B (Cdk/PKB) pathway, a signaling pathway that is involved in cell growth, differentiation, and apoptosis. - RACK1 is a key regulator of the activation of the TNF receptor superfamily (TNFRs), a family of immune receptors that are involved in inflammation and cell death. **Pathways and functions:** - RACK1 is a key regulator of apoptosis, a process by which cells die on their own. - It is a key regulator of the activation of the Cdk/PKB pathway, which is involved in cell growth, differentiation, and apoptosis. - It is also a key regulator of the activation of the TNFRs, a family of immune receptors that are involved in inflammation and cell death. - RACK1 is also involved in the regulation of cell migration, adhesion, and signaling. **Clinical significance:** - Mutations in RACK1 have been linked to several human diseases, including cancer, autoimmune disorders, and inflammatory diseases. - Targeting RACK1 has been explored as a therapeutic strategy for these diseases.

Genular Protein ID: 770579806

Symbol: RACK1_HUMAN

Name: Cell proliferation-inducing gene 21 protein

UniProtKB Accession Codes:

P63244 B3KTJ0 D3DWS0 P25388 P99049 Q53HU2 Q5J8M6 Q5VLR4 Q6FH47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 19 EMDB 54 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 69 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 79 PDBsum 71 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2499885

Title: Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex.

PubMed ID: 2499885

DOI: 10.1073/pnas.86.12.4594

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9584165

Title: RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.

PubMed ID: 9584165

DOI: 10.1128/mcb.18.6.3245

PubMed ID: 10849009

Title: The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1.

PubMed ID: 10849009

DOI: 10.1046/j.1432-1327.2000.01430.x

PubMed ID: 11279199

Title: The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1.

PubMed ID: 11279199

DOI: 10.1074/jbc.m101375200

PubMed ID: 11312657

Title: Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor.

PubMed ID: 11312657

DOI: 10.1006/viro.2001.0855

PubMed ID: 11956211

Title: Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor.

PubMed ID: 11956211

DOI: 10.1074/jbc.m201917200

PubMed ID: 11884618

Title: RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.

PubMed ID: 11884618

DOI: 10.1128/mcb.22.7.2345-2365.2002

PubMed ID: 12400005

Title: RACK1: a novel substrate for the Src protein-tyrosine kinase.

PubMed ID: 12400005

DOI: 10.1038/sj.onc.1206002

PubMed ID: 14500341

Title: Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus.

PubMed ID: 14500341

PubMed ID: 12958311

Title: The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway.

PubMed ID: 12958311

DOI: 10.1074/jbc.m306219200

PubMed ID: 12589061

Title: RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site.

PubMed ID: 12589061

DOI: 10.1091/mbc.e02-03-0142

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15140893

Title: Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization.

PubMed ID: 15140893

DOI: 10.1074/jbc.m402316200

PubMed ID: 15596539

Title: Muscle ring finger protein-1 inhibits PKC-epsilon activation and prevents cardiomyocyte hypertrophy.

PubMed ID: 15596539

DOI: 10.1083/jcb.200402033

PubMed ID: 14699138

Title: Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.

PubMed ID: 14699138

DOI: 10.1074/jbc.m306672200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17108144

Title: Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.

PubMed ID: 17108144

DOI: 10.1158/0008-5472.can-06-0596

PubMed ID: 17956333

Title: Interaction of integrin beta1 with cytokeratin 1 in neuroblastoma NMB7 cells.

PubMed ID: 17956333

DOI: 10.1042/bst0351292

PubMed ID: 17244529

Title: RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.

PubMed ID: 17244529

DOI: 10.1016/j.molcel.2007.01.001

PubMed ID: 18258429

Title: RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain.

PubMed ID: 18258429

DOI: 10.1016/j.cub.2007.12.058

PubMed ID: 18621736

Title: RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.

PubMed ID: 18621736

DOI: 10.1074/jbc.m709829200

PubMed ID: 18057008

Title: Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1.

PubMed ID: 18057008

DOI: 10.1074/jbc.m705146200

PubMed ID: 18088317

Title: RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2).

PubMed ID: 18088317

DOI: 10.1111/j.1600-0854.2007.00692.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19785988

Title: RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation.

PubMed ID: 19785988

DOI: 10.1016/j.bbrc.2009.09.087

PubMed ID: 18954305

Title: Structural basis and specificity of human otubain 1-mediated deubiquitination.

PubMed ID: 18954305

DOI: 10.1042/bj20081318

PubMed ID: 19674157

Title: Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4.

PubMed ID: 19674157

DOI: 10.1111/j.1872-034x.2009.00544.x

PubMed ID: 19423701

Title: Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

PubMed ID: 19423701

DOI: 10.1074/jbc.m109.017640

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20541605

Title: RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL.

PubMed ID: 20541605

DOI: 10.1016/j.cellsig.2010.05.018

PubMed ID: 20010870

Title: Copine-III interacts with ErbB2 and promotes tumor cell migration.

PubMed ID: 20010870

DOI: 10.1038/onc.2009.456

PubMed ID: 20976005

Title: RACK1 associates with muscarinic receptors and regulates M(2) receptor trafficking.

PubMed ID: 20976005

DOI: 10.1371/journal.pone.0013517

PubMed ID: 20573744

Title: A stimulatory role for the La-related protein 4B in translation.

PubMed ID: 20573744

DOI: 10.1261/rna.2146910

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20499158

Title: RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway.

PubMed ID: 20499158

DOI: 10.1007/s10549-010-0955-3

PubMed ID: 21212275

Title: RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway.

PubMed ID: 21212275

DOI: 10.1074/jbc.m110.165605

PubMed ID: 21098120

Title: La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.

PubMed ID: 21098120

DOI: 10.1128/mcb.01162-10

PubMed ID: 21347310

Title: The RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence function.

PubMed ID: 21347310

DOI: 10.1371/journal.pone.0016784

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22174419

Title: Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction.

PubMed ID: 22174419

DOI: 10.1074/jbc.m111.305854

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24006492

Title: Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling.

PubMed ID: 24006492

DOI: 10.1091/mbc.e12-06-0445

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25416947

Title: RACK1 controls IRES-mediated translation of viruses.

PubMed ID: 25416947

DOI: 10.1016/j.cell.2014.10.041

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28161490

Title: Structural analysis of ribosomal RACK1 and its role in translational control.

PubMed ID: 28161490

DOI: 10.1016/j.cellsig.2017.01.026

PubMed ID: 28636603

Title: Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.

PubMed ID: 28636603

DOI: 10.1038/nature22814

PubMed ID: 29743600

Title: Trafficking, localization and degradation of the Na+,HCO3- co-transporter NBCn1 in kidney and breast epithelial cells.

PubMed ID: 29743600

DOI: 10.1038/s41598-018-25059-7

PubMed ID: 37712706

Title: The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association.

PubMed ID: 37712706

DOI: 10.1128/jvi.00747-23

PubMed ID: 20529362

Title: Solution structure of the human signaling protein RACK1.

PubMed ID: 20529362

DOI: 10.1186/1472-6807-10-15

PubMed ID: 22869111

Title: Structure of human Rack1 protein at a resolution of 2.45 A.

PubMed ID: 22869111

DOI: 10.1107/s1744309112027480

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 317
  • Mass: 35077
  • Checksum: 257F91E369ED2044
  • Sequence:
    • MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR 
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI 
VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA 
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC 
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA 
GYTDNLVRVW QVTIGTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.