Details for: RACK1

Gene ID: 10399

Symbol: RACK1

Ensembl ID: ENSG00000204628

Description: receptor for activated C kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 662.4872
    Cell Significance Index: -272.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 589.2327
    Cell Significance Index: -239.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 540.2833
    Cell Significance Index: -255.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 511.4843
    Cell Significance Index: -263.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 381.9993
    Cell Significance Index: -256.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 254.9377
    Cell Significance Index: -243.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 58.7897
    Cell Significance Index: -180.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.5889
    Cell Significance Index: -89.9800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 13.8638
    Cell Significance Index: 81.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.3022
    Cell Significance Index: 157.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.8843
    Cell Significance Index: 412.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.2379
    Cell Significance Index: 295.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.7508
    Cell Significance Index: 204.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.5567
    Cell Significance Index: 1234.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 9.2325
    Cell Significance Index: 430.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 9.2169
    Cell Significance Index: 100.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.7593
    Cell Significance Index: 251.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.5449
    Cell Significance Index: 1173.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.5183
    Cell Significance Index: 150.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.4697
    Cell Significance Index: 96.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.0339
    Cell Significance Index: 568.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.9081
    Cell Significance Index: 371.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.7366
    Cell Significance Index: 951.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.2896
    Cell Significance Index: 543.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.2568
    Cell Significance Index: 1308.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.1499
    Cell Significance Index: 461.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.9965
    Cell Significance Index: 3820.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.9286
    Cell Significance Index: 3063.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.8309
    Cell Significance Index: 805.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.6386
    Cell Significance Index: 153.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.5973
    Cell Significance Index: 193.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.0417
    Cell Significance Index: 164.4500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.9472
    Cell Significance Index: 39.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.5760
    Cell Significance Index: 586.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.3285
    Cell Significance Index: 61.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.7317
    Cell Significance Index: 142.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2877
    Cell Significance Index: 454.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.9607
    Cell Significance Index: 1484.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7540
    Cell Significance Index: 79.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7402
    Cell Significance Index: 1571.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4671
    Cell Significance Index: 13.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.9679
    Cell Significance Index: 14.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8974
    Cell Significance Index: 47.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8896
    Cell Significance Index: 46.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8560
    Cell Significance Index: 162.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6457
    Cell Significance Index: 473.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4526
    Cell Significance Index: 44.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3729
    Cell Significance Index: 25.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3467
    Cell Significance Index: 9.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0790
    Cell Significance Index: 2.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0729
    Cell Significance Index: 1.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0099
    Cell Significance Index: -1.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0305
    Cell Significance Index: -3.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0494
    Cell Significance Index: -92.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0964
    Cell Significance Index: -16.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1165
    Cell Significance Index: -5.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1244
    Cell Significance Index: -229.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1272
    Cell Significance Index: -45.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1463
    Cell Significance Index: -225.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2143
    Cell Significance Index: -291.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.3121
    Cell Significance Index: -231.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3248
    Cell Significance Index: -206.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3300
    Cell Significance Index: -13.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.3625
    Cell Significance Index: -250.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4152
    Cell Significance Index: -67.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.4178
    Cell Significance Index: -235.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.4902
    Cell Significance Index: -306.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5147
    Cell Significance Index: -233.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7742
    Cell Significance Index: -61.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8107
    Cell Significance Index: -233.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8143
    Cell Significance Index: -26.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1654
    Cell Significance Index: -20.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2225
    Cell Significance Index: -31.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -1.3773
    Cell Significance Index: -290.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4223
    Cell Significance Index: -79.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4450
    Cell Significance Index: -165.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4701
    Cell Significance Index: -90.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5436
    Cell Significance Index: -224.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7086
    Cell Significance Index: -42.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.7142
    Cell Significance Index: -199.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.7645
    Cell Significance Index: -111.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.1609
    Cell Significance Index: -129.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.3052
    Cell Significance Index: -81.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.4096
    Cell Significance Index: -250.9000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -3.1386
    Cell Significance Index: -26.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.2047
    Cell Significance Index: -69.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.2605
    Cell Significance Index: -250.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.4206
    Cell Significance Index: -51.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.4311
    Cell Significance Index: -230.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.6819
    Cell Significance Index: -225.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -3.9383
    Cell Significance Index: -66.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -4.3289
    Cell Significance Index: -124.7300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -4.7578
    Cell Significance Index: -34.1700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -4.9984
    Cell Significance Index: -70.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.0609
    Cell Significance Index: -149.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.3556
    Cell Significance Index: -73.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.4497
    Cell Significance Index: -241.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.5482
    Cell Significance Index: -95.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -5.9320
    Cell Significance Index: -152.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.0127
    Cell Significance Index: -220.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** RACK1 is a cytoplasmic protein that belongs to the receptor-associated protein-1 (RAP-1) family. It is characterized by its ability to bind to various signaling molecules, including activated C kinase 1 (AKT), receptor tyrosine kinases (RTKs), and death receptors. RACK1 is also known for its involvement in the regulation of cell growth, apoptosis, and gene expression. **Pathways and functions** RACK1 is involved in numerous signaling pathways, including: 1. **Apoptotic process**: RACK1 interacts with pro-apoptotic proteins, such as BAX and BAK, and inhibits their activity, thereby promoting cell survival. 2. **Cell cycle regulation**: RACK1 regulates the cell cycle by interacting with cyclin-dependent kinases (CDKs) and inhibiting their activity. 3. **Gene expression regulation**: RACK1 modulates gene expression by interacting with transcription factors, such as NF-κB and AP-1. 4. **Signaling adaptor activity**: RACK1 serves as a scaffold protein, bridging signaling molecules and facilitating their interactions. 5. **Cell migration and invasion**: RACK1 regulates cell migration and invasion by interacting with proteins involved in the epithelial-to-mesenchymal transition (EMT) process. **Clinical significance** RACK1 is significantly expressed in various cell types, including follicular B cells, skeletal muscle satellite cells, and malignant cells. Its dysregulation has been implicated in several diseases, including: 1. **Cancer**: RACK1 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune diseases**: RACK1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious diseases**: RACK1 has been shown to interact with proteins involved in the regulation of immune responses, such as Toll-like receptors (TLRs) and cytokine receptors. In conclusion, RACK1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell signaling, apoptosis, and gene expression. Its dysregulation has been implicated in several diseases, highlighting the importance of RACK1 as a potential therapeutic target. **Future research directions** 1. **Investigate the role of RACK1 in cancer**: Further studies are needed to understand the mechanisms by which RACK1 contributes to cancer development and progression. 2. **Explore the therapeutic potential of RACK1 inhibitors**: RACK1 inhibitors may offer a novel therapeutic strategy for treating autoimmune diseases and cancer. 3. **Elucidate the mechanisms of RACK1 regulation**: Further research is needed to understand the mechanisms by which RACK1 is regulated, including the interactions between RACK1 and other signaling molecules.

Genular Protein ID: 770579806

Symbol: RACK1_HUMAN

Name: Cell proliferation-inducing gene 21 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2499885

Title: Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex.

PubMed ID: 2499885

DOI: 10.1073/pnas.86.12.4594

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9584165

Title: RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.

PubMed ID: 9584165

DOI: 10.1128/mcb.18.6.3245

PubMed ID: 10849009

Title: The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1.

PubMed ID: 10849009

DOI: 10.1046/j.1432-1327.2000.01430.x

PubMed ID: 11279199

Title: The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1.

PubMed ID: 11279199

DOI: 10.1074/jbc.m101375200

PubMed ID: 11312657

Title: Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor.

PubMed ID: 11312657

DOI: 10.1006/viro.2001.0855

PubMed ID: 11956211

Title: Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor.

PubMed ID: 11956211

DOI: 10.1074/jbc.m201917200

PubMed ID: 11884618

Title: RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.

PubMed ID: 11884618

DOI: 10.1128/mcb.22.7.2345-2365.2002

PubMed ID: 12400005

Title: RACK1: a novel substrate for the Src protein-tyrosine kinase.

PubMed ID: 12400005

DOI: 10.1038/sj.onc.1206002

PubMed ID: 14500341

Title: Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus.

PubMed ID: 14500341

PubMed ID: 12958311

Title: The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway.

PubMed ID: 12958311

DOI: 10.1074/jbc.m306219200

PubMed ID: 12589061

Title: RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site.

PubMed ID: 12589061

DOI: 10.1091/mbc.e02-03-0142

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15140893

Title: Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization.

PubMed ID: 15140893

DOI: 10.1074/jbc.m402316200

PubMed ID: 15596539

Title: Muscle ring finger protein-1 inhibits PKC-epsilon activation and prevents cardiomyocyte hypertrophy.

PubMed ID: 15596539

DOI: 10.1083/jcb.200402033

PubMed ID: 14699138

Title: Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.

PubMed ID: 14699138

DOI: 10.1074/jbc.m306672200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17108144

Title: Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor.

PubMed ID: 17108144

DOI: 10.1158/0008-5472.can-06-0596

PubMed ID: 17956333

Title: Interaction of integrin beta1 with cytokeratin 1 in neuroblastoma NMB7 cells.

PubMed ID: 17956333

DOI: 10.1042/bst0351292

PubMed ID: 17244529

Title: RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.

PubMed ID: 17244529

DOI: 10.1016/j.molcel.2007.01.001

PubMed ID: 18258429

Title: RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain.

PubMed ID: 18258429

DOI: 10.1016/j.cub.2007.12.058

PubMed ID: 18621736

Title: RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.

PubMed ID: 18621736

DOI: 10.1074/jbc.m709829200

PubMed ID: 18057008

Title: Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1.

PubMed ID: 18057008

DOI: 10.1074/jbc.m705146200

PubMed ID: 18088317

Title: RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2).

PubMed ID: 18088317

DOI: 10.1111/j.1600-0854.2007.00692.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19785988

Title: RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation.

PubMed ID: 19785988

DOI: 10.1016/j.bbrc.2009.09.087

PubMed ID: 18954305

Title: Structural basis and specificity of human otubain 1-mediated deubiquitination.

PubMed ID: 18954305

DOI: 10.1042/bj20081318

PubMed ID: 19674157

Title: Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4.

PubMed ID: 19674157

DOI: 10.1111/j.1872-034x.2009.00544.x

PubMed ID: 19423701

Title: Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

PubMed ID: 19423701

DOI: 10.1074/jbc.m109.017640

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20541605

Title: RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL.

PubMed ID: 20541605

DOI: 10.1016/j.cellsig.2010.05.018

PubMed ID: 20010870

Title: Copine-III interacts with ErbB2 and promotes tumor cell migration.

PubMed ID: 20010870

DOI: 10.1038/onc.2009.456

PubMed ID: 20976005

Title: RACK1 associates with muscarinic receptors and regulates M(2) receptor trafficking.

PubMed ID: 20976005

DOI: 10.1371/journal.pone.0013517

PubMed ID: 20573744

Title: A stimulatory role for the La-related protein 4B in translation.

PubMed ID: 20573744

DOI: 10.1261/rna.2146910

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20499158

Title: RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway.

PubMed ID: 20499158

DOI: 10.1007/s10549-010-0955-3

PubMed ID: 21212275

Title: RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway.

PubMed ID: 21212275

DOI: 10.1074/jbc.m110.165605

PubMed ID: 21098120

Title: La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.

PubMed ID: 21098120

DOI: 10.1128/mcb.01162-10

PubMed ID: 21347310

Title: The RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence function.

PubMed ID: 21347310

DOI: 10.1371/journal.pone.0016784

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22174419

Title: Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction.

PubMed ID: 22174419

DOI: 10.1074/jbc.m111.305854

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24006492

Title: Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling.

PubMed ID: 24006492

DOI: 10.1091/mbc.e12-06-0445

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25416947

Title: RACK1 controls IRES-mediated translation of viruses.

PubMed ID: 25416947

DOI: 10.1016/j.cell.2014.10.041

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28161490

Title: Structural analysis of ribosomal RACK1 and its role in translational control.

PubMed ID: 28161490

DOI: 10.1016/j.cellsig.2017.01.026

PubMed ID: 28636603

Title: Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.

PubMed ID: 28636603

DOI: 10.1038/nature22814

PubMed ID: 29743600

Title: Trafficking, localization and degradation of the Na+,HCO3- co-transporter NBCn1 in kidney and breast epithelial cells.

PubMed ID: 29743600

DOI: 10.1038/s41598-018-25059-7

PubMed ID: 37712706

Title: The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association.

PubMed ID: 37712706

DOI: 10.1128/jvi.00747-23

PubMed ID: 20529362

Title: Solution structure of the human signaling protein RACK1.

PubMed ID: 20529362

DOI: 10.1186/1472-6807-10-15

PubMed ID: 22869111

Title: Structure of human Rack1 protein at a resolution of 2.45 A.

PubMed ID: 22869111

DOI: 10.1107/s1744309112027480

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 317
  • Mass: 35077
  • Checksum: 257F91E369ED2044
  • Sequence:
  • MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR 
    GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI 
    VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA 
    NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC 
    FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA 
    GYTDNLVRVW QVTIGTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.