CSNK1E | ENSG00000213923 | NCBI 1454

Details for: CSNK1E

Gene ID: 1454

Symbol: CSNK1E

Ensembl ID: ENSG00000213923

Description: casein kinase 1 epsilon

Associated with

Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Circadian clock
(R-HSA-400253)
G2/m transition
(R-HSA-69275)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism of rna
(R-HSA-8953854)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Signaling by wnt
(R-HSA-195721)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Wnt mediated activation of dvl
(R-HSA-201688)
Atp binding
(GO:0005524)
Canonical wnt signaling pathway
(GO:0060070)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Chromatin remodeling
(GO:0006338)
Circadian behavior
(GO:0048512)
Circadian regulation of gene expression
(GO:0032922)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna repair
(GO:0006281)
Endocytosis
(GO:0006897)
Growth cone
(GO:0030426)
Histone h2as1 kinase activity
(GO:0044024)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of wnt signaling pathway
(GO:0030178)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of non-canonical wnt signaling pathway
(GO:2000052)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization
(GO:0008104)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of circadian rhythm
(GO:0042752)
Regulation of protein localization
(GO:0032880)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 339.8369
Cell Significance Index: -52.8600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 200.6755
Cell Significance Index: -50.9000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 108.4676
Cell Significance Index: -51.2100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 108.1509
Cell Significance Index: -44.5500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 43.1565
Cell Significance Index: -53.2100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.4369
Cell Significance Index: -49.3900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.0514
Cell Significance Index: -35.1300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.5046
Cell Significance Index: -53.2900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 3.0465
Cell Significance Index: 876.5800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.7097
Cell Significance Index: 36.9700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.5130
Cell Significance Index: 173.7900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5127
Cell Significance Index: 68.4000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.0948
Cell Significance Index: 60.0500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7175
Cell Significance Index: 344.5300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4809
Cell Significance Index: 76.9300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3572
Cell Significance Index: 186.3800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2188
Cell Significance Index: 73.1700
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1915
Cell Significance Index: 650.7300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.1454
Cell Significance Index: 32.0100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.0990
Cell Significance Index: 57.7000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0976
Cell Significance Index: 197.8600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0384
Cell Significance Index: 372.4500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9796
Cell Significance Index: 120.4500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.9364
Cell Significance Index: 52.5500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9278
Cell Significance Index: 150.8900
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.8590
Cell Significance Index: 7.6300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7834
Cell Significance Index: 35.5100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.7426
Cell Significance Index: 25.8100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6808
Cell Significance Index: 19.6200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5528
Cell Significance Index: 14.7600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5255
Cell Significance Index: 32.3000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5231
Cell Significance Index: 24.5900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4757
Cell Significance Index: 30.6900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4665
Cell Significance Index: 35.8000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4564
Cell Significance Index: 21.2800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4294
Cell Significance Index: 189.8700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3960
Cell Significance Index: 8.5800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3825
Cell Significance Index: 49.0300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.3626
Cell Significance Index: 2.8000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3375
Cell Significance Index: 25.1500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.3342
Cell Significance Index: 43.1800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.3197
Cell Significance Index: 3.9700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2836
Cell Significance Index: 28.0500
Cell Name: peg cell (CL4033014)
Fold Change: 0.2629
Cell Significance Index: 6.0800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1920
Cell Significance Index: 32.7900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1147
Cell Significance Index: 22.7700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0913
Cell Significance Index: 17.3800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0805
Cell Significance Index: 72.6900
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0680
Cell Significance Index: 1.6300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0169
Cell Significance Index: 0.5900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0087
Cell Significance Index: 16.4000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0041
Cell Significance Index: 0.2600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0166
Cell Significance Index: -12.3200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0173
Cell Significance Index: -26.6300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0191
Cell Significance Index: -35.2700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0261
Cell Significance Index: -16.6000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0288
Cell Significance Index: -39.2000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0463
Cell Significance Index: -33.9500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0463
Cell Significance Index: -35.0600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0517
Cell Significance Index: -23.4600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0524
Cell Significance Index: -32.7200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0577
Cell Significance Index: -32.5400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0714
Cell Significance Index: -1.2000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0795
Cell Significance Index: -11.5500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0892
Cell Significance Index: -9.1100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0961
Cell Significance Index: -6.8000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1069
Cell Significance Index: -2.8100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1394
Cell Significance Index: -15.9700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1459
Cell Significance Index: -30.7400
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2023
Cell Significance Index: -4.4300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2324
Cell Significance Index: -27.4100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2373
Cell Significance Index: -27.6600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2681
Cell Significance Index: -1.6200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3530
Cell Significance Index: -40.2900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3547
Cell Significance Index: -23.8500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3769
Cell Significance Index: -12.0700
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4259
Cell Significance Index: -4.6400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4827
Cell Significance Index: -21.3500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4832
Cell Significance Index: -10.2900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4939
Cell Significance Index: -51.4300
Cell Name: perivascular cell (CL4033054)
Fold Change: -0.5306
Cell Significance Index: -2.4500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5521
Cell Significance Index: -43.7300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6351
Cell Significance Index: -24.0500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.6494
Cell Significance Index: -5.9800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6803
Cell Significance Index: -17.0100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7081
Cell Significance Index: -43.4200
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.7866
Cell Significance Index: -13.6000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8138
Cell Significance Index: -23.9700
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.8509
Cell Significance Index: -5.2500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.9303
Cell Significance Index: -11.0900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.9515
Cell Significance Index: -34.9300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.9925
Cell Significance Index: -29.1500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.0054
Cell Significance Index: -28.6900
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.1057
Cell Significance Index: -15.7400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.1177
Cell Significance Index: -36.6000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.1294
Cell Significance Index: -23.6400
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.1799
Cell Significance Index: -16.9700
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.2342
Cell Significance Index: -31.5300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.2476
Cell Significance Index: -25.8800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.2727
Cell Significance Index: -19.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity:** CSNK1E possesses kinase activity, enabling it to phosphorylate and regulate the activity of various substrates, including proteins, lipids, and nucleic acids. 2. **Cell Cycle Regulation:** CSNK1E is involved in regulating the cell cycle, particularly during the G2/M transition, by phosphorylating and modulating the activity of key regulatory proteins. 3. **Signaling Pathways:** CSNK1E is a key regulator of various signaling pathways, including Wnt/β-catenin, canonical Wnt, and non-canonical Wnt signaling, which are essential for cell proliferation, differentiation, and survival. 4. **Circadian Rhythm Maintenance:** CSNK1E is involved in regulating the circadian rhythm, a complex process that involves the coordinated expression of genes in response to the 24-hour day-night cycle. **Pathways and Functions:** 1. **Anchoring of the Basal Body to the Plasma Membrane:** CSNK1E is involved in anchoring the basal body to the plasma membrane, a process critical for maintaining cellular polarity and organization. 2. **Aurka Activation by Tpx2:** CSNK1E phosphorylates and activates Aurora Kinase A (Aurka), a key regulator of cell cycle progression and mitotic spindle assembly. 3. **Canonical Wnt Signaling Pathway:** CSNK1E is a key regulator of the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 4. **Centrosome Maturation:** CSNK1E is involved in regulating centrosome maturation, a process critical for maintaining proper cell cycle progression and mitotic spindle assembly. 5. **Circadian Behavior:** CSNK1E is involved in regulating the circadian behavior, a complex process that involves the coordinated expression of genes in response to the 24-hour day-night cycle. **Clinical Significance:** 1. **Cancer:** Dysregulation of CSNK1E has been implicated in various cancers, including breast, prostate, and bladder cancer, highlighting its potential as a therapeutic target. 2. **Neurological Disorders:** CSNK1E has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, underscoring its potential as a therapeutic target. 3. **Circadian Rhythm Disorders:** CSNK1E plays a critical role in regulating the circadian rhythm, and dysregulation of this enzyme has been implicated in various circadian rhythm disorders, including jet lag and sleep disorders. In conclusion, CSNK1E is a multifaceted enzyme that plays a critical role in regulating various cellular processes, including cell cycle progression, signaling pathways, and circadian rhythm maintenance. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which CSNK1E regulates cellular processes and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.