Details for: DACH1

Gene ID: 1602

Symbol: DACH1

Ensembl ID: ENSG00000276644

Description: dachshund family transcription factor 1

Associated with

  • Cytosol
    (GO:0005829)
  • Development of primary female sexual characteristics
    (GO:0046545)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Golgi apparatus
    (GO:0005794)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell proliferation involved in contact inhibition
    (GO:0060244)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna biosynthetic process
    (GO:2000279)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear speck
    (GO:0016607)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of nuclear cell cycle dna replication
    (GO:0033262)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory gaseous exchange by respiratory system
    (GO:0007585)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Suckling behavior
    (GO:0001967)
  • Transcription regulator complex
    (GO:0005667)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 5.99
    Marker Score: 6,355
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 5.1
    Marker Score: 9,803
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.29
    Marker Score: 2,063
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.2
    Marker Score: 2,440
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 4.12
    Marker Score: 2,309
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.67
    Marker Score: 7,587
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.24
    Marker Score: 2,590
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.11
    Marker Score: 909
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.02
    Marker Score: 958
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.77
    Marker Score: 3,915
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.75
    Marker Score: 936
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.71
    Marker Score: 1,000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.65
    Marker Score: 11,111
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.39
    Marker Score: 1,841
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.2
    Marker Score: 1,529
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.14
    Marker Score: 555
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.96
    Marker Score: 1,172
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.94
    Marker Score: 4,258
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.94
    Marker Score: 612
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.85
    Marker Score: 113,955
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.84
    Marker Score: 16,160
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.8
    Marker Score: 493
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.79
    Marker Score: 802
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.79
    Marker Score: 993
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.78
    Marker Score: 1,580
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.77
    Marker Score: 1,689
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.74
    Marker Score: 942
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.62
    Marker Score: 677
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.59
    Marker Score: 505
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.54
    Marker Score: 13,231
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.48
    Marker Score: 3,012
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.48
    Marker Score: 3,090
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,687
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.46
    Marker Score: 1,683
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.44
    Marker Score: 2,380
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.43
    Marker Score: 955
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13,395
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.36
    Marker Score: 819
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.32
    Marker Score: 13,294
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.3
    Marker Score: 332
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.24
    Marker Score: 4,407
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.15
    Marker Score: 3,076
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.09
    Marker Score: 1,156
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.07
    Marker Score: 411
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.04
    Marker Score: 1,774
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,766
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.03
    Marker Score: 2,064
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.99
    Marker Score: 318
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.96
    Marker Score: 907
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.96
    Marker Score: 6,356
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.95
    Marker Score: 2,599
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.95
    Marker Score: 1,324
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.94
    Marker Score: 494
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14,523
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.91
    Marker Score: 1,104
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.91
    Marker Score: 5,479
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.89
    Marker Score: 2,249
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,049
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.82
    Marker Score: 1,612
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.82
    Marker Score: 192
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1,314
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.81
    Marker Score: 1,115
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.8
    Marker Score: 758
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.79
    Marker Score: 247
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 373
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.76
    Marker Score: 824
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1,793
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.76
    Marker Score: 213
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.74
    Marker Score: 189
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.73
    Marker Score: 297
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.73
    Marker Score: 5,487
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.72
    Marker Score: 266
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 472
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.71
    Marker Score: 608
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,947
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.69
    Marker Score: 735
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1,213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.68
    Marker Score: 258
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.68
    Marker Score: 2,765
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.66
    Marker Score: 1,508
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.65
    Marker Score: 381
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.64
    Marker Score: 234
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.64
    Marker Score: 239
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.63
    Marker Score: 914
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 159
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.6
    Marker Score: 311
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.58
    Marker Score: 621

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** DACH1 acts as a transcription factor, binding to specific DNA sequences to modulate gene expression. 2. **Developmental role:** DACH1 is essential for embryonic development, particularly in the formation of primary female sexual characteristics. 3. **Cellular localization:** DACH1 is found in the nucleus, cytosol, and Golgi apparatus, indicating its versatility in cellular processes. 4. **Signaling pathways:** DACH1 interacts with various signaling pathways, including those involved in cell migration, proliferation, and transcription regulation. **Pathways and Functions:** 1. **Cell migration and proliferation:** DACH1 negatively regulates cell migration and proliferation, particularly in response to contact inhibition. 2. **Transcription regulation:** DACH1 modulates transcription by binding to RNA polymerase II-specific sequences, influencing the expression of target genes. 3. **DNA biosynthesis:** DACH1 negatively regulates DNA biosynthetic processes, ensuring proper DNA replication and transcription. 4. **Golgi apparatus function:** DACH1 is involved in Golgi apparatus function, influencing protein secretion and modification. 5. **Nuclear speck formation:** DACH1 is associated with nuclear speck formation, a process involved in gene expression and transcription regulation. **Clinical Significance:** 1. **Cancer association:** Alterations in DACH1 expression have been linked to various cancers, including pancreatic cancer and lung cancer. 2. **Developmental disorders:** DACH1 mutations have been associated with developmental disorders, such as craniosynostosis and limb abnormalities. 3. **Neurological disorders:** DACH1 expression is altered in neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Kidney disease:** DACH1 is involved in kidney development and function, and its dysregulation may contribute to kidney disease and fibrosis. 5. **Pancreatic disease:** DACH1 expression is altered in pancreatic disease, including pancreatitis and pancreatic cancer. In conclusion, the DACH1 gene plays a crucial role in various cellular processes, including development, cell regulation, and transcription regulation. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the mechanisms underlying DACH1 function and its clinical significance.

Genular Protein ID: 282247221

Symbol: DACH1_HUMAN

Name: Dachshund homolog 1

UniProtKB Accession Codes:

Q9UI36 A0A087WZP2 D0FY35 D0FY36 O75523 O75687 Q5VYY3 Q5VYY4 Q96SG3 Q96SG4 Q9H524 Q9UMH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10502110

Title: Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene.

PubMed ID: 10502110

DOI: 10.1007/s004270050286

PubMed ID: 11543628

Title: Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog.

PubMed ID: 11543628

DOI: 10.1006/geno.2001.6618

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 9651501

Title: Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb.

PubMed ID: 9651501

DOI: 10.1016/s0925-4773(98)00071-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14525983

Title: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.

PubMed ID: 14525983

DOI: 10.1074/jbc.m310021200

PubMed ID: 12057194

Title: Structure of the retinal determination protein dachshund reveals a DNA binding motif.

PubMed ID: 12057194

DOI: 10.1016/s0969-2126(02)00769-4

Sequence Information:

  • Length: 758
  • Mass: 78562
  • Checksum: DFB5054D7EC5FF11
  • Sequence:
    • MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS GPTLFRPEPI 
ASAAAAAATV TSTGGGGGGG GSGGGGGSSG NGGGGGGGGG GSNCNPNLAA ASNGSGGGGG 
GISAGGGVAS STPINASTGS SSSSSSSSSS SSSSSSSSSS SSSCGPLPGK PVYSTPSPVE 
NTPQNNECKM VDLRGAKVAS FTVEGCELIC LPQAFDLFLK HLVGGLHTVY TKLKRLEITP 
VVCNVEQVRI LRGLGAIQPG VNRCKLISRK DFETLYNDCT NASSRPGRPP KRTQSVTSPE 
NSHIMPHSVP GLMSPGIIPP TGLTAAAAAA AAATNAAIAE AMKVKKIKLE AMSNYHASNN 
QHGADSENGD MNSSVGSSDG SWDKETLPSS PSQGPQASIT HPRMPGARSL PLSHPLNHLQ 
QSHLLPNGLE LPFMMMPHPL IPVSLPPASV TMAMSQMNHL STIANMAAAA QVQSPPSRVE 
TSVIKERVPD SPSPAPSLEE GRRPGSHPSS HRSSSVSSSP ARTESSSDRI PVHQNGLSMN 
QMLMGLSPNV LPGPKEGDLA GHDMGHESKR MHIEKDETPL STPTARDSLD KLSLTGHGQP 
LPPGFPSPFL FPDGLSSIET LLTNIQGLLK VAIDNARAQE KQVQLEKTEL KMDFLREREL 
RETLEKQLAM EQKNRAIVQK RLKKEKKAKR KLQEALEFET KRREQAEQTL KQAASTDSLR 
VLNDSLTPEI EADRSGGRTD AERTIQDGRL YLKTTVMY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.