Details for: DACH1

Gene ID: 1602

Symbol: DACH1

Ensembl ID: ENSG00000276644

Description: dachshund family transcription factor 1

Associated with

  • Cytosol
    (GO:0005829)
  • Development of primary female sexual characteristics
    (GO:0046545)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Golgi apparatus
    (GO:0005794)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell proliferation involved in contact inhibition
    (GO:0060244)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna biosynthetic process
    (GO:2000279)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear speck
    (GO:0016607)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of nuclear cell cycle dna replication
    (GO:0033262)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory gaseous exchange by respiratory system
    (GO:0007585)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Suckling behavior
    (GO:0001967)
  • Transcription regulator complex
    (GO:0005667)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 142.0605
    Cell Significance Index: -67.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 137.5976
    Cell Significance Index: -55.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.7383
    Cell Significance Index: -56.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 17.7419
    Cell Significance Index: 995.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5822
    Cell Significance Index: -23.1600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 6.0489
    Cell Significance Index: 63.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.6279
    Cell Significance Index: 123.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.5156
    Cell Significance Index: 243.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.3382
    Cell Significance Index: 202.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.0106
    Cell Significance Index: 1276.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9624
    Cell Significance Index: 102.2200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.8111
    Cell Significance Index: 18.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.5654
    Cell Significance Index: 22.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.5252
    Cell Significance Index: 2871.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2348
    Cell Significance Index: 200.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1172
    Cell Significance Index: 121.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0063
    Cell Significance Index: 181.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9803
    Cell Significance Index: 196.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8991
    Cell Significance Index: 811.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8822
    Cell Significance Index: 10.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8711
    Cell Significance Index: 385.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8047
    Cell Significance Index: 23.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7179
    Cell Significance Index: 43.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6820
    Cell Significance Index: 471.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5471
    Cell Significance Index: 248.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5342
    Cell Significance Index: 36.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2263
    Cell Significance Index: 44.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1572
    Cell Significance Index: 0.9500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1281
    Cell Significance Index: 0.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0585
    Cell Significance Index: 4.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0387
    Cell Significance Index: 2.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0175
    Cell Significance Index: 1.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0040
    Cell Significance Index: 2.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0006
    Cell Significance Index: -0.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0015
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0114
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0194
    Cell Significance Index: -4.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0208
    Cell Significance Index: -11.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0238
    Cell Significance Index: -8.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0499
    Cell Significance Index: -91.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0537
    Cell Significance Index: -2.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0588
    Cell Significance Index: -90.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0687
    Cell Significance Index: -50.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0769
    Cell Significance Index: -104.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0771
    Cell Significance Index: -2.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0886
    Cell Significance Index: -67.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0902
    Cell Significance Index: -15.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0932
    Cell Significance Index: -11.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1179
    Cell Significance Index: -2.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1250
    Cell Significance Index: -16.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1587
    Cell Significance Index: -30.2000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1814
    Cell Significance Index: -2.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2364
    Cell Significance Index: -68.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2734
    Cell Significance Index: -31.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2791
    Cell Significance Index: -32.5300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2892
    Cell Significance Index: -4.1100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3223
    Cell Significance Index: -2.4800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3249
    Cell Significance Index: -2.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3384
    Cell Significance Index: -5.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3477
    Cell Significance Index: -5.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4105
    Cell Significance Index: -56.3700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4153
    Cell Significance Index: -3.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4977
    Cell Significance Index: -15.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5135
    Cell Significance Index: -66.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5135
    Cell Significance Index: -58.6200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5325
    Cell Significance Index: -6.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5979
    Cell Significance Index: -15.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6183
    Cell Significance Index: -63.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6445
    Cell Significance Index: -48.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7482
    Cell Significance Index: -20.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7628
    Cell Significance Index: -60.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7806
    Cell Significance Index: -16.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8504
    Cell Significance Index: -65.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8796
    Cell Significance Index: -23.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9140
    Cell Significance Index: -56.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.9350
    Cell Significance Index: -110.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9352
    Cell Significance Index: -60.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9423
    Cell Significance Index: -15.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9429
    Cell Significance Index: -57.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0012
    Cell Significance Index: -63.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0664
    Cell Significance Index: -49.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0938
    Cell Significance Index: -35.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1837
    Cell Significance Index: -37.7000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -1.2120
    Cell Significance Index: -17.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3111
    Cell Significance Index: -68.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.3392
    Cell Significance Index: -62.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3411
    Cell Significance Index: -39.5000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -1.3756
    Cell Significance Index: -12.5100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.3830
    Cell Significance Index: -10.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.3944
    Cell Significance Index: -28.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.4101
    Cell Significance Index: -15.3300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -1.6068
    Cell Significance Index: -18.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.6157
    Cell Significance Index: -43.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.6500
    Cell Significance Index: -27.1900
  • Cell Name: PP cell (CL0000696)
    Fold Change: -1.6575
    Cell Significance Index: -16.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.7031
    Cell Significance Index: -33.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.7592
    Cell Significance Index: -11.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** DACH1 acts as a transcription factor, binding to specific DNA sequences to modulate gene expression. 2. **Developmental role:** DACH1 is essential for embryonic development, particularly in the formation of primary female sexual characteristics. 3. **Cellular localization:** DACH1 is found in the nucleus, cytosol, and Golgi apparatus, indicating its versatility in cellular processes. 4. **Signaling pathways:** DACH1 interacts with various signaling pathways, including those involved in cell migration, proliferation, and transcription regulation. **Pathways and Functions:** 1. **Cell migration and proliferation:** DACH1 negatively regulates cell migration and proliferation, particularly in response to contact inhibition. 2. **Transcription regulation:** DACH1 modulates transcription by binding to RNA polymerase II-specific sequences, influencing the expression of target genes. 3. **DNA biosynthesis:** DACH1 negatively regulates DNA biosynthetic processes, ensuring proper DNA replication and transcription. 4. **Golgi apparatus function:** DACH1 is involved in Golgi apparatus function, influencing protein secretion and modification. 5. **Nuclear speck formation:** DACH1 is associated with nuclear speck formation, a process involved in gene expression and transcription regulation. **Clinical Significance:** 1. **Cancer association:** Alterations in DACH1 expression have been linked to various cancers, including pancreatic cancer and lung cancer. 2. **Developmental disorders:** DACH1 mutations have been associated with developmental disorders, such as craniosynostosis and limb abnormalities. 3. **Neurological disorders:** DACH1 expression is altered in neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Kidney disease:** DACH1 is involved in kidney development and function, and its dysregulation may contribute to kidney disease and fibrosis. 5. **Pancreatic disease:** DACH1 expression is altered in pancreatic disease, including pancreatitis and pancreatic cancer. In conclusion, the DACH1 gene plays a crucial role in various cellular processes, including development, cell regulation, and transcription regulation. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the mechanisms underlying DACH1 function and its clinical significance.

Genular Protein ID: 282247221

Symbol: DACH1_HUMAN

Name: Dachshund homolog 1

UniProtKB Accession Codes:

Q9UI36 A0A087WZP2 D0FY35 D0FY36 O75523 O75687 Q5VYY3 Q5VYY4 Q96SG3 Q96SG4 Q9H524 Q9UMH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10502110

Title: Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene.

PubMed ID: 10502110

DOI: 10.1007/s004270050286

PubMed ID: 11543628

Title: Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog.

PubMed ID: 11543628

DOI: 10.1006/geno.2001.6618

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 9651501

Title: Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb.

PubMed ID: 9651501

DOI: 10.1016/s0925-4773(98)00071-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14525983

Title: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.

PubMed ID: 14525983

DOI: 10.1074/jbc.m310021200

PubMed ID: 12057194

Title: Structure of the retinal determination protein dachshund reveals a DNA binding motif.

PubMed ID: 12057194

DOI: 10.1016/s0969-2126(02)00769-4

Sequence Information:

  • Length: 758
  • Mass: 78562
  • Checksum: DFB5054D7EC5FF11
  • Sequence:
    • MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS GPTLFRPEPI 
ASAAAAAATV TSTGGGGGGG GSGGGGGSSG NGGGGGGGGG GSNCNPNLAA ASNGSGGGGG 
GISAGGGVAS STPINASTGS SSSSSSSSSS SSSSSSSSSS SSSCGPLPGK PVYSTPSPVE 
NTPQNNECKM VDLRGAKVAS FTVEGCELIC LPQAFDLFLK HLVGGLHTVY TKLKRLEITP 
VVCNVEQVRI LRGLGAIQPG VNRCKLISRK DFETLYNDCT NASSRPGRPP KRTQSVTSPE 
NSHIMPHSVP GLMSPGIIPP TGLTAAAAAA AAATNAAIAE AMKVKKIKLE AMSNYHASNN 
QHGADSENGD MNSSVGSSDG SWDKETLPSS PSQGPQASIT HPRMPGARSL PLSHPLNHLQ 
QSHLLPNGLE LPFMMMPHPL IPVSLPPASV TMAMSQMNHL STIANMAAAA QVQSPPSRVE 
TSVIKERVPD SPSPAPSLEE GRRPGSHPSS HRSSSVSSSP ARTESSSDRI PVHQNGLSMN 
QMLMGLSPNV LPGPKEGDLA GHDMGHESKR MHIEKDETPL STPTARDSLD KLSLTGHGQP 
LPPGFPSPFL FPDGLSSIET LLTNIQGLLK VAIDNARAQE KQVQLEKTEL KMDFLREREL 
RETLEKQLAM EQKNRAIVQK RLKKEKKAKR KLQEALEFET KRREQAEQTL KQAASTDSLR 
VLNDSLTPEI EADRSGGRTD AERTIQDGRL YLKTTVMY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.