Gene DAD1 - ENSG00000129562 | NCBI Gene ID: 1603

Details for: DAD1

Gene ID: 1603

Symbol: DAD1

Ensembl ID: ENSG00000129562

Description: defender against cell death 1

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of spike protein
(R-HSA-9694548)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Translation of structural proteins
(R-HSA-9694635)
Viral infection pathways
(R-HSA-9824446)
Apoptotic process
(GO:0006915)
Blastocyst development
(GO:0001824)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme activator activity
(GO:0008047)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Oligosaccharyltransferase complex
(GO:0008250)
Protein glycosylation
(GO:0006486)
Protein n-linked glycosylation
(GO:0006487)
Protein n-linked glycosylation via asparagine
(GO:0018279)
Regulation of protein stability
(GO:0031647)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.94
Marker Score: 3083
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.26
Marker Score: 5014
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.07
Marker Score: 7746
Cell Name: mature T cell (CL0002419)
Fold Change: 3.01
Marker Score: 29798
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.94
Marker Score: 101839.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.93
Marker Score: 7854
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.88
Marker Score: 38027
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.84
Marker Score: 2418
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.81
Marker Score: 18303
Cell Name: blood cell (CL0000081)
Fold Change: 2.81
Marker Score: 32663
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.79
Marker Score: 4041
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.78
Marker Score: 7687
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.78
Marker Score: 94444
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.77
Marker Score: 4600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.73
Marker Score: 6213
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.71
Marker Score: 1446
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.7
Marker Score: 2742
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.68
Marker Score: 7021
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.68
Marker Score: 1529
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.68
Marker Score: 4259
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.67
Marker Score: 6786
Cell Name: decidual cell (CL2000002)
Fold Change: 2.65
Marker Score: 11448
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.63
Marker Score: 2809
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.63
Marker Score: 2343
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.61
Marker Score: 3584.5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.61
Marker Score: 1528.5
Cell Name: basophil (CL0000767)
Fold Change: 2.6
Marker Score: 1234
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.58
Marker Score: 9956
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.57
Marker Score: 4218.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.57
Marker Score: 1829
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.57
Marker Score: 4133
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.56
Marker Score: 2669
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.54
Marker Score: 28662
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.54
Marker Score: 1207
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.51
Marker Score: 21675
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.5
Marker Score: 2690
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.49
Marker Score: 21651
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.47
Marker Score: 19284
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.47
Marker Score: 3495
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.45
Marker Score: 4903
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.45
Marker Score: 3473.5
Cell Name: supporting cell (CL0000630)
Fold Change: 2.45
Marker Score: 4598
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.43
Marker Score: 8645.5
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.42
Marker Score: 7638
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.41
Marker Score: 1087
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.41
Marker Score: 1240
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.39
Marker Score: 4240
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.39
Marker Score: 571
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.38
Marker Score: 4978
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.37
Marker Score: 2515.5
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.37
Marker Score: 10159
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.37
Marker Score: 2038
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.36
Marker Score: 1854.5
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.36
Marker Score: 5357
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.36
Marker Score: 1969
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.35
Marker Score: 2104
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.35
Marker Score: 17470
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.34
Marker Score: 935
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.34
Marker Score: 2261
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.34
Marker Score: 6365
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 2.33
Marker Score: 1761
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.33
Marker Score: 14910
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.33
Marker Score: 15161
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.32
Marker Score: 2574
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.31
Marker Score: 850
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.3
Marker Score: 2302.5
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.3
Marker Score: 2167
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.29
Marker Score: 2829
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.29
Marker Score: 735
Cell Name: Unknown (CL0000548)
Fold Change: 2.29
Marker Score: 1668
Cell Name: secretory cell (CL0000151)
Fold Change: 2.29
Marker Score: 4171
Cell Name: kidney cell (CL1000497)
Fold Change: 2.28
Marker Score: 1519
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.27
Marker Score: 22874
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.26
Marker Score: 119434
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.26
Marker Score: 557
Cell Name: club cell (CL0000158)
Fold Change: 2.25
Marker Score: 2626
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.25
Marker Score: 4013.5
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.24
Marker Score: 797
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.24
Marker Score: 14307
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.24
Marker Score: 2563
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.22
Marker Score: 123918
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.22
Marker Score: 3766
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.21
Marker Score: 2409
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.21
Marker Score: 1004
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.2
Marker Score: 13051
Cell Name: Leydig cell (CL0000178)
Fold Change: 2.2
Marker Score: 2371
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.2
Marker Score: 2468.5
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.2
Marker Score: 1446
Cell Name: Unknown (CL0002371)
Fold Change: 2.2
Marker Score: 2334
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.19
Marker Score: 11519
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.19
Marker Score: 1472.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.19
Marker Score: 3815
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 2.18
Marker Score: 1362
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 2.18
Marker Score: 4276
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.18
Marker Score: 629
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.18
Marker Score: 1367
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.17
Marker Score: 1909
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.17
Marker Score: 55654
Cell Name: naive T cell (CL0000898)
Fold Change: 2.17
Marker Score: 1396
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.16
Marker Score: 2289

Hover over a box to see details here...

**Key characteristics:** * The DAD1 gene is located on chromosome 15q21.1. * It is a protein of 123 amino acids. * It is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of cell death. **Pathways and functions:** * DAD1 binds to Apaf-1 and prevents it from interacting with its target proteins. * This prevents the inhibition of apoptosis and leads to the survival of the cell. * DAD1 is also involved in the regulation of cell cycle progression, as it is expressed in cells that are in the G1 phase of the cell cycle. * It is also involved in the regulation of inflammation, as it is expressed in immune cells. **Clinical significance:** * Mutations in the DAD1 gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. * Studies of the role of DAD1 in cancer have shown that inhibiting DAD1 can lead to the death of cancer cells. * Therefore, DAD1 is a potential target for cancer therapy. **Additional information:** * DAD1 is a member of the Apaf family of proteins, which are a group of proteins that are involved in the regulation of apoptosis. * DAD1 is a highly conserved protein, with a similar protein found in other vertebrates. * It is a well-studied protein in cancer research, as it is a key target for cancer therapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Defender against cell death 1
Q53G02_HUMAN

Genular Protein ID: 2150274928

Symbol: DAD1_HUMAN

Name: Defender against cell death 1

UniProtKB Accession Codes:

P61803 D3DS25 O08552 O70364 P46966 P46968 Q6FGA3 Q96GB7

Database IDs:

Citations:

PubMed ID: 8413235

Title: Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells.

PubMed ID: 8413235

DOI: 10.1128/mcb.13.10.6367-6374.1993

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22467853

Title: The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.

PubMed ID: 22467853

DOI: 10.1242/jcs.103952

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

Sequence Information:

Length: 113
Mass: 12497
Checksum: 481983CADCEB2345
Sequence:

MSASVVSVIS RFLEEYLSST PQRLKLLDAY LLYILLTGAL QFGYCLLVGT FPFNSFLSGF 
ISCVGSFILA VCLRIQINPQ NKADFQGISP ERAFADFLFA STILHLVVMN FVG

Genular Protein ID: 1841087295

Symbol: Q53G02_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53G02

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

Length: 113
Mass: 12425
Checksum: CA1983CADCEB20F3
Sequence:

MSASVVSVIS RFLEEYLSST PQRLKLLDAY LLYILLTGAL QFGYCLLVGT FPFNSFLSGF 
ISCVGSFILA VCLRIQINPQ NKADFQGISP GRAFADFLFA STILHLVVMN FVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DAD1

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. PubMed ID: 8413235

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Initial characterization of the human central proteome. PubMed ID: 21269460

The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation. PubMed ID: 22467853

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins. PubMed ID: 25135935

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. PubMed ID: 25489052

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. PubMed ID: 31831667

Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. PubMed ID: 8125298

Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. PubMed ID: 9373149