Details for: DAD1

Gene ID: 1603

Symbol: DAD1

Ensembl ID: ENSG00000129562

Description: defender against cell death 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 564.2732
    Cell Significance Index: -87.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 323.1308
    Cell Significance Index: -81.9600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 251.6582
    Cell Significance Index: -103.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 217.7193
    Cell Significance Index: -88.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 214.1605
    Cell Significance Index: -101.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 188.0108
    Cell Significance Index: -96.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 151.2171
    Cell Significance Index: -101.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 92.8417
    Cell Significance Index: -88.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 76.8722
    Cell Significance Index: -94.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.8892
    Cell Significance Index: -102.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.1747
    Cell Significance Index: -71.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4809
    Cell Significance Index: -44.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.0795
    Cell Significance Index: 190.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4284
    Cell Significance Index: 470.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1903
    Cell Significance Index: 149.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9914
    Cell Significance Index: 1633.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.8828
    Cell Significance Index: 32.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8653
    Cell Significance Index: 77.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.7639
    Cell Significance Index: 354.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7579
    Cell Significance Index: 22.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5395
    Cell Significance Index: 58.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4846
    Cell Significance Index: 22.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4577
    Cell Significance Index: 399.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4031
    Cell Significance Index: 179.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2654
    Cell Significance Index: 146.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1015
    Cell Significance Index: 61.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0185
    Cell Significance Index: 42.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9851
    Cell Significance Index: 357.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9357
    Cell Significance Index: 238.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8376
    Cell Significance Index: 48.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7460
    Cell Significance Index: 771.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4840
    Cell Significance Index: 42.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4174
    Cell Significance Index: 183.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3933
    Cell Significance Index: 98.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3487
    Cell Significance Index: 159.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9932
    Cell Significance Index: 12.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9384
    Cell Significance Index: 32.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8262
    Cell Significance Index: 42.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7473
    Cell Significance Index: 13.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7232
    Cell Significance Index: 19.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6710
    Cell Significance Index: 114.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4645
    Cell Significance Index: 92.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3948
    Cell Significance Index: 39.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3096
    Cell Significance Index: 58.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2312
    Cell Significance Index: 174.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1823
    Cell Significance Index: 133.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1640
    Cell Significance Index: 32.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1070
    Cell Significance Index: 1.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0554
    Cell Significance Index: 2.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0250
    Cell Significance Index: 8.9700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0122
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0258
    Cell Significance Index: -48.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0286
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0561
    Cell Significance Index: -35.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0563
    Cell Significance Index: -1.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0682
    Cell Significance Index: -125.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0806
    Cell Significance Index: -124.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0826
    Cell Significance Index: -57.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0956
    Cell Significance Index: -130.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1104
    Cell Significance Index: -70.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1266
    Cell Significance Index: -71.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1904
    Cell Significance Index: -40.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1912
    Cell Significance Index: -86.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2311
    Cell Significance Index: -26.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2475
    Cell Significance Index: -71.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3840
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4296
    Cell Significance Index: -49.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4468
    Cell Significance Index: -52.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4648
    Cell Significance Index: -32.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4809
    Cell Significance Index: -30.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4954
    Cell Significance Index: -26.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5697
    Cell Significance Index: -15.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5702
    Cell Significance Index: -82.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7541
    Cell Significance Index: -20.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7598
    Cell Significance Index: -19.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7702
    Cell Significance Index: -43.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8121
    Cell Significance Index: -26.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9572
    Cell Significance Index: -75.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9818
    Cell Significance Index: -21.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9856
    Cell Significance Index: -102.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.1553
    Cell Significance Index: -12.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1684
    Cell Significance Index: -89.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2797
    Cell Significance Index: -34.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2851
    Cell Significance Index: -66.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.3239
    Cell Significance Index: -46.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.3774
    Cell Significance Index: -84.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4344
    Cell Significance Index: -96.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6365
    Cell Significance Index: -100.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.6712
    Cell Significance Index: -68.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6920
    Cell Significance Index: -23.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.7096
    Cell Significance Index: -14.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9170
    Cell Significance Index: -47.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9484
    Cell Significance Index: -57.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.1086
    Cell Significance Index: -106.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.1212
    Cell Significance Index: -61.1200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -2.1619
    Cell Significance Index: -13.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.1767
    Cell Significance Index: -96.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.2339
    Cell Significance Index: -38.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.2994
    Cell Significance Index: -27.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Apoptosis regulation**: DAD1 acts as an anti-apoptotic protein, preventing excessive cell death and maintaining tissue homeostasis. 2. **Protein quality control**: DAD1 is involved in the regulation of protein stability and folding, ensuring the proper functioning of proteins in the cell. 3. **Glycosylation**: DAD1 is a substrate for the oligosaccharyltransferase complex, which is responsible for adding carbohydrate molecules (glycans) to proteins, thereby modifying their function and stability. 4. **Cell type specificity**: DAD1 is highly expressed in immune cells, such as mature T cells, and other cell types, including thyroid follicular cells and kidney collecting duct principal cells. **Pathways and Functions:** 1. **Apoptotic process**: DAD1 inhibits the activation of caspases, which are key enzymes responsible for inducing apoptosis. 2. **Protein glycosylation**: DAD1 is modified by the oligosaccharyltransferase complex, which adds glycans to the protein, influencing its function and stability. 3. **Endoplasmic reticulum membrane**: DAD1 is localized to the endoplasmic reticulum membrane, where it regulates protein folding and quality control. 4. **Metabolism of proteins**: DAD1 is involved in the regulation of protein degradation and metabolism, ensuring the proper functioning of proteins in the cell. **Clinical Significance:** 1. **Infectious diseases**: DAD1 dysregulation has been implicated in the pathogenesis of infectious diseases, such as SARS-CoV-2 infection, where it affects the regulation of protein stability and folding. 2. **Cancer**: Aberrant DAD1 expression has been observed in various types of cancer, where it contributes to tumorigenesis and cancer progression. 3. **Autoimmune diseases**: DAD1 dysregulation may also contribute to autoimmune diseases, such as rheumatoid arthritis, where it affects the regulation of protein stability and immune responses. 4. **Therapeutic potential**: Understanding the mechanisms of DAD1 regulation may lead to the development of novel therapeutic strategies for diseases where DAD1 is dysregulated. In conclusion, the DAD1 gene plays a critical role in regulating cellular homeostasis, protein quality control, and apoptosis. Its dysregulation has been implicated in various diseases, including infectious diseases, cancer, and autoimmune diseases. Further research is needed to elucidate the mechanisms of DAD1 regulation and to explore its therapeutic potential.

Genular Protein ID: 2150274928

Symbol: DAD1_HUMAN

Name: Defender against cell death 1

UniProtKB Accession Codes:

P61803 D3DS25 O08552 O70364 P46966 P46968 Q6FGA3 Q96GB7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8413235

Title: Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells.

PubMed ID: 8413235

DOI: 10.1128/mcb.13.10.6367-6374.1993

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22467853

Title: The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation.

PubMed ID: 22467853

DOI: 10.1242/jcs.103952

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

Sequence Information:

  • Length: 113
  • Mass: 12497
  • Checksum: 481983CADCEB2345
  • Sequence:
    • MSASVVSVIS RFLEEYLSST PQRLKLLDAY LLYILLTGAL QFGYCLLVGT FPFNSFLSGF 
ISCVGSFILA VCLRIQINPQ NKADFQGISP ERAFADFLFA STILHLVVMN FVG

Genular Protein ID: 1841087295

Symbol: Q53G02_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53G02

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 UniPathway 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 113
  • Mass: 12425
  • Checksum: CA1983CADCEB20F3
  • Sequence:
    • MSASVVSVIS RFLEEYLSST PQRLKLLDAY LLYILLTGAL QFGYCLLVGT FPFNSFLSGF 
ISCVGSFILA VCLRIQINPQ NKADFQGISP GRAFADFLFA STILHLVVMN FVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.