Details for: DBI

Gene ID: 1622

Symbol: DBI

Ensembl ID: ENSG00000155368

Description: diazepam binding inhibitor, acyl-CoA binding protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.09
    Marker Score: 2,183
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.63
    Marker Score: 23,687
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.36
    Marker Score: 26,233
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.3
    Marker Score: 11,731
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.2
    Marker Score: 31,671
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.18
    Marker Score: 9,974
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.18
    Marker Score: 2,487
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.14
    Marker Score: 3,356
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.11
    Marker Score: 36,127
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.1
    Marker Score: 4,776
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.08
    Marker Score: 9,001
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.07
    Marker Score: 8,241
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.04
    Marker Score: 170,274
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.02
    Marker Score: 19,282
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.02
    Marker Score: 4,855
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.01
    Marker Score: 3,449
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.01
    Marker Score: 5,495
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.01
    Marker Score: 6,848
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.99
    Marker Score: 2,665
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.99
    Marker Score: 7,529
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.97
    Marker Score: 4,924
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.96
    Marker Score: 4,709
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.92
    Marker Score: 15,343
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.9
    Marker Score: 25,006
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.9
    Marker Score: 8,012
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.88
    Marker Score: 99,633
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.88
    Marker Score: 38,638
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.85
    Marker Score: 10,974
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.82
    Marker Score: 24,459
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.81
    Marker Score: 1,337
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.81
    Marker Score: 13,467
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.79
    Marker Score: 3,352
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.79
    Marker Score: 8,271
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.78
    Marker Score: 1,108
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.74
    Marker Score: 1,596
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.73
    Marker Score: 3,033
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.71
    Marker Score: 69,457
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.69
    Marker Score: 8,496
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.68
    Marker Score: 27,172
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.68
    Marker Score: 1,319
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.67
    Marker Score: 19,840
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.65
    Marker Score: 2,692
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.62
    Marker Score: 5,095
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.61
    Marker Score: 5,927
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.61
    Marker Score: 1,857
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.61
    Marker Score: 3,620
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6
    Marker Score: 16,655
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.57
    Marker Score: 2,570
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.56
    Marker Score: 6,633
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.56
    Marker Score: 1,710
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.52
    Marker Score: 1,584
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.52
    Marker Score: 922
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.51
    Marker Score: 3,549
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.49
    Marker Score: 2,226
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.48
    Marker Score: 2,894
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.48
    Marker Score: 1,508
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.47
    Marker Score: 591
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.45
    Marker Score: 1,679
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.45
    Marker Score: 2,303
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.45
    Marker Score: 3,462
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.44
    Marker Score: 901
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.44
    Marker Score: 9,989
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.44
    Marker Score: 10,515
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.44
    Marker Score: 9,435
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.41
    Marker Score: 3,545
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.4
    Marker Score: 1,753
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.4
    Marker Score: 2,563
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.38
    Marker Score: 2,092
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.38
    Marker Score: 2,524
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.38
    Marker Score: 3,069
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.37
    Marker Score: 1,866
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.36
    Marker Score: 2,284
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.36
    Marker Score: 2,328
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.35
    Marker Score: 80,083
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.35
    Marker Score: 1,013
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.34
    Marker Score: 3,610
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.34
    Marker Score: 771
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.34
    Marker Score: 4,073
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.33
    Marker Score: 2,235
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3
    Marker Score: 3,387
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.3
    Marker Score: 13,973
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.3
    Marker Score: 1,933
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.28
    Marker Score: 5,425
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.28
    Marker Score: 1,066
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.28
    Marker Score: 1,082
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.28
    Marker Score: 1,429
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.25
    Marker Score: 1,913
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.25
    Marker Score: 920
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8,854
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.24
    Marker Score: 5,471
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.23
    Marker Score: 1,308
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.23
    Marker Score: 4,234
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.22
    Marker Score: 837
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.22
    Marker Score: 2,387
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.22
    Marker Score: 920
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.21
    Marker Score: 6,020
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.21
    Marker Score: 701
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.21
    Marker Score: 2,325
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.21
    Marker Score: 785
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.21
    Marker Score: 3,034

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Acyl-CoA binding**: DBI binds to acyl-CoA, a crucial intermediate in fatty acid metabolism, regulating its availability for various cellular processes. 2. **Regulation of coenzyme A transferase activity**: DBI positively regulates coenzyme A transferase activity, which is essential for fatty acid synthesis and degradation. 3. **Phospholipid transport**: DBI facilitates the transport of phospholipids, which is critical for maintaining cellular membrane structure and function. 4. **Mitochondrial fatty acid beta-oxidation**: DBI is involved in the regulation of mitochondrial fatty acid beta-oxidation, a key process in fatty acid degradation. **Pathways and Functions:** DBI is involved in various cellular pathways, including: 1. **Fatty acid metabolism**: DBI regulates fatty acid synthesis and degradation by binding to acyl-CoA and modulating coenzyme A transferase activity. 2. **Benzodiazepine receptor binding**: DBI interacts with benzodiazepine receptors, which are involved in regulating neuronal activity and anxiety responses. 3. **Endoplasmic reticulum and Golgi apparatus**: DBI is involved in the regulation of protein lipidation and phospholipid transport, which are critical for maintaining cellular homeostasis. 4. **Immune regulation**: DBI is expressed in immune cells, including T cells and macrophages, and regulates immune responses by modulating coenzyme A transferase activity and phospholipid transport. **Clinical Significance:** DBI has significant implications for various diseases, including: 1. **Metabolic disorders**: Dysregulation of DBI has been implicated in metabolic disorders, such as obesity and type 2 diabetes, due to its role in fatty acid metabolism. 2. **Neurological disorders**: DBI's interaction with benzodiazepine receptors has been linked to neurological disorders, such as anxiety and insomnia. 3. **Immune-related diseases**: DBI's expression in immune cells highlights its potential role in regulating immune responses and preventing immune-related diseases, such as autoimmune disorders. 4. **Cancer**: DBI's involvement in fatty acid metabolism and phospholipid transport has been implicated in cancer progression and metastasis. In conclusion, DBI is a critical gene that regulates fatty acid metabolism, immune responses, and cellular homeostasis. Its dysregulation has significant implications for various diseases, highlighting the need for further research into its molecular mechanisms and clinical applications.

Genular Protein ID: 2746284521

Symbol: ACBP_HUMAN

Name: Acyl-CoA-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3020548

Title: Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor.

PubMed ID: 3020548

DOI: 10.1073/pnas.83.19.7547

PubMed ID: 2881742

Title: Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand.

PubMed ID: 2881742

DOI: 10.1089/dna.1987.6.71

PubMed ID: 16055366

Title: Identification of new acyl-CoA binding protein transcripts in human and mouse.

PubMed ID: 16055366

DOI: 10.1016/j.biocel.2005.06.008

PubMed ID: 21698759

Title: Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain.

PubMed ID: 21698759

DOI: 10.1002/iub.471

PubMed ID: 20345851

Title: Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms.

PubMed ID: 20345851

DOI: 10.1111/j.1582-4934.2010.01055.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3525533

Title: Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor.

PubMed ID: 3525533

DOI: 10.1016/s0021-9258(18)67575-1

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1292782

Title: Purification and analysis of growth regulating proteins secreted by a human melanoma cell line.

PubMed ID: 1292782

DOI: 10.1097/00008390-199212000-00006

PubMed ID: 7534063

Title: The characterization of two diazepam binding inhibitor (DBI) transcripts in humans.

PubMed ID: 7534063

DOI: 10.1042/bj3060327

PubMed ID: 17953517

Title: Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells.

PubMed ID: 17953517

DOI: 10.1042/bj20070559

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 17044054

Title: High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand.

PubMed ID: 17044054

DOI: 10.1002/prot.21124

Sequence Information:

  • Length: 87
  • Mass: 10044
  • Checksum: B343A309F1B1AE28
  • Sequence:
  • MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN 
    ELKGTSKEDA MKAYINKVEE LKKKYGI

Genular Protein ID: 264561743

Symbol: B8ZWD1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 97
  • Mass: 11150
  • Checksum: D13D01564D422124
  • Sequence:
  • MSQVQRVHSQ AAKAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF 
    TGKAKWDAWN ELKGTSKEDA MKAYINKVEE LKKKYGI

Genular Protein ID: 3541104954

Symbol: A0A024RAF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 104
  • Mass: 11793
  • Checksum: 54D0238ABE40BCD2
  • Sequence:
  • MWGDLWLLPP ASANPGTGTE AEFEKAAEEV RHLKTKPSDE EMLFIYGHYK QATVGDINTE 
    RPGMLDFTGK AKWDAWNELK GTSKEDAMKA YINKVEELKK KYGI

Genular Protein ID: 3209869258

Symbol: B8ZWD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 63
  • Mass: 7272
  • Checksum: 7F4CBD01BC157263
  • Sequence:
  • MLFIYGHYKQ ATVGDINTER PGMLDFTGKA KWDAWNELKG TSKEDAMKAY INKVEELKKK 
    YGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.