Details for: DBI

Gene ID: 1622

Symbol: DBI

Ensembl ID: ENSG00000155368

Description: diazepam binding inhibitor, acyl-CoA binding protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.09
    Marker Score: 2183
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.63
    Marker Score: 23687
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.36
    Marker Score: 26233
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.3
    Marker Score: 11731
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.2
    Marker Score: 31671
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.18
    Marker Score: 9974
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.18
    Marker Score: 2486.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.14
    Marker Score: 3356
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.11
    Marker Score: 36127
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.1
    Marker Score: 4775.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.08
    Marker Score: 9000.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.07
    Marker Score: 8241
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.04
    Marker Score: 170273.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.02
    Marker Score: 19282
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.02
    Marker Score: 4855
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.01
    Marker Score: 3449
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.01
    Marker Score: 5495
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.01
    Marker Score: 6848
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.99
    Marker Score: 2665
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.99
    Marker Score: 7529
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.97
    Marker Score: 4924
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.96
    Marker Score: 4709
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.92
    Marker Score: 15343
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.9
    Marker Score: 25006
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.9
    Marker Score: 8012
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.88
    Marker Score: 99633
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.88
    Marker Score: 38638
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.85
    Marker Score: 10974
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.82
    Marker Score: 24458.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.81
    Marker Score: 1337
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.81
    Marker Score: 13467
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.79
    Marker Score: 3352
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.79
    Marker Score: 8271
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.78
    Marker Score: 1108
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.74
    Marker Score: 1596
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.73
    Marker Score: 3033
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.71
    Marker Score: 69456.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.69
    Marker Score: 8496
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.68
    Marker Score: 27172
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.68
    Marker Score: 1319
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.67
    Marker Score: 19840
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.65
    Marker Score: 2692
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.62
    Marker Score: 5095
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.61
    Marker Score: 5927
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.61
    Marker Score: 1857
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.61
    Marker Score: 3620
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6
    Marker Score: 16655
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.57
    Marker Score: 2569.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.56
    Marker Score: 6633
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.56
    Marker Score: 1710
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.52
    Marker Score: 1584
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.52
    Marker Score: 921.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.51
    Marker Score: 3548.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.49
    Marker Score: 2225.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.48
    Marker Score: 2894
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.48
    Marker Score: 1508
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.47
    Marker Score: 590.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.45
    Marker Score: 1679
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.45
    Marker Score: 2303
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.45
    Marker Score: 3462
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.44
    Marker Score: 901
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.44
    Marker Score: 9989
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.44
    Marker Score: 10515
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.44
    Marker Score: 9435
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.41
    Marker Score: 3545
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.4
    Marker Score: 1752.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.4
    Marker Score: 2563
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.38
    Marker Score: 2092
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.38
    Marker Score: 2524
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.38
    Marker Score: 3069
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.37
    Marker Score: 1866
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.36
    Marker Score: 2284
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.36
    Marker Score: 2327.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.35
    Marker Score: 80082.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.35
    Marker Score: 1013
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.34
    Marker Score: 3610
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.34
    Marker Score: 771
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.34
    Marker Score: 4073
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.33
    Marker Score: 2235
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3
    Marker Score: 3387
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.3
    Marker Score: 13972.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.3
    Marker Score: 1933
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.28
    Marker Score: 5425
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.28
    Marker Score: 1065.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.28
    Marker Score: 1082
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.28
    Marker Score: 1429
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.25
    Marker Score: 1913
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.25
    Marker Score: 920
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8853.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.24
    Marker Score: 5471
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.23
    Marker Score: 1308
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.23
    Marker Score: 4234
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.22
    Marker Score: 837
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.22
    Marker Score: 2387
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.22
    Marker Score: 919.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.21
    Marker Score: 6019.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.21
    Marker Score: 701
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.21
    Marker Score: 2324.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.21
    Marker Score: 784.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.21
    Marker Score: 3033.5

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Other Information

**Key characteristics:** - DBI is a protein of the CYP3A family. - It is a binding protein for acyl-CoA. - It is expressed in a variety of cell types. **Pathways and functions:** - DBI binds to acyl-CoA and helps to regulate its transport into the endoplasmic reticulum. - It also binds to the endoplasmic reticulum lumen and regulates the activity of protein disulfide isomerase, a protein that is involved in the folding of proteins. - DBI is involved in the metabolism of fatty acids. It is a key regulator of the synthesis of very-long-chain fatty acids (VLCFAs), which are involved in a variety of cellular processes, including cell signaling, membrane trafficking, and inflammation. **Clinical significance:** - Mutations in the DBI gene have been linked to a number of human diseases, including liver disease, cancer, and metabolic syndrome. - DBI is a potential therapeutic target for these diseases. **Additional information:** - DBI is a highly conserved protein, with a similar protein found in other mammals. - It is a relatively new protein, with the first known gene encoding DBI was identified in 2003.

Genular Protein ID: 2746284521

Symbol: ACBP_HUMAN

Name: Acyl-CoA-binding protein

UniProtKB Accession Codes:

P07108 B8ZWD2 B8ZWD6 B8ZWD7 P08869 Q4VWZ6 Q53SQ7 Q6IB48 Q9UCI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 15 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 4 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3020548

Title: Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor.

PubMed ID: 3020548

DOI: 10.1073/pnas.83.19.7547

PubMed ID: 2881742

Title: Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand.

PubMed ID: 2881742

DOI: 10.1089/dna.1987.6.71

PubMed ID: 16055366

Title: Identification of new acyl-CoA binding protein transcripts in human and mouse.

PubMed ID: 16055366

DOI: 10.1016/j.biocel.2005.06.008

PubMed ID: 21698759

Title: Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain.

PubMed ID: 21698759

DOI: 10.1002/iub.471

PubMed ID: 20345851

Title: Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms.

PubMed ID: 20345851

DOI: 10.1111/j.1582-4934.2010.01055.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3525533

Title: Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor.

PubMed ID: 3525533

DOI: 10.1016/s0021-9258(18)67575-1

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1292782

Title: Purification and analysis of growth regulating proteins secreted by a human melanoma cell line.

PubMed ID: 1292782

DOI: 10.1097/00008390-199212000-00006

PubMed ID: 7534063

Title: The characterization of two diazepam binding inhibitor (DBI) transcripts in humans.

PubMed ID: 7534063

DOI: 10.1042/bj3060327

PubMed ID: 17953517

Title: Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells.

PubMed ID: 17953517

DOI: 10.1042/bj20070559

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 17044054

Title: High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand.

PubMed ID: 17044054

DOI: 10.1002/prot.21124

Sequence Information:

  • Length: 87
  • Mass: 10044
  • Checksum: B343A309F1B1AE28
  • Sequence:
    • MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF TGKAKWDAWN 
ELKGTSKEDA MKAYINKVEE LKKKYGI

Genular Protein ID: 264561743

Symbol: B8ZWD1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B8ZWD1

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 PharmGKB 1 Proteomes 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 97
  • Mass: 11150
  • Checksum: D13D01564D422124
  • Sequence:
    • MSQVQRVHSQ AAKAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF 
TGKAKWDAWN ELKGTSKEDA MKAYINKVEE LKKKYGI

Genular Protein ID: 3541104954

Symbol: A0A024RAF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RAF2

Database IDs:

ARBA 7 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 RefSeq 5 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 104
  • Mass: 11793
  • Checksum: 54D0238ABE40BCD2
  • Sequence:
    • MWGDLWLLPP ASANPGTGTE AEFEKAAEEV RHLKTKPSDE EMLFIYGHYK QATVGDINTE 
RPGMLDFTGK AKWDAWNELK GTSKEDAMKA YINKVEELKK KYGI

Genular Protein ID: 3209869258

Symbol: B8ZWD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B8ZWD8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 63
  • Mass: 7272
  • Checksum: 7F4CBD01BC157263
  • Sequence:
    • MLFIYGHYKQ ATVGDINTER PGMLDFTGKA KWDAWNELKG TSKEDAMKAY INKVEELKKK 
YGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.