Details for: DGUOK

Gene ID: 1716

Symbol: DGUOK

Ensembl ID: ENSG00000114956

Description: deoxyguanosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.32
    Marker Score: 4900.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.18
    Marker Score: 2276
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.15
    Marker Score: 28415
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.14
    Marker Score: 3069
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.1
    Marker Score: 2967
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.06
    Marker Score: 71487
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.95
    Marker Score: 12666
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.94
    Marker Score: 22601
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.94
    Marker Score: 7639
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.92
    Marker Score: 707
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.91
    Marker Score: 3984
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9
    Marker Score: 8209
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.89
    Marker Score: 12109
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.89
    Marker Score: 3292
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.87
    Marker Score: 2101
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.85
    Marker Score: 5494
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.84
    Marker Score: 1967
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.83
    Marker Score: 2813
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.82
    Marker Score: 2190.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.81
    Marker Score: 3078.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.81
    Marker Score: 4996
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.8
    Marker Score: 1813
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.8
    Marker Score: 1025
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.79
    Marker Score: 1906
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.79
    Marker Score: 17744
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.79
    Marker Score: 18014
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.78
    Marker Score: 3151
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.78
    Marker Score: 876
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.77
    Marker Score: 2611
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.76
    Marker Score: 7217
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.76
    Marker Score: 1653
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.75
    Marker Score: 4771
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.75
    Marker Score: 1272
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.74
    Marker Score: 6460
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.74
    Marker Score: 1878
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.74
    Marker Score: 502
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.74
    Marker Score: 4251.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.74
    Marker Score: 1594
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.73
    Marker Score: 1834
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.7
    Marker Score: 4035
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.69
    Marker Score: 1063.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.69
    Marker Score: 22696.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.68
    Marker Score: 1118.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.63
    Marker Score: 367
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.62
    Marker Score: 4411.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.62
    Marker Score: 576
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.61
    Marker Score: 384
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.6
    Marker Score: 3993.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.6
    Marker Score: 538
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.6
    Marker Score: 4663
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6
    Marker Score: 17990
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.59
    Marker Score: 2901
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.58
    Marker Score: 2107
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.58
    Marker Score: 2822
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.55
    Marker Score: 1223
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.55
    Marker Score: 1383
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.54
    Marker Score: 725
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.53
    Marker Score: 2516
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.53
    Marker Score: 3610
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.53
    Marker Score: 1442
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.53
    Marker Score: 1795
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.53
    Marker Score: 2456
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.53
    Marker Score: 725
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.52
    Marker Score: 1910
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.52
    Marker Score: 3093
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.52
    Marker Score: 809
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.51
    Marker Score: 530
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.51
    Marker Score: 12989
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.51
    Marker Score: 38548
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.5
    Marker Score: 2928
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.5
    Marker Score: 732.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.5
    Marker Score: 79257
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.5
    Marker Score: 723
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.5
    Marker Score: 3646
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.49
    Marker Score: 1219
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.49
    Marker Score: 728
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.49
    Marker Score: 882
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.49
    Marker Score: 765
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.48
    Marker Score: 50284
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.48
    Marker Score: 474
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.46
    Marker Score: 4616
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.46
    Marker Score: 983
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.46
    Marker Score: 1374
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.46
    Marker Score: 2735
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.45
    Marker Score: 6978
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.45
    Marker Score: 1399
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.45
    Marker Score: 1048
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.45
    Marker Score: 651
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.44
    Marker Score: 1700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.44
    Marker Score: 2119
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.44
    Marker Score: 2384
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 336
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.43
    Marker Score: 10660
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.43
    Marker Score: 651
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.43
    Marker Score: 754
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.43
    Marker Score: 1257.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.43
    Marker Score: 2276
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.43
    Marker Score: 80002
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.43
    Marker Score: 12418
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.43
    Marker Score: 1275

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - DGUOK is a protein with a molecular weight of approximately 130 kDa. - It is a serine/threonine kinase. - It is present in both the nucleus and mitochondria of cells. - It is a key regulator of mitochondrial respiration, as it is involved in the regulation of ATP production and the maintenance of mitochondrial redox balance. **Pathways and functions:** - DGUOK is involved in the regulation of energy production through the mitochondrial atp synthesis coupled electron transport pathway. - It also plays a role in nucleotide salvage by regulating the degradation of deoxyadenosine and deoxyguanosine nucleotides. - It is involved in the regulation of purine deoxyribonucleoside metabolic process, and it is a key regulator of purine salvage. - It is also involved in the regulation of cell migration and proliferation. **Clinical significance:** - Mutations in DGUOK have been linked to several human diseases, including cancer and neurodegenerative disorders. - In cancer, mutations in DGUOK are associated with the development of aggressive tumors and resistance to therapy. - Therefore, DGUOK is a promising target for the development of novel therapeutic strategies for cancer.

Genular Protein ID: 346888577

Symbol: DGUOK_HUMAN

Name: Deoxyguanosine kinase, mitochondrial

UniProtKB Accession Codes:

Q16854 P78532 Q16759 Q4ZG09 Q7L1W9 Q96BC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 9 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8692979

Title: Cloning and expression of human deoxyguanosine kinase cDNA.

PubMed ID: 8692979

DOI: 10.1073/pnas.93.14.7258

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706825

Title: Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA.

PubMed ID: 8706825

DOI: 10.1016/0014-5793(96)00623-0

PubMed ID: 11687801

Title: Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.

PubMed ID: 11687801

DOI: 10.1038/ng751

PubMed ID: 17073823

Title: Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion.

PubMed ID: 17073823

DOI: 10.1042/bj20060705

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 11427893

Title: Structural basis for substrate specificities of cellular deoxyribonucleoside kinases.

PubMed ID: 11427893

DOI: 10.1038/89661

PubMed ID: 12205643

Title: Mitochondrial DNA depletion and dGK gene mutations.

PubMed ID: 12205643

DOI: 10.1002/ana.10284

PubMed ID: 15639197

Title: Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.

PubMed ID: 15639197

DOI: 10.1016/j.ymgme.2004.09.005

PubMed ID: 23043144

Title: Next-generation sequencing reveals DGUOK mutations in adult patients with mitochondrial DNA multiple deletions.

PubMed ID: 23043144

DOI: 10.1093/brain/aws258

PubMed ID: 26874653

Title: Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.

PubMed ID: 26874653

DOI: 10.1002/hep.28499

Sequence Information:

  • Length: 277
  • Mass: 32056
  • Checksum: 53E4514BFC2CB5E5
  • Sequence:
    • MAAGRLFLSR LRAPFSSMAK SPLEGVSSSR GLHAGRGPRR LSIEGNIAVG KSTFVKLLTK 
TYPEWHVATE PVATWQNIQA AGTQKACTAQ SLGNLLDMMY REPARWSYTF QTFSFLSRLK 
VQLEPFPEKL LQARKPVQIF ERSVYSDRYI FAKNLFENGS LSDIEWHIYQ DWHSFLLWEF 
ASRITLHGFI YLQASPQVCL KRLYQRAREE EKGIELAYLE QLHGQHEAWL IHKTTKLHFE 
ALMNIPVLVL DVNDDFSEEV TKQEDLMREV NTFVKNL

Genular Protein ID: 2731687767

Symbol: E5KSL6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KSL6

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 43 ExpressionAtlas 1 GO 4 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 Pfam 2 RefSeq 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 189
  • Mass: 21439
  • Checksum: 0E0CBD1BBBE34002
  • Sequence:
    • MAAGRLFLSR LRAPFSSMAK SPLEGVSSSR GLHAGRGPRR LSIEGNIAVG KSTFVKLLTK 
TYPEWHVATE PVATWQNIQA AGTQKACTAQ SLGNLLDMMY REPARWSYTF QTFSFLSRLK 
VQLEPFPEKL LQARKPVQIF ERSVYSDRLH FEALMNIPVL VLDVNDDFSE EVTKQEDLMR 
EVNTFVKNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.