Details for: SEPTIN1

Gene ID: 1731

Symbol: SEPTIN1

Ensembl ID: ENSG00000180096

Description: septin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.3789
    Cell Significance Index: -17.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.4251
    Cell Significance Index: -12.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.8933
    Cell Significance Index: -25.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.7463
    Cell Significance Index: -22.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6153
    Cell Significance Index: -18.0200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 8.8982
    Cell Significance Index: 20.7600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 8.0341
    Cell Significance Index: 21.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9112
    Cell Significance Index: -19.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.4782
    Cell Significance Index: 131.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2363
    Cell Significance Index: -9.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2462
    Cell Significance Index: 264.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8698
    Cell Significance Index: 184.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.8117
    Cell Significance Index: 28.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7576
    Cell Significance Index: 204.8300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.4745
    Cell Significance Index: 14.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9762
    Cell Significance Index: 20.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9421
    Cell Significance Index: 850.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8479
    Cell Significance Index: 44.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7762
    Cell Significance Index: 6.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7324
    Cell Significance Index: 119.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5925
    Cell Significance Index: 64.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5520
    Cell Significance Index: 35.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4956
    Cell Significance Index: 3.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4005
    Cell Significance Index: 177.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3398
    Cell Significance Index: 9.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3269
    Cell Significance Index: 44.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2726
    Cell Significance Index: 19.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2662
    Cell Significance Index: 7.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2555
    Cell Significance Index: 15.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2553
    Cell Significance Index: 17.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2390
    Cell Significance Index: 47.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2359
    Cell Significance Index: 11.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2319
    Cell Significance Index: 126.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2292
    Cell Significance Index: 29.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2181
    Cell Significance Index: 43.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2025
    Cell Significance Index: 9.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1964
    Cell Significance Index: 24.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1876
    Cell Significance Index: 2.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1709
    Cell Significance Index: 10.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1527
    Cell Significance Index: 27.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1189
    Cell Significance Index: 42.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0754
    Cell Significance Index: 14.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0596
    Cell Significance Index: 41.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0433
    Cell Significance Index: 81.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0420
    Cell Significance Index: 5.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0359
    Cell Significance Index: 55.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0316
    Cell Significance Index: 0.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0287
    Cell Significance Index: 52.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0230
    Cell Significance Index: 0.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0111
    Cell Significance Index: 0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0047
    Cell Significance Index: 6.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0013
    Cell Significance Index: -0.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0102
    Cell Significance Index: -0.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0134
    Cell Significance Index: -10.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0163
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0204
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0226
    Cell Significance Index: -16.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0254
    Cell Significance Index: -16.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0285
    Cell Significance Index: -1.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0368
    Cell Significance Index: -16.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0391
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0529
    Cell Significance Index: -0.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0617
    Cell Significance Index: -3.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0694
    Cell Significance Index: -7.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0735
    Cell Significance Index: -1.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0736
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0786
    Cell Significance Index: -9.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0819
    Cell Significance Index: -2.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0840
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0861
    Cell Significance Index: -18.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0958
    Cell Significance Index: -13.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1120
    Cell Significance Index: -1.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1163
    Cell Significance Index: -6.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1270
    Cell Significance Index: -5.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1544
    Cell Significance Index: -11.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1649
    Cell Significance Index: -17.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1702
    Cell Significance Index: -9.5500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1907
    Cell Significance Index: -1.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1939
    Cell Significance Index: -6.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1971
    Cell Significance Index: -4.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2038
    Cell Significance Index: -2.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2100
    Cell Significance Index: -6.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2230
    Cell Significance Index: -13.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2603
    Cell Significance Index: -6.9500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2669
    Cell Significance Index: -2.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2797
    Cell Significance Index: -8.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2905
    Cell Significance Index: -23.0100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3127
    Cell Significance Index: -4.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3139
    Cell Significance Index: -6.5700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3337
    Cell Significance Index: -3.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3494
    Cell Significance Index: -6.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3497
    Cell Significance Index: -9.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3533
    Cell Significance Index: -5.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3649
    Cell Significance Index: -9.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3988
    Cell Significance Index: -6.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4007
    Cell Significance Index: -14.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4084
    Cell Significance Index: -5.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4279
    Cell Significance Index: -14.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SEPT1 is a highly conserved protein that belongs to the septin family, which consists of seven members in humans. SEPT1 is a GTP-binding protein that interacts with various cellular components, including microtubules, actin filaments, and other septins, to regulate cytoskeletal dynamics and cell division. SEPT1 is characterized by its ability to form ring-like structures, known as septin rings, which are involved in regulating cell division and cytokinesis. **Pathways and Functions** SEPT1 is involved in several cellular pathways, including: 1. **Cell Division**: SEPT1 plays a crucial role in regulating cell division, including mitosis and cytokinesis. It interacts with microtubules and actin filaments to regulate the formation of the cell division ring and the separation of chromosomes. 2. **Cytoskeleton-dependent Cytokinesis**: SEPT1 is involved in regulating the cytoskeletal dynamics required for cytokinesis, the process by which a cell divides into two daughter cells. 3. **GTPase Activity**: SEPT1 is a GTP-binding protein that regulates its activity through the hydrolysis of GTP. This process is essential for regulating cell division and cytoskeletal dynamics. 4. **Protein Binding**: SEPT1 interacts with various proteins, including microtubules, actin filaments, and other septins, to regulate cellular processes. **Clinical Significance** SEPT1 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases**: SEPT1 has been shown to play a role in regulating immune cell function and cytokine production, which is critical in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: SEPT1 has been implicated in cancer progression, where it regulates cell proliferation and migration. 3. **Infectious Diseases**: SEPT1 has been shown to play a role in regulating immune responses to infections, including HIV and tuberculosis. In summary, SEPT1 is a highly conserved protein that plays a critical role in regulating cell division, cytoskeletal dynamics, and immune cell function. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. Further studies are needed to fully elucidate the mechanisms by which SEPT1 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2958036768

Symbol: SEPT1_HUMAN

Name: LARP

UniProtKB Accession Codes:

Q8WYJ6 B4DVE6 Q658T1 Q8NEZ1 Q96EL4 Q9H285

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12747765

Title: Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.

PubMed ID: 12747765

PubMed ID: 16179162

Title: Septin1, a new interaction partner for human serine/threonine kinase aurora-B.

PubMed ID: 16179162

DOI: 10.1016/j.bbrc.2005.06.212

PubMed ID: 15915442

Title: Expression profiling the human septin gene family.

PubMed ID: 15915442

DOI: 10.1002/path.1789

PubMed ID: 19799413

Title: From midbody protein-protein interaction network construction to novel regulators in cytokinesis.

PubMed ID: 19799413

DOI: 10.1021/pr900325f

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 372
  • Mass: 42386
  • Checksum: 00F2752A819E1F16
  • Sequence:
    • MAGGVMDKEY VGFAALPNQL HRKSVKKGFD FTLMVAGESG LGKSTLINSL FLTNLYEDRQ 
VPEASARLTQ TLAIERRGVE IEEGGVKVKL TLVDTPGFGD SVDCSDCWLP VVKFIEEQFE 
QYLRDESGLN RKNIQDSRVH CCLYFISPFG RGLRPLDVAF LRAVHEKVNI IPVIGKADAL 
MPQETQALKQ KIRDQLKEEE IHIYQFPECD SDEDEDFKRQ DAEMKESIPF AVVGSCEVVR 
DGGNRPVRGR RYSWGTVEVE NPHHCDFLNL RRMLVQTHLQ DLKEVTHDLL YEGYRARCLQ 
SLARPGARDR ASRSKLSRQS ATEIPLPMLP LADTEKLIRE KDEELRRMQE MLEKMQAQMQ 
QSQAQGEQSD AL

Genular Protein ID: 89314691

Symbol: J3KNL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KNL2

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 HGNC 1 HOGENOM 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 414
  • Mass: 46918
  • Checksum: 58EDCDAF3B33AE2D
  • Sequence:
    • MSHHDDGATV GLGIQMCEGW RVEAALSFLP HQRKWGETAG AVMAGGVMDK EYVGFAALPN 
QLHRKSVKKG FDFTLMVAGE SGLGKSTLIN SLFLTNLYED RQVPEASARL TQTLAIERRG 
VEIEEGGVKV KLTLVDTPGF GDSVDCSDCW LPVVKFIEEQ FEQYLRDESG LNRKNIQDSR 
VHCCLYFISP FGRGLRPLDV AFLRAVHEKV NIIPVIGKAD ALMPQETQAL KQKIRDQLKE 
EEIHIYQFPE CDSDEDEDFK RQDAEMKESI PFAVVGSCEV VRDGGNRPVR GRRYSWGTVE 
VENPHHCDFL NLRRMLVQTH LQDLKEVTHD LLYEGYRARC LQSLARPGAR DRASRSKLSR 
QSATEIPLPM LPLADTEKLI REKDEELRRM QEMLEKMQAQ MQQSQAQGEQ SDAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.