Details for: DLD
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 11.78rCSI 20.77%PRS 57.64
-
CSI 7.39rCSI 16.58%PRS 33.75
-
CSI 7.22rCSI 11.71%PRS 47.46
-
CSI 6.88rCSI 17.39%PRS 57.71
-
CSI 6.76rCSI 6.92%PRS 67.02
-
CSI 6.62rCSI 9.38%PRS 46.02
-
CSI 5.78rCSI 8.84%PRS 58.92
-
CSI 5.63rCSI 32.26%PRS 60.27
-
CSI 5.48rCSI 40.3%PRS 37.02
-
CSI 5.46rCSI 7.46%PRS 51.94
-
CSI 5.42rCSI 4.81%PRS 48.12
-
CSI 4.91rCSI 8.67%PRS 32.01
-
CSI 4.88rCSI 6.04%PRS 45.3
-
CSI 4.84rCSI 18.11%PRS 42.09
-
CSI 4.78rCSI 7.3%PRS 66.61
-
CSI 4.39rCSI 12.59%PRS 68.09
-
CSI 4.39rCSI 11.12%PRS 39.5
-
CSI 4.2rCSI 5.27%PRS 59.5
-
CSI 4.17rCSI 4.35%PRS 48.45
-
CSI 4.17rCSI 7.48%PRS 42.77
-
CSI 3.97rCSI 3.18%PRS 71.08
-
CSI 3.78rCSI 2.63%PRS 59.1
-
CSI 3.64rCSI 9.24%PRS 44.86
-
CSI 3.47rCSI 5.36%PRS 47.26
-
CSI 3.37rCSI 5.9%PRS 41.61
-
CSI 3.35rCSI 2.55%PRS 61.54
-
CSI 3.32rCSI 16.64%PRS 61.11
-
CSI 3.27rCSI 6.78%PRS 47.12
-
CSI 3.26rCSI 2.52%PRS 50.08
-
CSI 3.16rCSI 7.23%PRS 48.85
-
CSI 3.11rCSI 13.51%PRS 65.03
-
CSI 3.1rCSI 2.06%PRS 53.19
-
CSI 2.99rCSI 4.93%PRS 54.92
-
CSI 2.89rCSI 4.14%PRS 55.87
-
CSI 2.88rCSI 3.99%PRS 53.4
-
CSI 2.78rCSI 11.23%PRS 47.88
-
CSI 2.77rCSI 6.38%PRS 40.16
-
CSI 2.68rCSI 2.11%PRS 36.91
-
CSI 2.67rCSI 1.98%PRS 42.57
-
CSI 2.66rCSI 2.57%PRS 40.08
-
CSI 2.55rCSI 4.41%PRS 39.98
-
CSI 2.54rCSI 1.96%PRS 48.6
-
CSI 2.49rCSI 3.75%PRS 52.04
-
CSI 2.46rCSI 2.22%PRS 46.22
-
CSI 2.45rCSI 2.03%PRS 48.17
-
CSI 2.41rCSI 2.12%PRS 38.32
-
CSI 2.38rCSI 4.63%PRS 51.66
-
CSI 2.37rCSI 2.47%PRS 50
-
CSI 2.32rCSI 3.69%PRS 60.32
-
CSI 2.32rCSI 3.73%PRS 35.14
-
CSI 2.3rCSI 2.69%PRS 65.45
-
CSI 2.29rCSI 7.84%PRS 78.87
-
CSI 2.29rCSI 8.9%PRS 70.22
-
CSI 2.27rCSI 2.41%PRS 63.44
-
CSI 2.26rCSI 24.77%PRS 65.11
-
CSI 2.25rCSI 2.89%PRS 44.1
-
CSI 2.23rCSI 3.59%PRS 39.85
-
CSI 2.23rCSI 3.05%PRS 58.68
-
CSI 2.22rCSI 3.19%PRS 40.08
-
CSI 2.21rCSI 1.66%PRS 53.48
-
CSI 2.21rCSI 1.92%PRS 53.63
-
CSI 2.21rCSI 1.49%PRS 60.92
-
CSI 2.21rCSI 6.39%PRS 51.61
-
CSI 2.18rCSI 2.14%PRS 52.02
-
CSI 2.14rCSI 2.02%PRS 50.08
-
CSI 2.11rCSI 3.04%PRS 59.4
-
CSI 2.1rCSI 6.21%PRS 53.51
-
CSI 2.09rCSI 2.86%PRS 54.62
-
CSI 2.08rCSI 1.64%PRS 56.09
-
CSI 2.07rCSI 2.13%PRS 67.69
-
CSI 2.06rCSI 4.14%PRS 39.05
-
CSI 2.04rCSI 1.9%PRS 49.18
-
CSI 2.03rCSI 2.59%PRS 55.24
-
CSI 2.02rCSI 15.2%PRS 68.51
-
CSI 2.01rCSI 2.2%PRS 53.27
-
CSI 1.97rCSI 1.63%PRS 50.84
-
CSI 1.96rCSI 1.46%PRS 62.89
-
CSI 1.95rCSI 5.54%PRS 48.57
-
CSI 1.95rCSI 46.58%PRS 32.46
-
CSI 1.95rCSI 1.15%PRS 65.65
-
CSI 1.94rCSI 1.35%PRS 63.1
-
CSI 1.93rCSI 2.07%PRS 47.63
-
CSI 1.9rCSI 4.92%PRS 45.18
-
CSI 1.86rCSI 1.63%PRS 54.76
-
CSI 1.85rCSI 2.14%PRS 43.51
-
CSI 1.85rCSI 2.47%PRS 58.04
-
CSI 1.85rCSI 3.15%PRS 75.52
-
CSI 1.82rCSI 1.58%PRS 59.59
-
CSI 1.81rCSI 7.39%PRS 45.97
-
CSI 1.75rCSI 11.29%PRS 70.83
-
CSI 1.75rCSI 1.69%PRS 49.73
-
CSI 1.74rCSI 1.21%PRS 51.64
-
CSI 1.71rCSI 2.5%PRS 52.76
-
CSI 1.71rCSI 2.37%PRS 48.82
-
CSI 1.7rCSI 1.78%PRS 46.41
-
CSI 1.7rCSI 2.17%PRS 54.23
-
CSI 1.69rCSI 2.01%PRS 32.85
-
CSI 1.64rCSI 1.38%PRS 54.43
-
CSI 1.59rCSI 2.44%PRS 65.29
-
CSI 1.57rCSI 5.06%PRS 48.21
-
CSI 0.2rCSI 4.9%PRS 72.6%
-
CSI 0.2rCSI 2.1%PRS 82.9%
-
CSI 0.3rCSI 1.6%PRS 34.4%
-
CSI 0.3rCSI 4.7%PRS 72.7%
-
CSI 0.4rCSI 1.5%PRS 33.9%
-
CSI 0.5rCSI 1.0%PRS 37.1%
-
CSI 0.5rCSI 1.7%PRS 31.8%
-
CSI 0.5rCSI 1.5%PRS 40.4%
-
CSI 0.5rCSI 4.7%PRS 91.2%
-
CSI 0.6rCSI 1.7%PRS 34.4%
-
CSI 0.6rCSI 1.8%PRS 36.7%
-
CSI 0.6rCSI 2.6%PRS 48.3%
-
CSI 0.6rCSI 3.2%PRS 64.0%
-
CSI 0.6rCSI 1.5%PRS 31.9%
-
CSI 0.7rCSI 2.9%PRS 42.2%
-
CSI 0.7rCSI 2.8%PRS 64.6%
-
CSI 0.7rCSI 1.3%PRS 48.0%
-
CSI 0.7rCSI 1.4%PRS 59.9%
-
CSI 0.7rCSI 1.4%PRS 68.3%
-
CSI 0.7rCSI 3.8%PRS 73.3%
-
CSI 0.8rCSI 3.9%PRS 86.3%
-
CSI 0.8rCSI 1.3%PRS 50.6%
-
CSI 0.9rCSI 3.8%PRS 67.3%
-
CSI 0.9rCSI 2.0%PRS 54.8%
-
CSI 0.9rCSI 4.2%PRS 48.3%
-
CSI 0.9rCSI 2.1%PRS 60.9%
-
CSI 1.0rCSI 3.6%PRS 64.3%
-
CSI 1.1rCSI 1.9%PRS 65.8%
-
CSI 1.1rCSI 1.4%PRS 54.7%
-
CSI 1.1rCSI 1.2%PRS 39.5%
-
CSI 1.1rCSI 1.3%PRS 59.1%
-
CSI 1.1rCSI 1.6%PRS 48.0%
-
CSI 1.1rCSI 2.7%PRS 68.1%
-
CSI 1.1rCSI 1.7%PRS 45.9%
-
CSI 1.1rCSI 2.1%PRS 72.0%
-
CSI 1.1rCSI 1.2%PRS 52.7%
-
CSI 1.1rCSI 2.8%PRS 44.5%
-
CSI 1.2rCSI 1.2%PRS 43.4%
-
CSI 1.2rCSI 2.6%PRS 56.3%
-
CSI 1.2rCSI 1.6%PRS 42.4%
-
CSI 1.2rCSI 1.4%PRS 47.4%
-
CSI 1.2rCSI 3.2%PRS 57.9%
-
CSI 1.2rCSI 2.1%PRS 47.1%
-
CSI 1.2rCSI 2.8%PRS 47.4%
-
CSI 1.2rCSI 0.9%PRS 62.8%
-
CSI 1.2rCSI 29.5%PRS 33.4%
-
CSI 1.2rCSI 1.3%PRS 55.4%
-
CSI 1.3rCSI 2.0%PRS 43.0%
-
CSI 1.3rCSI 1.0%PRS 50.3%
-
CSI 1.3rCSI 3.3%PRS 54.0%
-
CSI 1.3rCSI 1.6%PRS 34.0%
-
CSI 1.3rCSI 8.0%PRS 41.7%
-
CSI 1.3rCSI 2.0%PRS 50.1%
-
CSI 1.3rCSI 2.8%PRS 67.7%
-
CSI 1.3rCSI 2.1%PRS 39.6%
-
CSI 1.3rCSI 2.2%PRS 56.9%
-
CSI 1.4rCSI 2.1%PRS 54.2%
-
CSI 1.4rCSI 1.6%PRS 52.5%
-
CSI 1.4rCSI 1.7%PRS 57.3%
-
CSI 1.4rCSI 2.8%PRS 70.5%
-
CSI 1.4rCSI 2.0%PRS 52.0%
-
CSI 1.4rCSI 2.3%PRS 32.9%
-
CSI 1.4rCSI 1.3%PRS 57.5%
-
CSI 1.4rCSI 1.3%PRS 50.4%
-
CSI 1.4rCSI 1.7%PRS 51.9%
-
CSI 1.4rCSI 3.5%PRS 47.4%
-
CSI 1.4rCSI 4.6%PRS 46.2%
-
CSI 1.4rCSI 4.0%PRS 63.4%
-
CSI 1.5rCSI 2.7%PRS 38.7%
-
CSI 1.5rCSI 1.9%PRS 47.4%
-
CSI 1.5rCSI 4.3%PRS 66.3%
-
CSI 1.5rCSI 2.2%PRS 60.9%
-
CSI 1.5rCSI 2.2%PRS 66.8%
-
CSI 1.5rCSI 3.3%PRS 46.9%
-
CSI 1.5rCSI 2.4%PRS 57.0%
-
CSI 1.5rCSI 1.9%PRS 31.3%
-
CSI 1.6rCSI 3.7%PRS 51.0%
-
CSI 1.6rCSI 5.1%PRS 48.2%
-
CSI 1.6rCSI 2.4%PRS 65.3%
-
CSI 1.6rCSI 1.4%PRS 54.4%
-
CSI 1.7rCSI 2.0%PRS 32.9%
-
CSI 1.7rCSI 2.2%PRS 54.2%
-
CSI 1.7rCSI 1.8%PRS 46.4%
-
CSI 1.7rCSI 2.4%PRS 48.8%
-
CSI 1.7rCSI 2.5%PRS 52.8%
-
CSI 1.7rCSI 1.2%PRS 51.6%
-
CSI 1.8rCSI 1.7%PRS 49.7%
-
CSI 1.8rCSI 11.3%PRS 70.8%
-
CSI 1.8rCSI 7.4%PRS 46.0%
-
CSI 1.8rCSI 1.6%PRS 59.6%
-
CSI 1.9rCSI 3.2%PRS 75.5%
-
CSI 1.9rCSI 2.5%PRS 58.0%
-
CSI 1.9rCSI 2.1%PRS 43.5%
-
CSI 1.9rCSI 1.6%PRS 54.8%
-
CSI 1.9rCSI 4.9%PRS 45.2%
-
CSI 1.9rCSI 2.1%PRS 47.6%
-
CSI 1.9rCSI 1.4%PRS 63.1%
-
CSI 2.0rCSI 1.2%PRS 65.7%
-
CSI 2.0rCSI 46.6%PRS 32.5%
-
CSI 2.0rCSI 5.5%PRS 48.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2953229596
Symbol: DLDH_HUMAN
Name: Dihydrolipoyl dehydrogenase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3693355
Title: Isolation and sequence determination of cDNA clones for porcine and human lipoamide dehydrogenase. Homology to other disulfide oxidoreductases.
PubMed ID: 3693355
PubMed ID: 3278312
Title: Cloning and cDNA sequence of the dihydrolipoamide dehydrogenase component human alpha-ketoacid dehydrogenase complexes.
PubMed ID: 3278312
PubMed ID: 8406489
Title: The structure of the human dihydrolipoamide dehydrogenase gene (DLD) and its upstream elements.
PubMed ID: 8406489
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1332063
Title: Characterization of the transcriptional regulatory region of the human dihydrolipoamide dehydrogenase gene.
PubMed ID: 1332063
PubMed ID: 14638692
Title: Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
PubMed ID: 14638692
PubMed ID: 15888450
Title: Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation.
PubMed ID: 15888450
PubMed ID: 17404228
Title: Cryptic proteolytic activity of dihydrolipoamide dehydrogenase.
PubMed ID: 17404228
PubMed ID: 20160912
Title: Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.
PubMed ID: 20160912
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20385101
Title: Characterization of interactions of dihydrolipoamide dehydrogenase with its binding protein in the human pyruvate dehydrogenase complex.
PubMed ID: 20385101
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29211711
Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.
PubMed ID: 29211711
DOI: 10.1038/nature25003
PubMed ID: 15946682
Title: Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.
PubMed ID: 15946682
PubMed ID: 16263718
Title: How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex.
PubMed ID: 16263718
PubMed ID: 16442803
Title: Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.
PubMed ID: 16442803
PubMed ID: 20361979
Title: Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.
PubMed ID: 20361979
PubMed ID: 8506365
Title: Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.
PubMed ID: 8506365
PubMed ID: 9540846
Title: Deficiency of dihydrolipoamide dehydrogenase due to two mutant alleles (E340K and G101del). Analysis of a family and prenatal testing.
PubMed ID: 9540846
PubMed ID: 8968745
Title: Identification of two mutations in a compound heterozygous child with dihydrolipoamide dehydrogenase deficiency.
PubMed ID: 8968745
PubMed ID: 10448086
Title: Lipoamide dehydrogenase deficiency due to a novel mutation in the interface domain.
PubMed ID: 10448086
PubMed ID: 11687750
Title: Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency.
PubMed ID: 11687750
PubMed ID: 12925875
Title: Leigh syndrome due to compound heterozygosity of dihydrolipoamide dehydrogenase gene mutations. Description of the first E3 splice site mutation.
PubMed ID: 12925875
PubMed ID: 15712224
Title: A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency.
PubMed ID: 15712224
DOI: 10.1002/humu.9319
PubMed ID: 16770810
Title: Novel mutations in dihydrolipoamide dehydrogenase deficiency in two cousins with borderline-normal PDH complex activity.
PubMed ID: 16770810
DOI: 10.1002/ajmg.a.31313
PubMed ID: 9934985
Title: Molecular basis of lipoamide dehydrogenase deficiency in Ashkenazi Jews.
PubMed ID: 9934985
DOI: 10.1002/(sici)1096-8628(19990115)82:2<177::aid-ajmg15>3.3.co;2-0
Sequence Information:
- Length: 509
- Mass: 54177
- Checksum: 7613492C516F3835
- Sequence:
MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEMSEVRLNL DKMMEQKSTA VKALTGGIAH LFKQNKVVHV NGYGKITGKN QVTATKADGG TQVIDTKNIL IATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKMVVIG AGVIGVELGS VWQRLGADVT AVEFLGHVGG VGIDMEISKN FQRILQKQGF KFKLNTKVTG ATKKSDGKID VSIEAASGGK AEVITCDVLL VCIGRRPFTK NLGLEELGIE LDPRGRIPVN TRFQTKIPNI YAIGDVVAGP MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEYKVGK FPFAANSRAK TNADTDGMVK ILGQKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI ARVCHAHPTL SEAFREANLA ASFGKSINF
Genular Protein ID: 895214609
Symbol: E9PEX6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 12853948
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 486
- Mass: 51815
- Checksum: 256F9EA37D0740B6
- Sequence:
MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA AQLGFKALLN NSHYYHMAHG KDFASRGIEM SEVRLNLDKM MEQKSTAVKA LTGGIAHLFK QNKVVHVNGY GKITGKNQVT ATKADGGTQV IDTKNILIAT GSEVTPFPGI TIDEDTIVSS TGALSLKKVP EKMVVIGAGV IGVELGSVWQ RLGADVTAVE FLGHVGGVGI DMEISKNFQR ILQKQGFKFK LNTKVTGATK KSDGKIDVSI EAASGGKAEV ITCDVLLVCI GRRPFTKNLG LEELGIELDP RGRIPVNTRF QTKIPNIYAI GDVVAGPMLA HKAEDEGIIC VEGMAGGAVH IDYNCVPSVI YTHPEVAWVG KSEEQLKEEG IEYKVGKFPF AANSRAKTNA DTDGMVKILG QKSTDRVLGA HILGPGAGEM VNEAALALEY GASCEDIARV CHAHPTLSEA FREANLAASF GKSINF