Details for: DLD

Gene ID: 1738

Symbol: DLD

Ensembl ID: ENSG00000091140

Description: dihydrolipoamide dehydrogenase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.97
    Marker Score: 2051
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.86
    Marker Score: 4993
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.85
    Marker Score: 3060
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.81
    Marker Score: 2602
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.72
    Marker Score: 6762
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.63
    Marker Score: 4119
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.5
    Marker Score: 1586
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.49
    Marker Score: 12800
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.4
    Marker Score: 748
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.39
    Marker Score: 5995
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.37
    Marker Score: 684
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.37
    Marker Score: 929
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.34
    Marker Score: 1680
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.32
    Marker Score: 33879
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.32
    Marker Score: 6315
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.3
    Marker Score: 3091
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3
    Marker Score: 1913
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.3
    Marker Score: 47845
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.28
    Marker Score: 4561
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.28
    Marker Score: 746
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.28
    Marker Score: 2602
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1974
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.27
    Marker Score: 3986
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.26
    Marker Score: 364
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.25
    Marker Score: 1326
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.24
    Marker Score: 1759
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.24
    Marker Score: 1332
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2549
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.22
    Marker Score: 301
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.22
    Marker Score: 74866
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.21
    Marker Score: 4493
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.21
    Marker Score: 12502
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.21
    Marker Score: 905
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.19
    Marker Score: 4997
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.18
    Marker Score: 277
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.18
    Marker Score: 4883
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.17
    Marker Score: 409
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.17
    Marker Score: 615
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.15
    Marker Score: 645
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.13
    Marker Score: 8431
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.13
    Marker Score: 752
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.13
    Marker Score: 1134
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.12
    Marker Score: 1907
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.12
    Marker Score: 544
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.12
    Marker Score: 9622
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.11
    Marker Score: 1129
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.11
    Marker Score: 1154
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.1
    Marker Score: 1804
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.1
    Marker Score: 2586
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.09
    Marker Score: 10279
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.08
    Marker Score: 594
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.06
    Marker Score: 372
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.06
    Marker Score: 36605.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.05
    Marker Score: 1106
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.05
    Marker Score: 9982
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.04
    Marker Score: 311
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.04
    Marker Score: 1341
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.04
    Marker Score: 1256
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.03
    Marker Score: 1098
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.03
    Marker Score: 330
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.03
    Marker Score: 2255
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.03
    Marker Score: 1199
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.03
    Marker Score: 300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.02
    Marker Score: 4180
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.02
    Marker Score: 1864
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.02
    Marker Score: 411
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15921
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 693
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1
    Marker Score: 732
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1
    Marker Score: 1332
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1
    Marker Score: 6369
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71608
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47831
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.98
    Marker Score: 5984
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.98
    Marker Score: 37252
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30372
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.98
    Marker Score: 294
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.98
    Marker Score: 2788
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.97
    Marker Score: 11286.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.97
    Marker Score: 2629
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.97
    Marker Score: 335
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.96
    Marker Score: 1358
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.96
    Marker Score: 17028
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.96
    Marker Score: 956
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.96
    Marker Score: 229
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.96
    Marker Score: 315
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.95
    Marker Score: 399
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.95
    Marker Score: 794
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.95
    Marker Score: 186
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.95
    Marker Score: 357
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.95
    Marker Score: 9545
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.95
    Marker Score: 273
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.94
    Marker Score: 632
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.94
    Marker Score: 461
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.94
    Marker Score: 3647
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.94
    Marker Score: 18735
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.94
    Marker Score: 682
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.94
    Marker Score: 2140

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Other Information

**Key characteristics:** * DLD is a single-pass enzyme that is highly expressed in the mitochondria of eukaryotic cells. * It is a key enzyme in the citric acid cycle and the mitochondrial protein degradation pathway. * DLD is also involved in the regulation of pyruvate dehydrogenase (PDH), a key enzyme in the citric acid cycle. **Pathways and functions:** * DLD is involved in the following pathways and functions: * Branched-chain amino acid catabolism * Citric acid cycle (tca cycle) * Dihydrolipoyl dehydrogenase activity * Glycine degradation * Lysine catabolism * Metabolism of proteins * Mitochondrial protein degradation * Protein binding * Pyruvate dehydrogenase (nad+) activity * Pyruvate metabolism * Pyruvate metabolism and citric acid (tca) cycle * Regulation of pyruvate dehydrogenase (pdh) complex * Signaling by nuclear receptors * Signaling by retinoic acid * Signal transduction * The citric acid (tca) cycle and respiratory electron transport **Clinical significance:** * Mutations in the DLD gene have been linked to several human diseases, including: * Diabetic ketoacidosis * Mitochondrial disorders * Kidney diseases **Additional information:** * The DLD gene is located on chromosome 15q21.1. * It is a highly conserved gene, with a similar sequence in humans, mice, and rats. * DLD is a well-studied enzyme, with a number of drugs targeting it for the treatment of cancer and other diseases.

Genular Protein ID: 2953229596

Symbol: DLDH_HUMAN

Name: Dihydrolipoyl dehydrogenase, mitochondrial

UniProtKB Accession Codes:

P09622 B2R5X0 B4DHG0 B4DT69 Q14131 Q14167 Q59EV8 Q8WTS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 4 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 1 CTD 1 ChEBI 16 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 26 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 17 PIR 1 PIRSF 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 8 RefSeq 4 Rhea 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3693355

Title: Isolation and sequence determination of cDNA clones for porcine and human lipoamide dehydrogenase. Homology to other disulfide oxidoreductases.

PubMed ID: 3693355

DOI: 10.1016/s0021-9258(18)45379-3

PubMed ID: 3278312

Title: Cloning and cDNA sequence of the dihydrolipoamide dehydrogenase component human alpha-ketoacid dehydrogenase complexes.

PubMed ID: 3278312

DOI: 10.1073/pnas.85.5.1422

PubMed ID: 8406489

Title: The structure of the human dihydrolipoamide dehydrogenase gene (DLD) and its upstream elements.

PubMed ID: 8406489

DOI: 10.1006/geno.1993.1335

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1332063

Title: Characterization of the transcriptional regulatory region of the human dihydrolipoamide dehydrogenase gene.

PubMed ID: 1332063

DOI: 10.1073/pnas.89.22.10964

PubMed ID: 14638692

Title: Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.

PubMed ID: 14638692

DOI: 10.1074/jbc.m308172200

PubMed ID: 15888450

Title: Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation.

PubMed ID: 15888450

DOI: 10.1074/jbc.m500310200

PubMed ID: 17404228

Title: Cryptic proteolytic activity of dihydrolipoamide dehydrogenase.

PubMed ID: 17404228

DOI: 10.1073/pnas.0610618104

PubMed ID: 20160912

Title: Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.

PubMed ID: 20160912

DOI: 10.1016/j.molcatb.2009.05.001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20385101

Title: Characterization of interactions of dihydrolipoamide dehydrogenase with its binding protein in the human pyruvate dehydrogenase complex.

PubMed ID: 20385101

DOI: 10.1016/j.bbrc.2010.04.038

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

PubMed ID: 15946682

Title: Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.

PubMed ID: 15946682

DOI: 10.1016/j.jmb.2005.05.014

PubMed ID: 16263718

Title: How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex.

PubMed ID: 16263718

DOI: 10.1074/jbc.m507850200

PubMed ID: 16442803

Title: Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.

PubMed ID: 16442803

DOI: 10.1016/j.str.2006.01.001

PubMed ID: 20361979

Title: Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.

PubMed ID: 20361979

DOI: 10.1016/j.jmb.2010.03.043

PubMed ID: 8506365

Title: Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.

PubMed ID: 8506365

DOI: 10.1073/pnas.90.11.5186

PubMed ID: 9540846

Title: Deficiency of dihydrolipoamide dehydrogenase due to two mutant alleles (E340K and G101del). Analysis of a family and prenatal testing.

PubMed ID: 9540846

DOI: 10.1016/s0925-4439(97)00073-2

PubMed ID: 8968745

Title: Identification of two mutations in a compound heterozygous child with dihydrolipoamide dehydrogenase deficiency.

PubMed ID: 8968745

DOI: 10.1093/hmg/5.12.1925

PubMed ID: 10448086

Title: Lipoamide dehydrogenase deficiency due to a novel mutation in the interface domain.

PubMed ID: 10448086

DOI: 10.1006/bbrc.1999.1133

PubMed ID: 11687750

Title: Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency.

PubMed ID: 11687750

PubMed ID: 12925875

Title: Leigh syndrome due to compound heterozygosity of dihydrolipoamide dehydrogenase gene mutations. Description of the first E3 splice site mutation.

PubMed ID: 12925875

DOI: 10.1007/s00431-003-1282-z

PubMed ID: 15712224

Title: A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiency.

PubMed ID: 15712224

DOI: 10.1002/humu.9319

PubMed ID: 16770810

Title: Novel mutations in dihydrolipoamide dehydrogenase deficiency in two cousins with borderline-normal PDH complex activity.

PubMed ID: 16770810

DOI: 10.1002/ajmg.a.31313

PubMed ID: 9934985

Title: Molecular basis of lipoamide dehydrogenase deficiency in Ashkenazi Jews.

PubMed ID: 9934985

DOI: 10.1002/(sici)1096-8628(19990115)82:2<177::aid-ajmg15>3.3.co;2-0

Sequence Information:

  • Length: 509
  • Mass: 54177
  • Checksum: 7613492C516F3835
  • Sequence:
    • MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA 
AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEMSEVRLNL 
DKMMEQKSTA VKALTGGIAH LFKQNKVVHV NGYGKITGKN QVTATKADGG TQVIDTKNIL 
IATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKMVVIG AGVIGVELGS VWQRLGADVT 
AVEFLGHVGG VGIDMEISKN FQRILQKQGF KFKLNTKVTG ATKKSDGKID VSIEAASGGK 
AEVITCDVLL VCIGRRPFTK NLGLEELGIE LDPRGRIPVN TRFQTKIPNI YAIGDVVAGP 
MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEYKVGK 
FPFAANSRAK TNADTDGMVK ILGQKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI 
ARVCHAHPTL SEAFREANLA ASFGKSINF

Genular Protein ID: 895214609

Symbol: E9PEX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PEX6

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 6 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRIDE 1 PRINTS 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 486
  • Mass: 51815
  • Checksum: 256F9EA37D0740B6
  • Sequence:
    • MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA 
AQLGFKALLN NSHYYHMAHG KDFASRGIEM SEVRLNLDKM MEQKSTAVKA LTGGIAHLFK 
QNKVVHVNGY GKITGKNQVT ATKADGGTQV IDTKNILIAT GSEVTPFPGI TIDEDTIVSS 
TGALSLKKVP EKMVVIGAGV IGVELGSVWQ RLGADVTAVE FLGHVGGVGI DMEISKNFQR 
ILQKQGFKFK LNTKVTGATK KSDGKIDVSI EAASGGKAEV ITCDVLLVCI GRRPFTKNLG 
LEELGIELDP RGRIPVNTRF QTKIPNIYAI GDVVAGPMLA HKAEDEGIIC VEGMAGGAVH 
IDYNCVPSVI YTHPEVAWVG KSEEQLKEEG IEYKVGKFPF AANSRAKTNA DTDGMVKILG 
QKSTDRVLGA HILGPGAGEM VNEAALALEY GASCEDIARV CHAHPTLSEA FREANLAASF 
GKSINF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.