Details for: DPAGT1

Gene ID: 1798

Symbol: DPAGT1

Ensembl ID: ENSG00000172269

Description: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.9341
    Cell Significance Index: -12.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.4719
    Cell Significance Index: -11.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.2207
    Cell Significance Index: -14.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1926
    Cell Significance Index: -13.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7670
    Cell Significance Index: -12.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5491
    Cell Significance Index: -14.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6559
    Cell Significance Index: 163.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3928
    Cell Significance Index: 83.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2183
    Cell Significance Index: 132.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9371
    Cell Significance Index: 152.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9086
    Cell Significance Index: 24.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7739
    Cell Significance Index: 40.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4127
    Cell Significance Index: 19.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4027
    Cell Significance Index: 10.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3887
    Cell Significance Index: 6.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3481
    Cell Significance Index: 4.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3185
    Cell Significance Index: 6.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2591
    Cell Significance Index: 35.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2545
    Cell Significance Index: 138.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2535
    Cell Significance Index: 228.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2483
    Cell Significance Index: 7.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2469
    Cell Significance Index: 46.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2363
    Cell Significance Index: 42.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2346
    Cell Significance Index: 4.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2184
    Cell Significance Index: 25.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2142
    Cell Significance Index: 9.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2018
    Cell Significance Index: 15.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1907
    Cell Significance Index: 5.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1753
    Cell Significance Index: 21.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1657
    Cell Significance Index: 5.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1633
    Cell Significance Index: 4.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1589
    Cell Significance Index: 1.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1534
    Cell Significance Index: 19.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1444
    Cell Significance Index: 28.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1413
    Cell Significance Index: 3.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1393
    Cell Significance Index: 18.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1302
    Cell Significance Index: 3.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1234
    Cell Significance Index: 5.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1076
    Cell Significance Index: 2.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1024
    Cell Significance Index: 2.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0847
    Cell Significance Index: 37.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0790
    Cell Significance Index: 2.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0721
    Cell Significance Index: 14.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0681
    Cell Significance Index: 0.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0578
    Cell Significance Index: 1.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0424
    Cell Significance Index: 15.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0211
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0207
    Cell Significance Index: 14.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0183
    Cell Significance Index: 3.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0177
    Cell Significance Index: 1.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0176
    Cell Significance Index: 1.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0083
    Cell Significance Index: 6.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0088
    Cell Significance Index: -11.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0089
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0139
    Cell Significance Index: -1.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0142
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0240
    Cell Significance Index: -13.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0245
    Cell Significance Index: -11.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0271
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0279
    Cell Significance Index: -0.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0307
    Cell Significance Index: -0.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0401
    Cell Significance Index: -1.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0406
    Cell Significance Index: -11.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0438
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0465
    Cell Significance Index: -5.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0474
    Cell Significance Index: -2.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0548
    Cell Significance Index: -7.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0585
    Cell Significance Index: -6.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0670
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1217
    Cell Significance Index: -6.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1286
    Cell Significance Index: -6.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1297
    Cell Significance Index: -7.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1303
    Cell Significance Index: -13.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1462
    Cell Significance Index: -9.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1695
    Cell Significance Index: -13.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1914
    Cell Significance Index: -9.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1918
    Cell Significance Index: -1.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1938
    Cell Significance Index: -3.2600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2068
    Cell Significance Index: -2.1400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2070
    Cell Significance Index: -3.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2295
    Cell Significance Index: -10.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2422
    Cell Significance Index: -14.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2626
    Cell Significance Index: -3.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2715
    Cell Significance Index: -10.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2716
    Cell Significance Index: -5.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2818
    Cell Significance Index: -8.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2840
    Cell Significance Index: -7.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2856
    Cell Significance Index: -4.2800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2914
    Cell Significance Index: -1.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2940
    Cell Significance Index: -14.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2991
    Cell Significance Index: -10.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3079
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3112
    Cell Significance Index: -8.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DPAGT1 is a glycosyltransferase enzyme that belongs to the UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase family. It is primarily expressed in various cell types, including pulmonary interstitial fibroblasts, cardiac endothelial cells, pancreatic D cells, and cerebral cortex GABAergic interneurons. DPAGT1 is involved in the transfer of N-acetylglucosamine (GlcNAc) to dolichol, resulting in the formation of DLOs. These DLOs are then further modified by other enzymes, ultimately leading to the creation of complex N-linked glycan structures on target proteins. **Pathways and Functions** DPAGT1 is integral to the following pathways: 1. **Asparagine N-linked Glycosylation**: DPAGT1 catalyzes the transfer of GlcNAc to dolichol, initiating the biosynthesis of N-linked glycosylation. 2. **Biosynthesis of the n-glycan precursor (DLO)**: DPAGT1 plays a crucial role in the formation of DLOs, which are essential for the proper functioning of proteins. 3. **Transfer to a nascent protein**: DPAGT1 facilitates the transfer of DLOs to nascent proteins as they mature in the endoplasmic reticulum. 4. **Defective dpagt1 causes CDG-1J, CMSTA2**: Mutations in DPAGT1 have been linked to these diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis. **Clinical Significance** Dysfunctions in DPAGT1 have been associated with several diseases, including: 1. **Congenital Dysglycans-1J (CDG1J)**: A rare genetic disorder characterized by defective glycosylation of proteins. 2. **Congenital Muscular Dystrophy of the Seydoux type (CMSTA2)**: A severe neuromuscular disorder caused by mutations in the DPAGT1 gene. 3. **Diseases of glycosylation**: DPAGT1 mutations can lead to various diseases, including congenital disorders, cancer, and neurodegenerative diseases. 4. **Diseases of metabolism**: Defects in DPAGT1 can also lead to metabolic disorders, highlighting the importance of this enzyme in maintaining cellular homeostasis. In conclusion, DPAGT1 is a vital enzyme involved in the biosynthesis of N-linked glycosylation of proteins. Its dysfunction can lead to various diseases, emphasizing the importance of this enzyme in maintaining cellular homeostasis. Further research is needed to elucidate the mechanisms underlying DPAGT1-mediated glycosylation and to develop therapeutic strategies for diseases associated with DPAGT1 deficiencies.

Genular Protein ID: 25908798

Symbol: GPT_HUMAN

Name: N-acetylglucosamine-1-phosphate transferase

UniProtKB Accession Codes:

Q9H3H5 O15216 Q86WV9 Q9BWE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 11 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9451016

Title: Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae.

PubMed ID: 9451016

DOI: 10.1093/glycob/8.1.77

PubMed ID: 29459785

Title: GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.

PubMed ID: 29459785

DOI: 10.1038/s41594-018-0031-y

PubMed ID: 30388443

Title: Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

PubMed ID: 30388443

DOI: 10.1016/j.cell.2018.10.037

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12872255

Title: Deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij.

PubMed ID: 12872255

DOI: 10.1002/humu.10239

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22742743

Title: Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates.

PubMed ID: 22742743

DOI: 10.1016/j.ajhg.2012.05.022

Sequence Information:

  • Length: 408
  • Mass: 46090
  • Checksum: 0AE10EFE55E7B9E0
  • Sequence:
    • MWAFSELPMP LLINLIVSLL GFVATVTLIP AFRGHFIAAR LCGQDLNKTS RQQIPESQGV 
ISGAVFLIIL FCFIPFPFLN CFVKEQCKAF PHHEFVALIG ALLAICCMIF LGFADDVLNL 
RWRHKLLLPT AASLPLLMVY FTNFGNTTIV VPKPFRPILG LHLDLGILYY VYMGLLAVFC 
TNAINILAGI NGLEAGQSLV ISASIIVFNL VELEGDCRDD HVFSLYFMIP FFFTTLGLLY 
HNWYPSRVFV GDTFCYFAGM TFAVVGILGH FSKTMLLFFM PQVFNFLYSL PQLLHIIPCP 
RHRIPRLNIK TGKLEMSYSK FKTKSLSFLG TFILKVAESL QLVTVHQSET EDGEFTECNN 
MTLINLLLKV LGPIHERNLT LLLLLLQILG SAITFSIRYQ LVRLFYDV

Genular Protein ID: 3369921055

Symbol: A0A804HI18_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804HI18

Database IDs:

ARBA 17 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChEBI 5 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 GO 4 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 4 SAM 1 SMR 1 UniPathway 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 242
  • Mass: 26979
  • Checksum: 3A57A255B86B53B5
  • Sequence:
    • MWAFSELPMP LLINLIVSLL GFVATVTLIP AFRGHFIAAR LCGQDLNKTS RQQIPESQGV 
ISGAVFLIIL FCFIPFPFLN CFVKEQCKAF PHHEFVALIG ALLAICCMIF LGFADDVLNL 
RWRHKLLLPT AASLPLLMVY FTNFGNTTIV VPKPFRPILG LHLDLGILYY VYMGLLAVFC 
TNAINILAGI NGLEAGQSLV ISASIIVFNL VELEGDCRDD HVFSLYFMIP FFFTTLGLLY 
HN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.