Details for: DPAGT1

Gene ID: 1798

Symbol: DPAGT1

Ensembl ID: ENSG00000172269

Description: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.25
    Marker Score: 1003
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.12
    Marker Score: 2122
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.09
    Marker Score: 475.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71731
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47955
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15374
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.98
    Marker Score: 1716
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.97
    Marker Score: 2206
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5226
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1212
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2710
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.89
    Marker Score: 3508
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.87
    Marker Score: 2046
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5245
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 499
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 266
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.79
    Marker Score: 393
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.77
    Marker Score: 3339
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.77
    Marker Score: 1140
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.75
    Marker Score: 733
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.73
    Marker Score: 1738
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.73
    Marker Score: 346
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.73
    Marker Score: 909
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.71
    Marker Score: 1502
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.71
    Marker Score: 201
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.7
    Marker Score: 752
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.7
    Marker Score: 741
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.69
    Marker Score: 216
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.69
    Marker Score: 5956
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.66
    Marker Score: 366
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.66
    Marker Score: 682
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.65
    Marker Score: 441
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.64
    Marker Score: 1334
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.62
    Marker Score: 416
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.62
    Marker Score: 581
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.61
    Marker Score: 7038
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 288
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.6
    Marker Score: 330
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.6
    Marker Score: 145
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.59
    Marker Score: 996
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.58
    Marker Score: 935
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.57
    Marker Score: 277
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.57
    Marker Score: 133
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.56
    Marker Score: 392
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.56
    Marker Score: 4813
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.56
    Marker Score: 260
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.55
    Marker Score: 556
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.55
    Marker Score: 192
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.55
    Marker Score: 3575
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.55
    Marker Score: 395
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.54
    Marker Score: 1235
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.54
    Marker Score: 1480
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.53
    Marker Score: 400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.53
    Marker Score: 356
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 351
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 338
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.53
    Marker Score: 1806
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.52
    Marker Score: 3303
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.52
    Marker Score: 461
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 214
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.51
    Marker Score: 537
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.51
    Marker Score: 153
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5096
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.5
    Marker Score: 249
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.5
    Marker Score: 958
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5
    Marker Score: 893
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.5
    Marker Score: 1232
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5
    Marker Score: 289
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.49
    Marker Score: 354
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.49
    Marker Score: 240
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.49
    Marker Score: 2328.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.48
    Marker Score: 169
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.48
    Marker Score: 121
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.48
    Marker Score: 876
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.48
    Marker Score: 16615
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.48
    Marker Score: 234
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.48
    Marker Score: 124
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.48
    Marker Score: 1295.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.48
    Marker Score: 179
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.47
    Marker Score: 249
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.47
    Marker Score: 427
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.47
    Marker Score: 1190
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.47
    Marker Score: 253
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122

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Other Information

**Key characteristics:** * DPAGT1 is a glycosyltransferase that catalyzes the transfer of a phosphate group from UDP-glucuronic acid to dolichol, resulting in the formation of dolichyl phosphate. * It is a transmembrane protein with a catalytic domain that is responsible for the transfer of the phosphate group. * It is a key enzyme in the biosynthesis of the N-glycan precursor. **Pathways and functions:** * DPAGT1 is involved in the post-translational modification of proteins. * It is responsible for the addition of a phosphate group to dolichol, which is a precursor to the N-glycan. * This modification is essential for the proper folding and function of many proteins. **Clinical significance:** * Mutations in DPAGT1 have been linked to several diseases. * These diseases are characterized by the abnormal expression of proteins that are modified by DPAGT1. * Understanding the role of DPAGT1 in protein glycosylation may lead to the development of new therapies for these diseases. **Additional information:** * DPAGT1 is a member of the UDP-glucuronic acid:dolichyl phosphate N-acetylglucosaminephosphotransferase family of enzymes. * It is regulated by a variety of factors, including growth factors, hormones, and cytokines. * It is a highly conserved protein, with similar sequences found in organisms from yeast to humans.

Genular Protein ID: 25908798

Symbol: GPT_HUMAN

Name: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

UniProtKB Accession Codes:

Q9H3H5 O15216 Q86WV9 Q9BWE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 7 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9451016

Title: Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae.

PubMed ID: 9451016

DOI: 10.1093/glycob/8.1.77

PubMed ID: 29459785

Title: GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.

PubMed ID: 29459785

DOI: 10.1038/s41594-018-0031-y

PubMed ID: 30388443

Title: Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

PubMed ID: 30388443

DOI: 10.1016/j.cell.2018.10.037

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12872255

Title: Deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij.

PubMed ID: 12872255

DOI: 10.1002/humu.10239

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22742743

Title: Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates.

PubMed ID: 22742743

DOI: 10.1016/j.ajhg.2012.05.022

Sequence Information:

  • Length: 408
  • Mass: 46090
  • Checksum: 0AE10EFE55E7B9E0
  • Sequence:
    • MWAFSELPMP LLINLIVSLL GFVATVTLIP AFRGHFIAAR LCGQDLNKTS RQQIPESQGV 
ISGAVFLIIL FCFIPFPFLN CFVKEQCKAF PHHEFVALIG ALLAICCMIF LGFADDVLNL 
RWRHKLLLPT AASLPLLMVY FTNFGNTTIV VPKPFRPILG LHLDLGILYY VYMGLLAVFC 
TNAINILAGI NGLEAGQSLV ISASIIVFNL VELEGDCRDD HVFSLYFMIP FFFTTLGLLY 
HNWYPSRVFV GDTFCYFAGM TFAVVGILGH FSKTMLLFFM PQVFNFLYSL PQLLHIIPCP 
RHRIPRLNIK TGKLEMSYSK FKTKSLSFLG TFILKVAESL QLVTVHQSET EDGEFTECNN 
MTLINLLLKV LGPIHERNLT LLLLLLQILG SAITFSIRYQ LVRLFYDV

Genular Protein ID: 3369921055

Symbol: A0A804HI18_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A804HI18

Database IDs:

ARBA 16 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChEBI 5 EC 1 EMBL 1 EPD 1 Ensembl 2 GO 4 GeneTree 1 HGNC 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 3 SAM 1 SMR 1 UniPathway 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 242
  • Mass: 26979
  • Checksum: 3A57A255B86B53B5
  • Sequence:
    • MWAFSELPMP LLINLIVSLL GFVATVTLIP AFRGHFIAAR LCGQDLNKTS RQQIPESQGV 
ISGAVFLIIL FCFIPFPFLN CFVKEQCKAF PHHEFVALIG ALLAICCMIF LGFADDVLNL 
RWRHKLLLPT AASLPLLMVY FTNFGNTTIV VPKPFRPILG LHLDLGILYY VYMGLLAVFC 
TNAINILAGI NGLEAGQSLV ISASIIVFNL VELEGDCRDD HVFSLYFMIP FFFTTLGLLY 
HN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.