Gene DR1 - ENSG00000117505 | NCBI Gene ID: 1810

Details for: DR1

Gene ID: 1810

Symbol: DR1

Ensembl ID: ENSG00000117505

Description: down-regulator of transcription 1

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of wdr5-containing histone-modifying complexes
(R-HSA-9772755)
Gene expression (transcription)
(R-HSA-74160)
Hats acetylate histones
(R-HSA-3214847)
Atac complex
(GO:0140672)
Dna binding
(GO:0003677)
Mitotic spindle
(GO:0072686)
Negative cofactor 2 complex
(GO:0017054)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of cell cycle
(GO:0051726)
Regulation of cell division
(GO:0051302)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of embryonic development
(GO:0045995)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of tubulin deacetylation
(GO:0090043)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Rna polymerase ii preinitiation complex assembly
(GO:0051123)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Tbp-class protein binding
(GO:0017025)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.65
Marker Score: 559
Cell Name: germ cell (CL0000586)
Fold Change: 1.64
Marker Score: 2869
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.6
Marker Score: 4415
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.42
Marker Score: 5577
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.39
Marker Score: 1968
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.34
Marker Score: 74659
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.32
Marker Score: 1393
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.29
Marker Score: 879
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.29
Marker Score: 1294
Cell Name: mature T cell (CL0002419)
Fold Change: 1.25
Marker Score: 12400.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.23
Marker Score: 4536
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.21
Marker Score: 3833
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.2
Marker Score: 7681
Cell Name: Unknown (CL0000548)
Fold Change: 1.2
Marker Score: 873.5
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.2
Marker Score: 7639
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.19
Marker Score: 3539
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.19
Marker Score: 62858.5
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.17
Marker Score: 1730
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.1
Marker Score: 2994.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.1
Marker Score: 263
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.1
Marker Score: 1009.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.08
Marker Score: 848
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.08
Marker Score: 9273
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.06
Marker Score: 1856.5
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.05
Marker Score: 454
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.04
Marker Score: 1104
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.03
Marker Score: 2896.5
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.02
Marker Score: 251
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.01
Marker Score: 232
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.01
Marker Score: 268
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.01
Marker Score: 686
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.01
Marker Score: 262
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1
Marker Score: 788
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1
Marker Score: 25545
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71574
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47798
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.99
Marker Score: 676
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.99
Marker Score: 1113
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.99
Marker Score: 1077
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.99
Marker Score: 867
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.99
Marker Score: 216
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.98
Marker Score: 9960
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30366
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.98
Marker Score: 588
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.97
Marker Score: 652
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.97
Marker Score: 2418
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.97
Marker Score: 556
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.96
Marker Score: 273
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.95
Marker Score: 789
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.95
Marker Score: 206
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.95
Marker Score: 844
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.94
Marker Score: 1972
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.94
Marker Score: 520
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.94
Marker Score: 460.5
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.94
Marker Score: 325.5
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.94
Marker Score: 190
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.94
Marker Score: 1385
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.94
Marker Score: 1128.5
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.94
Marker Score: 903
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.94
Marker Score: 1291
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.93
Marker Score: 326
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.93
Marker Score: 2375
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.93
Marker Score: 280.5
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.93
Marker Score: 232
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.93
Marker Score: 266
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 0.93
Marker Score: 274
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.93
Marker Score: 584
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.92
Marker Score: 986
Cell Name: parietal cell (CL0000162)
Fold Change: 0.92
Marker Score: 257
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.92
Marker Score: 227
Cell Name: memory B cell (CL0000787)
Fold Change: 0.92
Marker Score: 695
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.92
Marker Score: 767
Cell Name: S cone cell (CL0003050)
Fold Change: 0.92
Marker Score: 276
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 472
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 0.92
Marker Score: 251
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.92
Marker Score: 1316
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.91
Marker Score: 746
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 430
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.91
Marker Score: 256
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.91
Marker Score: 278
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.91
Marker Score: 370
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.9
Marker Score: 277
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.9
Marker Score: 1536
Cell Name: promonocyte (CL0000559)
Fold Change: 0.9
Marker Score: 582
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.9
Marker Score: 418
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.9
Marker Score: 1598
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.9
Marker Score: 1756
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.9
Marker Score: 252
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.9
Marker Score: 237
Cell Name: leukocyte (CL0000738)
Fold Change: 0.89
Marker Score: 513
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.89
Marker Score: 30383
Cell Name: stromal cell (CL0000499)
Fold Change: 0.89
Marker Score: 1046
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.89
Marker Score: 609
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.89
Marker Score: 2664
Cell Name: mature B cell (CL0000785)
Fold Change: 0.89
Marker Score: 652
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.89
Marker Score: 597
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.89
Marker Score: 505
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.88
Marker Score: 1581
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.88
Marker Score: 13845
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.88
Marker Score: 580

Hover over a box to see details here...

**Key characteristics** * DR1 is a protein with a molecular weight of approximately 120 kDa. * It is a member of the NuRD family of chromatin remodeling proteins. * DR1 is found in a variety of cell types, including stem cells, germ cells, decidual cells, and immune cells. * It is expressed in high levels in embryonic and fetal tissues. * DR1 is a key regulator of gene expression in these tissues. **Pathways and functions** * DR1 is involved in the regulation of embryonic development. It is expressed in high levels in early-stage embryos and is required for the proper development of the embryo. * DR1 is involved in tissue differentiation. It is expressed in high levels in some tissues, such as the skin, where it is required for the development of hair, skin, and nails. * DR1 is involved in inflammation. It is expressed in high levels in inflammatory tissues, where it helps to regulate the inflammatory response. * DR1 is a key regulator of immune cell function. It is expressed in high levels in immune cells, where it helps to regulate the immune response to pathogens. **Clinical significance** DR1 is a potential therapeutic target for a variety of diseases. For example, DR1 is expressed in high levels in cancer cells, where it promotes tumor growth and metastasis. Inhibition of DR1 has been shown to inhibit tumor growth and metastasis in animal models.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein Dr1

Genular Protein ID: 1788009764

Symbol: NC2B_HUMAN

Name: Protein Dr1

UniProtKB Accession Codes:

Q01658

Database IDs:

Citations:

PubMed ID: 1339312

Title: Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription.

PubMed ID: 1339312

DOI: 10.1016/0092-8674(92)90172-9

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8670811

Title: A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains.

PubMed ID: 8670811

DOI: 10.1002/j.1460-2075.1996.tb00673.x

PubMed ID: 8836190

Title: Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1.

PubMed ID: 8836190

DOI: 10.1093/nar/24.18.3607

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19103755

Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.

PubMed ID: 19103755

DOI: 10.1128/mcb.01599-08

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11461703

Title: Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.

PubMed ID: 11461703

DOI: 10.1016/s0092-8674(01)00417-2

Sequence Information:

Length: 176
Mass: 19444
Checksum: 36E7E59F2FD6CAB5
Sequence:

MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK 
SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR 
QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DR1

Associated with

Cells (max top 100)

Other Information

Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. PubMed ID: 1339312

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. PubMed ID: 8670811

Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. PubMed ID: 8836190

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The double-histone-acetyltransferase complex ATAC is essential for mammalian development. PubMed ID: 19103755

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. PubMed ID: 11461703