Details for: DR1

Gene ID: 1810

Symbol: DR1

Ensembl ID: ENSG00000117505

Description: down-regulator of transcription 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.6905
    Cell Significance Index: -27.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 121.4698
    Cell Significance Index: -30.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.2969
    Cell Significance Index: -37.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.5114
    Cell Significance Index: -36.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.7194
    Cell Significance Index: -38.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.1299
    Cell Significance Index: -33.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6422
    Cell Significance Index: -25.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9938
    Cell Significance Index: -35.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4878
    Cell Significance Index: -26.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1266
    Cell Significance Index: -11.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 3.0396
    Cell Significance Index: 64.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4533
    Cell Significance Index: 158.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3461
    Cell Significance Index: 218.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1618
    Cell Significance Index: 1048.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0449
    Cell Significance Index: 27.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0272
    Cell Significance Index: 126.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7588
    Cell Significance Index: 89.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6610
    Cell Significance Index: 119.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6491
    Cell Significance Index: 19.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6023
    Cell Significance Index: 173.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5849
    Cell Significance Index: 37.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5316
    Cell Significance Index: 14.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5253
    Cell Significance Index: 11.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5058
    Cell Significance Index: 50.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4748
    Cell Significance Index: 209.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4449
    Cell Significance Index: 30.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4258
    Cell Significance Index: 7.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4250
    Cell Significance Index: 58.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4152
    Cell Significance Index: 21.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4037
    Cell Significance Index: 80.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4034
    Cell Significance Index: 220.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3531
    Cell Significance Index: 70.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3451
    Cell Significance Index: 16.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3147
    Cell Significance Index: 112.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2523
    Cell Significance Index: 18.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2301
    Cell Significance Index: 10.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1919
    Cell Significance Index: 8.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1834
    Cell Significance Index: 12.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1825
    Cell Significance Index: 23.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1424
    Cell Significance Index: 27.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1172
    Cell Significance Index: 81.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1116
    Cell Significance Index: 3.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1045
    Cell Significance Index: 17.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0881
    Cell Significance Index: 0.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0296
    Cell Significance Index: 0.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0038
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0010
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0079
    Cell Significance Index: -1.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0155
    Cell Significance Index: -23.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0170
    Cell Significance Index: -31.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0176
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0245
    Cell Significance Index: -33.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0247
    Cell Significance Index: -15.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0254
    Cell Significance Index: -19.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0382
    Cell Significance Index: -21.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0410
    Cell Significance Index: -26.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0477
    Cell Significance Index: -21.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0557
    Cell Significance Index: -5.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0640
    Cell Significance Index: -3.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0729
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0884
    Cell Significance Index: -18.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1067
    Cell Significance Index: -8.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1173
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1182
    Cell Significance Index: -13.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1260
    Cell Significance Index: -3.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1383
    Cell Significance Index: -20.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1437
    Cell Significance Index: -4.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1478
    Cell Significance Index: -5.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1750
    Cell Significance Index: -20.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1774
    Cell Significance Index: -2.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1980
    Cell Significance Index: -4.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2012
    Cell Significance Index: -13.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2189
    Cell Significance Index: -5.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2259
    Cell Significance Index: -25.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2770
    Cell Significance Index: -7.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2891
    Cell Significance Index: -7.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2903
    Cell Significance Index: -12.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3198
    Cell Significance Index: -33.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3363
    Cell Significance Index: -9.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3711
    Cell Significance Index: -6.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3735
    Cell Significance Index: -29.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3885
    Cell Significance Index: -14.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4020
    Cell Significance Index: -10.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4207
    Cell Significance Index: -25.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4452
    Cell Significance Index: -2.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5363
    Cell Significance Index: -5.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5408
    Cell Significance Index: -4.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5581
    Cell Significance Index: -6.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6120
    Cell Significance Index: -14.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6299
    Cell Significance Index: -31.8300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.7040
    Cell Significance Index: -9.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7372
    Cell Significance Index: -23.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7588
    Cell Significance Index: -22.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7965
    Cell Significance Index: -22.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7976
    Cell Significance Index: -29.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8024
    Cell Significance Index: -28.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8367
    Cell Significance Index: -11.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DR1 is a transcriptional regulator that belongs to the Polycomb group of proteins, which are known for their role in maintaining cellular identity and repressing gene expression. DR1 is characterized by its ability to interact with various components of the transcriptional machinery, including RNA polymerase II and histone-modifying enzymes. Its expression is widespread, with significant levels found in stem cells, immune cells, and epithelial cells. **Pathways and Functions:** DR1 is involved in multiple signaling pathways that regulate gene expression, cell cycle progression, and embryonic development. Some of the key pathways and functions of DR1 include: * **Epigenetic regulation of gene expression:** DR1 interacts with histone-modifying enzymes to repress gene expression and maintain cellular identity. * **Negative regulation of transcription by RNA polymerase II:** DR1 inhibits the activity of RNA polymerase II, a key enzyme responsible for transcriptional initiation. * **Regulation of cell cycle and cell division:** DR1 is involved in the regulation of cell cycle progression and cell division, ensuring that cells enter the appropriate phase of the cell cycle. * **Regulation of embryonic development:** DR1 plays a crucial role in embryonic development, regulating the expression of genes involved in cell fate determination and patterning. **Clinical Significance:** The DR1 gene has been implicated in various diseases, including cancer, autoimmune disorders, and developmental abnormalities. Some of the clinical significance of DR1 includes: * **Cancer:** DR1 is often down-regulated in cancer cells, leading to the loss of cellular identity and the promotion of tumorigenesis. * **Autoimmune disorders:** DR1 is involved in the regulation of immune responses, and its dysregulation can contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. * **Developmental abnormalities:** DR1 is essential for embryonic development, and its dysregulation can lead to developmental abnormalities, such as neural tube defects and congenital heart defects. In conclusion, the DR1 gene is a critical regulator of gene expression, cell cycle progression, and embryonic development. Its widespread expression and multiple regulatory functions make it a key player in maintaining cellular homeostasis and responding to environmental cues. Further research is needed to fully understand the mechanisms of DR1 and its clinical significance in various diseases.

Genular Protein ID: 1788009764

Symbol: NC2B_HUMAN

Name: Protein Dr1

UniProtKB Accession Codes:

Q01658

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339312

Title: Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription.

PubMed ID: 1339312

DOI: 10.1016/0092-8674(92)90172-9

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8670811

Title: A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains.

PubMed ID: 8670811

DOI: 10.1002/j.1460-2075.1996.tb00673.x

PubMed ID: 8836190

Title: Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1.

PubMed ID: 8836190

DOI: 10.1093/nar/24.18.3607

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19103755

Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.

PubMed ID: 19103755

DOI: 10.1128/mcb.01599-08

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11461703

Title: Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.

PubMed ID: 11461703

DOI: 10.1016/s0092-8674(01)00417-2

Sequence Information:

  • Length: 176
  • Mass: 19444
  • Checksum: 36E7E59F2FD6CAB5
  • Sequence:
    • MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK 
SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR 
QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.