Details for: EGR3

Gene ID: 1960

Symbol: EGR3

Ensembl ID: ENSG00000179388

Description: early growth response 3

Associated with

  • Ngf-stimulated transcription
    (R-HSA-9031628)
  • Nuclear events (kinase and transcription factor activation)
    (R-HSA-198725)
  • Signaling by ntrk1 (trka)
    (R-HSA-187037)
  • Signaling by ntrks
    (R-HSA-166520)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signal transduction
    (R-HSA-162582)
  • Cell migration involved in sprouting angiogenesis
    (GO:0002042)
  • Cellular response to fibroblast growth factor stimulus
    (GO:0044344)
  • Cellular response to vascular endothelial growth factor stimulus
    (GO:0035924)
  • Chromatin
    (GO:0000785)
  • Circadian rhythm
    (GO:0007623)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endothelial cell chemotaxis
    (GO:0035767)
  • Metal ion binding
    (GO:0046872)
  • Muscle organ development
    (GO:0007517)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Neuromuscular synaptic transmission
    (GO:0007274)
  • Nucleoplasm
    (GO:0005654)
  • Peripheral nervous system development
    (GO:0007422)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of t cell differentiation in thymus
    (GO:0033089)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of gamma-delta t cell differentiation
    (GO:0045586)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Synapse
    (GO:0045202)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.56
    Marker Score: 6292
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.61
    Marker Score: 657
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.35
    Marker Score: 5014
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.13
    Marker Score: 1204
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.08
    Marker Score: 1328
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1942.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.01
    Marker Score: 378
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15590
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1880
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5252
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.91
    Marker Score: 314
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.88
    Marker Score: 1478
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.85
    Marker Score: 1180.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.85
    Marker Score: 890
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.83
    Marker Score: 4924
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.81
    Marker Score: 1247
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1188
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1231
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.72
    Marker Score: 701
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 650
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 542.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 275
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2768
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.65
    Marker Score: 22144
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 383
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.61
    Marker Score: 593
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 286
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6
    Marker Score: 6744
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6
    Marker Score: 1191
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.59
    Marker Score: 594
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.59
    Marker Score: 960.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.58
    Marker Score: 579
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 350
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.56
    Marker Score: 1272
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.53
    Marker Score: 272
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 216.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.51
    Marker Score: 238
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.5
    Marker Score: 191
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 318.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.49
    Marker Score: 234
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.49
    Marker Score: 134
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.48
    Marker Score: 116
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.48
    Marker Score: 4850
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.48
    Marker Score: 276
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.47
    Marker Score: 169
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.46
    Marker Score: 266
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.45
    Marker Score: 195
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.45
    Marker Score: 124
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.44
    Marker Score: 375.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.44
    Marker Score: 673
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.43
    Marker Score: 14870
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 186
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.42
    Marker Score: 111
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.42
    Marker Score: 361
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.42
    Marker Score: 325
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.41
    Marker Score: 512
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.41
    Marker Score: 1075
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.4
    Marker Score: 227
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.39
    Marker Score: 506
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.39
    Marker Score: 162
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.38
    Marker Score: 88
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.38
    Marker Score: 553
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.38
    Marker Score: 132
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.38
    Marker Score: 112
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.37
    Marker Score: 2247
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.37
    Marker Score: 167
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 95
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 236
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 113
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.35
    Marker Score: 172
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 234
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.34
    Marker Score: 21190
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.34
    Marker Score: 640
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.34
    Marker Score: 164
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.34
    Marker Score: 828
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 302
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.33
    Marker Score: 238
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.33
    Marker Score: 365
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.33
    Marker Score: 330
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.33
    Marker Score: 846
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.33
    Marker Score: 928
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.32
    Marker Score: 565
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.32
    Marker Score: 111
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.32
    Marker Score: 133.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.32
    Marker Score: 215

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Other Information

## Summary EGR3 (Early growth response protein 3) is a transcription factor that plays a crucial role in various cellular processes, including cell migration, proliferation, and differentiation. It is highly expressed in different cell types, including epithelial cells, myoblasts, and neural cells. ## Key characteristics * **Function:** Regulates cell migration, proliferation, and differentiation. * **Location:** Found in the nucleus and cytoplasm. * **Protein structure:** A protein of approximately 130 kDa. * **Expression:** Expressed in high levels in various cell types, including epithelial cells, myoblasts, and neural cells. ## Pathways and functions * **Cell migration:** Through the regulation of epithelial cell migration, it plays a crucial role in embryonic development and tissue remodeling. * **Proliferation:** Promotes cell proliferation in epithelial and endothelial cells. * **Differentiation:** Regulates the differentiation of myoblasts into muscle cells and neural cells. * **Circadian rhythm:** Contributes to the regulation of circadian rhythm through the control of cell proliferation and migration. * **Tissue development:** Plays a role in the development of the peripheral nervous system and the heart. ## Clinical significance * **Cancer:** Deregulation of EGR3 has been implicated in tumor growth and metastasis. * **Cardiovascular diseases:** Mutations in the EGR3 gene have been associated with cardiovascular diseases, such as atherosclerosis and heart failure. * **Cancer immunotherapy:** Targeting EGR3 has emerged as a promising therapeutic strategy for cancer treatment. ## Other important points * **Regulation by other transcription factors:** EGR3 interacts with various other transcription factors, including EGF, Sox2, and NF-κB. * **Post-translational modifications:** Regulation of EGR3 activity can be affected by phosphorylation and acetylation. * **Clinical testing:** Several clinical trials are evaluating the use of antibodies and small molecules to modulate EGR3 signaling in various diseases.

Genular Protein ID: 1966248341

Symbol: EGR3_HUMAN

Name: Early growth response protein 3

UniProtKB Accession Codes:

Q06889 A8K8U9 B4DHJ5 E7EW38 Q2M3W2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8443122

Title: Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells.

PubMed ID: 8443122

DOI: 10.1093/intimm/5.1.63

PubMed ID: 1906159

Title: EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

PubMed ID: 1906159

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 387
  • Mass: 42613
  • Checksum: 77FAF7D5A278C68E
  • Sequence:
    • MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVVHYNQMA TENVMDIGLT 
NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL 
STQTSTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK 
PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH 
PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE 
KKAEKGGAPS ASSAPPVSLA PVVTTCA

Genular Protein ID: 3902035284

Symbol: B4DH80_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DH80

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 333
  • Mass: 36736
  • Checksum: 846A3E579E71B66C
  • Sequence:
    • MDIGLTNEKP NPELSYSGSF QPAPGNKTVT YLGKFAFDSP SNWCQDNIIS LMSAGILGVP 
PASGALSTQT STASMVQPPQ GDVEAMYPAL PPYSNCGDLY SEPVSFHDPQ GNPGLAYSPQ 
DYQSAKPALD SNLFPMIPDY NLYHHPNDMG SIPEHKPFQG MDPIRVNPPP ITPLETIKAF 
KDKQIHPGFG SLPQPPLTLK PIRPRKYPNR PSKTPLHERP HACPAEGCDR RFSRSDELTR 
HLRIHTGHKP FQCRICMRSF SRSDHLTTHI RTHTGEKPFA CEFCGRKFAR SDERKRHAKI 
HLKQKEKKAE KGGAPSASSA PPVSLAPVVT TCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.