Gene EIF1AX - ENSG00000173674 | NCBI Gene ID: 1964

Details for: EIF1AX

Gene ID: 1964

Symbol: EIF1AX

Ensembl ID: ENSG00000173674

Description: eukaryotic translation initiation factor 1A X-linked

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Cap-dependent translation initiation
(R-HSA-72737)
Eukaryotic translation initiation
(R-HSA-72613)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Metabolism of proteins
(R-HSA-392499)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Translation
(R-HSA-72766)
Translation initiation complex formation
(R-HSA-72649)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Eukaryotic 43s preinitiation complex
(GO:0016282)
Eukaryotic 48s preinitiation complex
(GO:0033290)
Multi-eif complex
(GO:0043614)
Protein binding
(GO:0005515)
Ribosome assembly
(GO:0042255)
Rna binding
(GO:0003723)
Synapse
(GO:0045202)
Translational initiation
(GO:0006413)
Translation factor activity, rna binding
(GO:0008135)
Translation initiation factor activity
(GO:0003743)
Trna binding
(GO:0000049)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.43
Marker Score: 3668
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.33
Marker Score: 113443
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.11
Marker Score: 2649
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.1
Marker Score: 7559.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.73
Marker Score: 2149
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.62
Marker Score: 34608.5
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.62
Marker Score: 1091
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.59
Marker Score: 9998
Cell Name: decidual cell (CL2000002)
Fold Change: 2.54
Marker Score: 10961.5
Cell Name: supporting cell (CL0000630)
Fold Change: 2.51
Marker Score: 4715
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.45
Marker Score: 24826
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.44
Marker Score: 27476
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.42
Marker Score: 6695
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.42
Marker Score: 1410
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.4
Marker Score: 83223
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.39
Marker Score: 5424
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.39
Marker Score: 1361
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.38
Marker Score: 4976
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.38
Marker Score: 18554
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.33
Marker Score: 3029.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.32
Marker Score: 2438.5
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.31
Marker Score: 782
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.31
Marker Score: 3668
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.3
Marker Score: 2774
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.29
Marker Score: 4065
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.29
Marker Score: 14903
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.25
Marker Score: 19361
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.24
Marker Score: 4551
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.24
Marker Score: 2109
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.23
Marker Score: 4456
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.2
Marker Score: 14026
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.2
Marker Score: 547
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.18
Marker Score: 547
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.18
Marker Score: 8065.5
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.18
Marker Score: 14186
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.17
Marker Score: 4934
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.16
Marker Score: 517
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.15
Marker Score: 10556
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.13
Marker Score: 3137
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.12
Marker Score: 4986
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.11
Marker Score: 2254
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.11
Marker Score: 2199
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.11
Marker Score: 5314
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.11
Marker Score: 8624
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.1
Marker Score: 2226
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 2.1
Marker Score: 1323.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 2.1
Marker Score: 1431
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.09
Marker Score: 604
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.09
Marker Score: 3353.5
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.08
Marker Score: 3453.5
Cell Name: peptic cell (CL0000155)
Fold Change: 2.06
Marker Score: 863
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.06
Marker Score: 1616.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.05
Marker Score: 5492
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.05
Marker Score: 1927
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.04
Marker Score: 505
Cell Name: theca cell (CL0000503)
Fold Change: 2.04
Marker Score: 1465
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.03
Marker Score: 10673
Cell Name: stem cell (CL0000034)
Fold Change: 2.02
Marker Score: 4798
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.02
Marker Score: 5277
Cell Name: stromal cell (CL0000499)
Fold Change: 2.01
Marker Score: 2358
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.01
Marker Score: 7132
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.01
Marker Score: 3089
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.01
Marker Score: 819
Cell Name: kidney cell (CL1000497)
Fold Change: 2
Marker Score: 1337
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2
Marker Score: 3387
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2
Marker Score: 2015
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2
Marker Score: 595
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.96
Marker Score: 1985
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 1.95
Marker Score: 895
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.95
Marker Score: 1283
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.95
Marker Score: 1003
Cell Name: basal cell (CL0000646)
Fold Change: 1.95
Marker Score: 2513
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.94
Marker Score: 1635
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.94
Marker Score: 7617
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.94
Marker Score: 1907.5
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.93
Marker Score: 2386.5
Cell Name: blood cell (CL0000081)
Fold Change: 1.93
Marker Score: 22410
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.92
Marker Score: 1204
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.91
Marker Score: 606
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.91
Marker Score: 712
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.91
Marker Score: 954
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.91
Marker Score: 1594
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.91
Marker Score: 2700.5
Cell Name: granulocyte (CL0000094)
Fold Change: 1.91
Marker Score: 855
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.9
Marker Score: 48761
Cell Name: reticular cell (CL0000432)
Fold Change: 1.9
Marker Score: 694
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.9
Marker Score: 1352
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.9
Marker Score: 4012.5
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.9
Marker Score: 5158
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.89
Marker Score: 1140
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.88
Marker Score: 707
Cell Name: leukocyte (CL0000738)
Fold Change: 1.87
Marker Score: 1074
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.87
Marker Score: 708
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.87
Marker Score: 849
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.87
Marker Score: 1938
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.86
Marker Score: 1670.5
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.86
Marker Score: 724
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.86
Marker Score: 2024
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.85
Marker Score: 1789.5
Cell Name: memory B cell (CL0000787)
Fold Change: 1.85
Marker Score: 1402

Hover over a box to see details here...

**Key characteristics:** - EIF1AX is a protein of the Ran GTPase family. - It is a key factor in the initiation of protein synthesis in eukaryotic cells. - It is required for the binding of the cap-binding complex and eifs to 43s, Cap-dependent translation initiation. - It is also required for the formation of the ternary complex, which is the initiation complex that is responsible for finding and binding to the start codon of an mRNA. **Pathways and functions:** - EIF1AX is involved in the activation of the mrna upon binding of the cap-binding complex and eifs. - It is also involved in the formation of the ternary complex, which is the initiation complex that is responsible for finding and binding to the start codon of an mRNA. - EIF1AX is also involved in the translation initiation complex formation, which is the process that assembles the initiation complex on the mRNA. - Finally, EIF1AX is involved in the regulation of protein synthesis, as it is required for the initiation of translation. **Clinical significance:** - Mutations in the EIF1AX gene have been linked to a number of human diseases, including breast cancer, prostate cancer, and muscle dystrophy. - These mutations can lead to the loss of EIF1AX function, which can result in the inability of cells to initiate translation properly. - As a result, these mutations can lead to the accumulation of mRNA and proteins that are not properly translated, which can contribute to the development of cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Eukaryotic translation initiation factor 1A, X-chromosomal

Genular Protein ID: 4283716708

Symbol: IF1AX_HUMAN

Name: Eukaryotic translation initiation factor 1A, X-chromosomal

UniProtKB Accession Codes:

P47813 B2R5U5 Q0VGC2 Q5JPS5 Q5JPS6

Database IDs:

Citations:

PubMed ID: 8106356

Title: Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing.

PubMed ID: 8106356

DOI: 10.1016/s0021-9258(17)41850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9732867

Title: Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

PubMed ID: 9732867

DOI: 10.1038/29703

PubMed ID: 12569173

Title: Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.

PubMed ID: 12569173

DOI: 10.1073/pnas.0437845100

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24319994

Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

PubMed ID: 24319994

DOI: 10.1021/bi4009775

PubMed ID: 25479059

Title: The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus.

PubMed ID: 25479059

DOI: 10.1371/journal.pone.0114447

PubMed ID: 30211544

Title: Human eIF5 and eIF1A compete for binding to eIF5B.

PubMed ID: 30211544

DOI: 10.1021/acs.biochem.8b00839

PubMed ID: 10678173

Title: The eIF1A solution structure reveals a large RNA-binding surface important for scanning function.

PubMed ID: 10678173

DOI: 10.1016/s1097-2765(00)80407-4

PubMed ID: 35732735

Title: eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.

PubMed ID: 35732735

DOI: 10.1038/s41586-022-04858-z

Sequence Information:

Length: 144
Mass: 16460
Checksum: 1C4209855B21BFD4
Sequence:

MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH 
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT 
FGPGDDDEIQ FDDIGDDDED IDDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EIF1AX

Associated with

Cells (max top 100)

Other Information

Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. PubMed ID: 8106356

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. PubMed ID: 9732867

Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. PubMed ID: 12569173

Initial characterization of the human central proteome. PubMed ID: 21269460

The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes. PubMed ID: 24319994

The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus. PubMed ID: 25479059

Human eIF5 and eIF1A compete for binding to eIF5B. PubMed ID: 30211544

The eIF1A solution structure reveals a large RNA-binding surface important for scanning function. PubMed ID: 10678173

eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining. PubMed ID: 35732735