Details for: EIF1AX

Gene ID: 1964

Symbol: EIF1AX

Ensembl ID: ENSG00000173674

Description: eukaryotic translation initiation factor 1A X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 468.9311
    Cell Significance Index: -72.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 275.9386
    Cell Significance Index: -69.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 222.5768
    Cell Significance Index: -91.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 194.0174
    Cell Significance Index: -91.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 171.7973
    Cell Significance Index: -88.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 137.1341
    Cell Significance Index: -92.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.5273
    Cell Significance Index: -88.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.5938
    Cell Significance Index: -73.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.3854
    Cell Significance Index: -92.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.9477
    Cell Significance Index: -64.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.3152
    Cell Significance Index: -31.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.5144
    Cell Significance Index: 95.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.4138
    Cell Significance Index: 97.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.3122
    Cell Significance Index: 155.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3041
    Cell Significance Index: 453.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.1019
    Cell Significance Index: 19.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.0767
    Cell Significance Index: 184.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7954
    Cell Significance Index: 180.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6667
    Cell Significance Index: 327.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.6345
    Cell Significance Index: 186.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5649
    Cell Significance Index: 191.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.4105
    Cell Significance Index: 1065.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3783
    Cell Significance Index: 428.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.3691
    Cell Significance Index: 303.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3265
    Cell Significance Index: 80.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1257
    Cell Significance Index: 99.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0673
    Cell Significance Index: 54.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0580
    Cell Significance Index: 1123.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0577
    Cell Significance Index: 265.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9762
    Cell Significance Index: 103.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7673
    Cell Significance Index: 40.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7643
    Cell Significance Index: 350.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6014
    Cell Significance Index: 42.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2992
    Cell Significance Index: 14.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2829
    Cell Significance Index: 22.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2484
    Cell Significance Index: 250.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1667
    Cell Significance Index: 24.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0106
    Cell Significance Index: 119.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9933
    Cell Significance Index: 51.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8769
    Cell Significance Index: 55.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8483
    Cell Significance Index: 144.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8155
    Cell Significance Index: 7.5100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.7885
    Cell Significance Index: 6.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7559
    Cell Significance Index: 682.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6962
    Cell Significance Index: 249.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6439
    Cell Significance Index: 7.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6302
    Cell Significance Index: 43.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5276
    Cell Significance Index: 57.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4557
    Cell Significance Index: 25.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4119
    Cell Significance Index: 11.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3830
    Cell Significance Index: 11.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3734
    Cell Significance Index: 22.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2978
    Cell Significance Index: 56.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2435
    Cell Significance Index: 5.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1994
    Cell Significance Index: 19.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1024
    Cell Significance Index: 77.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0865
    Cell Significance Index: 63.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0144
    Cell Significance Index: 27.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0094
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0335
    Cell Significance Index: -24.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0412
    Cell Significance Index: -75.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0444
    Cell Significance Index: -1.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0460
    Cell Significance Index: -70.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0463
    Cell Significance Index: -29.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0591
    Cell Significance Index: -80.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0710
    Cell Significance Index: -44.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0929
    Cell Significance Index: -9.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1124
    Cell Significance Index: -63.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1203
    Cell Significance Index: -83.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1245
    Cell Significance Index: -56.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1328
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1552
    Cell Significance Index: -17.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1792
    Cell Significance Index: -37.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2568
    Cell Significance Index: -29.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2591
    Cell Significance Index: -74.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2869
    Cell Significance Index: -6.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3873
    Cell Significance Index: -56.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4216
    Cell Significance Index: -48.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4455
    Cell Significance Index: -5.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4968
    Cell Significance Index: -39.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5241
    Cell Significance Index: -23.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5320
    Cell Significance Index: -17.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5451
    Cell Significance Index: -36.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5842
    Cell Significance Index: -7.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6348
    Cell Significance Index: -48.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6455
    Cell Significance Index: -16.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7403
    Cell Significance Index: -12.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8435
    Cell Significance Index: -87.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8792
    Cell Significance Index: -25.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8865
    Cell Significance Index: -22.1600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0229
    Cell Significance Index: -6.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1145
    Cell Significance Index: -56.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1913
    Cell Significance Index: -28.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2579
    Cell Significance Index: -55.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2593
    Cell Significance Index: -23.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.4057
    Cell Significance Index: -27.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.4328
    Cell Significance Index: -17.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4787
    Cell Significance Index: -90.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5727
    Cell Significance Index: -59.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.6124
    Cell Significance Index: -43.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF1AX is a member of the eIF1A family, which is essential for the initiation of translation in eukaryotic cells. The X-linked variant of eIF1A is specifically characterized by its ability to bind to the eIF3 complex, facilitating the recruitment of the 43S ribosomal subunit to the mRNA. EIF1AX has been shown to interact with various proteins, including eIF3, eIF4E, and eIF2, thereby regulating the assembly of the 40S ribosomal subunit. **Pathways and Functions:** EIF1AX is involved in several key pathways, including: 1. **Cap-dependent translation initiation**: EIF1AX plays a crucial role in the recruitment of the 43S ribosomal subunit to the mRNA, which is a critical step in cap-dependent translation initiation. 2. **Ribosome assembly**: EIF1AX is involved in the formation of the 40S ribosomal subunit, which is essential for the initiation of protein synthesis. 3. **Translation initiation complex formation**: EIF1AX interacts with eIF3 and eIF4E to form the translation initiation complex, which is necessary for the initiation of protein synthesis. 4. **GTP hydrolysis and joining of the 60S ribosomal subunit**: EIF1AX is involved in the recruitment of the 60S ribosomal subunit to the 40S ribosomal subunit, which is a critical step in the initiation of protein synthesis. **Clinical Significance:** EIF1AX has been implicated in various diseases, including: 1. **Ceruloplasmin expression regulation**: EIF1AX has been shown to regulate the expression of ceruloplasmin, a protein involved in copper metabolism. Mutations in EIF1AX have been linked to ceruloplasmin deficiency, a rare genetic disorder. 2. **Muscle wasting**: EIF1AX has been implicated in muscle wasting diseases, such as muscular dystrophy. Mutations in EIF1AX have been shown to disrupt the assembly of the 40S ribosomal subunit, leading to impaired protein synthesis and muscle wasting. 3. **Cancer**: EIF1AX has been shown to be overexpressed in certain types of cancer, including breast and prostate cancer. EIF1AX may play a role in the regulation of protein synthesis and cell growth in these cancers. In conclusion, EIF1AX is a critical gene involved in the initiation of protein synthesis in eukaryotic cells. Its expression has been identified in various cell types, and its dysregulation has been implicated in various diseases, including ceruloplasmin deficiency, muscle wasting, and cancer. Further research is needed to fully elucidate the role of EIF1AX in human disease.

Genular Protein ID: 4283716708

Symbol: IF1AX_HUMAN

Name: Eukaryotic translation initiation factor 1A, X-chromosomal

UniProtKB Accession Codes:

P47813 B2R5U5 Q0VGC2 Q5JPS5 Q5JPS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 EMDB 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8106356

Title: Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing.

PubMed ID: 8106356

DOI: 10.1016/s0021-9258(17)41850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9732867

Title: Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

PubMed ID: 9732867

DOI: 10.1038/29703

PubMed ID: 12569173

Title: Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners.

PubMed ID: 12569173

DOI: 10.1073/pnas.0437845100

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24319994

Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

PubMed ID: 24319994

DOI: 10.1021/bi4009775

PubMed ID: 25479059

Title: The eukaryotic elongation factor 1A is critical for genome replication of the paramyxovirus respiratory syncytial virus.

PubMed ID: 25479059

DOI: 10.1371/journal.pone.0114447

PubMed ID: 30211544

Title: Human eIF5 and eIF1A compete for binding to eIF5B.

PubMed ID: 30211544

DOI: 10.1021/acs.biochem.8b00839

PubMed ID: 10678173

Title: The eIF1A solution structure reveals a large RNA-binding surface important for scanning function.

PubMed ID: 10678173

DOI: 10.1016/s1097-2765(00)80407-4

PubMed ID: 35732735

Title: eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.

PubMed ID: 35732735

DOI: 10.1038/s41586-022-04858-z

Sequence Information:

  • Length: 144
  • Mass: 16460
  • Checksum: 1C4209855B21BFD4
  • Sequence:
    • MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH 
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT 
FGPGDDDEIQ FDDIGDDDED IDDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.