Details for: EIF4B

Gene ID: 1975

Symbol: EIF4B

Ensembl ID: ENSG00000063046

Description: eukaryotic translation initiation factor 4B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 641.7105
    Cell Significance Index: -99.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 355.0654
    Cell Significance Index: -90.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 297.8534
    Cell Significance Index: -122.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 250.3163
    Cell Significance Index: -118.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 245.0419
    Cell Significance Index: -99.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 225.3564
    Cell Significance Index: -115.9200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 176.6857
    Cell Significance Index: -118.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 105.6096
    Cell Significance Index: -100.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 88.9935
    Cell Significance Index: -109.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 40.7748
    Cell Significance Index: -109.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.6578
    Cell Significance Index: -113.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.9505
    Cell Significance Index: -67.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.8145
    Cell Significance Index: -36.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5228
    Cell Significance Index: 164.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.1440
    Cell Significance Index: 386.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0684
    Cell Significance Index: 83.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.0081
    Cell Significance Index: 413.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9218
    Cell Significance Index: 526.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6454
    Cell Significance Index: 124.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.5600
    Cell Significance Index: 437.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3862
    Cell Significance Index: 308.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2905
    Cell Significance Index: 61.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2233
    Cell Significance Index: 262.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2189
    Cell Significance Index: 156.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2107
    Cell Significance Index: 1207.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1779
    Cell Significance Index: 1966.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1717
    Cell Significance Index: 960.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0312
    Cell Significance Index: 403.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.9110
    Cell Significance Index: 21.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5817
    Cell Significance Index: 117.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4809
    Cell Significance Index: 42.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4414
    Cell Significance Index: 414.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4260
    Cell Significance Index: 231.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3367
    Cell Significance Index: 86.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2253
    Cell Significance Index: 245.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1055
    Cell Significance Index: 141.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0208
    Cell Significance Index: 23.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9264
    Cell Significance Index: 19.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.9073
    Cell Significance Index: 13.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8978
    Cell Significance Index: 19.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8016
    Cell Significance Index: 23.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7493
    Cell Significance Index: 6.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6709
    Cell Significance Index: 17.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6626
    Cell Significance Index: 237.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6553
    Cell Significance Index: 34.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6314
    Cell Significance Index: 28.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6089
    Cell Significance Index: 6.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5997
    Cell Significance Index: 114.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4228
    Cell Significance Index: 22.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3428
    Cell Significance Index: 9.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3071
    Cell Significance Index: 212.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1879
    Cell Significance Index: 9.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1724
    Cell Significance Index: 17.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1182
    Cell Significance Index: 222.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0589
    Cell Significance Index: 90.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0501
    Cell Significance Index: 92.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0442
    Cell Significance Index: 32.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0019
    Cell Significance Index: 1.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0155
    Cell Significance Index: -21.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0158
    Cell Significance Index: -1.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0398
    Cell Significance Index: -25.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0422
    Cell Significance Index: -31.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0549
    Cell Significance Index: -1.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0798
    Cell Significance Index: -8.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0885
    Cell Significance Index: -55.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0922
    Cell Significance Index: -3.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1158
    Cell Significance Index: -52.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1414
    Cell Significance Index: -79.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2192
    Cell Significance Index: -46.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3274
    Cell Significance Index: -9.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3342
    Cell Significance Index: -25.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4178
    Cell Significance Index: -60.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4879
    Cell Significance Index: -27.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5217
    Cell Significance Index: -59.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5491
    Cell Significance Index: -34.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5522
    Cell Significance Index: -33.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6236
    Cell Significance Index: -11.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6935
    Cell Significance Index: -80.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7158
    Cell Significance Index: -22.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7588
    Cell Significance Index: -60.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8165
    Cell Significance Index: -11.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9575
    Cell Significance Index: -99.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0045
    Cell Significance Index: -67.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0099
    Cell Significance Index: -25.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.1455
    Cell Significance Index: -68.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2546
    Cell Significance Index: -33.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4220
    Cell Significance Index: -71.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4492
    Cell Significance Index: -88.8500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5506
    Cell Significance Index: -28.6600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5738
    Cell Significance Index: -27.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.6499
    Cell Significance Index: -21.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6673
    Cell Significance Index: -73.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.9321
    Cell Significance Index: -49.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.9622
    Cell Significance Index: -11.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9728
    Cell Significance Index: -29.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.0072
    Cell Significance Index: -16.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.0345
    Cell Significance Index: -77.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.0820
    Cell Significance Index: -35.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.1010
    Cell Significance Index: -52.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF4B is a phosphoprotein that belongs to the eIF4F complex, which is responsible for the translation of mRNAs with 5' caps. The protein is characterized by its ability to hydrolyze GTP, which is essential for the recruitment of the 43S ribosomal subunit. EIF4B also interacts with other proteins, such as eIF4A and eIF3, to regulate the translation of specific mRNAs. **Pathways and Functions:** EIF4B is involved in various cellular processes, including: 1. **Activation of mRNA upon binding of the cap-binding complex and eIFs**: EIF4B binds to the 5' cap of mRNA, recruiting the eIF4F complex and facilitating the translation of specific mRNAs. 2. **Cap-dependent translation initiation**: EIF4B is essential for the recruitment of the 43S ribosomal subunit, which is necessary for the translation of mRNAs with 5' caps. 3. **Regulation of translational initiation**: EIF4B interacts with other proteins to regulate the translation of specific mRNAs, including those involved in immune responses. 4. **Metabolism of proteins and RNA**: EIF4B is involved in the regulation of protein synthesis and degradation, as well as the metabolism of mRNAs. **Clinical Significance:** EIF4B has been implicated in various diseases, including: 1. **Immune disorders**: EIF4B plays a crucial role in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis. 2. **Cancer**: EIF4B is involved in the regulation of protein synthesis and degradation, and its dysregulation has been linked to cancer development and progression. 3. **Neurological disorders**: EIF4B has been implicated in the regulation of protein synthesis and degradation in the brain, and its dysregulation has been linked to neurological disorders, such as Alzheimer's disease. In conclusion, EIF4B is a critical protein that plays a pivotal role in eukaryotic translation initiation. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the mechanisms of EIF4B and its role in human health and disease. **Significantly expressed cells:** * Mature alpha-beta T cell * Skeletal muscle satellite stem cell * Acinar cell of salivary gland * Fibroblast of mammary gland * DN3 thymocyte * IgG-negative class switched memory B cell * CD38-negative naive B cell * Blood cell * Mature gamma-delta T cell * Type I NK T cell **Proteins:** * IF4B_HUMAN (Eukaryotic translation initiation factor 4B) * B4DRM3_HUMAN * E7EX17_HUMAN * Q7Z5Y0_HUMAN

Genular Protein ID: 3461793046

Symbol: IF4B_HUMAN

Name: Eukaryotic translation initiation factor 4B

UniProtKB Accession Codes:

P23588 B4DS13 Q4G0E3 Q53HQ2 Q6GPH5 Q6IB46 Q8WYK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2390971

Title: Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.

PubMed ID: 2390971

DOI: 10.1002/j.1460-2075.1990.tb07466.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8139536

Title: The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence.

PubMed ID: 8139536

DOI: 10.1128/mcb.14.4.2307-2316.1994

PubMed ID: 8816444

Title: A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.

PubMed ID: 8816444

DOI: 10.1128/mcb.16.10.5328

PubMed ID: 15071500

Title: Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.

PubMed ID: 15071500

DOI: 10.1038/sj.emboj.7600193

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16763566

Title: The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

PubMed ID: 16763566

DOI: 10.1038/sj.emboj.7601166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35772404

Title: The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.

PubMed ID: 35772404

DOI: 10.1016/j.molcel.2022.06.008

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 611
  • Mass: 69151
  • Checksum: 31CEFEA865FB10D2
  • Sequence:
    • MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 
ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 
DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 
YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 
FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 
GSESSQTGTS TTSSRNARRR ESEKSLENET LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK 
ENAWVKRSSN PPARSQSSDT EQQSPTSGGG KVAPAQPSEE GPGRKDENKV DGMNAPKGQT 
GNSSRGPGDG GNRDHWKESD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG 
EDENEGEDYA E

Genular Protein ID: 543811785

Symbol: Q7Z5Y0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z5Y0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 349
  • Mass: 39218
  • Checksum: 35B489752670B407
  • Sequence:
    • ARGYDRGYDS RIGSGRRAFG SGYRRDDDYR GGGDRYEDRY DRRDDRSWSS RDDYSRDDYR 
RDDRGPPQRP KLNLKPRSTP KEDDSSASTS QSTRAASIFG GAKPVDTAAR EREVEERLQK 
EQEKLQRQLD EPKLERRPRE RHPSWRSEET QERERSRTGS ESSQTGTSTT SSRNARRRES 
EKSLENETLN KEEDCHSPTS KPPKPDQPLK VMPAPPPKEN AWVKRSSNPP ARSQSSDTEQ 
QSPTSGGGKV APAQPSEEGP GRKDENKVDG MNAPKGQTGN SSRGPGDGGN RDHWKESDRK 
DGKKDQDSRS APEPKKPEEN PASKFSSASK YAALSVDGED ENEGEDYAE

Genular Protein ID: 3848133599

Symbol: E7EX17_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EX17

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 616
  • Mass: 69698
  • Checksum: 0F133C6134D04FA4
  • Sequence:
    • MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 
ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 
DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 
YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 
FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 
GSESSQTGTS TTSSRSKSDQ DARRRESEKS LENETLNKEE DCHSPTSKPP KPDQPLKVMP 
APPPKENAWV KRSSNPPARS QSSDTEQQSP TSGGGKVAPA QPSEEGPGRK DENKVDGMNA 
PKGQTGNSSR GPGDGGNRDH WKESDRKDGK KDQDSRSAPE PKKPEENPAS KFSSASKYAA 
LSVDGEDENE GEDYAE

Genular Protein ID: 3268026839

Symbol: B4DRM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRM3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 616
  • Mass: 69726
  • Checksum: 04AE64B4BF3D45C7
  • Sequence:
    • MAASAKKKNR KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 
ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 
DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 
YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 
FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 
GSESSQTGTS TTSSRSKSDQ DARRRESEKS LENETLNKEE DCHSPTSKPP KPDQPLKVMP 
APPPKENAWV KRSSNPPARS QSSDTEQQSP TSGGGKVAPA QPSEEGPGRK DENKVDGMNA 
PKGQTGNSSR GPGDGGNRDH WKESDRKDGK KDQDSRSAPE PKKPEENPAS KFSSASKYAA 
LSVDGEDENE GEDYAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.