Details for: EIF4B

Gene ID: 1975

Symbol: EIF4B

Ensembl ID: ENSG00000063046

Description: eukaryotic translation initiation factor 4B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.29
    Marker Score: 173839
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.29
    Marker Score: 3510
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.21
    Marker Score: 7318
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.11
    Marker Score: 105657
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.03
    Marker Score: 1511
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.85
    Marker Score: 2812
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.84
    Marker Score: 5959
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.84
    Marker Score: 33006
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.83
    Marker Score: 8917
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.81
    Marker Score: 2204.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.77
    Marker Score: 11872
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.69
    Marker Score: 2522
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.67
    Marker Score: 637
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.65
    Marker Score: 7438
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.65
    Marker Score: 4540
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.64
    Marker Score: 35467.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.64
    Marker Score: 2480
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.6
    Marker Score: 34274
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.58
    Marker Score: 6293
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.57
    Marker Score: 2296
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.56
    Marker Score: 88674
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.54
    Marker Score: 1533
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.54
    Marker Score: 2452
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.52
    Marker Score: 2245
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.5
    Marker Score: 16282
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.5
    Marker Score: 885
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.48
    Marker Score: 4660
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.47
    Marker Score: 1867
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.46
    Marker Score: 4365
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.43
    Marker Score: 5923.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.42
    Marker Score: 846
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.41
    Marker Score: 4725
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4
    Marker Score: 2522.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.39
    Marker Score: 5420
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.38
    Marker Score: 17705
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.37
    Marker Score: 9145
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.37
    Marker Score: 8417
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.36
    Marker Score: 2073
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.36
    Marker Score: 1517
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.34
    Marker Score: 6955
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.34
    Marker Score: 3842
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.34
    Marker Score: 3229
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.33
    Marker Score: 1005
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.33
    Marker Score: 3430
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.32
    Marker Score: 1224
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.31
    Marker Score: 4621
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.31
    Marker Score: 2978
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.29
    Marker Score: 4099
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.29
    Marker Score: 22696
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.29
    Marker Score: 525
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.29
    Marker Score: 14912
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.29
    Marker Score: 1305
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.29
    Marker Score: 709
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.28
    Marker Score: 3782
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.27
    Marker Score: 4802
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.27
    Marker Score: 25613
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.27
    Marker Score: 792
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.27
    Marker Score: 2469
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.26
    Marker Score: 1848
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.25
    Marker Score: 2722
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.25
    Marker Score: 6031
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.25
    Marker Score: 1626
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.24
    Marker Score: 1363
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.24
    Marker Score: 709
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.23
    Marker Score: 2404
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.22
    Marker Score: 1093
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.22
    Marker Score: 1842
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.22
    Marker Score: 587
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.21
    Marker Score: 1600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.21
    Marker Score: 1489
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.21
    Marker Score: 6007
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.21
    Marker Score: 2357
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 2.2
    Marker Score: 624
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.19
    Marker Score: 626
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.19
    Marker Score: 3105
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.18
    Marker Score: 5502
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.18
    Marker Score: 10702.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.18
    Marker Score: 661
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.17
    Marker Score: 3786
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.16
    Marker Score: 1702
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.16
    Marker Score: 1817
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.16
    Marker Score: 1571
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.15
    Marker Score: 813
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.14
    Marker Score: 4479
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.14
    Marker Score: 600.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.13
    Marker Score: 119219
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 2.13
    Marker Score: 640
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.13
    Marker Score: 2494
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.13
    Marker Score: 1247
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 2.13
    Marker Score: 620
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 2.12
    Marker Score: 599
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3127
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.11
    Marker Score: 522
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.11
    Marker Score: 1410.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.11
    Marker Score: 1319
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.11
    Marker Score: 559
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.11
    Marker Score: 4960
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.09
    Marker Score: 1532
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.09
    Marker Score: 1286
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.09
    Marker Score: 21174

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Other Information

**Key characteristics:** * The EIF4B gene is located on chromosome 17q21.1. * It is a member of the EIF4 family of translation initiation factors. * The protein is composed of 145 amino acids. * It is a key regulator of translation initiation. **Pathways and functions:** The EIF4B protein is involved in a variety of pathways, including: * Activation of the mrna upon binding of the cap-binding complex and eifs. * Subsequent binding to 43s, Cap-dependent translation initiation. * Deadenylation-dependent mrna decay. * Deadenylation of mrna. * Developmental biology. * Eukaryotic translation initiation. * Gtp hydrolysis and joining of the 60s ribosomal subunit. * L13a-mediated translational silencing of ceruloplasmin expression. * M-decay: degradation of maternal mrnas by maternally stored factors. * Maternal to zygotic transition (mzt). * Metabolism of proteins. * Metabolism of rna. * Mtorc1-mediated signaling. * Mtor signaling. **Clinical significance:** Mutations in the EIF4B gene have been linked to a number of human diseases, including: * Cancer. * Cardiovascular disease. * Diabetes. * Rheumatoid arthritis. * Inflammatory bowel disease. EIF4B is a promising target for cancer therapy. Studies have shown that inhibitors of EIF4B can effectively inhibit cancer cell growth in vitro and in vivo.

Genular Protein ID: 3461793046

Symbol: IF4B_HUMAN

Name: Eukaryotic translation initiation factor 4B

UniProtKB Accession Codes:

P23588 B4DS13 Q4G0E3 Q53HQ2 Q6GPH5 Q6IB46 Q8WYK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2390971

Title: Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.

PubMed ID: 2390971

DOI: 10.1002/j.1460-2075.1990.tb07466.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8139536

Title: The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence.

PubMed ID: 8139536

DOI: 10.1128/mcb.14.4.2307-2316.1994

PubMed ID: 8816444

Title: A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.

PubMed ID: 8816444

DOI: 10.1128/mcb.16.10.5328

PubMed ID: 15071500

Title: Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.

PubMed ID: 15071500

DOI: 10.1038/sj.emboj.7600193

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16763566

Title: The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

PubMed ID: 16763566

DOI: 10.1038/sj.emboj.7601166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35772404

Title: The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.

PubMed ID: 35772404

DOI: 10.1016/j.molcel.2022.06.008

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 611
  • Mass: 69151
  • Checksum: 31CEFEA865FB10D2
  • Sequence:
    • MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 
ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 
DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 
YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 
FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 
GSESSQTGTS TTSSRNARRR ESEKSLENET LNKEEDCHSP TSKPPKPDQP LKVMPAPPPK 
ENAWVKRSSN PPARSQSSDT EQQSPTSGGG KVAPAQPSEE GPGRKDENKV DGMNAPKGQT 
GNSSRGPGDG GNRDHWKESD RKDGKKDQDS RSAPEPKKPE ENPASKFSSA SKYAALSVDG 
EDENEGEDYA E

Genular Protein ID: 3268026839

Symbol: B4DRM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRM3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 616
  • Mass: 69726
  • Checksum: 04AE64B4BF3D45C7
  • Sequence:
    • MAASAKKKNR KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 
ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 
DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 
YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 
FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 
GSESSQTGTS TTSSRSKSDQ DARRRESEKS LENETLNKEE DCHSPTSKPP KPDQPLKVMP 
APPPKENAWV KRSSNPPARS QSSDTEQQSP TSGGGKVAPA QPSEEGPGRK DENKVDGMNA 
PKGQTGNSSR GPGDGGNRDH WKESDRKDGK KDQDSRSAPE PKKPEENPAS KFSSASKYAA 
LSVDGEDENE GEDYAE

Genular Protein ID: 3848133599

Symbol: E7EX17_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EX17

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 616
  • Mass: 69698
  • Checksum: 0F133C6134D04FA4
  • Sequence:
    • MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD VSTTWHSNDD 
DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL GNLPYDVTEE SIKEFFRGLN 
ISAVRLPREP SNPERLKGFG YAEFEDLDSL LSALSLNEES LGNRRIRVDV ADQAQDKDRD 
DRSFGRDRNR DSDKTDTDWR ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG 
YRDGPRRDMD RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED 
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS TSQSTRAASI 
FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP RERHPSWRSE ETQERERSRT 
GSESSQTGTS TTSSRSKSDQ DARRRESEKS LENETLNKEE DCHSPTSKPP KPDQPLKVMP 
APPPKENAWV KRSSNPPARS QSSDTEQQSP TSGGGKVAPA QPSEEGPGRK DENKVDGMNA 
PKGQTGNSSR GPGDGGNRDH WKESDRKDGK KDQDSRSAPE PKKPEENPAS KFSSASKYAA 
LSVDGEDENE GEDYAE

Genular Protein ID: 543811785

Symbol: Q7Z5Y0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z5Y0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GenomeRNAi 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 349
  • Mass: 39218
  • Checksum: 35B489752670B407
  • Sequence:
    • ARGYDRGYDS RIGSGRRAFG SGYRRDDDYR GGGDRYEDRY DRRDDRSWSS RDDYSRDDYR 
RDDRGPPQRP KLNLKPRSTP KEDDSSASTS QSTRAASIFG GAKPVDTAAR EREVEERLQK 
EQEKLQRQLD EPKLERRPRE RHPSWRSEET QERERSRTGS ESSQTGTSTT SSRNARRRES 
EKSLENETLN KEEDCHSPTS KPPKPDQPLK VMPAPPPKEN AWVKRSSNPP ARSQSSDTEQ 
QSPTSGGGKV APAQPSEEGP GRKDENKVDG MNAPKGQTGN SSRGPGDGGN RDHWKESDRK 
DGKKDQDSRS APEPKKPEEN PASKFSSASK YAALSVDGED ENEGEDYAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.