Details for: ELF5

Gene ID: 2001

Symbol: ELF5

Ensembl ID: ENSG00000135374

Description: E74 like ETS transcription factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.9884
    Cell Significance Index: -5.6600
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 11.8402
    Cell Significance Index: 50.9200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 5.4769
    Cell Significance Index: 63.6700
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 3.3543
    Cell Significance Index: 18.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2174
    Cell Significance Index: 150.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8469
    Cell Significance Index: 147.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5438
    Cell Significance Index: 23.4300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.0826
    Cell Significance Index: 35.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7625
    Cell Significance Index: 227.7000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.7443
    Cell Significance Index: 17.4600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.3915
    Cell Significance Index: 29.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3083
    Cell Significance Index: 61.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1949
    Cell Significance Index: 19.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.1620
    Cell Significance Index: 24.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0990
    Cell Significance Index: 198.1100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.8347
    Cell Significance Index: 8.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4690
    Cell Significance Index: 57.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4262
    Cell Significance Index: 13.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4017
    Cell Significance Index: 5.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3982
    Cell Significance Index: 6.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3252
    Cell Significance Index: 8.1300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3199
    Cell Significance Index: 4.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2397
    Cell Significance Index: 27.9400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.2364
    Cell Significance Index: 0.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2023
    Cell Significance Index: 20.6600
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1857
    Cell Significance Index: 1.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1798
    Cell Significance Index: 4.8000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1732
    Cell Significance Index: 1.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1147
    Cell Significance Index: 1.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0892
    Cell Significance Index: 3.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0892
    Cell Significance Index: 16.9700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0886
    Cell Significance Index: 1.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0706
    Cell Significance Index: 6.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0331
    Cell Significance Index: 1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0290
    Cell Significance Index: 2.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0112
    Cell Significance Index: 8.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0034
    Cell Significance Index: -3.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0072
    Cell Significance Index: -5.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0073
    Cell Significance Index: -0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0080
    Cell Significance Index: -5.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0080
    Cell Significance Index: -4.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0110
    Cell Significance Index: -1.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0123
    Cell Significance Index: -0.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0125
    Cell Significance Index: -0.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0141
    Cell Significance Index: -5.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0149
    Cell Significance Index: -0.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0159
    Cell Significance Index: -0.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0177
    Cell Significance Index: -5.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0183
    Cell Significance Index: -3.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0189
    Cell Significance Index: -3.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0207
    Cell Significance Index: -1.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0218
    Cell Significance Index: -3.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0245
    Cell Significance Index: -1.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0250
    Cell Significance Index: -5.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0282
    Cell Significance Index: -5.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0307
    Cell Significance Index: -0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0324
    Cell Significance Index: -4.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0408
    Cell Significance Index: -0.5900
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0417
    Cell Significance Index: -0.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0438
    Cell Significance Index: -6.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0665
    Cell Significance Index: -5.2700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0693
    Cell Significance Index: -0.7600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0782
    Cell Significance Index: -1.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0852
    Cell Significance Index: -4.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0888
    Cell Significance Index: -5.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0902
    Cell Significance Index: -6.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0913
    Cell Significance Index: -2.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0919
    Cell Significance Index: -5.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1160
    Cell Significance Index: -4.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1213
    Cell Significance Index: -6.8100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1222
    Cell Significance Index: -1.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1232
    Cell Significance Index: -1.6900
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: -0.1284
    Cell Significance Index: -0.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1302
    Cell Significance Index: -1.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1422
    Cell Significance Index: -2.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1433
    Cell Significance Index: -6.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1496
    Cell Significance Index: -5.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1531
    Cell Significance Index: -3.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1549
    Cell Significance Index: -3.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1553
    Cell Significance Index: -5.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1570
    Cell Significance Index: -4.3900
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1588
    Cell Significance Index: -1.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1658
    Cell Significance Index: -6.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1682
    Cell Significance Index: -4.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1778
    Cell Significance Index: -2.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1817
    Cell Significance Index: -4.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1849
    Cell Significance Index: -6.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1855
    Cell Significance Index: -4.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1878
    Cell Significance Index: -5.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1963
    Cell Significance Index: -5.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2049
    Cell Significance Index: -5.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology**: ELF5 shares a high degree of structural homology with other ETS transcription factors, suggesting a conserved mechanism of action. 2. **DNA-binding Specificity**: ELF5 exhibits specific DNA-binding properties, indicating its ability to interact with target gene promoters and regulatory elements. 3. **Transcriptional Regulation**: ELF5 modulates gene expression by interacting with RNA polymerase II and other transcriptional regulators, influencing the transcriptional output of target genes. 4. **Cell-type Specificity**: ELF5 expression is highly restricted to specific cell types, including hematopoietic stem cells, epithelial cells, and endothelial cells, highlighting its role in tissue-specific differentiation and development. **Pathways and Functions:** 1. **Cell Differentiation**: ELF5 regulates the transition of cells from a progenitor state to a differentiated state by modulating the expression of key transcription factors and cellular markers. 2. **Chromatin Remodeling**: ELF5 interacts with chromatin-modifying enzymes to alter chromatin structure, facilitating the access of transcriptional regulators to target gene promoters. 3. **Apoptosis Regulation**: ELF5 has been implicated in the regulation of apoptosis, influencing the survival and death of cells in response to various stimuli. 4. **Immune Cell Development**: ELF5 plays a critical role in the development and function of hematopoietic stem cells, influencing the differentiation of immune cells and the maintenance of immune homeostasis. **Clinical Significance:** ELF5 has been implicated in various immunological disorders, including: 1. **Autoimmune Diseases**: ELF5 dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to the disruption of immune tolerance and the development of autoimmunity. 2. **Cancer**: ELF5 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it may contribute to tumorigenesis and cancer progression. 3. **Infectious Diseases**: ELF5 has been implicated in the regulation of immune responses to infections, influencing the expression of cytokines and chemokines that mediate inflammation and tissue damage. In conclusion, ELF5 is a critical transcription factor that plays a multifaceted role in regulating cellular processes, including cell differentiation, proliferation, and survival. Its dysregulation has been implicated in various immunological disorders, highlighting the importance of further research into the mechanisms underlying ELF5-mediated immune responses.

Genular Protein ID: 2723002471

Symbol: ELF5_HUMAN

Name: ETS-related transcription factor Elf-5

UniProtKB Accession Codes:

Q9UKW6 A6XAE6 A8K452 O95175 Q8N2K9 Q96QY3 Q9UKW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9840936

Title: A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines.

PubMed ID: 9840936

DOI: 10.1038/sj.onc.1202198

PubMed ID: 10506207

Title: Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.

PubMed ID: 10506207

DOI: 10.1074/jbc.274.41.29439

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 265
  • Mass: 31263
  • Checksum: 43821A79A45768FE
  • Sequence:
    • MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH 
PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC SMTQEEFVEA AGLCGEYLYF 
ILQNIRTQGY SFFNDAEESK ATIKDYADSN CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR 
DLLLSPEENC GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG 
ILERVDRRLV YKFGKNAHGW QEDKL

Genular Protein ID: 2919818347

Symbol: A8K443_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K443

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 ExpressionAtlas 1 GO 4 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 Pfam 2 PharmGKB 1 RefSeq 4 RuleBase 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 255
  • Mass: 30121
  • Checksum: AE61C5B178ECB555
  • Sequence:
    • MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH PEYWTKRHVW 
EWLQFCCDQY KLDTNCISFC NFNISGLQLC SMTQEEFVEA AGLCGEYLYF ILQNIRTQGY 
SFFNDAEESK ATIKDYADSN CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR DLLLSPEENC 
GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG ILERVDRRLV 
YKFGKNAHGW QEDKL

Genular Protein ID: 416448363

Symbol: A0A087X1W9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1W9

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 187
  • Mass: 21961
  • Checksum: 3141FF6878DBD4C1
  • Sequence:
    • MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT GYSFFNDAEE 
SKATIKDYAD SNCLKTSGIK SQDCHSHSRT SLQSSHLWEF VRDLLLSPEE NCGILEWEDR 
EQGIFRVVKS EALAKMWGQR KKNDRMTYEK LSRALRYYYK TGILERVDRR LVYKFGKNAH 
GWQEDKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.