Details for: ELF5

Gene ID: 2001

Symbol: ELF5

Ensembl ID: ENSG00000135374

Description: E74 like ETS transcription factor 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.06
    Marker Score: 2076
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.04
    Marker Score: 4657
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.54
    Marker Score: 301
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.51
    Marker Score: 1304
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.44
    Marker Score: 756
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.4
    Marker Score: 655
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.37
    Marker Score: 1369
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.21
    Marker Score: 1781
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.08
    Marker Score: 431
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.05
    Marker Score: 2660
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2011
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1804
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.94
    Marker Score: 723
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.93
    Marker Score: 340
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.93
    Marker Score: 387
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.83
    Marker Score: 240
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12177.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.73
    Marker Score: 2872
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2944
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.65
    Marker Score: 132
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.6
    Marker Score: 296
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 381
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.56
    Marker Score: 372
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.52
    Marker Score: 3901.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 564
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.48
    Marker Score: 341
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 289
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.48
    Marker Score: 679
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.46
    Marker Score: 3024
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.45
    Marker Score: 1878
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.44
    Marker Score: 775
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.4
    Marker Score: 649
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 253
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.38
    Marker Score: 685
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.36
    Marker Score: 165
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.36
    Marker Score: 875
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 200
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 193
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.33
    Marker Score: 382
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 143
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.29
    Marker Score: 88
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.26
    Marker Score: 177
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 592
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.24
    Marker Score: 385
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.24
    Marker Score: 830
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 680
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.24
    Marker Score: 3841
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.23
    Marker Score: 3030
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.22
    Marker Score: 363
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 117
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.21
    Marker Score: 1085
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.2
    Marker Score: 384
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2
    Marker Score: 207
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.18
    Marker Score: 111
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 157
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.17
    Marker Score: 95
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.17
    Marker Score: 283
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.16
    Marker Score: 143
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.16
    Marker Score: 1378
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 173
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.15
    Marker Score: 155
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.13
    Marker Score: 172
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 131.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 151.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.13
    Marker Score: 494

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Other Information

**Key characteristics:** * ELF5 is a member of the ETS family of transcription factors, which are known for their ability to regulate gene expression by binding to specific DNA sequences. * It is a key regulator of cell differentiation, promoting the differentiation of pluripotent stem cells into various cell types. * It is also involved in maintaining tissue homeostasis and preventing cancer development. * It is a key regulator of inflammation and immune responses. **Pathways and functions:** * ELF5 primarily regulates gene expression through the DNA-binding domain of its protein, which is responsible for interacting with DNA. * It binds to DNA sequences known as E-box elements, which are found in the promoters of many cell type-specific genes. * Through this binding, ELF5 recruits RNA polymerase II to the E-box sites and facilitates the initiation of transcription. * It also regulates the expression of downstream target genes through chromatin remodeling and the regulation of gene expression. **Clinical significance:** * Mutations in ELF5 have been linked to various human diseases, including cancer, cardiovascular diseases, and inflammatory diseases. * Targeting ELF5 has emerged as a potential therapeutic strategy for these diseases. * Small molecule inhibitors of ELF5 have shown promise in preclinical studies, suggesting their potential to treat cancer and other diseases characterized by abnormal cell growth. **Other important points:** * ELF5 is a highly conserved protein with significant expression in vertebrates. * It is a well-studied transcription factor that has been extensively investigated for its role in health and disease. * The dysregulation of ELF5 signaling has been implicated in various human diseases, including cancer and cardiovascular diseases.

Genular Protein ID: 2723002471

Symbol: ELF5_HUMAN

Name: ETS-related transcription factor Elf-5

UniProtKB Accession Codes:

Q9UKW6 A6XAE6 A8K452 O95175 Q8N2K9 Q96QY3 Q9UKW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9840936

Title: A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines.

PubMed ID: 9840936

DOI: 10.1038/sj.onc.1202198

PubMed ID: 10506207

Title: Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.

PubMed ID: 10506207

DOI: 10.1074/jbc.274.41.29439

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 265
  • Mass: 31263
  • Checksum: 43821A79A45768FE
  • Sequence:
    • MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH 
PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC SMTQEEFVEA AGLCGEYLYF 
ILQNIRTQGY SFFNDAEESK ATIKDYADSN CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR 
DLLLSPEENC GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG 
ILERVDRRLV YKFGKNAHGW QEDKL

Genular Protein ID: 416448363

Symbol: A0A087X1W9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1W9

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 187
  • Mass: 21961
  • Checksum: 3141FF6878DBD4C1
  • Sequence:
    • MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT GYSFFNDAEE 
SKATIKDYAD SNCLKTSGIK SQDCHSHSRT SLQSSHLWEF VRDLLLSPEE NCGILEWEDR 
EQGIFRVVKS EALAKMWGQR KKNDRMTYEK LSRALRYYYK TGILERVDRR LVYKFGKNAH 
GWQEDKL

Genular Protein ID: 2919818347

Symbol: A8K443_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K443

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 ExpressionAtlas 1 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 Pfam 2 PharmGKB 1 RefSeq 4 RuleBase 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 255
  • Mass: 30121
  • Checksum: AE61C5B178ECB555
  • Sequence:
    • MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH PEYWTKRHVW 
EWLQFCCDQY KLDTNCISFC NFNISGLQLC SMTQEEFVEA AGLCGEYLYF ILQNIRTQGY 
SFFNDAEESK ATIKDYADSN CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR DLLLSPEENC 
GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG ILERVDRRLV 
YKFGKNAHGW QEDKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.