Details for: EMP1

Gene ID: 2012

Symbol: EMP1

Ensembl ID: ENSG00000134531

Description: epithelial membrane protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 326.4645
    Cell Significance Index: -50.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 185.4572
    Cell Significance Index: -47.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 129.8223
    Cell Significance Index: -53.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.6563
    Cell Significance Index: -47.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.1775
    Cell Significance Index: -50.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.2685
    Cell Significance Index: -46.2600
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 15.7775
    Cell Significance Index: 46.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 13.4040
    Cell Significance Index: 236.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7849
    Cell Significance Index: -50.4500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 10.6713
    Cell Significance Index: 76.6400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 5.9013
    Cell Significance Index: 74.3100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.3614
    Cell Significance Index: 33.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.7342
    Cell Significance Index: 135.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.3759
    Cell Significance Index: 326.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.8205
    Cell Significance Index: 493.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.2131
    Cell Significance Index: 62.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.9934
    Cell Significance Index: 28.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.9929
    Cell Significance Index: 22.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8219
    Cell Significance Index: 49.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7851
    Cell Significance Index: 83.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.7197
    Cell Significance Index: 24.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3791
    Cell Significance Index: 71.6400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.0446
    Cell Significance Index: 6.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8403
    Cell Significance Index: 107.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8181
    Cell Significance Index: 361.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6910
    Cell Significance Index: 19.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5989
    Cell Significance Index: 73.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5279
    Cell Significance Index: 7.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5197
    Cell Significance Index: 3.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5137
    Cell Significance Index: 11.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4124
    Cell Significance Index: 20.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3819
    Cell Significance Index: 52.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3215
    Cell Significance Index: 290.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2563
    Cell Significance Index: 139.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2005
    Cell Significance Index: 377.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1496
    Cell Significance Index: 3.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0978
    Cell Significance Index: 18.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0708
    Cell Significance Index: 44.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0687
    Cell Significance Index: 4.8600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0413
    Cell Significance Index: 0.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0290
    Cell Significance Index: 5.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0222
    Cell Significance Index: 0.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0203
    Cell Significance Index: 3.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0170
    Cell Significance Index: 26.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0152
    Cell Significance Index: 0.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0022
    Cell Significance Index: -0.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0079
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0255
    Cell Significance Index: -2.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0273
    Cell Significance Index: -20.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0281
    Cell Significance Index: -20.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0284
    Cell Significance Index: -52.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0389
    Cell Significance Index: -52.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0464
    Cell Significance Index: -28.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0526
    Cell Significance Index: -1.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0561
    Cell Significance Index: -31.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0564
    Cell Significance Index: -0.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0672
    Cell Significance Index: -4.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0836
    Cell Significance Index: -37.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0979
    Cell Significance Index: -19.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1039
    Cell Significance Index: -15.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1163
    Cell Significance Index: -13.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1264
    Cell Significance Index: -45.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1306
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1362
    Cell Significance Index: -23.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1422
    Cell Significance Index: -40.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1740
    Cell Significance Index: -36.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2258
    Cell Significance Index: -45.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2506
    Cell Significance Index: -25.6000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2749
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3151
    Cell Significance Index: -36.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3265
    Cell Significance Index: -37.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3304
    Cell Significance Index: -14.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3408
    Cell Significance Index: -15.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4039
    Cell Significance Index: -47.6300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.4086
    Cell Significance Index: -5.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4171
    Cell Significance Index: -25.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4367
    Cell Significance Index: -45.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4601
    Cell Significance Index: -29.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5225
    Cell Significance Index: -41.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5875
    Cell Significance Index: -45.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6235
    Cell Significance Index: -13.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6290
    Cell Significance Index: -21.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6386
    Cell Significance Index: -9.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6778
    Cell Significance Index: -24.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7458
    Cell Significance Index: -50.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7883
    Cell Significance Index: -48.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8662
    Cell Significance Index: -18.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9206
    Cell Significance Index: -17.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9614
    Cell Significance Index: -53.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0319
    Cell Significance Index: -23.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0622
    Cell Significance Index: -55.7700
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -1.0844
    Cell Significance Index: -6.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1466
    Cell Significance Index: -24.4200
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -1.1515
    Cell Significance Index: -10.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.1981
    Cell Significance Index: -9.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.2020
    Cell Significance Index: -30.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2074
    Cell Significance Index: -53.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2389
    Cell Significance Index: -36.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.2495
    Cell Significance Index: -36.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EMP1 is a 40-kDa protein that belongs to the immunoglobulin superfamily. It is primarily expressed on the surface of epithelial cells, including those of the thyroid, lung, prostate, and urinary tract. EMP1 has been shown to play a crucial role in maintaining epithelial cell integrity, modulating cell-cell interactions, and regulating the migration and invasion of epithelial cells. Its expression is often upregulated in response to tissue injury, inflammation, and cancer. **Pathways and Functions:** EMP1 is involved in several key signaling pathways, including: 1. **Apoptotic Process:** EMP1 has been shown to regulate apoptosis (programmed cell death) by interacting with pro-apoptotic and anti-apoptotic proteins. 2. **Bleb Assembly:** EMP1 plays a crucial role in the formation and maintenance of cell blebs, which are membrane protrusions that regulate cell migration and invasion. 3. **Epidermis Development:** EMP1 is involved in the development and differentiation of epithelial cells during embryogenesis. 4. **Protein Binding:** EMP1 interacts with various proteins, including integrins, cadherins, and E-cadherin, to regulate cell-cell adhesion and signaling. **Clinical Significance:** EMP1 has been implicated in various diseases, including: 1. **Cancer:** EMP1 is overexpressed in several types of cancer, including breast, lung, and prostate cancer, where it promotes tumor progression, metastasis, and resistance to chemotherapy. 2. **Autoimmune Diseases:** EMP1 has been linked to autoimmune diseases, such as autoimmune thyroiditis and rheumatoid arthritis, where it contributes to the disruption of epithelial cell barriers and tissue damage. 3. **Inflammatory Diseases:** EMP1 is involved in the regulation of inflammation and immune responses, making it a potential target for the treatment of inflammatory diseases, such as asthma and psoriasis. In conclusion, EMP1 is a multifunctional protein that plays a critical role in maintaining epithelial cell integrity and regulating immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying EMP1's functions and its potential as a therapeutic target. **Recommendations:** 1. **Further Investigation:** Additional studies are needed to elucidate the precise mechanisms by which EMP1 regulates cell-cell interactions and immune responses. 2. **Therapeutic Targeting:** EMP1 may serve as a potential therapeutic target for the treatment of cancer, autoimmune diseases, and inflammatory diseases. 3. **Epithelial Cell Function:** EMP1's role in maintaining epithelial cell integrity highlights the importance of preserving epithelial barriers in various diseases. By exploring the complex functions of EMP1, we can gain a deeper understanding of its role in immune regulation and disease, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 1670241345

Symbol: EMP1_HUMAN

Name: Epithelial membrane protein 1

UniProtKB Accession Codes:

P54849 B2R5N1 B4DRR1 O00681 Q13481 Q13834

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8996089

Title: Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.

PubMed ID: 8996089

DOI: 10.1016/s0378-1119(96)00475-1

PubMed ID: 9126480

Title: cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family.

PubMed ID: 9126480

DOI: 10.1006/geno.1997.4524

PubMed ID: 8683158

Title: B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain.

PubMed ID: 8683158

PubMed ID: 9066625

Title: Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family.

PubMed ID: 9066625

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 157
  • Mass: 17563
  • Checksum: B470B4ADC5C16821
  • Sequence:
    • MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS DSLSYASEDA 
LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA TTLVCWLCIL VGVSIYTSHY 
ANRDGTQYHH GYSYILGWIC FCFSFIIGVL YLVLRKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.