Details for: EMP1

Gene ID: 2012

Symbol: EMP1

Ensembl ID: ENSG00000134531

Description: epithelial membrane protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.81
    Marker Score: 2983
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.65
    Marker Score: 5306
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.35
    Marker Score: 2281
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.26
    Marker Score: 2810
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.19
    Marker Score: 108609
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.17
    Marker Score: 2703
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.12
    Marker Score: 2461.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.01
    Marker Score: 23468
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.9
    Marker Score: 24968.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.89
    Marker Score: 1203
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.81
    Marker Score: 10819
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.77
    Marker Score: 2920
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.71
    Marker Score: 919
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.71
    Marker Score: 6876
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.65
    Marker Score: 4484
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.61
    Marker Score: 5220
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.54
    Marker Score: 6649
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.52
    Marker Score: 980
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.47
    Marker Score: 1063
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.47
    Marker Score: 3391
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.38
    Marker Score: 1359
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.32
    Marker Score: 9999
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.31
    Marker Score: 4096
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.26
    Marker Score: 827
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.23
    Marker Score: 556
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.21
    Marker Score: 556
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3129
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.11
    Marker Score: 2327
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.11
    Marker Score: 1177
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.04
    Marker Score: 1922
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.01
    Marker Score: 2905
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.98
    Marker Score: 2552
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.94
    Marker Score: 2216
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.91
    Marker Score: 2044
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.89
    Marker Score: 671
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.88
    Marker Score: 4599
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.88
    Marker Score: 433
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.86
    Marker Score: 11323
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.83
    Marker Score: 1153.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.74
    Marker Score: 1560
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.68
    Marker Score: 4133
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.66
    Marker Score: 5212
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.63
    Marker Score: 392
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.61
    Marker Score: 1736
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.6
    Marker Score: 21502
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.6
    Marker Score: 1048
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.6
    Marker Score: 387
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.53
    Marker Score: 432
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.52
    Marker Score: 3090
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.51
    Marker Score: 552
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.5
    Marker Score: 1450
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.5
    Marker Score: 620
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.49
    Marker Score: 16811
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.49
    Marker Score: 1346
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.47
    Marker Score: 313
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167533
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.46
    Marker Score: 360
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.42
    Marker Score: 574
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.41
    Marker Score: 1418
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.4
    Marker Score: 357
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.38
    Marker Score: 805
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.36
    Marker Score: 3635
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.35
    Marker Score: 326
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.33
    Marker Score: 1115
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.32
    Marker Score: 5530.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.32
    Marker Score: 1587
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.31
    Marker Score: 304
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.31
    Marker Score: 8330
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.28
    Marker Score: 840
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.24
    Marker Score: 307
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1241
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.21
    Marker Score: 5802
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.19
    Marker Score: 382
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.17
    Marker Score: 1807
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.16
    Marker Score: 269
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.15
    Marker Score: 259
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.15
    Marker Score: 298
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.15
    Marker Score: 639
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.15
    Marker Score: 7485
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.14
    Marker Score: 713
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.14
    Marker Score: 1333
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.13
    Marker Score: 528
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.12
    Marker Score: 1382
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.11
    Marker Score: 294
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1
    Marker Score: 17727
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.08
    Marker Score: 276
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.07
    Marker Score: 640
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.04
    Marker Score: 298
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.03
    Marker Score: 297
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1
    Marker Score: 6018
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1
    Marker Score: 313
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47958.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.99
    Marker Score: 674
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.96
    Marker Score: 961.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.95
    Marker Score: 398
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.95
    Marker Score: 555

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Other Information

**Key characteristics:** * EMP1 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed in a wide range of epithelial cell types, including thyroid follicular cells, endothelial cells of the vascular tree, squamous epithelial cells, pulmonary artery endothelial cells, fibroblasts of the mammary gland, fibroblasts of connective tissue of the nonglandular part of the prostate, epithelial cells of the urethra, and stratified epithelial cells. * EMP1 is a key regulator of epithelial cell survival, proliferation, and differentiation. * It is involved in the regulation of cell cycle progression, apoptosis, and migration. * EMP1 is also involved in the regulation of inflammation and tissue remodeling. **Pathways and functions:** * EMP1 is involved in the regulation of apoptosis. It is a key regulator of the process, and its overexpression can lead to cell death. * It is also involved in the regulation of cell migration. * EMP1 is involved in the development of the epidermis. * It is also involved in the maintenance of epithelial integrity. **Clinical significance:** * Mutations in EMP1 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * The development of drugs that target EMP1 is a promising area of research for the treatment of these diseases.

Genular Protein ID: 1670241345

Symbol: EMP1_HUMAN

Name: Epithelial membrane protein 1

UniProtKB Accession Codes:

P54849 B2R5N1 B4DRR1 O00681 Q13481 Q13834

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8996089

Title: Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.

PubMed ID: 8996089

DOI: 10.1016/s0378-1119(96)00475-1

PubMed ID: 9126480

Title: cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family.

PubMed ID: 9126480

DOI: 10.1006/geno.1997.4524

PubMed ID: 8683158

Title: B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain.

PubMed ID: 8683158

PubMed ID: 9066625

Title: Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family.

PubMed ID: 9066625

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 157
  • Mass: 17563
  • Checksum: B470B4ADC5C16821
  • Sequence:
    • MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS DSLSYASEDA 
LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA TTLVCWLCIL VGVSIYTSHY 
ANRDGTQYHH GYSYILGWIC FCFSFIIGVL YLVLRKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.