Details for: ENPEP

Gene ID: 2028

Symbol: ENPEP

Ensembl ID: ENSG00000138792

Description: glutamyl aminopeptidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 70.9119
    Cell Significance Index: -11.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.3680
    Cell Significance Index: -11.0000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 17.0114
    Cell Significance Index: -11.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.6540
    Cell Significance Index: 124.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 3.9139
    Cell Significance Index: 58.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.1726
    Cell Significance Index: 91.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6786
    Cell Significance Index: -10.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6730
    Cell Significance Index: -5.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.6322
    Cell Significance Index: 22.1100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9006
    Cell Significance Index: 15.1800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7734
    Cell Significance Index: 17.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6218
    Cell Significance Index: 97.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5106
    Cell Significance Index: 164.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4705
    Cell Significance Index: 1327.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3516
    Cell Significance Index: 26.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2093
    Cell Significance Index: 30.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9119
    Cell Significance Index: 63.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8359
    Cell Significance Index: 18.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6629
    Cell Significance Index: 65.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6587
    Cell Significance Index: 10.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6299
    Cell Significance Index: 10.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6250
    Cell Significance Index: 13.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6190
    Cell Significance Index: 15.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4360
    Cell Significance Index: 10.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3631
    Cell Significance Index: 8.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2982
    Cell Significance Index: 56.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2661
    Cell Significance Index: 43.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2454
    Cell Significance Index: 48.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2381
    Cell Significance Index: 12.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1884
    Cell Significance Index: 5.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1089
    Cell Significance Index: 21.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0843
    Cell Significance Index: 10.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0578
    Cell Significance Index: 2.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0287
    Cell Significance Index: 0.6000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0282
    Cell Significance Index: 0.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0278
    Cell Significance Index: 19.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0174
    Cell Significance Index: 0.7900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0174
    Cell Significance Index: 0.2600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0170
    Cell Significance Index: 0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0162
    Cell Significance Index: 7.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0108
    Cell Significance Index: 3.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0061
    Cell Significance Index: 9.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0059
    Cell Significance Index: 1.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0023
    Cell Significance Index: 4.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0036
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -9.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0126
    Cell Significance Index: -1.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0176
    Cell Significance Index: -9.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0184
    Cell Significance Index: -11.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0186
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0187
    Cell Significance Index: -10.5600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0188
    Cell Significance Index: -0.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0241
    Cell Significance Index: -6.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0282
    Cell Significance Index: -0.9800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0336
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0336
    Cell Significance Index: -2.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0538
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0548
    Cell Significance Index: -11.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0550
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0555
    Cell Significance Index: -9.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0562
    Cell Significance Index: -0.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0646
    Cell Significance Index: -2.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0719
    Cell Significance Index: -8.8400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0776
    Cell Significance Index: -0.4800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0789
    Cell Significance Index: -0.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0797
    Cell Significance Index: -4.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0922
    Cell Significance Index: -1.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0951
    Cell Significance Index: -12.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0965
    Cell Significance Index: -11.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0971
    Cell Significance Index: -2.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0989
    Cell Significance Index: -10.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1081
    Cell Significance Index: -1.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1139
    Cell Significance Index: -9.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1281
    Cell Significance Index: -8.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1424
    Cell Significance Index: -7.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1453
    Cell Significance Index: -2.4900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1642
    Cell Significance Index: -1.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1677
    Cell Significance Index: -12.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1678
    Cell Significance Index: -4.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1745
    Cell Significance Index: -4.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1804
    Cell Significance Index: -8.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1838
    Cell Significance Index: -8.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1948
    Cell Significance Index: -12.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2044
    Cell Significance Index: -7.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2053
    Cell Significance Index: -9.6500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2074
    Cell Significance Index: -1.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2187
    Cell Significance Index: -11.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2213
    Cell Significance Index: -8.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2227
    Cell Significance Index: -2.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2304
    Cell Significance Index: -11.9700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2406
    Cell Significance Index: -1.9900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2491
    Cell Significance Index: -3.5400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2516
    Cell Significance Index: -4.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2614
    Cell Significance Index: -7.7000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2670
    Cell Significance Index: -4.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** Glutamyl aminopeptidase is a metalloaminopeptidase that catalyzes the removal of glutamic acid from the N-terminus of peptides and proteins, thereby regulating protein function and stability. 2. **Cellular Localization:** Enpep is predominantly expressed in the apical plasma membrane of epithelial cells, where it plays a crucial role in maintaining cellular polarity and regulating ion transport. 3. **Tissue Distribution:** Enpep is widely expressed in various tissues, including the kidney, liver, intestine, and placenta, highlighting its involvement in multiple physiological processes. 4. **Protein Interaction:** Enpep interacts with various proteins, including metalloproteins, peptides, and hormones, influencing their activity and stability. **Pathways and Functions:** 1. **Aminopeptidase Activity:** Enpep catalyzes the removal of glutamic acid from peptides and proteins, regulating their activity and stability. 2. **Angiogenesis:** Enpep plays a role in angiogenesis by regulating the activity of vascular endothelial growth factor (VEGF) and other angiogenic factors. 3. **Angiotensin Maturation:** Enpep is involved in the maturation of angiotensinogen to angiotensin II, a potent vasoconstrictor that regulates blood pressure. 4. **Cell Migration:** Enpep regulates cell migration by influencing the activity of various proteins involved in the migration process. 5. **Protein Metabolism:** Enpep participates in protein metabolism by regulating the activity of various enzymes and proteins involved in protein degradation and synthesis. **Clinical Significance:** 1. **Hypertension:** Dysregulation of Enpep has been implicated in hypertension, suggesting its potential as a therapeutic target for blood pressure regulation. 2. **Cancer:** Enpep overexpression has been observed in various cancers, including lung, breast, and colon cancer, highlighting its potential role in tumor progression and metastasis. 3. **Autoimmune Disorders:** Enpep has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, suggesting its potential as a therapeutic target for disease treatment. 4. **Renal Disease:** Enpep plays a crucial role in kidney function, and its dysregulation has been implicated in various renal diseases, including diabetic nephropathy and chronic kidney disease. In conclusion, the Enpep gene plays a vital role in regulating various biological processes, including protein metabolism, peptide hormone regulation, and immune responses. Further research on this gene is necessary to fully understand its mechanisms and potential therapeutic applications, particularly in the context of disease pathogenesis.

Genular Protein ID: 2068981603

Symbol: AMPE_HUMAN

Name: Glutamyl aminopeptidase

UniProtKB Accession Codes:

Q07075 Q504U2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8346219

Title: Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A.

PubMed ID: 8346219

DOI: 10.1073/pnas.90.15.7069

PubMed ID: 8244382

Title: cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A).

PubMed ID: 8244382

DOI: 10.1006/geno.1993.1386

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10692253

Title: Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues.

PubMed ID: 10692253

DOI: 10.1053/plac.1999.0456

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23888046

Title: Structural insights into central hypertension regulation by human aminopeptidase A.

PubMed ID: 23888046

DOI: 10.1074/jbc.m113.494955

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 957
  • Mass: 109244
  • Checksum: AB6407432A45A7C6
  • Sequence:
    • MNFAEREGSK RYCIQTKHVA ILCAVVVGVG LIVGLAVGLT RSCDSSGDGG PGTAPAPSHL 
PSSTASPSGP PAQDQDICPA SEDESGQWKN FRLPDFVNPV HYDLHVKPLL EEDTYTGTVS 
ISINLSAPTR YLWLHLRETR ITRLPELKRP SGDQVQVRRC FEYKKQEYVV VEAEEELTPS 
SGDGLYLLTM EFAGWLNGSL VGFYRTTYTE NGQVKSIVAT DHEPTDARKS FPCFDEPNKK 
ATYTISITHP KEYGALSNMP VAKEESVDDK WTRTTFEKSV PMSTYLVCFA VHQFDSVKRI 
SNSGKPLTIY VQPEQKHTAE YAANITKSVF DYFEEYFAMN YSLPKLDKIA IPDFGTGAME 
NWGLITYRET NLLYDPKESA SSNQQRVATV VAHELVHQWF GNIVTMDWWE DLWLNEGFAS 
FFEFLGVNHA ETDWQMRDQM LLEDVLPVQE DDSLMSSHPI IVTVTTPDEI TSVFDGISYS 
KGSSILRMLE DWIKPENFQK GCQMYLEKYQ FKNAKTSDFW AALEEASRLP VKEVMDTWTR 
QMGYPVLNVN GVKNITQKRF LLDPRANPSQ PPSDLGYTWN IPVKWTEDNI TSSVLFNRSE 
KEGITLNSSN PSGNAFLKIN PDHIGFYRVN YEVATWDSIA TALSLNHKTF SSADRASLID 
DAFALARAQL LDYKVALNLT KYLKREENFL PWQRVISAVT YIISMFEDDK ELYPMIEEYF 
QGQVKPIADS LGWNDAGDHV TKLLRSSVLG FACKMGDREA LNNASSLFEQ WLNGTVSLPV 
NLRLLVYRYG MQNSGNEISW NYTLEQYQKT SLAQEKEKLL YGLASVKNVT LLSRYLDLLK 
DTNLIKTQDV FTVIRYISYN SYGKNMAWNW IQLNWDYLVN RYTLNNRNLG RIVTIAEPFN 
TELQLWQMES FFAKYPQAGA GEKPREQVLE TVKNNIEWLK QHRNTIREWF FNLLESG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.