Details for: ENPEP

Gene ID: 2028

Symbol: ENPEP

Ensembl ID: ENSG00000138792

Description: glutamyl aminopeptidase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.7
    Marker Score: 10,802
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.32
    Marker Score: 8,254
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.29
    Marker Score: 3,522
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.17
    Marker Score: 1,784
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.51
    Marker Score: 3,549
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.48
    Marker Score: 6,385
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,130
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.41
    Marker Score: 765
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.29
    Marker Score: 372
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.27
    Marker Score: 325
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.22
    Marker Score: 10,294
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.19
    Marker Score: 535
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2,312
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.05
    Marker Score: 383
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,794
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,037
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.99
    Marker Score: 372
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.94
    Marker Score: 4,519
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.93
    Marker Score: 352
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.93
    Marker Score: 1,796
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.92
    Marker Score: 439
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14,368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.91
    Marker Score: 548
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9
    Marker Score: 10,137
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,125
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.88
    Marker Score: 3,779
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3,304
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.84
    Marker Score: 229
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8
    Marker Score: 532
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.79
    Marker Score: 1,741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.78
    Marker Score: 895
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.77
    Marker Score: 4,981
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.75
    Marker Score: 278
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.75
    Marker Score: 425
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.72
    Marker Score: 1,118
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.71
    Marker Score: 3,827
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.69
    Marker Score: 2,544
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.68
    Marker Score: 380
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,850
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.62
    Marker Score: 143
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.61
    Marker Score: 577
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 372
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3,416
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 178
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.57
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.55
    Marker Score: 382
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 175
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.53
    Marker Score: 311
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.52
    Marker Score: 134
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.51
    Marker Score: 1,814
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.49
    Marker Score: 608
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.49
    Marker Score: 416
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.48
    Marker Score: 329
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.47
    Marker Score: 473
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.46
    Marker Score: 598
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.45
    Marker Score: 15,412
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.44
    Marker Score: 3,394
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.44
    Marker Score: 476
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 182
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.44
    Marker Score: 818
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.43
    Marker Score: 412
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.42
    Marker Score: 104
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.41
    Marker Score: 104
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 177
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.39
    Marker Score: 249
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.39
    Marker Score: 207
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 247
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.39
    Marker Score: 466
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.38
    Marker Score: 293
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.38
    Marker Score: 96
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.37
    Marker Score: 504
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.36
    Marker Score: 953
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.35
    Marker Score: 161
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.35
    Marker Score: 580
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.33
    Marker Score: 223
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.33
    Marker Score: 462
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.32
    Marker Score: 344
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.31
    Marker Score: 140
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 561
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.29
    Marker Score: 615
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 131

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** Glutamyl aminopeptidase is a metalloaminopeptidase that catalyzes the removal of glutamic acid from the N-terminus of peptides and proteins, thereby regulating protein function and stability. 2. **Cellular Localization:** Enpep is predominantly expressed in the apical plasma membrane of epithelial cells, where it plays a crucial role in maintaining cellular polarity and regulating ion transport. 3. **Tissue Distribution:** Enpep is widely expressed in various tissues, including the kidney, liver, intestine, and placenta, highlighting its involvement in multiple physiological processes. 4. **Protein Interaction:** Enpep interacts with various proteins, including metalloproteins, peptides, and hormones, influencing their activity and stability. **Pathways and Functions:** 1. **Aminopeptidase Activity:** Enpep catalyzes the removal of glutamic acid from peptides and proteins, regulating their activity and stability. 2. **Angiogenesis:** Enpep plays a role in angiogenesis by regulating the activity of vascular endothelial growth factor (VEGF) and other angiogenic factors. 3. **Angiotensin Maturation:** Enpep is involved in the maturation of angiotensinogen to angiotensin II, a potent vasoconstrictor that regulates blood pressure. 4. **Cell Migration:** Enpep regulates cell migration by influencing the activity of various proteins involved in the migration process. 5. **Protein Metabolism:** Enpep participates in protein metabolism by regulating the activity of various enzymes and proteins involved in protein degradation and synthesis. **Clinical Significance:** 1. **Hypertension:** Dysregulation of Enpep has been implicated in hypertension, suggesting its potential as a therapeutic target for blood pressure regulation. 2. **Cancer:** Enpep overexpression has been observed in various cancers, including lung, breast, and colon cancer, highlighting its potential role in tumor progression and metastasis. 3. **Autoimmune Disorders:** Enpep has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, suggesting its potential as a therapeutic target for disease treatment. 4. **Renal Disease:** Enpep plays a crucial role in kidney function, and its dysregulation has been implicated in various renal diseases, including diabetic nephropathy and chronic kidney disease. In conclusion, the Enpep gene plays a vital role in regulating various biological processes, including protein metabolism, peptide hormone regulation, and immune responses. Further research on this gene is necessary to fully understand its mechanisms and potential therapeutic applications, particularly in the context of disease pathogenesis.

Genular Protein ID: 2068981603

Symbol: AMPE_HUMAN

Name: Glutamyl aminopeptidase

UniProtKB Accession Codes:

Q07075 Q504U2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8346219

Title: Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A.

PubMed ID: 8346219

DOI: 10.1073/pnas.90.15.7069

PubMed ID: 8244382

Title: cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A).

PubMed ID: 8244382

DOI: 10.1006/geno.1993.1386

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10692253

Title: Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues.

PubMed ID: 10692253

DOI: 10.1053/plac.1999.0456

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23888046

Title: Structural insights into central hypertension regulation by human aminopeptidase A.

PubMed ID: 23888046

DOI: 10.1074/jbc.m113.494955

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 957
  • Mass: 109244
  • Checksum: AB6407432A45A7C6
  • Sequence:
    • MNFAEREGSK RYCIQTKHVA ILCAVVVGVG LIVGLAVGLT RSCDSSGDGG PGTAPAPSHL 
PSSTASPSGP PAQDQDICPA SEDESGQWKN FRLPDFVNPV HYDLHVKPLL EEDTYTGTVS 
ISINLSAPTR YLWLHLRETR ITRLPELKRP SGDQVQVRRC FEYKKQEYVV VEAEEELTPS 
SGDGLYLLTM EFAGWLNGSL VGFYRTTYTE NGQVKSIVAT DHEPTDARKS FPCFDEPNKK 
ATYTISITHP KEYGALSNMP VAKEESVDDK WTRTTFEKSV PMSTYLVCFA VHQFDSVKRI 
SNSGKPLTIY VQPEQKHTAE YAANITKSVF DYFEEYFAMN YSLPKLDKIA IPDFGTGAME 
NWGLITYRET NLLYDPKESA SSNQQRVATV VAHELVHQWF GNIVTMDWWE DLWLNEGFAS 
FFEFLGVNHA ETDWQMRDQM LLEDVLPVQE DDSLMSSHPI IVTVTTPDEI TSVFDGISYS 
KGSSILRMLE DWIKPENFQK GCQMYLEKYQ FKNAKTSDFW AALEEASRLP VKEVMDTWTR 
QMGYPVLNVN GVKNITQKRF LLDPRANPSQ PPSDLGYTWN IPVKWTEDNI TSSVLFNRSE 
KEGITLNSSN PSGNAFLKIN PDHIGFYRVN YEVATWDSIA TALSLNHKTF SSADRASLID 
DAFALARAQL LDYKVALNLT KYLKREENFL PWQRVISAVT YIISMFEDDK ELYPMIEEYF 
QGQVKPIADS LGWNDAGDHV TKLLRSSVLG FACKMGDREA LNNASSLFEQ WLNGTVSLPV 
NLRLLVYRYG MQNSGNEISW NYTLEQYQKT SLAQEKEKLL YGLASVKNVT LLSRYLDLLK 
DTNLIKTQDV FTVIRYISYN SYGKNMAWNW IQLNWDYLVN RYTLNNRNLG RIVTIAEPFN 
TELQLWQMES FFAKYPQAGA GEKPREQVLE TVKNNIEWLK QHRNTIREWF FNLLESG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.