Details for: EPS15
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.09
Marker Score: 54,784 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.76
Marker Score: 11,536 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.73
Marker Score: 58,164 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.63
Marker Score: 58,863 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.57
Marker Score: 5,647 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.5
Marker Score: 730 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.45
Marker Score: 3,298 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.43
Marker Score: 3,030 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.39
Marker Score: 5,983 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.39
Marker Score: 2,890 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.39
Marker Score: 1,391 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.38
Marker Score: 4,579 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.27
Marker Score: 1,262 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.26
Marker Score: 5,405 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.24
Marker Score: 2,583 - Cell Name: contractile cell (CL0000183)
Fold Change: 2.18
Marker Score: 1,183 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.16
Marker Score: 1,422 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.16
Marker Score: 682 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.09
Marker Score: 876 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.02
Marker Score: 1,066 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.02
Marker Score: 2,235 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2
Marker Score: 2,141 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.99
Marker Score: 1,768 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.99
Marker Score: 1,379 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.97
Marker Score: 1,151 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.94
Marker Score: 702 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.93
Marker Score: 1,151 - Cell Name: fat cell (CL0000136)
Fold Change: 1.88
Marker Score: 1,048 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.87
Marker Score: 1,618 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.86
Marker Score: 5,528 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.86
Marker Score: 17,509 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.86
Marker Score: 1,770 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.85
Marker Score: 113,950 - Cell Name: centroblast (CL0009112)
Fold Change: 1.84
Marker Score: 909 - Cell Name: podocyte (CL0000653)
Fold Change: 1.84
Marker Score: 680 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.78
Marker Score: 16,947 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.77
Marker Score: 879 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.76
Marker Score: 599 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.75
Marker Score: 1,892 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.75
Marker Score: 1,981 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.74
Marker Score: 452 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.73
Marker Score: 17,904 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.72
Marker Score: 1,130 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.71
Marker Score: 435 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.7
Marker Score: 1,472 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.7
Marker Score: 937 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.7
Marker Score: 6,035 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.7
Marker Score: 823 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.68
Marker Score: 12,884 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.66
Marker Score: 1,280 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.66
Marker Score: 2,004 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.66
Marker Score: 453 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.65
Marker Score: 14,161 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.63
Marker Score: 32,431 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.59
Marker Score: 25,610 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.59
Marker Score: 6,602 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.58
Marker Score: 6,098 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.58
Marker Score: 58,126 - Cell Name: neuron (CL0000540)
Fold Change: 1.56
Marker Score: 6,370 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.56
Marker Score: 4,379 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.54
Marker Score: 2,242 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.54
Marker Score: 23,043 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.51
Marker Score: 1,237 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.47
Marker Score: 549 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.45
Marker Score: 55,003 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.43
Marker Score: 864 - Cell Name: erythroblast (CL0000765)
Fold Change: 1.43
Marker Score: 895 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.43
Marker Score: 2,020 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.43
Marker Score: 411 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.39
Marker Score: 506 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.39
Marker Score: 1,279 - Cell Name: Schwann cell (CL0002573)
Fold Change: 1.38
Marker Score: 478 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.37
Marker Score: 414 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.37
Marker Score: 1,439 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.37
Marker Score: 553 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.36
Marker Score: 702 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.36
Marker Score: 1,438 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.36
Marker Score: 2,277 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.35
Marker Score: 1,944 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.35
Marker Score: 477 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.34
Marker Score: 911 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.34
Marker Score: 661 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.34
Marker Score: 813 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.33
Marker Score: 488 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.33
Marker Score: 2,060 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.33
Marker Score: 574 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.32
Marker Score: 823 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.32
Marker Score: 315 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.29
Marker Score: 1,561 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.29
Marker Score: 281 - Cell Name: blood cell (CL0000081)
Fold Change: 1.29
Marker Score: 14,983 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.29
Marker Score: 1,267 - Cell Name: centrocyte (CL0009111)
Fold Change: 1.28
Marker Score: 304 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.27
Marker Score: 313 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.27
Marker Score: 5,280 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.24
Marker Score: 385 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.24
Marker Score: 1,113 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.23
Marker Score: 7,936 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.23
Marker Score: 298 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.23
Marker Score: 282
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2393200955
Symbol: EPS15_HUMAN
Name: Epidermal growth factor receptor substrate 15
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8183552
Title: The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.
PubMed ID: 8183552
PubMed ID: 8134107
Title: A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.
PubMed ID: 8134107
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 8662907
Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
PubMed ID: 8662907
PubMed ID: 9723620
Title: Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.
PubMed ID: 9723620
DOI: 10.1038/29555
PubMed ID: 10393179
Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.
PubMed ID: 10393179
PubMed ID: 12551915
Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.
PubMed ID: 12551915
PubMed ID: 16325581
Title: TTP specifically regulates the internalization of the transferrin receptor.
PubMed ID: 16325581
PubMed ID: 16159959
Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.
PubMed ID: 16159959
DOI: 10.1242/jcs.02571
PubMed ID: 16314522
Title: Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
PubMed ID: 16314522
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18362181
Title: An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.
PubMed ID: 18362181
PubMed ID: 18088087
PubMed ID: 18199683
Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
PubMed ID: 18199683
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19458185
Title: Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits.
PubMed ID: 19458185
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 20448150
Title: FCHo proteins are nucleators of clathrin-mediated endocytosis.
PubMed ID: 20448150
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21762413
Title: Characterization of the EFC/F-BAR domain protein, FCHO2.
PubMed ID: 21762413
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22648170
Title: The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis.
PubMed ID: 22648170
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22484487
Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
PubMed ID: 22484487
DOI: 10.1038/ncb2473
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24768539
Title: K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking.
PubMed ID: 24768539
PubMed ID: 27670116
Title: NPF motifs in the vaccinia virus protein A36 recruit intersectin-1 to promote Cdc42:N-WASP-mediated viral release from infected cells.
PubMed ID: 27670116
PubMed ID: 9721102
Title: Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.
PubMed ID: 9721102
PubMed ID: 10757979
Title: Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.
PubMed ID: 10757979
DOI: 10.1021/bi9927383
PubMed ID: 11062555
PubMed ID: 16903783
Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
PubMed ID: 16903783
PubMed ID: 18200045
Title: Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.
PubMed ID: 18200045
PubMed ID: 26822536
Title: Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.
PubMed ID: 26822536
DOI: 10.1038/srep19565
Sequence Information:
- Length: 896
- Mass: 98656
- Checksum: A1B9FE15B47ABAFF
- Sequence:
MAAAAQLSLT QLSSGNPVYE KYYRQVDTGN TGRVLASDAA AFLKKSGLPD LILGKIWDLA DTDGKGILNK QEFFVALRLV ACAQNGLEVS LSSLNLAVPP PRFHDTSSPL LISGTSAAEL PWAVKPEDKA KYDAIFDSLS PVNGFLSGDK VKPVLLNSKL PVDILGRVWE LSDIDHDGML DRDEFAVAMF LVYCALEKEP VPMSLPPALV PPSKRKTWVV SPAEKAKYDE IFLKTDKDMD GFVSGLEVRE IFLKTGLPST LLAHIWSLCD TKDCGKLSKD QFALAFHLIS QKLIKGIDPP HVLTPEMIPP SDRASLQKNI IGSSPVADFS AIKELDTLNN EIVDLQREKN NVEQDLKEKE DTIKQRTSEV QDLQDEVQRE NTNLQKLQAQ KQQVQELLDE LDEQKAQLEE QLKEVRKKCA EEAQLISSLK AELTSQESQI STYEEELAKA REELSRLQQE TAELEESVES GKAQLEPLQQ HLQDSQQEIS SMQMKLMEMK DLENHNSQLN WCSSPHSILV NGATDYCSLS TSSSETANLN EHVEGQSNLE SEPIHQESPA RSSPELLPSG VTDENEVTTA VTEKVCSELD NNRHSKEEDP FNVDSSSLTG PVADTNLDFF QSDPFVGSDP FKDDPFGKID PFGGDPFKGS DPFASDCFFR QSTDPFATSS TDPFSAANNS SITSVETLKH NDPFAPGGTV VAASDSATDP FASVFGNESF GGGFADFSTL SKVNNEDPFR SATSSSVSNV VITKNVFEET SVKSEDEPPA LPPKIGTPTR PCPLPPGKRS INKLDSPDPF KLNDPFQPFP GNDSPKEKDP EIFCDPFTSA TTTTNKEADP SNFANFSAYP SEEDMIEWAK RESEREEEQR LARLNQQEQE DLELAIALSK SEISEA
Genular Protein ID: 1838165190
Symbol: B7Z240_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 573
- Mass: 63622
- Checksum: 7C74EA492335003C
- Sequence:
MILMVRDCLK SQHRDPHCDP SDKREKNNVE QDLKEKEDTI KQRTSEVQDL QDEVQRENTN LQKLQAQKQQ VQELLDELDE QKAQLEEQLK EVRKKCAEEA QLISSLKAEL TSQESQISTY EEELAKAREE LSRLQQETAE LEESVESGKA QLEPLQQHLQ DSQQEISSMQ MKLMEMKDLE NHNSQLNWCS SPHSILVNGA TDYCSLSTSS SETANLNEHV EGQSNLESEP IHQESPARSS PELLPSGVTD ENEVTTAVTE KVCSELDNNR HSKEEDPFNV DSSSLTGPVA DTNLDFFQSD PFVGSDPFKD DPFGKIDPFG GDPFKGSDPF ASDCFFRQST DPFATSSTDP FSAANNSSIT SVETLKHNDP FAPGGTVVAA SDSATDPFAS VFGNESFGGG FADFSTLSKV NNEDPFRSAT SSSVSNVVIT KNVFEETSVK SEDEPPALPP KIGTPTRPCP LPPGKRSINK LDSPDPFKLN DPFQPFPGND SPKEIDPEIF CDPFTSATTT TNKEADPSNF ANFSAYPSEE DMIEWAKRES EREEEQRLAR LNQQEQEDLE LAIALSKSEI SEA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.