Details for: EPS15

Gene ID: 2060

Symbol: EPS15

Ensembl ID: ENSG00000085832

Description: epidermal growth factor receptor pathway substrate 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 423.8960
    Cell Significance Index: -65.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 267.6593
    Cell Significance Index: -67.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 150.3211
    Cell Significance Index: -70.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.6252
    Cell Significance Index: -57.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.5309
    Cell Significance Index: -65.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.3932
    Cell Significance Index: -57.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.4149
    Cell Significance Index: -70.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.2865
    Cell Significance Index: -65.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.7166
    Cell Significance Index: -63.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.6056
    Cell Significance Index: -40.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.2803
    Cell Significance Index: -72.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.3778
    Cell Significance Index: 112.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.4892
    Cell Significance Index: 68.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.6190
    Cell Significance Index: 200.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.2133
    Cell Significance Index: 59.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8302
    Cell Significance Index: 102.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.7570
    Cell Significance Index: 42.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7472
    Cell Significance Index: 350.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5153
    Cell Significance Index: 178.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4488
    Cell Significance Index: 40.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1968
    Cell Significance Index: 237.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.1674
    Cell Significance Index: 7.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0969
    Cell Significance Index: 393.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0259
    Cell Significance Index: 111.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7848
    Cell Significance Index: 48.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7643
    Cell Significance Index: 93.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.6895
    Cell Significance Index: 10.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6308
    Cell Significance Index: 37.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6226
    Cell Significance Index: 112.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6180
    Cell Significance Index: 427.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5661
    Cell Significance Index: 16.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5255
    Cell Significance Index: 72.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4958
    Cell Significance Index: 933.5000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4589
    Cell Significance Index: 6.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4554
    Cell Significance Index: 411.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4508
    Cell Significance Index: 286.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3350
    Cell Significance Index: 4.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3063
    Cell Significance Index: 139.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2402
    Cell Significance Index: 369.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2396
    Cell Significance Index: 441.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2357
    Cell Significance Index: 104.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2330
    Cell Significance Index: 127.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2036
    Cell Significance Index: 20.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1948
    Cell Significance Index: 37.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1645
    Cell Significance Index: 4.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1505
    Cell Significance Index: 3.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1223
    Cell Significance Index: 166.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1056
    Cell Significance Index: 6.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0193
    Cell Significance Index: -3.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0262
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0389
    Cell Significance Index: -28.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0454
    Cell Significance Index: -6.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0465
    Cell Significance Index: -34.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0508
    Cell Significance Index: -31.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0740
    Cell Significance Index: -2.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0747
    Cell Significance Index: -56.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0807
    Cell Significance Index: -45.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1059
    Cell Significance Index: -13.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1063
    Cell Significance Index: -7.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1112
    Cell Significance Index: -5.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1719
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1816
    Cell Significance Index: -38.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1861
    Cell Significance Index: -8.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2096
    Cell Significance Index: -60.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2404
    Cell Significance Index: -28.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2545
    Cell Significance Index: -26.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2798
    Cell Significance Index: -45.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2826
    Cell Significance Index: -6.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3060
    Cell Significance Index: -39.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3476
    Cell Significance Index: -23.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3730
    Cell Significance Index: -38.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3851
    Cell Significance Index: -20.0100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4270
    Cell Significance Index: -6.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4292
    Cell Significance Index: -48.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4564
    Cell Significance Index: -52.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5004
    Cell Significance Index: -12.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5013
    Cell Significance Index: -37.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5713
    Cell Significance Index: -9.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5879
    Cell Significance Index: -41.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6344
    Cell Significance Index: -13.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6480
    Cell Significance Index: -13.8000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6480
    Cell Significance Index: -8.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6625
    Cell Significance Index: -33.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6747
    Cell Significance Index: -35.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6868
    Cell Significance Index: -30.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6946
    Cell Significance Index: -11.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7109
    Cell Significance Index: -19.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7191
    Cell Significance Index: -56.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7547
    Cell Significance Index: -4.5600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.7798
    Cell Significance Index: -9.8200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.8224
    Cell Significance Index: -7.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8347
    Cell Significance Index: -52.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8389
    Cell Significance Index: -20.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8445
    Cell Significance Index: -31.9800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8795
    Cell Significance Index: -11.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9013
    Cell Significance Index: -8.3000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9195
    Cell Significance Index: -11.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9854
    Cell Significance Index: -31.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0421
    Cell Significance Index: -19.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EPS15 is a cytosolic protein that belongs to the eps15 family of proteins, which are known for their involvement in endocytic processes. The protein is characterized by its ability to bind to polyubiquitin chains and regulate the activity of various signaling pathways. EPS15 has been shown to interact with multiple proteins, including clathrin, AP-2, and SH3 domain-containing proteins, which are essential for endocytosis and membrane trafficking. **Pathways and Functions:** EPS15 is involved in several critical signaling pathways, including: 1. **Clathrin-mediated endocytosis**: EPS15 regulates the internalization of receptors, such as EGFR and MET, through the formation of clathrin-coated pits. 2. **Membrane trafficking**: EPS15 is involved in the transport of vesicles within the cell, including those involved in endocytosis and exocytosis. 3. **Signaling by EGFR and MET**: EPS15 modulates the activity of these receptor tyrosine kinases, influencing their downstream signaling pathways. 4. **Immune responses**: EPS15 has been shown to regulate the internalization and recycling of receptors involved in immune responses, such as those expressed on the surface of antigen-presenting cells. **Clinical Significance:** Dysregulation of EPS15 has been implicated in various diseases, including: 1. **Cancer**: EPS15 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth and metastasis. 2. **Infectious diseases**: EPS15 has been implicated in the entry of pathogens, such as Listeria monocytogenes, into host cells, highlighting its importance in understanding the mechanisms of infection and immune evasion. 3. **Neurological disorders**: EPS15 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in the dysregulation of endocytic pathways and protein trafficking. In conclusion, EPS15 is a critical gene involved in various cellular processes, including endocytosis, membrane trafficking, and signaling pathways. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding its role in immune responses and disease pathogenesis. Further research is needed to elucidate the mechanisms by which EPS15 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2393200955

Symbol: EPS15_HUMAN

Name: Epidermal growth factor receptor substrate 15

UniProtKB Accession Codes:

P42566 B2R8J7 D3DPJ2 Q5SRH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8183552

Title: The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.

PubMed ID: 8183552

PubMed ID: 8134107

Title: A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.

PubMed ID: 8134107

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8662907

Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.

PubMed ID: 8662907

DOI: 10.1074/jbc.271.24.14468

PubMed ID: 9723620

Title: Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.

PubMed ID: 9723620

DOI: 10.1038/29555

PubMed ID: 10393179

Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

PubMed ID: 10393179

DOI: 10.1093/emboj/18.13.3629

PubMed ID: 12551915

Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

PubMed ID: 12551915

DOI: 10.1074/jbc.m210843200

PubMed ID: 16325581

Title: TTP specifically regulates the internalization of the transferrin receptor.

PubMed ID: 16325581

DOI: 10.1016/j.cell.2005.10.021

PubMed ID: 16159959

Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.

PubMed ID: 16159959

DOI: 10.1242/jcs.02571

PubMed ID: 16314522

Title: Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.

PubMed ID: 16314522

DOI: 10.1128/mcb.25.24.11005-11018.2005

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18362181

Title: An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.

PubMed ID: 18362181

DOI: 10.1083/jcb.200708115

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18199683

Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

PubMed ID: 18199683

DOI: 10.1091/mbc.e07-08-0775

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19458185

Title: Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits.

PubMed ID: 19458185

DOI: 10.1091/mbc.e09-03-0256

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20448150

Title: FCHo proteins are nucleators of clathrin-mediated endocytosis.

PubMed ID: 20448150

DOI: 10.1126/science.1188462

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21762413

Title: Characterization of the EFC/F-BAR domain protein, FCHO2.

PubMed ID: 21762413

DOI: 10.1111/j.1365-2443.2011.01536.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22648170

Title: The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis.

PubMed ID: 22648170

DOI: 10.1091/mbc.e11-12-1007

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24768539

Title: K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking.

PubMed ID: 24768539

DOI: 10.1016/j.molcel.2014.03.035

PubMed ID: 27670116

Title: NPF motifs in the vaccinia virus protein A36 recruit intersectin-1 to promote Cdc42:N-WASP-mediated viral release from infected cells.

PubMed ID: 27670116

DOI: 10.1038/nmicrobiol.2016.141

PubMed ID: 9721102

Title: Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.

PubMed ID: 9721102

DOI: 10.1126/science.281.5381.1357

PubMed ID: 10757979

Title: Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.

PubMed ID: 10757979

DOI: 10.1021/bi9927383

PubMed ID: 11062555

Title: Molecular mechanism of NPF recognition by EH domains.

PubMed ID: 11062555

DOI: 10.1038/80924

PubMed ID: 16903783

Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.

PubMed ID: 16903783

DOI: 10.1371/journal.pbio.0040262

PubMed ID: 18200045

Title: Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.

PubMed ID: 18200045

DOI: 10.1038/sj.emboj.7601980

PubMed ID: 26822536

Title: Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.

PubMed ID: 26822536

DOI: 10.1038/srep19565

Sequence Information:

  • Length: 896
  • Mass: 98656
  • Checksum: A1B9FE15B47ABAFF
  • Sequence:
    • MAAAAQLSLT QLSSGNPVYE KYYRQVDTGN TGRVLASDAA AFLKKSGLPD LILGKIWDLA 
DTDGKGILNK QEFFVALRLV ACAQNGLEVS LSSLNLAVPP PRFHDTSSPL LISGTSAAEL 
PWAVKPEDKA KYDAIFDSLS PVNGFLSGDK VKPVLLNSKL PVDILGRVWE LSDIDHDGML 
DRDEFAVAMF LVYCALEKEP VPMSLPPALV PPSKRKTWVV SPAEKAKYDE IFLKTDKDMD 
GFVSGLEVRE IFLKTGLPST LLAHIWSLCD TKDCGKLSKD QFALAFHLIS QKLIKGIDPP 
HVLTPEMIPP SDRASLQKNI IGSSPVADFS AIKELDTLNN EIVDLQREKN NVEQDLKEKE 
DTIKQRTSEV QDLQDEVQRE NTNLQKLQAQ KQQVQELLDE LDEQKAQLEE QLKEVRKKCA 
EEAQLISSLK AELTSQESQI STYEEELAKA REELSRLQQE TAELEESVES GKAQLEPLQQ 
HLQDSQQEIS SMQMKLMEMK DLENHNSQLN WCSSPHSILV NGATDYCSLS TSSSETANLN 
EHVEGQSNLE SEPIHQESPA RSSPELLPSG VTDENEVTTA VTEKVCSELD NNRHSKEEDP 
FNVDSSSLTG PVADTNLDFF QSDPFVGSDP FKDDPFGKID PFGGDPFKGS DPFASDCFFR 
QSTDPFATSS TDPFSAANNS SITSVETLKH NDPFAPGGTV VAASDSATDP FASVFGNESF 
GGGFADFSTL SKVNNEDPFR SATSSSVSNV VITKNVFEET SVKSEDEPPA LPPKIGTPTR 
PCPLPPGKRS INKLDSPDPF KLNDPFQPFP GNDSPKEKDP EIFCDPFTSA TTTTNKEADP 
SNFANFSAYP SEEDMIEWAK RESEREEEQR LARLNQQEQE DLELAIALSK SEISEA

Genular Protein ID: 1838165190

Symbol: B7Z240_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z240

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1

Sequence Information:

  • Length: 573
  • Mass: 63622
  • Checksum: 7C74EA492335003C
  • Sequence:
    • MILMVRDCLK SQHRDPHCDP SDKREKNNVE QDLKEKEDTI KQRTSEVQDL QDEVQRENTN 
LQKLQAQKQQ VQELLDELDE QKAQLEEQLK EVRKKCAEEA QLISSLKAEL TSQESQISTY 
EEELAKAREE LSRLQQETAE LEESVESGKA QLEPLQQHLQ DSQQEISSMQ MKLMEMKDLE 
NHNSQLNWCS SPHSILVNGA TDYCSLSTSS SETANLNEHV EGQSNLESEP IHQESPARSS 
PELLPSGVTD ENEVTTAVTE KVCSELDNNR HSKEEDPFNV DSSSLTGPVA DTNLDFFQSD 
PFVGSDPFKD DPFGKIDPFG GDPFKGSDPF ASDCFFRQST DPFATSSTDP FSAANNSSIT 
SVETLKHNDP FAPGGTVVAA SDSATDPFAS VFGNESFGGG FADFSTLSKV NNEDPFRSAT 
SSSVSNVVIT KNVFEETSVK SEDEPPALPP KIGTPTRPCP LPPGKRSINK LDSPDPFKLN 
DPFQPFPGND SPKEIDPEIF CDPFTSATTT TNKEADPSNF ANFSAYPSEE DMIEWAKRES 
EREEEQRLAR LNQQEQEDLE LAIALSKSEI SEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.