Details for: EPS15

Gene ID: 2060

Symbol: EPS15

Ensembl ID: ENSG00000085832

Description: epidermal growth factor receptor pathway substrate 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.09
    Marker Score: 54,784
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.76
    Marker Score: 11,536
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.73
    Marker Score: 58,164
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.63
    Marker Score: 58,863
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.57
    Marker Score: 5,647
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.5
    Marker Score: 730
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.45
    Marker Score: 3,298
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.43
    Marker Score: 3,030
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.39
    Marker Score: 5,983
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.39
    Marker Score: 2,890
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.39
    Marker Score: 1,391
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.38
    Marker Score: 4,579
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.27
    Marker Score: 1,262
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.26
    Marker Score: 5,405
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.24
    Marker Score: 2,583
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.18
    Marker Score: 1,183
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.16
    Marker Score: 1,422
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.16
    Marker Score: 682
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.09
    Marker Score: 876
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.02
    Marker Score: 1,066
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.02
    Marker Score: 2,235
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2
    Marker Score: 2,141
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.99
    Marker Score: 1,768
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.99
    Marker Score: 1,379
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.97
    Marker Score: 1,151
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.94
    Marker Score: 702
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.93
    Marker Score: 1,151
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.88
    Marker Score: 1,048
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.87
    Marker Score: 1,618
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.86
    Marker Score: 5,528
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.86
    Marker Score: 17,509
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.86
    Marker Score: 1,770
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.85
    Marker Score: 113,950
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.84
    Marker Score: 909
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.84
    Marker Score: 680
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,947
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.77
    Marker Score: 879
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.76
    Marker Score: 599
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.75
    Marker Score: 1,892
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.75
    Marker Score: 1,981
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.74
    Marker Score: 452
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.73
    Marker Score: 17,904
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.72
    Marker Score: 1,130
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.71
    Marker Score: 435
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.7
    Marker Score: 1,472
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.7
    Marker Score: 937
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.7
    Marker Score: 6,035
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.7
    Marker Score: 823
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.68
    Marker Score: 12,884
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.66
    Marker Score: 1,280
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.66
    Marker Score: 2,004
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.66
    Marker Score: 453
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14,161
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.63
    Marker Score: 32,431
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.59
    Marker Score: 25,610
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.59
    Marker Score: 6,602
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.58
    Marker Score: 6,098
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.58
    Marker Score: 58,126
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.56
    Marker Score: 6,370
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.56
    Marker Score: 4,379
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.54
    Marker Score: 2,242
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.54
    Marker Score: 23,043
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.51
    Marker Score: 1,237
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.47
    Marker Score: 549
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.45
    Marker Score: 55,003
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.43
    Marker Score: 864
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.43
    Marker Score: 895
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.43
    Marker Score: 2,020
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.43
    Marker Score: 411
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.39
    Marker Score: 506
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.39
    Marker Score: 1,279
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.38
    Marker Score: 478
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.37
    Marker Score: 414
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.37
    Marker Score: 1,439
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.37
    Marker Score: 553
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.36
    Marker Score: 702
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.36
    Marker Score: 1,438
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.36
    Marker Score: 2,277
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.35
    Marker Score: 1,944
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.35
    Marker Score: 477
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.34
    Marker Score: 911
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.34
    Marker Score: 661
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.34
    Marker Score: 813
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.33
    Marker Score: 488
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2,060
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.33
    Marker Score: 574
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.32
    Marker Score: 823
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.32
    Marker Score: 315
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.29
    Marker Score: 1,561
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.29
    Marker Score: 281
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.29
    Marker Score: 14,983
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.29
    Marker Score: 1,267
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.28
    Marker Score: 304
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.27
    Marker Score: 313
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.27
    Marker Score: 5,280
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.24
    Marker Score: 385
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.24
    Marker Score: 1,113
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.23
    Marker Score: 7,936
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.23
    Marker Score: 298
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.23
    Marker Score: 282

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EPS15 is a cytosolic protein that belongs to the eps15 family of proteins, which are known for their involvement in endocytic processes. The protein is characterized by its ability to bind to polyubiquitin chains and regulate the activity of various signaling pathways. EPS15 has been shown to interact with multiple proteins, including clathrin, AP-2, and SH3 domain-containing proteins, which are essential for endocytosis and membrane trafficking. **Pathways and Functions:** EPS15 is involved in several critical signaling pathways, including: 1. **Clathrin-mediated endocytosis**: EPS15 regulates the internalization of receptors, such as EGFR and MET, through the formation of clathrin-coated pits. 2. **Membrane trafficking**: EPS15 is involved in the transport of vesicles within the cell, including those involved in endocytosis and exocytosis. 3. **Signaling by EGFR and MET**: EPS15 modulates the activity of these receptor tyrosine kinases, influencing their downstream signaling pathways. 4. **Immune responses**: EPS15 has been shown to regulate the internalization and recycling of receptors involved in immune responses, such as those expressed on the surface of antigen-presenting cells. **Clinical Significance:** Dysregulation of EPS15 has been implicated in various diseases, including: 1. **Cancer**: EPS15 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth and metastasis. 2. **Infectious diseases**: EPS15 has been implicated in the entry of pathogens, such as Listeria monocytogenes, into host cells, highlighting its importance in understanding the mechanisms of infection and immune evasion. 3. **Neurological disorders**: EPS15 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in the dysregulation of endocytic pathways and protein trafficking. In conclusion, EPS15 is a critical gene involved in various cellular processes, including endocytosis, membrane trafficking, and signaling pathways. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding its role in immune responses and disease pathogenesis. Further research is needed to elucidate the mechanisms by which EPS15 regulates cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2393200955

Symbol: EPS15_HUMAN

Name: Epidermal growth factor receptor substrate 15

UniProtKB Accession Codes:

P42566 B2R8J7 D3DPJ2 Q5SRH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 13 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8183552

Title: The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.

PubMed ID: 8183552

PubMed ID: 8134107

Title: A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.

PubMed ID: 8134107

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8662907

Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.

PubMed ID: 8662907

DOI: 10.1074/jbc.271.24.14468

PubMed ID: 9723620

Title: Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.

PubMed ID: 9723620

DOI: 10.1038/29555

PubMed ID: 10393179

Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.

PubMed ID: 10393179

DOI: 10.1093/emboj/18.13.3629

PubMed ID: 12551915

Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

PubMed ID: 12551915

DOI: 10.1074/jbc.m210843200

PubMed ID: 16325581

Title: TTP specifically regulates the internalization of the transferrin receptor.

PubMed ID: 16325581

DOI: 10.1016/j.cell.2005.10.021

PubMed ID: 16159959

Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.

PubMed ID: 16159959

DOI: 10.1242/jcs.02571

PubMed ID: 16314522

Title: Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.

PubMed ID: 16314522

DOI: 10.1128/mcb.25.24.11005-11018.2005

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18362181

Title: An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.

PubMed ID: 18362181

DOI: 10.1083/jcb.200708115

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18199683

Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.

PubMed ID: 18199683

DOI: 10.1091/mbc.e07-08-0775

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19458185

Title: Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits.

PubMed ID: 19458185

DOI: 10.1091/mbc.e09-03-0256

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20448150

Title: FCHo proteins are nucleators of clathrin-mediated endocytosis.

PubMed ID: 20448150

DOI: 10.1126/science.1188462

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21762413

Title: Characterization of the EFC/F-BAR domain protein, FCHO2.

PubMed ID: 21762413

DOI: 10.1111/j.1365-2443.2011.01536.x

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22648170

Title: The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis.

PubMed ID: 22648170

DOI: 10.1091/mbc.e11-12-1007

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24768539

Title: K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking.

PubMed ID: 24768539

DOI: 10.1016/j.molcel.2014.03.035

PubMed ID: 27670116

Title: NPF motifs in the vaccinia virus protein A36 recruit intersectin-1 to promote Cdc42:N-WASP-mediated viral release from infected cells.

PubMed ID: 27670116

DOI: 10.1038/nmicrobiol.2016.141

PubMed ID: 9721102

Title: Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.

PubMed ID: 9721102

DOI: 10.1126/science.281.5381.1357

PubMed ID: 10757979

Title: Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.

PubMed ID: 10757979

DOI: 10.1021/bi9927383

PubMed ID: 11062555

Title: Molecular mechanism of NPF recognition by EH domains.

PubMed ID: 11062555

DOI: 10.1038/80924

PubMed ID: 16903783

Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.

PubMed ID: 16903783

DOI: 10.1371/journal.pbio.0040262

PubMed ID: 18200045

Title: Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.

PubMed ID: 18200045

DOI: 10.1038/sj.emboj.7601980

PubMed ID: 26822536

Title: Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.

PubMed ID: 26822536

DOI: 10.1038/srep19565

Sequence Information:

  • Length: 896
  • Mass: 98656
  • Checksum: A1B9FE15B47ABAFF
  • Sequence:
    • MAAAAQLSLT QLSSGNPVYE KYYRQVDTGN TGRVLASDAA AFLKKSGLPD LILGKIWDLA 
DTDGKGILNK QEFFVALRLV ACAQNGLEVS LSSLNLAVPP PRFHDTSSPL LISGTSAAEL 
PWAVKPEDKA KYDAIFDSLS PVNGFLSGDK VKPVLLNSKL PVDILGRVWE LSDIDHDGML 
DRDEFAVAMF LVYCALEKEP VPMSLPPALV PPSKRKTWVV SPAEKAKYDE IFLKTDKDMD 
GFVSGLEVRE IFLKTGLPST LLAHIWSLCD TKDCGKLSKD QFALAFHLIS QKLIKGIDPP 
HVLTPEMIPP SDRASLQKNI IGSSPVADFS AIKELDTLNN EIVDLQREKN NVEQDLKEKE 
DTIKQRTSEV QDLQDEVQRE NTNLQKLQAQ KQQVQELLDE LDEQKAQLEE QLKEVRKKCA 
EEAQLISSLK AELTSQESQI STYEEELAKA REELSRLQQE TAELEESVES GKAQLEPLQQ 
HLQDSQQEIS SMQMKLMEMK DLENHNSQLN WCSSPHSILV NGATDYCSLS TSSSETANLN 
EHVEGQSNLE SEPIHQESPA RSSPELLPSG VTDENEVTTA VTEKVCSELD NNRHSKEEDP 
FNVDSSSLTG PVADTNLDFF QSDPFVGSDP FKDDPFGKID PFGGDPFKGS DPFASDCFFR 
QSTDPFATSS TDPFSAANNS SITSVETLKH NDPFAPGGTV VAASDSATDP FASVFGNESF 
GGGFADFSTL SKVNNEDPFR SATSSSVSNV VITKNVFEET SVKSEDEPPA LPPKIGTPTR 
PCPLPPGKRS INKLDSPDPF KLNDPFQPFP GNDSPKEKDP EIFCDPFTSA TTTTNKEADP 
SNFANFSAYP SEEDMIEWAK RESEREEEQR LARLNQQEQE DLELAIALSK SEISEA

Genular Protein ID: 1838165190

Symbol: B7Z240_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z240

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1

Sequence Information:

  • Length: 573
  • Mass: 63622
  • Checksum: 7C74EA492335003C
  • Sequence:
    • MILMVRDCLK SQHRDPHCDP SDKREKNNVE QDLKEKEDTI KQRTSEVQDL QDEVQRENTN 
LQKLQAQKQQ VQELLDELDE QKAQLEEQLK EVRKKCAEEA QLISSLKAEL TSQESQISTY 
EEELAKAREE LSRLQQETAE LEESVESGKA QLEPLQQHLQ DSQQEISSMQ MKLMEMKDLE 
NHNSQLNWCS SPHSILVNGA TDYCSLSTSS SETANLNEHV EGQSNLESEP IHQESPARSS 
PELLPSGVTD ENEVTTAVTE KVCSELDNNR HSKEEDPFNV DSSSLTGPVA DTNLDFFQSD 
PFVGSDPFKD DPFGKIDPFG GDPFKGSDPF ASDCFFRQST DPFATSSTDP FSAANNSSIT 
SVETLKHNDP FAPGGTVVAA SDSATDPFAS VFGNESFGGG FADFSTLSKV NNEDPFRSAT 
SSSVSNVVIT KNVFEETSVK SEDEPPALPP KIGTPTRPCP LPPGKRSINK LDSPDPFKLN 
DPFQPFPGND SPKEIDPEIF CDPFTSATTT TNKEADPSNF ANFSAYPSEE DMIEWAKRES 
EREEEQRLAR LNQQEQEDLE LAIALSKSEI SEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.