Details for: EPS15
Gene ID: 2060
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EPS15
Ensembl ID: ENSG00000085832
Description: epidermal growth factor receptor pathway substrate 15
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 31.29rCSI 59.06%PRS 61.11
-
CSI 31.28rCSI 23.35%PRS 68.68
-
CSI 24.83rCSI 54.86%PRS 38.1
-
CSI 22.46rCSI 32.23%PRS 41.2
-
CSI 21.87rCSI 57.02%PRS 49.7
-
CSI 21.46rCSI 33.16%PRS 48.47
-
CSI 17.82rCSI 20.88%PRS 66.89
-
CSI 17.73rCSI 31.24%PRS 48.25
-
CSI 16.46rCSI 40.01%PRS 32.8
-
CSI 16.13rCSI 60.94%PRS 34.76
-
CSI 13.66rCSI 17.61%PRS 34.97
-
CSI 13.46rCSI 18.4%PRS 53.04
-
CSI 12.64rCSI 15.73%PRS 32.24
-
CSI 11.49rCSI 15.73%PRS 45.85
-
CSI 11.37rCSI 35.53%PRS 35.31
-
CSI 11.3rCSI 13.53%PRS 69.43
-
CSI 11.05rCSI 22.92%PRS 48.13
-
CSI 10.95rCSI 21.74%PRS 49.15
-
CSI 10.77rCSI 63.42%PRS 35.34
-
CSI 10.68rCSI 32.92%PRS 61.28
-
CSI 10.46rCSI 22.92%PRS 59.96
-
CSI 10.45rCSI 23.42%PRS 34.71
-
CSI 10.29rCSI 7.7%PRS 65.86
-
CSI 10rCSI 41.18%PRS 65.19
-
CSI 9.96rCSI 7.48%PRS 54.86
-
CSI 9.46rCSI 11.78%PRS 61.88
-
CSI 9.28rCSI 27.44%PRS 39.41
-
CSI 8.88rCSI 7.81%PRS 39.33
-
CSI 8.8rCSI 12.69%PRS 60.57
-
CSI 8.73rCSI 32.72%PRS 43.15
-
CSI 8.17rCSI 11.35%PRS 50.04
-
CSI 8.13rCSI 7.22%PRS 49.17
-
CSI 7.91rCSI 12.62%PRS 44.17
-
CSI 7.8rCSI 7.2%PRS 51.58
-
CSI 7.56rCSI 61.51%PRS 44.36
-
CSI 7.44rCSI 5.18%PRS 64.55
-
CSI 6.33rCSI 9.03%PRS 53.14
-
CSI 6.14rCSI 7.89%PRS 45.05
-
CSI 5.96rCSI 7.64%PRS 55.44
-
CSI 5.88rCSI 7.87%PRS 59.24
-
CSI 5.85rCSI 4.42%PRS 64.09
-
CSI 5.29rCSI 13.67%PRS 46.3
-
CSI 5.21rCSI 18.76%PRS 32.67
-
CSI 5.15rCSI 3.58%PRS 60.53
-
CSI 5.1rCSI 6.13%PRS 48.6
-
CSI 5.1rCSI 5.59%PRS 54.32
-
CSI 4.94rCSI 9.25%PRS 39.79
-
CSI 4.86rCSI 8.59%PRS 32.98
-
CSI 4.8rCSI 26.23%PRS 51.46
-
CSI 4.79rCSI 12.61%PRS 72
-
CSI 4.72rCSI 3.67%PRS 68.68
-
CSI 4.47rCSI 10.31%PRS 41.19
-
CSI 4.47rCSI 8.52%PRS 67.15
-
CSI 4.42rCSI 3.41%PRS 49.91
-
CSI 4.38rCSI 10.83%PRS 48.53
-
CSI 4.37rCSI 14.05%PRS 49.5
-
CSI 4.34rCSI 5.26%PRS 42.86
-
CSI 4.34rCSI 6.77%PRS 77.25
-
CSI 4.33rCSI 8.69%PRS 40.15
-
CSI 4.25rCSI 3.4%PRS 72.38
-
CSI 4.21rCSI 7.29%PRS 41.04
-
CSI 4.16rCSI 4.31%PRS 56.57
-
CSI 4.16rCSI 5.45%PRS 64.34
-
CSI 4.15rCSI 3.44%PRS 52.09
-
CSI 4.12rCSI 3.62%PRS 55.98
-
CSI 4.12rCSI 9.12%PRS 48.23
-
CSI 4.08rCSI 3.22%PRS 37.95
-
CSI 4.05rCSI 6.57%PRS 48.5
-
CSI 3.91rCSI 3.76%PRS 74.45
-
CSI 3.86rCSI 2.94%PRS 62.97
-
CSI 3.85rCSI 6.35%PRS 56.18
-
CSI 3.85rCSI 15.5%PRS 58.93
-
CSI 3.84rCSI 3.96%PRS 68.69
-
CSI 3.78rCSI 9.83%PRS 55.09
-
CSI 3.78rCSI 5.8%PRS 58.46
-
CSI 3.77rCSI 10.08%PRS 42.65
-
CSI 3.77rCSI 6.06%PRS 36.01
-
CSI 3.77rCSI 76.75%PRS 42.25
-
CSI 3.74rCSI 3.22%PRS 57.9
-
CSI 3.71rCSI 5.07%PRS 55.89
-
CSI 3.7rCSI 6.33%PRS 76.52
-
CSI 3.68rCSI 74.96%PRS 43.6
-
CSI 3.66rCSI 18.34%PRS 62.52
-
CSI 3.5rCSI 3.07%PRS 60.68
-
CSI 3.5rCSI 18.85%PRS 65.33
-
CSI 3.42rCSI 8.16%PRS 52.09
-
CSI 3.41rCSI 3.13%PRS 58.91
-
CSI 3.39rCSI 48.18%PRS 42.31
-
CSI 3.39rCSI 13.12%PRS 67.34
-
CSI 3.39rCSI 4.96%PRS 54.06
-
CSI 3.35rCSI 13.03%PRS 58.19
-
CSI 3.35rCSI 4%PRS 33.81
-
CSI 3.29rCSI 4.49%PRS 43.47
-
CSI 3.29rCSI 2.82%PRS 58.51
-
CSI 3.25rCSI 4.14%PRS 56.47
-
CSI 3.21rCSI 17.96%PRS 60.82
-
CSI 3.18rCSI 6.54%PRS 43.28
-
CSI 3.16rCSI 4.83%PRS 60.06
-
CSI 3.16rCSI 2.27%PRS 64.37
-
CSI 3.13rCSI 12.22%PRS 27.37
-
CSI 0.1rCSI 1.6%PRS 66.0%
-
CSI 0.1rCSI 0.8%PRS 61.9%
-
CSI 0.2rCSI 1.4%PRS 61.1%
-
CSI 0.3rCSI 4.1%PRS 55.1%
-
CSI 0.3rCSI 1.7%PRS 61.3%
-
CSI 0.3rCSI 3.3%PRS 50.4%
-
CSI 0.4rCSI 2.0%PRS 49.1%
-
CSI 0.5rCSI 7.3%PRS 80.5%
-
CSI 0.5rCSI 2.7%PRS 63.5%
-
CSI 0.5rCSI 3.3%PRS 42.9%
-
CSI 0.5rCSI 3.3%PRS 73.5%
-
CSI 0.6rCSI 2.3%PRS 69.0%
-
CSI 0.6rCSI 1.4%PRS 55.8%
-
CSI 0.6rCSI 4.5%PRS 42.6%
-
CSI 0.7rCSI 2.6%PRS 71.3%
-
CSI 0.7rCSI 1.7%PRS 45.9%
-
CSI 0.7rCSI 1.0%PRS 68.0%
-
CSI 0.7rCSI 3.6%PRS 74.1%
-
CSI 0.7rCSI 2.3%PRS 38.8%
-
CSI 0.7rCSI 2.8%PRS 51.3%
-
CSI 0.7rCSI 3.4%PRS 72.1%
-
CSI 0.8rCSI 3.3%PRS 47.8%
-
CSI 0.8rCSI 3.9%PRS 62.3%
-
CSI 0.8rCSI 1.6%PRS 52.9%
-
CSI 0.8rCSI 2.2%PRS 63.9%
-
CSI 0.8rCSI 2.4%PRS 52.8%
-
CSI 0.8rCSI 0.7%PRS 55.0%
-
CSI 0.8rCSI 7.3%PRS 50.0%
-
CSI 0.9rCSI 1.3%PRS 47.2%
-
CSI 0.9rCSI 3.5%PRS 65.7%
-
CSI 0.9rCSI 4.6%PRS 57.4%
-
CSI 0.9rCSI 0.6%PRS 62.4%
-
CSI 0.9rCSI 5.1%PRS 65.2%
-
CSI 1.0rCSI 2.0%PRS 55.0%
-
CSI 1.0rCSI 2.6%PRS 59.1%
-
CSI 1.0rCSI 1.2%PRS 58.8%
-
CSI 1.0rCSI 1.5%PRS 55.4%
-
CSI 1.0rCSI 4.4%PRS 49.7%
-
CSI 1.0rCSI 2.0%PRS 69.1%
-
CSI 1.0rCSI 2.9%PRS 77.2%
-
CSI 1.0rCSI 0.9%PRS 55.7%
-
CSI 1.0rCSI 2.7%PRS 49.3%
-
CSI 1.0rCSI 2.2%PRS 40.0%
-
CSI 1.0rCSI 24.9%PRS 34.3%
-
CSI 1.0rCSI 3.1%PRS 71.7%
-
CSI 1.1rCSI 1.0%PRS 41.2%
-
CSI 1.1rCSI 2.8%PRS 80.1%
-
CSI 1.1rCSI 0.9%PRS 60.9%
-
CSI 1.1rCSI 4.3%PRS 62.0%
-
CSI 1.1rCSI 1.5%PRS 58.3%
-
CSI 1.1rCSI 3.9%PRS 70.5%
-
CSI 1.1rCSI 3.6%PRS 80.8%
-
CSI 1.1rCSI 1.5%PRS 60.0%
-
CSI 1.1rCSI 4.4%PRS 42.8%
-
CSI 1.2rCSI 2.4%PRS 70.5%
-
CSI 1.2rCSI 2.0%PRS 70.8%
-
CSI 1.2rCSI 4.1%PRS 40.9%
-
CSI 1.2rCSI 2.6%PRS 64.9%
-
CSI 1.2rCSI 2.1%PRS 58.9%
-
CSI 1.2rCSI 2.9%PRS 60.2%
-
CSI 1.2rCSI 4.1%PRS 37.6%
-
CSI 1.2rCSI 5.0%PRS 49.0%
-
CSI 1.2rCSI 2.8%PRS 57.7%
-
CSI 1.3rCSI 5.9%PRS 68.0%
-
CSI 1.3rCSI 2.0%PRS 59.4%
-
CSI 1.3rCSI 3.1%PRS 39.1%
-
CSI 1.3rCSI 31.1%PRS 33.4%
-
CSI 1.3rCSI 1.0%PRS 73.2%
-
CSI 1.3rCSI 3.7%PRS 49.2%
-
CSI 1.3rCSI 4.3%PRS 52.0%
-
CSI 1.3rCSI 2.2%PRS 40.6%
-
CSI 1.3rCSI 2.2%PRS 40.9%
-
CSI 1.4rCSI 1.7%PRS 64.0%
-
CSI 1.4rCSI 1.5%PRS 53.9%
-
CSI 1.4rCSI 2.1%PRS 56.1%
-
CSI 1.4rCSI 10.3%PRS 52.6%
-
CSI 1.5rCSI 3.3%PRS 54.8%
-
CSI 1.5rCSI 2.4%PRS 43.2%
-
CSI 1.5rCSI 3.9%PRS 57.4%
-
CSI 1.6rCSI 7.4%PRS 49.5%
-
CSI 1.6rCSI 4.4%PRS 69.6%
-
CSI 1.6rCSI 1.7%PRS 48.9%
-
CSI 1.6rCSI 7.5%PRS 50.6%
-
CSI 1.6rCSI 4.4%PRS 64.4%
-
CSI 1.6rCSI 1.8%PRS 60.2%
-
CSI 1.6rCSI 3.8%PRS 61.7%
-
CSI 1.6rCSI 3.6%PRS 56.0%
-
CSI 1.6rCSI 4.1%PRS 59.0%
-
CSI 1.6rCSI 3.9%PRS 64.6%
-
CSI 1.6rCSI 1.9%PRS 40.6%
-
CSI 1.6rCSI 2.6%PRS 61.6%
-
CSI 1.6rCSI 38.1%PRS 72.7%
-
CSI 1.6rCSI 12.3%PRS 69.5%
-
CSI 1.7rCSI 3.2%PRS 83.1%
-
CSI 1.7rCSI 4.6%PRS 46.7%
-
CSI 1.7rCSI 4.5%PRS 41.7%
-
CSI 1.8rCSI 3.1%PRS 49.2%
-
CSI 1.8rCSI 1.8%PRS 47.6%
-
CSI 1.8rCSI 2.4%PRS 56.0%
-
CSI 1.8rCSI 3.5%PRS 70.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2393200955
Symbol: EPS15_HUMAN
Name: Epidermal growth factor receptor substrate 15
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8183552
Title: The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.
PubMed ID: 8183552
PubMed ID: 8134107
Title: A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.
PubMed ID: 8134107
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 8662907
Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
PubMed ID: 8662907
PubMed ID: 9723620
Title: Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.
PubMed ID: 9723620
DOI: 10.1038/29555
PubMed ID: 10393179
Title: Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors.
PubMed ID: 10393179
PubMed ID: 12551915
Title: STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.
PubMed ID: 12551915
PubMed ID: 16325581
Title: TTP specifically regulates the internalization of the transferrin receptor.
PubMed ID: 16325581
PubMed ID: 16159959
Title: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.
PubMed ID: 16159959
DOI: 10.1242/jcs.02571
PubMed ID: 16314522
Title: Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
PubMed ID: 16314522
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18362181
Title: An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.
PubMed ID: 18362181
PubMed ID: 18088087
PubMed ID: 18199683
Title: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
PubMed ID: 18199683
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19458185
Title: Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits.
PubMed ID: 19458185
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 20448150
Title: FCHo proteins are nucleators of clathrin-mediated endocytosis.
PubMed ID: 20448150
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21762413
Title: Characterization of the EFC/F-BAR domain protein, FCHO2.
PubMed ID: 21762413
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22648170
Title: The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis.
PubMed ID: 22648170
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22484487
Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
PubMed ID: 22484487
DOI: 10.1038/ncb2473
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24768539
Title: K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking.
PubMed ID: 24768539
PubMed ID: 27670116
Title: NPF motifs in the vaccinia virus protein A36 recruit intersectin-1 to promote Cdc42:N-WASP-mediated viral release from infected cells.
PubMed ID: 27670116
PubMed ID: 9721102
Title: Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain.
PubMed ID: 9721102
PubMed ID: 10757979
Title: Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites.
PubMed ID: 10757979
DOI: 10.1021/bi9927383
PubMed ID: 11062555
PubMed ID: 16903783
Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
PubMed ID: 16903783
PubMed ID: 18200045
Title: Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.
PubMed ID: 18200045
PubMed ID: 26822536
Title: Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 mu homology domain.
PubMed ID: 26822536
DOI: 10.1038/srep19565
Sequence Information:
- Length: 896
- Mass: 98656
- Checksum: A1B9FE15B47ABAFF
- Sequence:
MAAAAQLSLT QLSSGNPVYE KYYRQVDTGN TGRVLASDAA AFLKKSGLPD LILGKIWDLA DTDGKGILNK QEFFVALRLV ACAQNGLEVS LSSLNLAVPP PRFHDTSSPL LISGTSAAEL PWAVKPEDKA KYDAIFDSLS PVNGFLSGDK VKPVLLNSKL PVDILGRVWE LSDIDHDGML DRDEFAVAMF LVYCALEKEP VPMSLPPALV PPSKRKTWVV SPAEKAKYDE IFLKTDKDMD GFVSGLEVRE IFLKTGLPST LLAHIWSLCD TKDCGKLSKD QFALAFHLIS QKLIKGIDPP HVLTPEMIPP SDRASLQKNI IGSSPVADFS AIKELDTLNN EIVDLQREKN NVEQDLKEKE DTIKQRTSEV QDLQDEVQRE NTNLQKLQAQ KQQVQELLDE LDEQKAQLEE QLKEVRKKCA EEAQLISSLK AELTSQESQI STYEEELAKA REELSRLQQE TAELEESVES GKAQLEPLQQ HLQDSQQEIS SMQMKLMEMK DLENHNSQLN WCSSPHSILV NGATDYCSLS TSSSETANLN EHVEGQSNLE SEPIHQESPA RSSPELLPSG VTDENEVTTA VTEKVCSELD NNRHSKEEDP FNVDSSSLTG PVADTNLDFF QSDPFVGSDP FKDDPFGKID PFGGDPFKGS DPFASDCFFR QSTDPFATSS TDPFSAANNS SITSVETLKH NDPFAPGGTV VAASDSATDP FASVFGNESF GGGFADFSTL SKVNNEDPFR SATSSSVSNV VITKNVFEET SVKSEDEPPA LPPKIGTPTR PCPLPPGKRS INKLDSPDPF KLNDPFQPFP GNDSPKEKDP EIFCDPFTSA TTTTNKEADP SNFANFSAYP SEEDMIEWAK RESEREEEQR LARLNQQEQE DLELAIALSK SEISEA
Genular Protein ID: 1838165190
Symbol: B7Z240_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 573
- Mass: 63622
- Checksum: 7C74EA492335003C
- Sequence:
MILMVRDCLK SQHRDPHCDP SDKREKNNVE QDLKEKEDTI KQRTSEVQDL QDEVQRENTN LQKLQAQKQQ VQELLDELDE QKAQLEEQLK EVRKKCAEEA QLISSLKAEL TSQESQISTY EEELAKAREE LSRLQQETAE LEESVESGKA QLEPLQQHLQ DSQQEISSMQ MKLMEMKDLE NHNSQLNWCS SPHSILVNGA TDYCSLSTSS SETANLNEHV EGQSNLESEP IHQESPARSS PELLPSGVTD ENEVTTAVTE KVCSELDNNR HSKEEDPFNV DSSSLTGPVA DTNLDFFQSD PFVGSDPFKD DPFGKIDPFG GDPFKGSDPF ASDCFFRQST DPFATSSTDP FSAANNSSIT SVETLKHNDP FAPGGTVVAA SDSATDPFAS VFGNESFGGG FADFSTLSKV NNEDPFRSAT SSSVSNVVIT KNVFEETSVK SEDEPPALPP KIGTPTRPCP LPPGKRSINK LDSPDPFKLN DPFQPFPGND SPKEIDPEIF CDPFTSATTT TNKEADPSNF ANFSAYPSEE DMIEWAKRES EREEEQRLAR LNQQEQEDLE LAIALSKSEI SEA