Details for: ETV3

Gene ID: 2117

Symbol: ETV3

Ensembl ID: ENSG00000117036

Description: ETS variant transcription factor 3

Associated with

  • Biological_process
    (GO:0008150)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to granulocyte macrophage colony-stimulating factor stimulus
    (GO:0097011)
  • Chromatin
    (GO:0000785)
  • Dead/h-box rna helicase binding
    (GO:0017151)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Rna polymerase ii transcription repressor complex
    (GO:0090571)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.55
    Marker Score: 2281.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.35
    Marker Score: 1423
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.17
    Marker Score: 2051
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71721
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47945.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.99
    Marker Score: 672
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.95
    Marker Score: 1046
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2702
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5237
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.86
    Marker Score: 307.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4818
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.84
    Marker Score: 774
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.84
    Marker Score: 284
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1674
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.76
    Marker Score: 598
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.73
    Marker Score: 504
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.73
    Marker Score: 24839
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.73
    Marker Score: 936
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.7
    Marker Score: 1710.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.68
    Marker Score: 583
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.68
    Marker Score: 457
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.68
    Marker Score: 5987
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2813.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.66
    Marker Score: 645.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.66
    Marker Score: 1707
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 394
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.65
    Marker Score: 324
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.64
    Marker Score: 656
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.64
    Marker Score: 35891.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 781
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 398
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.62
    Marker Score: 154
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.62
    Marker Score: 5326
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.61
    Marker Score: 649
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.61
    Marker Score: 2248
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.61
    Marker Score: 1702.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6
    Marker Score: 596
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.59
    Marker Score: 407
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.58
    Marker Score: 635
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.58
    Marker Score: 368
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.58
    Marker Score: 330
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.57
    Marker Score: 178
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.57
    Marker Score: 633
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.56
    Marker Score: 646
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 372
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 264
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.54
    Marker Score: 1084
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.54
    Marker Score: 411
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.53
    Marker Score: 1683
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.53
    Marker Score: 731
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.53
    Marker Score: 356
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.52
    Marker Score: 516
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.52
    Marker Score: 3870
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.51
    Marker Score: 443
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3058
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.51
    Marker Score: 115
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.5
    Marker Score: 719
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.5
    Marker Score: 257
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.5
    Marker Score: 4939
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.5
    Marker Score: 601
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.5
    Marker Score: 108
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.5
    Marker Score: 904
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.49
    Marker Score: 1693
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.49
    Marker Score: 593
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.49
    Marker Score: 25909
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.49
    Marker Score: 96
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.49
    Marker Score: 754
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.49
    Marker Score: 117
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.49
    Marker Score: 570
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.49
    Marker Score: 116
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.48
    Marker Score: 322
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.48
    Marker Score: 411
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.48
    Marker Score: 108
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.48
    Marker Score: 120
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.48
    Marker Score: 4954.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.48
    Marker Score: 218
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.48
    Marker Score: 1977
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.48
    Marker Score: 198
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.48
    Marker Score: 121
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.47
    Marker Score: 221
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.47
    Marker Score: 125
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.47
    Marker Score: 112
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.47
    Marker Score: 28807

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Other Information

**Key characteristics:** * ETV3 is a protein of approximately 170 kDa. * It is a member of the ETS family of transcription factors. * It is expressed in a variety of cell types. * It is involved in cell differentiation, proliferation, and apoptosis. **Pathways and functions:** * ETV3 is involved in the regulation of cell differentiation. * It is expressed in neural stem cells and plays a role in the specification of neural cell fate. * It is also expressed in various cell types, including epithelial cells, and is involved in their differentiation into specific cell types. * ETV3 is a key regulator of epithelial cell proliferation and survival. **Clinical significance:** Mutations in the ETV3 gene have been linked to a number of human diseases, including cancer and developmental disorders. This gene is a potential target for cancer therapy, as it is often overexpressed in cancer cells. **Additional information:** * ETV3 is a transcription factor that is highly conserved across species. * It is a key regulator of cell proliferation and survival. * It is a target for cancer therapy.

Genular Protein ID: 870019562

Symbol: ETV3_HUMAN

Name: ETS translocation variant 3

UniProtKB Accession Codes:

P41162 B4E3M7 Q8TAC8 Q9BX30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12007404

Title: An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.

PubMed ID: 12007404

DOI: 10.1016/s0092-8674(02)00714-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020980

Title: PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23.

PubMed ID: 8020980

DOI: 10.1006/geno.1994.1169

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 512
  • Mass: 57001
  • Checksum: 3E50323BF9910062
  • Sequence:
    • MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF RHVIAWQQGE 
YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK RILHKTKGKR FTYKFNFNKL 
VMPNYPFINI RSSGVVPQSA PPVPTASSRF HFPPLDTHSP TNDVQPGRFS ASSLTASGQE 
SSNGTDRKTE LSELEDGSAA DWRRGVDPVS SRNAIGGGGI GHQKRKPDIM LPLFARPGMY 
PDPHSPFAVS PIPGRGGVLN VPISPALSLT PTIFSYSPSP GLSPFTSSSC FSFNPEEMKH 
YLHSQACSVF NYHLSPRTFP RYPGLMVPPL QCQMHPEEST QFSIKLQPPP VGRKNRERVE 
SSEESAPVTT PTMASIPPRI KVEPASEKDP ESLRQSAREK EEHTQEEGTV PSRTIEEEKG 
TIFARPAAPP IWPSVPISTP SGEPLEVTED SEDRPGKEPS APEKKEDALM PPKLRLKRRW 
NDDPEARELS KSGKFLWNGS GPQGLATAAA DA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.