Details for: ETV3

Gene ID: 2117

Symbol: ETV3

Ensembl ID: ENSG00000117036

Description: ETS variant transcription factor 3

Associated with

  • Biological_process
    (GO:0008150)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to granulocyte macrophage colony-stimulating factor stimulus
    (GO:0097011)
  • Chromatin
    (GO:0000785)
  • Dead/h-box rna helicase binding
    (GO:0017151)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Rna polymerase ii transcription repressor complex
    (GO:0090571)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 127.9371
    Cell Significance Index: -19.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.8689
    Cell Significance Index: -18.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.6085
    Cell Significance Index: -21.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.3962
    Cell Significance Index: -17.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.4818
    Cell Significance Index: -21.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6647
    Cell Significance Index: -17.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.5821
    Cell Significance Index: -20.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7402
    Cell Significance Index: -20.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2305
    Cell Significance Index: -20.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0502
    Cell Significance Index: -12.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9452
    Cell Significance Index: 101.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.9091
    Cell Significance Index: 31.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9826
    Cell Significance Index: 114.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9428
    Cell Significance Index: 27.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9059
    Cell Significance Index: 89.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7978
    Cell Significance Index: 720.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7547
    Cell Significance Index: 16.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6520
    Cell Significance Index: 17.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6341
    Cell Significance Index: 28.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5883
    Cell Significance Index: 72.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5571
    Cell Significance Index: 29.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5130
    Cell Significance Index: 92.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5122
    Cell Significance Index: 83.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4561
    Cell Significance Index: 4.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4271
    Cell Significance Index: 6.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2972
    Cell Significance Index: 131.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2880
    Cell Significance Index: 57.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2815
    Cell Significance Index: 8.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2793
    Cell Significance Index: 55.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2049
    Cell Significance Index: 7.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1747
    Cell Significance Index: 8.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1655
    Cell Significance Index: 2.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1456
    Cell Significance Index: 27.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1397
    Cell Significance Index: 3.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1386
    Cell Significance Index: 75.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1374
    Cell Significance Index: 9.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1363
    Cell Significance Index: 3.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0865
    Cell Significance Index: 6.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0802
    Cell Significance Index: 28.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0754
    Cell Significance Index: 10.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0718
    Cell Significance Index: 49.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0555
    Cell Significance Index: 7.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0392
    Cell Significance Index: 1.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0352
    Cell Significance Index: 1.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0287
    Cell Significance Index: 0.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0141
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0055
    Cell Significance Index: -10.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0118
    Cell Significance Index: -21.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0168
    Cell Significance Index: -22.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0212
    Cell Significance Index: -16.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0214
    Cell Significance Index: -15.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0240
    Cell Significance Index: -17.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0291
    Cell Significance Index: -1.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0311
    Cell Significance Index: -14.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0383
    Cell Significance Index: -21.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0419
    Cell Significance Index: -26.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0518
    Cell Significance Index: -14.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0556
    Cell Significance Index: -5.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0579
    Cell Significance Index: -0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0599
    Cell Significance Index: -7.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0660
    Cell Significance Index: -9.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0695
    Cell Significance Index: -8.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0748
    Cell Significance Index: -12.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0866
    Cell Significance Index: -5.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0903
    Cell Significance Index: -5.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0992
    Cell Significance Index: -7.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1002
    Cell Significance Index: -11.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1117
    Cell Significance Index: -23.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1242
    Cell Significance Index: -6.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1264
    Cell Significance Index: -3.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1448
    Cell Significance Index: -10.7900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1883
    Cell Significance Index: -1.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1907
    Cell Significance Index: -19.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1910
    Cell Significance Index: -11.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1950
    Cell Significance Index: -11.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2217
    Cell Significance Index: -11.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2259
    Cell Significance Index: -1.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2278
    Cell Significance Index: -5.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2319
    Cell Significance Index: -18.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2379
    Cell Significance Index: -4.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2381
    Cell Significance Index: -2.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2602
    Cell Significance Index: -11.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2966
    Cell Significance Index: -15.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3011
    Cell Significance Index: -11.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3176
    Cell Significance Index: -2.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3260
    Cell Significance Index: -8.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3367
    Cell Significance Index: -5.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3505
    Cell Significance Index: -12.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3558
    Cell Significance Index: -8.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3592
    Cell Significance Index: -10.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3708
    Cell Significance Index: -9.2700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4013
    Cell Significance Index: -5.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4037
    Cell Significance Index: -7.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4064
    Cell Significance Index: -6.5200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4180
    Cell Significance Index: -5.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4481
    Cell Significance Index: -16.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4684
    Cell Significance Index: -16.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4726
    Cell Significance Index: -13.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional Transcription Factor:** ETV3 is a transcription factor that regulates gene expression by interacting with RNA polymerase II and other transcriptional regulatory proteins. 2. **Cell-Specific Expression:** ETV3 is highly expressed in bladder urothelial cells, conjunctival epithelial cells, germ cells, and neural tissues, indicating its involvement in specific cellular processes. 3. **Chromatin Remodeling:** ETV3 interacts with chromatin remodeling complexes, influencing chromatin structure and gene expression. 4. **Regulation of Transcription:** ETV3 regulates transcription by binding to specific DNA sequences, influencing the recruitment of RNA polymerase II and other transcriptional regulatory proteins. 5. **Negative Regulation of Cell Proliferation:** ETV3 is involved in the negative regulation of cell proliferation, suggesting its role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Cell Differentiation:** ETV3 regulates cellular differentiation by controlling the expression of genes involved in cell fate specification and differentiation. 2. **Chromatin Remodeling:** ETV3 interacts with chromatin remodeling complexes, influencing chromatin structure and gene expression. 3. **Transcriptional Regulation:** ETV3 regulates transcription by binding to specific DNA sequences, influencing the recruitment of RNA polymerase II and other transcriptional regulatory proteins. 4. **Response to Environmental Stimuli:** ETV3 is involved in the response to environmental stimuli, such as granulocyte macrophage colony-stimulating factor (GM-CSF), influencing cellular behavior and gene expression. 5. **Negative Regulation of Cell Proliferation:** ETV3 is involved in the negative regulation of cell proliferation, suggesting its role in maintaining cellular homeostasis. **Clinical Significance:** 1. **Cancer Association:** ETV3 has been implicated in various cancers, including bladder cancer, where it is often overexpressed and associated with poor prognosis. 2. **Neurological Disorders:** ETV3's role in neuronal development and function has been linked to neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Inflammatory Diseases:** ETV3's involvement in the response to environmental stimuli has been implicated in inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 4. **Regulatory Functions:** ETV3's regulatory functions in cellular differentiation, transcriptional regulation, and chromatin remodeling make it a potential target for therapeutic interventions in various diseases. In conclusion, ETV3 is a multifaceted gene involved in cellular differentiation, regulation, and response to environmental stimuli. Its clinical significance is underscored by its association with various diseases, including cancer, neurological disorders, and inflammatory diseases. Further research is needed to fully elucidate ETV3's role in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 870019562

Symbol: ETV3_HUMAN

Name: ETS translocation variant 3

UniProtKB Accession Codes:

P41162 B4E3M7 Q8TAC8 Q9BX30

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12007404

Title: An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.

PubMed ID: 12007404

DOI: 10.1016/s0092-8674(02)00714-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020980

Title: PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23.

PubMed ID: 8020980

DOI: 10.1006/geno.1994.1169

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 512
  • Mass: 57001
  • Checksum: 3E50323BF9910062
  • Sequence:
    • MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF RHVIAWQQGE 
YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK RILHKTKGKR FTYKFNFNKL 
VMPNYPFINI RSSGVVPQSA PPVPTASSRF HFPPLDTHSP TNDVQPGRFS ASSLTASGQE 
SSNGTDRKTE LSELEDGSAA DWRRGVDPVS SRNAIGGGGI GHQKRKPDIM LPLFARPGMY 
PDPHSPFAVS PIPGRGGVLN VPISPALSLT PTIFSYSPSP GLSPFTSSSC FSFNPEEMKH 
YLHSQACSVF NYHLSPRTFP RYPGLMVPPL QCQMHPEEST QFSIKLQPPP VGRKNRERVE 
SSEESAPVTT PTMASIPPRI KVEPASEKDP ESLRQSAREK EEHTQEEGTV PSRTIEEEKG 
TIFARPAAPP IWPSVPISTP SGEPLEVTED SEDRPGKEPS APEKKEDALM PPKLRLKRRW 
NDDPEARELS KSGKFLWNGS GPQGLATAAA DA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.